Gene: PLCG1

5335
NCKAP3|PLC-II|PLC1|PLC148|PLCgamma1
phospholipase C gamma 1
protein-coding
20q12
Ensembl:ENSG00000124181 MIM:172420 Vega:OTTHUMG00000033082 UniprotKB:P19174
NC_000020.11
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.951e-1 (AD)  3.318e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AKT20.886
WDR60.883
MINK10.867
MED120.864
NUMA10.863
PLEC0.858
PLXNB20.858
LTBP30.856
CPSF70.855
MTMR30.855

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.659
OR4F29-0.642
CD8B-0.333
C9orf135-0.313
GZMK-0.308
SIM1-0.307
IAPP-0.304
PAGE4-0.304
CD3G-0.3
CCDC140-0.3

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of PLCG1 mRNA"26377693
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of PLCG1 protein"21705713
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of PLCG1 protein modified form"21705713
C0602291-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCG1 mRNA]"16714034
C0602291-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCG1 protein]"16714034
C0602031-stearoyl-2-arachidonoylphosphatidic acid1-stearoyl-2-arachidonoylphosphatidic acid results in increased activity of PLCG1 protein2001791
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PLCG1 mRNA"25510870
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of PLCG1 mRNA]16714034
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of PLCG1 protein]16714034
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of PLCG1 mRNA"20702594
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PLCG1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PLCG1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PLCG1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PLCG1 mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of PLCG1 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of PLCG1 mRNA"18648102
D000079AcetaldehydePLCG1 protein affects the reaction [EGF protein inhibits the reaction [Acetaldehyde affects the localization of OCLN protein]]17991733
D000079AcetaldehydePLCG1 protein affects the reaction [EGF protein inhibits the reaction [Acetaldehyde affects the localization of TJP1 protein]]17991733
D000082AcetaminophenAcetaminophen results in increased expression of PLCG1 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of PLCG1 mRNA17562736
D000181AcrylonitrileAcrylonitrile results in increased expression of PLCG1 protein12850505
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PLCG1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PLCG1 mRNA19770486
D000638AmiodaroneAmiodarone results in decreased expression of PLCG1 protein21224497
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PLCG1 mRNA16483693
D000643Ammonium ChlorideAmmonium Chloride results in decreased expression of PLCG1 protein16483693
C106407ampelopsinampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PLCG1 protein]21871475
C032456antimycinantimycin results in increased phosphorylation of PLCG1 protein19901985
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PLCG1 mRNA24449571
D001151ArsenicArsenic affects the methylation of PLCG1 gene25304211
D001194AsbestosAsbestos results in decreased expression of PLCG1 mRNA22398240
C058278atpenin A5atpenin A5 results in increased phosphorylation of PLCG1 protein19901985
C030233benzo(a)pyrene-1,6-quinone"benzo(a)pyrene-1,6-quinone results in increased phosphorylation of PLCG1 protein"19166869
C018003benzo(a)pyrene-3,6-quinone"benzo(a)pyrene-3,6-quinone results in increased phosphorylation of PLCG1 protein"19166869
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of PLCG1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene metabolite results in increased expression of PLCG1 mRNA26314263
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of PLCG1 gene25435355
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of PLCG1 mRNA26496021
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCG1 mRNA]16714034
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCG1 protein]16714034
C006780bisphenol Abisphenol A results in increased expression of PLCG1 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of PLCG1 mRNA12233820
C006780bisphenol Abisphenol A affects the expression of PLCG1 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of PLCG1 mRNA26496021
