Gene: TM6SF2

53345
-
transmembrane 6 superfamily member 2
protein-coding
19p13.11
Ensembl:ENSG00000213996 MIM:606563 Vega:OTTHUMG00000182222 UniprotKB:Q9BZW4
NC_000019.10
PubMed
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.311e-1 (AD)  6.252e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TRIM450.631
NOXA10.622
IDUA0.621
NAA400.62
CCDC570.607
PGAP30.601
CRHR10.597
TTC21A0.596
VWA3A0.593
ADAMTS100.59

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C7orf61-0.387
HIST1H4E-0.373
MIA-0.339
CYP39A1-0.314
HIST1H2BJ-0.314
SLC27A6-0.303
OR4F5-0.295
HIST1H2AH-0.292
SHISA2-0.29
HIST1H2AG-0.285

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TM6SF2 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TM6SF2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TM6SF2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TM6SF2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TM6SF2 mRNA"25510870
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of TM6SF2 mRNA"18648102
D016604Aflatoxin B1Aflatoxin B1 affects the expression of TM6SF2 protein20106945
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of TM6SF2 mRNA21298039
C547126AZM551248AZM551248 results in decreased expression of TM6SF2 mRNA22323515
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of TM6SF2 mRNA23656968
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of TM6SF2 mRNA19737606
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TM6SF2 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to TM6SF2 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TM6SF2 mRNA22228805
D004958EstradiolEstradiol results in decreased expression of TM6SF2 mRNA20106945
C006780bisphenol Abisphenol A affects the expression of TM6SF2 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of TM6SF2 mRNA26079696
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of TM6SF2 mRNA28472532
C000541cyclopaminecyclopamine results in decreased expression of TM6SF2 mRNA22265815
D016572CyclosporineCyclosporine results in decreased expression of TM6SF2 mRNA20106945
D016572CyclosporineCyclosporine results in decreased expression of TM6SF2 mRNA19770486
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of TM6SF2 mRNA24317228
C016366dibenzothiophenedibenzothiophene results in decreased expression of TM6SF2 mRNA23656968
D005485FlutamideFlutamide results in decreased expression of TM6SF2 mRNA24793618
C412815GW 4064GW 4064 results in increased expression of TM6SF2 mRNA26655953
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of TM6SF2 mRNA"20188158
C568376MT19c compoundMT19c compound results in decreased expression of TM6SF2 mRNA21781307
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TM6SF2 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TM6SF2 mRNA"25620056
C028007nickel monoxidenickel monoxide results in decreased expression of TM6SF2 mRNA19167457
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TM6SF2 mRNA"25510870
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of TM6SF2 mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of TM6SF2 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of TM6SF2 mRNA19482888
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TM6SF2 mRNA19710929
D010936Plant ExtractsPlant Extracts results in decreased expression of TM6SF2 mRNA23557933
C089730rosiglitazonerosiglitazone results in decreased expression of TM6SF2 mRNA25572481
D012969Sodium FluorideSodium Fluoride results in increased expression of TM6SF2 mRNA27862939
D013629TamoxifenTamoxifen results in decreased expression of TM6SF2 mRNA25123088
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TM6SF2 mRNA21215274
D014635Valproic AcidValproic Acid results in increased methylation of TM6SF2 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TM6SF2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006629lipid metabolic process-IEA-  
GO:0019216regulation of lipid metabolic process-IDA24927523  
GO ID GO Term Qualifier Evidence PubMed
GO:0005789endoplasmic reticulum membrane-IDA24927523  
GO:0016021integral component of membrane-IEA-  
GO:0033116endoplasmic reticulum-Golgi intermediate compartment membrane-IDA24927523  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27575312The genetics of alcohol dependence and alcohol-related liver disease. (2017 Jan)Stickel FJ Hepatol
27235307Childhood predictors of adult fatty liver. The Cardiovascular Risk in Young Finns Study. (2016 Oct)Suomela EJ Hepatol
27627804Epicardial Adipose Tissue (EAT) Thickness Is Associated with Cardiovascular and Liver Damage in Nonalcoholic Fatty Liver Disease. (2016)Fracanzani ALPLoS One