Gene: PLD1

5337
CVDD
phospholipase D1
protein-coding
3q26.31
Ensembl:ENSG00000075651 MIM:602382 Vega:OTTHUMG00000156947 UniprotKB:Q13393
NG_029851.1
PubMed
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.252e-2 (AD)  6.764e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYO1D0.93
FRMD4B0.929
SH3TC20.917
ST180.916
C21orf910.906
ENPP20.905
HHIP0.904
EVI2A0.903
SLC44A10.902
TRIM590.901

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC29A4-0.438
CALB2-0.374
CHRNA2-0.37
CUX2-0.369
SHISA8-0.365
PAX2-0.36
WNT7B-0.357
PRTN3-0.356
NEUROD1-0.351
POU3F1-0.345

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00122CholineSmall Molecule62-49-7Approved|NutraceuticalTarget
DB05301LAX-101Small Molecule-InvestigationalTarget
DB09031MiltefosineSmall Molecule58066-85-6Approved|InvestigationalEnzyme
ID Drug Name Action PubMed
C05598720-hydroxy-5,8,11,14-eicosatetraenoic acid"20-hydroxy-5,8,11,14-eicosatetraenoic acid results in increased activity of PLD1 protein"15964316
C49466720-hydroxyeicosa-6(Z),15(Z)-dienoic acid"20-hydroxyeicosa-6(Z),15(Z)-dienoic acid results in increased activity of PLD1 protein"15964316
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of PLD1 mRNA19933214
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of PLD1 mRNA"27291303
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in increased activity of PLD1 protein"17427178
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PLD1 mRNA"21346803
C4086042-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [PLD1 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]]17640750
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of PLD1 mRNA"21346803
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of PLD1 protein26194647
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of PLD1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLD1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLD1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLD1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLD1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of PLD1 mRNA21420995
D000111AcetylcysteineAcetylcysteine inhibits the reaction [PLD1 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]]17640750
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PLD1 mRNA21641981
D000393Air PollutantsAir Pollutants analog results in decreased expression of PLD1 mRNA21757418
D0150812-Naphthylamine2-Naphthylamine results in decreased expression of PLD1 mRNA18247414
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PLD1 mRNA16483693
C028617aroclor 1248aroclor 1248 results in increased activity of PLD1 protein17427178
D001151ArsenicArsenic affects the methylation of PLD1 gene25304211
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of PLD1 mRNA"17331233
D001280AtrazineAtrazine results in decreased expression of PLD1 mRNA25929836
D001554Benzene[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of PLD1 mRNA17905399
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PLD1 mRNA18247414
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PLD1 mRNA17879257|2623829
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PLD1 mRNA23735875
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of PLD1 mRNA"26238291
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PLD1 mRNA19619570
D004958EstradiolEstradiol results in increased expression of PLD1 mRNA19619570
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of PLD1 mRNA19693291
D004958EstradiolEstradiol results in decreased expression of PLD1 mRNA19693291
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [lysophosphatidic acid results in increased activity of PLD1 protein]11243883
C006780bisphenol Abisphenol A results in decreased expression of PLD1 protein28273538
C006780bisphenol Abisphenol A results in decreased expression of PLD1 mRNA20678512
C006780bisphenol Abisphenol A results in increased expression of PLD1 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of PLD1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PLD1 gene28505145
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of and results in increased activity of PLD1 protein17065600
D0151248-Bromo Cyclic Adenosine MonophosphatePLD1 protein affects the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of IGFBP1 mRNA]17065600
D0151248-Bromo Cyclic Adenosine MonophosphatePLD1 protein affects the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of PRL mRNA]17065600
D0200011-Butanol1-Butanol results in decreased activity of PLD1 protein16449385
D0200011-Butanol[1-Butanol results in decreased activity of PLD1 protein] which affects the localization of APP protein16449385
D0200011-Butanol1-Butanol results in decreased activity of PLD1 protein19284563
D0200011-Butanol1-Butanol inhibits the reaction [PLD1 protein affects the reaction [lysophosphatidic acid results in increased phosphorylation of MAPK1 protein]]11243883