C013418bromfenacoumbromfenacoum results in increased expression of PLCG1 protein28903499
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PLCG1 mRNA12160620
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PLCG1 mRNA20360939
D002220CarbamazepineCarbamazepine affects the expression of PLCG1 mRNA24752500
D002259Carbonyl Cyanide p-TrifluoromethoxyphenylhydrazoneCarbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased phosphorylation of PLCG1 protein19901985
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PLCG1 mRNA20938992
C043561chrysinBCL2 protein inhibits the reaction [chrysin results in increased degradation of PLCG1 protein]16215670
C043561chrysinchrysin results in increased degradation of PLCG1 protein16215670
D002927CimetidineCimetidine inhibits the reaction [EGF protein results in increased phosphorylation of PLCG1 protein]17295779
D002994ClofibrateClofibrate results in decreased expression of PLCG1 mRNA23811191
C018021cobaltous chloridecobaltous chloride results in decreased expression of PLCG1 mRNA26314263
D003042CocaineCocaine affects the phosphorylation of PLCG1 protein17618281
C107676deguelindeguelin results in increased phosphorylation of PLCG1 protein19901985
C548688dehydroglyasperin Cdehydroglyasperin C inhibits the reaction [PDGFB protein results in increased phosphorylation of PLCG1 protein]23298457
D003907DexamethasoneDexamethasone results in decreased phosphorylation of PLCG1 protein8648096
D002945CisplatinCisplatin results in increased expression of PLCG1 mRNA27594783
D004008DiclofenacDiclofenac affects the expression of PLCG1 mRNA24752500
C000944dicrotophosdicrotophos results in increased expression of PLCG1 mRNA28302478
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PLCG1 mRNA20360939
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of PLCG1 mRNA"22485181
C025602dimyristoylphosphatidic aciddimyristoylphosphatidic acid results in increased activity of PLCG1 protein2001791
C034638dinitrophenyl-bovine serum albumindinitrophenyl-bovine serum albumin results in increased phosphorylation of PLCG1 protein7730640
C037657dioleoylphosphatidic aciddioleoylphosphatidic acid results in increased activity of PLCG1 protein2001791
C031599dipalmitoylphosphatidic acid"dipalmitoylphosphatidic acid inhibits the reaction [1,2-Dipalmitoylphosphatidylcholine results in decreased activity of PLCG1 protein]"2001791
C031599dipalmitoylphosphatidic aciddipalmitoylphosphatidic acid results in increased activity of PLCG1 protein2001791
D0150601,2-Dipalmitoylphosphatidylcholine"1,2-Dipalmitoylphosphatidylcholine results in decreased activity of PLCG1 protein"2001791
D0150601,2-Dipalmitoylphosphatidylcholine"dipalmitoylphosphatidic acid inhibits the reaction [1,2-Dipalmitoylphosphatidylcholine results in decreased activity of PLCG1 protein]"2001791
D000431Ethanol[Ethanol co-treated with sodium arsenite] results in increased localization of PLCG1 protein18182400
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of PLCG1 mRNA23649840
C049639evodiamineEGFR mutant form inhibits the reaction [evodiamine results in increased phosphorylation of PLCG1 protein]19854188
C049639evodiamineevodiamine results in increased phosphorylation of PLCG1 protein19854188
D005472FluorouracilPLCG1 protein results in decreased susceptibility to Fluorouracil17531112
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PLCG1 mRNA20938992
D005557FormaldehydeFormaldehyde results in increased expression of PLCG1 mRNA23649840
D019833Genistein[Genistein co-treated with Methoxychlor] results in decreased expression of PLCG1 mRNA21782745
D019833GenisteinGenistein results in decreased expression of PLCG1 mRNA21782745
C035054ginsenoside Rg1PLCG1 affects the reaction [ginsenoside Rg1 affects the phosphorylation of MAPK1 protein]22214447
C035054ginsenoside Rg1PLCG1 affects the reaction [ginsenoside Rg1 affects the phosphorylation of MAPK3 protein]22214447
C035054ginsenoside Rg1PLCG1 affects the reaction [ginsenoside Rg1 affects the phosphorylation of NFKBIA protein]22214447
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of PLCG1 mRNA22634610
D006534Heptachlor EpoxideHeptachlor Epoxide results in increased expression of PLCG1 protein11246134
