Gene: SHC3

53358
N-Shc|NSHC|RAI|SHCC
SHC adaptor protein 3
protein-coding
9q22.1
Ensembl:ENSG00000148082 MIM:605263 Vega:OTTHUMG00000020179 UniprotKB:Q92529
NC_000009.12
PubMed|SNP Mapped
2   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.072e-1 (AD)  5.025e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs13295927chr9:89117794 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs1331189chr9:89105730 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg13614383chr9:91762376SHC3Gene body5.048e-5Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FBXL180.916
PHACTR10.914
SHANK10.911
PITPNM30.879
MMP240.877
DOC2B0.874
HS6ST30.872
DOK60.868
RGS7BP0.868
KCNQ20.868

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ROM1-0.541
AGTRAP-0.528
SNHG18-0.522
RAB13-0.513
HEBP2-0.509
PLEKHF1-0.5
CLEC4E-0.492
TGIF1-0.491
CSAG1-0.483
CPM-0.478

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of SHC3 mRNA"19162173
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of SHC3 mRNA24140754
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SHC3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SHC3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SHC3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] affects the expression of SHC3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SHC3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SHC3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SHC3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] affects the expression of SHC3 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SHC3 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SHC3 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SHC3 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of SHC3 mRNA24449571
C015001arsenitearsenite results in increased methylation of SHC3 promoter23974009
D001280AtrazineAtrazine results in decreased expression of SHC3 mRNA22378314
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SHC3 mRNA"27188386
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of SHC3 mRNA21635667
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of SHC3 mRNA21635667
C006780bisphenol Abisphenol A results in increased expression of SHC3 mRNA29275510
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SHC3 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of SHC3 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of SHC3 mRNA29097150
C006780bisphenol Abisphenol A results in increased methylation of SHC3 gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SHC3 mRNA28628672
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of SHC3 promoter22457795
D002220CarbamazepineCarbamazepine affects the expression of SHC3 mRNA25979313
D003907DexamethasoneDexamethasone results in increased expression of SHC3 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SHC3 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SHC3 mRNA28628672
C118739entinostatentinostat results in decreased expression of SHC3 mRNA26272509
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SHC3 mRNA29097150
D019833GenisteinGenistein results in decreased expression of SHC3 mRNA22228119
C041508indeno(1,2,3-cd)pyrene"indeno(1,2,3-cd)pyrene results in decreased expression of SHC3 mRNA"21635667
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SHC3 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SHC3 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SHC3 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SHC3 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SHC3 mRNA24796395
D007854LeadLead affects the splicing of SHC3 mRNA28903495
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SHC3 mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SHC3 mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SHC3 mRNA"20188158
D009532NickelNickel results in decreased expression of SHC3 mRNA24768652
C510784ormosil[ormosil binds to Polyethylene Glycols] which results in increased expression of SHC3 mRNA24888373
D010100OxygenOxygen deficiency results in decreased expression of SHC3 mRNA26516004
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SHC3 mRNA"27188386
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] affects the expression of SHC3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate affects the expression of SHC3 mRNA26272509
D010936Plant ExtractsPlant Extracts results in decreased expression of SHC3 mRNA23557933
D011092Polyethylene Glycols[ormosil binds to Polyethylene Glycols] which results in increased expression of SHC3 mRNA24888373
D012834SilverSilver results in decreased expression of SHC3 mRNA26551752
D012834SilverSilver results in increased expression of SHC3 mRNA27131904
C017947sodium arsenitesodium arsenite results in decreased expression of and affects the splicing of SHC3 mRNA25879800
C017947sodium arsenitesodium arsenite results in increased expression of SHC3 mRNA16014739
D010042OuabainOuabain results in increased expression of SHC3 mRNA28795476
D014635Valproic AcidValproic Acid results in decreased expression of SHC3 mRNA28001369
D014635Valproic AcidValproic Acid results in increased expression of SHC3 mRNA23179753|2438349

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001784phosphotyrosine residue binding-IPI20624904  
GO:0005088Ras guanyl-nucleotide exchange factor activity-TAS-  
GO:0005515protein binding-IPI11877420  16273093  24728074  25416956  
GO:0019901protein kinase binding-IBA21873635  
GO:0030971receptor tyrosine kinase binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-TAS-  
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway-IBA21873635  
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway-TAS8808684  
GO:0007173epidermal growth factor receptor signaling pathway-TAS8808684  
GO:0007265Ras protein signal transduction-TAS-  
GO:0007411axon guidance-TAS-  
GO:0007417central nervous system development-IEA-  
GO:0007611learning or memory-IEA-  
GO:0035249synaptic transmission, glutamatergic-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IBA21873635  
KEGG ID KEGG Term
hsa04012ErbB signaling pathway
hsa04062Chemokine signaling pathway
hsa04510Focal adhesion
hsa04650Natural killer cell mediated cytotoxicity
hsa04722Neurotrophin signaling pathway
hsa04910Insulin signaling pathway
hsa05100Bacterial invasion of epithelial cells
hsa05214Glioma
hsa05220Chronic myeloid leukemia
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-166520Signaling by NTRKsTAS
R-HSA-166520Signaling by NTRKsIEA
R-HSA-167044Signalling to RASTAS
R-HSA-167044Signalling to RASIEA
R-HSA-187037Signaling by NTRK1 (TRKA)TAS
R-HSA-187037Signaling by NTRK1 (TRKA)IEA
R-HSA-187687Signalling to ERKsTAS
R-HSA-187687Signalling to ERKsIEA
R-HSA-422475Axon guidanceTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-8853659RET signalingTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17179996Linkage and association studies in African- and Caucasian-American populations demonstrate that SHC3 is a novel susceptibility locus for nicotine dependence. (2007 May)Li MDMol Psychiatry