D0200011-Butanol1-Butanol inhibits the reaction [PLD1 protein affects the reaction [lysophosphatidic acid results in increased phosphorylation of MAPK3 protein]]11243883
D0200011-Butanol[1-Butanol inhibits the reaction [PRKCA protein binds to PLD1 protein]] which results in decreased activity of PLD1 protein15652502
D0200011-Butanol1-Butanol results in decreased activity of PLD1 protein15652502|1834460
D0200011-Butanol1-Butanol results in decreased activity of PLD1 protein16178010
D000074262Canola OilCanola Oil metabolite results in decreased expression of PLD1 mRNA27363782
D002922CiguatoxinsCiguatoxins affects the expression of PLD1 mRNA18353800
D002994ClofibrateClofibrate results in decreased expression of PLD1 mRNA17585979
C018021cobaltous chloride2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [PLD1 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]]17640750
C018021cobaltous chlorideAcetylcysteine inhibits the reaction [PLD1 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]]17640750
C018021cobaltous chloridecobaltous chloride results in increased activity of PLD1 protein17640750
C018021cobaltous chlorideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [PLD1 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]]17640750
C018021cobaltous chloridePLD1 protein promotes the reaction [cobaltous chloride results in increased abundance of Dinoprostone]17640750
C018021cobaltous chloridePLD1 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]17640750
C018021cobaltous chlorideReactive Oxygen Species affects the reaction [PLD1 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]]17640750
C018021cobaltous chloriderottlerin inhibits the reaction [PLD1 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]]17640750
C018021cobaltous chloridecobaltous chloride results in decreased expression of PLD1 mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of PLD1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of PLD1 mRNA20106945|2556210
D003609DactinomycinPLD1 protein inhibits the reaction [Dactinomycin results in increased cleavage of PARP1 protein]14640974
D003609DactinomycinPLD1 protein inhibits the reaction [Dactinomycin results in increased cleavage of PRKCD protein]14640974
D003609DactinomycinPLD1 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of AKT1 protein]14640974
D003609DactinomycinPLD1 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of MAPK1 protein]14640974
D003609DactinomycinPLD1 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of MAPK3 protein]14640974
D003609DactinomycinPLD1 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]14640974
C117975DDMSDDMS results in increased activity of PLD1 protein15964316
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of PLD1 mRNA23640034
C017180decamethrindecamethrin results in decreased expression of PLD1 mRNA19017407
C014347decitabinedecitabine affects the expression of PLD1 mRNA17145863
D003907DexamethasoneDexamethasone results in increased expression of PLD1 mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PLD1 mRNA21266533
D002945CisplatinCisplatin results in increased expression of PLD1 mRNA21151649
D004008DiclofenacDiclofenac results in increased expression of PLD1 mRNA26934552
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of PLD1 protein21079920
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of PLD1 mRNA24535843
C034638dinitrophenyl-bovine serum albuminPLD1 protein affects the reaction [dinitrophenyl-bovine serum albumin affects the localization of G(M1) Ganglioside]19794068
C034638dinitrophenyl-bovine serum albuminPLD1 protein affects the reaction [dinitrophenyl-bovine serum albumin affects the localization of LYN protein]19794068
D0197942,3-Diphosphoglycerate"2,3-Diphosphoglycerate results in decreased activity of PLD1 protein"16857255
D004237DiuronDiuron results in increased expression of PLD1 mRNA21551480
D052244Endocrine DisruptorsEndocrine Disruptors results in decreased expression of PLD1 mRNA25198161
C118739entinostatentinostat results in increased expression of PLD1 mRNA27188386
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of PLD1 mRNA22079256
C045651epigallocatechin gallatePLD1 protein promotes the reaction [epigallocatechin gallate results in increased expression of PTGS2 protein]15210717
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PLD1 mRNA22079256
D011345FenofibrateFenofibrate inhibits the reaction [Norepinephrine results in increased activity of PLD1 protein]15964316
D011345FenofibrateFenofibrate results in decreased activity of PLD1 protein15964316
D005557FormaldehydeFormaldehyde results in increased expression of PLD1 mRNA23649840
D009240N-Formylmethionine Leucyl-PhenylalaninePLD1 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK1 protein]11427526
D009240N-Formylmethionine Leucyl-PhenylalaninePLD1 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK3 protein]11427526