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of PLCG1 mRNA17183730
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of PLCG1 protein21179406
D007099ImipramineImipramine promotes the reaction [NTRK2 protein binds to PLCG1 protein modified form]22396798
D007295Inositol PhosphatesPLCG1 protein mutant form results in increased chemical synthesis of Inositol Phosphates27542411
D007295Inositol PhosphatesPLCG1 protein results in increased chemical synthesis of Inositol Phosphates27542411
D007295Inositol Phosphates[RAC2 protein mutant form binds to and results in increased activity of PLCG1 protein mutant form] which results in increased chemical synthesis of Inositol Phosphates27542411
D007295Inositol Phosphates[RAC2 protein mutant form binds to and results in increased activity of PLCG1 protein] which results in increased chemical synthesis of Inositol Phosphates27542411
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PLCG1 mRNA25613284
C506002ircinin-1ircinin-1 results in increased cleavage of PLCG1 protein16163705
C544151jinfukangjinfukang results in increased expression of PLCG1 mRNA27392435
C482199lipopolysaccharide, E coli O55-B5"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of PLCG1 mRNA"20371263
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PLCG1 mRNA12057914
C480486malvidin-3-O-glucoside-4 vinylmalvidin-3-O-glucoside-4 vinyl inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PLCG1 protein]21871475
D008555MelittenMelitten results in decreased phosphorylation of PLCG1 protein17654254
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PLCG1 mRNA20938992
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in decreased expression of PLCG1 mRNA21782745
D008731MethoxychlorMethoxychlor results in decreased expression of PLCG1 mRNA21782745
C072239methyl jasmonatemethyl jasmonate metabolite promotes the reaction [TNFSF10 protein results in increased cleavage of PLCG1 protein]22079975
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of PLCG1 mRNA27544571
C030957methylmercury IImethylmercury II results in decreased expression of PLCG1 mRNA26314263
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PLCG1 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PLCG1 mRNA"20188158
D008777MethyltestosteroneMethyltestosterone results in decreased expression of PLCG1 mRNA29191790
C064769N-acetylsphingosineBCL2 protein inhibits the reaction [N-acetylsphingosine results in increased degradation of PLCG1 protein]16215670
C064769N-acetylsphingosineN-acetylsphingosine results in increased degradation of PLCG1 protein16215670
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PLCG1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PLCG1 mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of PLCG1 mRNA19167457
D009538NicotineNicotine results in increased phosphorylation of and results in increased activity of PLCG1 protein15138183
D009638Norepinephrine"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCG1 mRNA]"16714034
D009638Norepinephrine"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCG1 protein]"16714034
D009638Norepinephrine2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of PLCG1 mRNA]16714034
D009638Norepinephrine2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of PLCG1 protein]16714034
D009638Norepinephrinebisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCG1 mRNA]16714034
D009638Norepinephrinebisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCG1 protein]16714034
D009638NorepinephrineNorepinephrine results in increased activity of PLCG1 protein16714034
D009638NorepinephrineNorepinephrine results in increased expression of and results in increased activity of PLCG1 protein19225867
D009638NorepinephrineNorepinephrine results in increased expression of PLCG1 mRNA16714034|1922586
D009638NorepinephrineNorepinephrine results in increased expression of PLCG1 protein16714034
D009638NorepinephrinePrazosin inhibits the reaction [Norepinephrine results in increased expression of and results in increased activity of PLCG1 protein]19225867
D009638NorepinephrinePrazosin inhibits the reaction [Norepinephrine results in increased expression of PLCG1 mRNA]16714034|1922586