D009240N-Formylmethionine Leucyl-PhenylalaninePLD1 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Reactive Oxygen Species]17560994
C039281furanfuran results in increased expression of PLD1 mRNA27387713
D019833GenisteinGenistein inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of PLD1 protein]15150437
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of PLD1 mRNA22634610
C081021Go 6976Go 6976 inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of PLD1 mRNA]26763395
C081021Go 6976Go 6976 inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of PLD1 protein]26763395
C081021Go 6976Go 6976 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of PLD1 protein]15150437
D012701SerotoninHTR2A protein affects the reaction [Serotonin results in increased activity of PLD1 protein]18621911
D012701SerotoninKetanserin inhibits the reaction [HTR2A protein affects the reaction [Serotonin results in increased activity of PLD1 protein]]18621911
D012701SerotoninPLD1 protein affects the reaction [Serotonin results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]18621911
D012701SerotoninSerotonin results in increased activity of PLD1 protein18621911
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of PLD1 mRNA20044591
D006861Hydrogen PeroxideGenistein inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of PLD1 protein]15150437
D006861Hydrogen PeroxideGo 6976 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of PLD1 protein]15150437
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Vanadates] results in increased phosphorylation of PLD1 protein15150437
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Vanadates] results in increased phosphorylation of [PLD1 protein binds to PRKCA protein]15150437
D006861Hydrogen PeroxideHydrogen Peroxide results in increased phosphorylation of and results in increased activity of PLD1 protein15150437
D007213IndomethacinIndomethacin results in decreased expression of PLD1 mRNA25972201
C051890irinotecanirinotecan affects the expression of PLD1 mRNA20097248
D007545IsoproterenolIsoproterenol results in increased expression of PLD1 mRNA20003209
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of PLD1 mRNA26752646
D007650KetanserinKetanserin inhibits the reaction [HTR2A protein affects the reaction [Serotonin results in increased activity of PLD1 protein]]18621911
D018021Lithium ChlorideLithium Chloride results in increased expression of PLD1 mRNA23527032
D008095Lithocholic AcidLithocholic Acid results in increased expression of PLD1 mRNA21480330|2303421
D008095Lithocholic AcidSMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of PLD1 mRNA]23034213
C032881lysophosphatidic acid1-Butanol inhibits the reaction [PLD1 protein affects the reaction [lysophosphatidic acid results in increased phosphorylation of MAPK1 protein]]11243883
C032881lysophosphatidic acid1-Butanol inhibits the reaction [PLD1 protein affects the reaction [lysophosphatidic acid results in increased phosphorylation of MAPK3 protein]]11243883
C032881lysophosphatidic acidbisindolylmaleimide I inhibits the reaction [lysophosphatidic acid results in increased activity of PLD1 protein]11243883
C032881lysophosphatidic acidlysophosphatidic acid results in increased activity of PLD1 protein11243883
C032881lysophosphatidic acidPertussis Toxin inhibits the reaction [lysophosphatidic acid results in increased activity of PLD1 protein]11243883
C032881lysophosphatidic acidPLD1 protein affects the reaction [lysophosphatidic acid results in increased phosphorylation of MAPK1 protein]11243883
C032881lysophosphatidic acidPLD1 protein affects the reaction [lysophosphatidic acid results in increased phosphorylation of MAPK3 protein]11243883
C032881lysophosphatidic acid"toxB protein, Clostridium difficile inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of PLD1 protein]"14769825
D008543Melanins[TYR protein results in decreased expression of and results in decreased activity of PLD1 protein] which results in decreased abundance of Melanins14615486
D009074Melanocyte-Stimulating HormonesMelanocyte-Stimulating Hormones results in decreased expression of and results in decreased activity of PLD1 protein14615486
D008628MercuryMercury results in increased phosphorylation of PLD1 protein21994240
C030957methylmercury II[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of PLD1 mRNA17905399
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PLD1 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of PLD1 mRNA"26251327
D015735MifepristoneMifepristone results in increased expression of PLD1 mRNA17584828
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of PLD1 mRNA16809437
D005677G(M1) GangliosidePLD1 protein affects the reaction [dinitrophenyl-bovine serum albumin affects the localization of G(M1) Ganglioside]19794068
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [PLD1 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]]17640750