D009638NorepinephrinePrazosin inhibits the reaction [Norepinephrine results in increased expression of PLCG1 protein]16714034
C025589ochratoxin Aochratoxin A metabolite results in decreased expression of PLCG1 mRNA26314263
C025589ochratoxin Aochratoxin A results in decreased expression of PLCG1 mRNA26314263
D009840OligomycinsOligomycins results in increased phosphorylation of PLCG1 protein19901985
C029341oxophenylarsineoxophenylarsine affects the localization of PLCG1 protein9546377
C029341oxophenylarsineoxophenylarsine results in decreased phosphorylation of PLCG1 protein1325458|9281317
C029341oxophenylarsine[oxophenylarsine results in decreased phosphorylation of PLCG1 protein] inhibits the reaction [PLCG1 protein binds to GRB2 protein]9281317
D010100OxygenOxygen deficiency results in increased expression of PLCG1 mRNA17914565
D010100OxygenOxygen results in decreased expression of and affects the localization of PLCG1 protein12850505
D010126OzoneOzone results in decreased expression of PLCG1 mRNA16330353
C016030pantogabpantogab results in decreased expression of PLCG1 mRNA17379144
D010269ParaquatParaquat results in decreased expression of PLCG1 mRNA17077588
D010269ParaquatParaquat results in increased expression of PLCG1 mRNA18198484
D052638Particulate MatterParticulate Matter results in increased expression of PLCG1 mRNA28412507
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PLCG1 mRNA"25510870
D010629PhenforminPhenformin results in increased phosphorylation of PLCG1 protein19901985
D010656PhenylephrinePhenylephrine results in increased expression of PLCG1 mRNA16714034
C016658phorbolol myristate acetatephorbolol myristate acetate results in increased expression of PLCG1 mRNA16714034
C016658phorbolol myristate acetatephorbolol myristate acetate results in increased expression of PLCG1 protein16714034
D011192Potassium DichromatePotassium Dichromate results in decreased expression of PLCG1 mRNA23608068
D011224PrazosinPrazosin inhibits the reaction [Norepinephrine results in increased expression of and results in increased activity of PLCG1 protein]19225867
D011224PrazosinPrazosin inhibits the reaction [Norepinephrine results in increased expression of PLCG1 mRNA]16714034|1922586
D011224PrazosinPrazosin inhibits the reaction [Norepinephrine results in increased expression of PLCG1 protein]16714034
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of PLCG1 mRNA28903501
C059514resveratrolBCL2 protein inhibits the reaction [resveratrol results in increased cleavage of PLCG1 protein]11577002
C059514resveratrolBCL2 protein inhibits the reaction [resveratrol results in increased degradation of PLCG1 protein]11577002
C059514resveratrolresveratrol results in decreased expression of PLCG1 mRNA12569576
C059514resveratrolresveratrol results in increased cleavage of PLCG1 protein11577002
C059514resveratrolresveratrol results in increased degradation of PLCG1 protein11577002
C059514resveratrolresveratrol results in decreased phosphorylation of and results in decreased activity of PLCG1 protein23514766
C059514resveratrolresveratrol results in decreased phosphorylation of and results in decreased activity of PLCG1 protein23514766
D012715Sesame OilSesame Oil results in increased expression of PLCG1 mRNA29191790
C017947sodium arsenite[Ethanol co-treated with sodium arsenite] results in increased localization of PLCG1 protein18182400
C017947sodium arsenitesodium arsenite results in decreased expression of PLCG1 mRNA12760830
D010042OuabainOuabain results in decreased expression of PLCG1 mRNA28795476
D013467Sulindac"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of PLCG1 mRNA"20371263
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PLCG1 mRNA20702594
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of PLCG1 mRNA16214954
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of PLCG1 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PLCG1 mRNA18796159|2597527
D013749TetrachlorodibenzodioxinAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of PLCG1 mRNA]21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PLCG1 mRNA21215274
D013752TetracyclineTetracycline results in increased expression of PLCG1 mRNA16917069
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PLCG1 mRNA25613284
D013849ThimerosalThimerosal results in increased cleavage of PLCG1 protein16649253
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of PLCG1 mRNA20133372
C032910triadimefontriadimefon results in increased expression of PLCG1 mRNA26238599
C011559tributyltintributyltin results in decreased expression of PLCG1 mRNA26314263
D014520UrethaneUrethane results in increased expression of PLCG1 mRNA28818685
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of PLCG1 mRNA17183730
D014635Valproic AcidValproic Acid affects the expression of PLCG1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased methylation of PLCG1 gene29154799
C412469vitisin Avitisin A inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PLCG1 protein]21871475

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004435phosphatidylinositol phospholipase C activity-IDA2550068  
GO:0004435phosphatidylinositol phospholipase C activity-TAS-  
GO:0004629phospholipase C activity-TAS-  
GO:0005168neurotrophin TRKA receptor binding-IPI15488758  
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI1396585  1656221  7537096  7537265  7693694  7993895  
8321198  8627166  8628282  8657103  8892607  9020117  
9045636  9489702  9593725  10811803  10873601  11796522  
11896612  14568990  14570588  14722116  15641795  15929943  
16273093  16525023  16921170  16938345  17229814  17474147  
17936057  19264842  20808760  20932831  21706016  21725281  
23063561  23397142  23460737  24440983  24642916  24728074  
25241761  
GO:0019901protein kinase binding-IPI22454520  
GO:0030971receptor tyrosine kinase binding-IEA-  
GO:0035254glutamate receptor binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001701in utero embryonic development-IEA-  
GO:0007165signal transduction-TAS-  
GO:0007173epidermal growth factor receptor signaling pathway-IMP22454520  
GO:0007202activation of phospholipase C activity-TAS-  
GO:0007411axon guidance-TAS-  
GO:0009395phospholipid catabolic process-IEA-  
GO:0010634positive regulation of epithelial cell migration-IMP17229814  
GO:0016032viral process-IEA-  
GO:0016477cell migration-IMP22454520  
GO:0019722calcium-mediated signaling-IMP22454520  
GO:0038095Fc-epsilon receptor signaling pathway-TAS-  
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis-TAS-  
GO:0043536positive regulation of blood vessel endothelial cell migration-IDA20011604  
GO:0043647inositol phosphate metabolic process-TAS-  
GO:0045766positive regulation of angiogenesis-IDA20011604  
GO:0050852T cell receptor signaling pathway-TAS-  
GO:0050900leukocyte migration-TAS-  
GO:0051281positive regulation of release of sequestered calcium ion into cytosol-IMP22454520  
GO:0071364cellular response to epidermal growth factor stimulus-IDA17229814  
GO:0071364cellular response to epidermal growth factor stimulus-IMP22454520  
GO:1905564positive regulation of vascular endothelial cell proliferation-IMP27464494  
GO:2000353positive regulation of endothelial cell apoptotic process-IMP27464494  
GO ID GO Term Qualifier Evidence PubMed
GO:0001726ruffle-IDA17229814  
GO:0005737cytoplasm-IDA15702972  
GO:0005829cytosol-IDA2550068  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA2550068  22454520  
GO:0005886plasma membrane-TAS-  
GO:0005911cell-cell junction-IEA-  
GO:0008180COP9 signalosome-IDA22561606  
GO:0030027lamellipodium-IDA17229814  
GO:0042995cell projection-IDA22454520  
KEGG ID KEGG Term
hsa00562Inositol phosphate metabolism
hsa01100Metabolic pathways
hsa04012ErbB signaling pathway
hsa04020Calcium signaling pathway
hsa04070Phosphatidylinositol signaling system
hsa04370VEGF signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04660T cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04670Leukocyte transendothelial migration
hsa04722Neurotrophin signaling pathway
hsa05110Vibrio cholerae infection
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa05200Pathways in cancer
hsa05214Glioma
hsa05223Non-small cell lung cancer
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-1169408ISG15 antiviral mechanismTAS
R-HSA-1169410Antiviral mechanism by IFN-stimulated genesTAS
R-HSA-1226099Signaling by FGFR in diseaseTAS