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PLD1 mRNA"25620056
C433446N-hydroxy-N'-(4-butyl-2-methylphenyl)formamidineN-hydroxy-N'-(4-butyl-2-methylphenyl)formamidine results in increased activity of PLD1 protein15964316
C028007nickel monoxidenickel monoxide results in increased expression of PLD1 mRNA19167457
D009538NicotineNicotine results in decreased expression of PLD1 mRNA18247414
D009638NorepinephrineFenofibrate inhibits the reaction [Norepinephrine results in increased activity of PLD1 protein]15964316
D009638NorepinephrineNorepinephrine results in increased activity of PLD1 protein15964316
D009638Norepinephrinepirinixic acid inhibits the reaction [Norepinephrine results in increased activity of PLD1 protein]15964316
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of PLD1 mRNA25729387
C029341oxophenylarsineoxophenylarsine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of PLD1 mRNA]26763395
C029341oxophenylarsineoxophenylarsine inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of PLD1 protein]26763395
D010098OxycodoneOxycodone results in decreased expression of PLD1 mRNA23439660
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of PLD1 mRNA28973697
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of PLD1 mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of PLD1 mRNA19162173
D037342Pertussis ToxinPertussis Toxin inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of PLD1 mRNA]26763395
D037342Pertussis ToxinPertussis Toxin inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of PLD1 protein]26763395
D037342Pertussis ToxinPertussis Toxin inhibits the reaction [lysophosphatidic acid results in increased activity of PLD1 protein]11243883
D015232DinoprostonePLD1 protein promotes the reaction [cobaltous chloride results in increased abundance of Dinoprostone]17640750
D010634PhenobarbitalPhenobarbital affects the expression of PLD1 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLD1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of PLD1 mRNA26272509
D010712Phosphatidic AcidsPhosphatidic Acids results in increased activity of PLD1 protein16857255
D010712Phosphatidic AcidsPLD1 protein results in increased chemical synthesis of Phosphatidic Acids16178010
C068564phosphatidylbutanolPLD1 protein results in increased chemical synthesis of phosphatidylbutanol14640974
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PLD1 mRNA19710929
C006253pirinixic acidpirinixic acid inhibits the reaction [Norepinephrine results in increased activity of PLD1 protein]15964316
C006253pirinixic acidpirinixic acid results in decreased activity of PLD1 protein15964316
D010936Plant ExtractsPlant Extracts results in increased expression of PLD1 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PLD1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PLD1 mRNA22079256
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of PLD1 mRNA19693291
D011374ProgesteroneProgesterone results in decreased expression of PLD1 mRNA19693291
C045950propiconazolepropiconazole results in increased expression of PLD1 mRNA21278054
D011794QuercetinQuercetin results in decreased expression of PLD1 mRNA21632981|2186767
D011794QuercetinQuercetin results in decreased expression of PLD1 protein21867678
D017382Reactive Oxygen SpeciesReactive Oxygen Species affects the reaction [PLD1 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]]17640750
D017382Reactive Oxygen SpeciesPLD1 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Reactive Oxygen Species]17560994
C059514resveratrolresveratrol results in decreased activity of [C5 protein results in increased localization of and results in increased activity of PLD1 protein]19284563
C085746rottlerinrottlerin inhibits the reaction [PLD1 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]]17640750
C093642SB 203580SB 203580 inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of PLD1 mRNA]26763395
C093642SB 203580SB 203580 inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of PLD1 protein]26763395
D012906SmokeSmoke results in decreased expression of PLD1 mRNA21095227
C017947sodium arsenitesodium arsenite results in decreased expression of PLD1 mRNA20371982|2859598
D012999SomanSoman results in increased expression of PLD1 mRNA19281266
D013109SphingomyelinsPLD1 protein results in increased hydrolysis of Sphingomyelins21692149
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of PLD1 mRNA"26680231
D013739TestosteroneTestosterone results in decreased expression of PLD1 mRNA19693291
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PLD1 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PLD1 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PLD1 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PLD1 mRNA21570461
D013752TetracyclineTetracycline results in increased expression of PLD1 mRNA16917069
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased activity of PLD1 protein15067002