R-HSA-1227986Signaling by ERBB2IEA
R-HSA-1236382Constitutive Signaling by Ligand-Responsive EGFR Cancer VariantsTAS
R-HSA-1251932PLCG1 events in ERBB2 signalingIEA
R-HSA-1266738Developmental BiologyIEA
R-HSA-1266738Developmental BiologyTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-1430728MetabolismTAS
R-HSA-1483249Inositol phosphate metabolismTAS
R-HSA-1489509DAG and IP3 signalingIEA
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-1643685DiseaseTAS
R-HSA-1643713Signaling by EGFR in CancerTAS
R-HSA-166520Signaling by NTRKsIEA
R-HSA-166520Signaling by NTRKsTAS
R-HSA-167021PLC-gamma1 signallingIEA
R-HSA-168249Innate Immune SystemTAS
R-HSA-168249Innate Immune SystemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-169893Prolonged ERK activation eventsTAS
R-HSA-170968Frs2-mediated activationTAS
R-HSA-177929Signaling by EGFRTAS
R-HSA-1855204Synthesis of IP3 and IP4 in the cytosolTAS
R-HSA-186763Downstream signal transductionTAS
R-HSA-186797Signaling by PDGFTAS
R-HSA-187037Signaling by NTRK1 (TRKA)IEA
R-HSA-187037Signaling by NTRK1 (TRKA)TAS
R-HSA-187687Signalling to ERKsTAS
R-HSA-190236Signaling by FGFRTAS
R-HSA-194138Signaling by VEGFTAS
R-HSA-194138Signaling by VEGFIEA
R-HSA-202403TCR signalingTAS
R-HSA-202433Generation of second messenger moleculesTAS
R-HSA-202733Cell surface interactions at the vascular wallTAS
R-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosisTAS
R-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosisIEA
R-HSA-2029485Role of phospholipids in phagocytosisTAS
R-HSA-2029485Role of phospholipids in phagocytosisIEA
R-HSA-210990PECAM1 interactionsTAS
R-HSA-212718EGFR interacts with phospholipase C-gammaTAS
R-HSA-2172127DAP12 interactionsTAS
R-HSA-2424491DAP12 signalingTAS
R-HSA-2454202Fc epsilon receptor (FCERI) signalingTAS
R-HSA-2454202Fc epsilon receptor (FCERI) signalingIEA
R-HSA-2871796FCERI mediated MAPK activationTAS
R-HSA-2871809FCERI mediated Ca+2 mobilizationIEA
R-HSA-2871809FCERI mediated Ca+2 mobilizationTAS
R-HSA-373752Netrin-1 signalingIEA
R-HSA-418890Role of second messengers in netrin-1 signalingIEA
R-HSA-422475Axon guidanceIEA
R-HSA-422475Axon guidanceTAS
R-HSA-4420097VEGFA-VEGFR2 PathwayTAS
R-HSA-4420097VEGFA-VEGFR2 PathwayIEA
R-HSA-5218921VEGFR2 mediated cell proliferationTAS
R-HSA-5218921VEGFR2 mediated cell proliferationIEA
R-HSA-5637810Constitutive Signaling by EGFRvIIITAS
R-HSA-5637812Signaling by EGFRvIII in CancerTAS
R-HSA-5637815Signaling by Ligand-Responsive EGFR Variants in CancerTAS
R-HSA-5654219Phospholipase C-mediated cascade: FGFR1TAS
R-HSA-5654221Phospholipase C-mediated cascade; FGFR2TAS
R-HSA-5654227Phospholipase C-mediated cascade; FGFR3TAS
R-HSA-5654228Phospholipase C-mediated cascade; FGFR4TAS
R-HSA-5654687Downstream signaling of activated FGFR1TAS
R-HSA-5654696Downstream signaling of activated FGFR2TAS
R-HSA-5654708Downstream signaling of activated FGFR3TAS
R-HSA-5654716Downstream signaling of activated FGFR4TAS
R-HSA-5654736Signaling by FGFR1TAS
R-HSA-5654738Signaling by FGFR2TAS
R-HSA-5654741Signaling by FGFR3TAS
R-HSA-5654743Signaling by FGFR4TAS
R-HSA-5655253Signaling by FGFR2 in diseaseTAS
R-HSA-5655291Signaling by FGFR4 in diseaseTAS
R-HSA-5655302Signaling by FGFR1 in diseaseTAS
R-HSA-5655332Signaling by FGFR3 in diseaseTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-8853338Signaling by FGFR3 point mutants in cancerTAS
R-HSA-8853659RET signalingTAS
R-HSA-9006115Signaling by NTRK2 (TRKB)IEA
R-HSA-9006115Signaling by NTRK2 (TRKB)TAS
R-HSA-9006925Intracellular signaling by second messengersIEA
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesIEA
R-HSA-9026527Activated NTRK2 signals through PLCG1IEA
R-HSA-9026527Activated NTRK2 signals through PLCG1TAS
R-HSA-913531Interferon SignalingTAS
R-HSA-983695Antigen activates B Cell Receptor (BCR) leading to generation of second messengersTAS
R-HSA-983705Signaling by the B Cell Receptor (BCR)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27827461Association and interaction of APOA5, BUD13, CETP, LIPA and health-related behavior with metabolic syndrome in a Taiwanese population. (2016 Nov 9)Lin ESci Rep
26518718Identification of gene markers in the development of smoking-induced lung cancer. (2016 Jan 15)Yang ZGene