D013755Tetradecanoylphorbol Acetate"toxB protein, Clostridium difficile inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of PLD1 protein]"14769825
C009495titanium dioxidetitanium dioxide results in increased expression of PLD1 mRNA23557971
D014028Tobacco Smoke PollutionGo 6976 inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of PLD1 mRNA]26763395
D014028Tobacco Smoke PollutionGo 6976 inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of PLD1 protein]26763395
D014028Tobacco Smoke Pollutionoxophenylarsine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of PLD1 mRNA]26763395
D014028Tobacco Smoke Pollutionoxophenylarsine inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of PLD1 protein]26763395
D014028Tobacco Smoke PollutionPertussis Toxin inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of PLD1 mRNA]26763395
D014028Tobacco Smoke PollutionPertussis Toxin inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of PLD1 protein]26763395
D014028Tobacco Smoke PollutionPLD1 protein affects the reaction [Tobacco Smoke Pollution analog results in increased expression of IL6 mRNA]26763395
D014028Tobacco Smoke PollutionPLD1 protein affects the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of ATF2 protein]26763395
D014028Tobacco Smoke PollutionSB 203580 inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of PLD1 mRNA]26763395
D014028Tobacco Smoke PollutionSB 203580 inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of PLD1 protein]26763395
D014028Tobacco Smoke PollutionTobacco Smoke Pollution analog results in increased activity of PLD1 protein26763395
D014028Tobacco Smoke PollutionTobacco Smoke Pollution analog results in increased expression of PLD1 mRNA26763395
D014028Tobacco Smoke PollutionTobacco Smoke Pollution analog results in increased phosphorylation of PLD1 protein26763395
C052342topiramatetopiramate results in increased expression of PLD1 mRNA16979414
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of PLD1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of PLD1 mRNA25729387
C031815toxB protein, Clostridium difficile"toxB protein, Clostridium difficile inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of PLD1 protein]"14769825
C031815toxB protein, Clostridium difficile"toxB protein, Clostridium difficile inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of PLD1 protein]"14769825
D014212TretinoinTretinoin results in increased expression of PLD1 mRNA16249480|2193413
D014241Trichloroethylene[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of PLD1 mRNA17905399
C012589trichostatin Atrichostatin A results in increased expression of PLD1 mRNA24935251|2623859
C057693troglitazonetroglitazone results in increased expression of PLD1 mRNA19140230
C057693troglitazonetroglitazone results in decreased expression of PLD1 mRNA28973697
C406224valdecoxibvaldecoxib results in decreased expression of PLD1 mRNA24136188
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLD1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of PLD1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PLD1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of PLD1 mRNA17963808
D014638Vanadates[Hydrogen Peroxide co-treated with Vanadates] results in increased phosphorylation of PLD1 protein15150437
D014638Vanadates[Hydrogen Peroxide co-treated with Vanadates] results in increased phosphorylation of [PLD1 protein binds to PRKCA protein]15150437
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PLD1 gene25560391
C029297vinylidene chloridevinylidene chloride results in increased expression of PLD1 mRNA26682919
C111237vorinostatvorinostat results in increased expression of PLD1 mRNA26238599
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of PLD1 mRNA"25198161

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004630phospholipase D activity-TAS-  
GO:0005515protein binding-IPI11259428  17853892  18550814  
GO:0035091phosphatidylinositol binding-IEA-  
GO:0070290N-acylphosphatidylethanolamine-specific phospholipase D activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006654phosphatidic acid biosynthetic process-TAS-  
GO:0006935chemotaxis-TAS10848592  
GO:0007264small GTPase mediated signal transduction-TAS8530346  
GO:0007265Ras protein signal transduction-TAS10848592  
GO:0016042lipid catabolic process-IEA-  
GO:0032534regulation of microvillus assembly-IBA21873635  
GO:0032534regulation of microvillus assembly-IMP22797597  
GO:0043312neutrophil degranulation-TAS-  
GO:0048017inositol lipid-mediated signaling-IEA-  
GO:0048870cell motility-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0005765lysosomal membrane-HDA17897319  
GO:0005768endosome-IDA14718562  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005794Golgi apparatus-IBA21873635  
GO:0005794Golgi apparatus-IDA14718562  
GO:0005886plasma membrane-TAS-  
GO:0016020membrane-HDA19946888  
GO:0016324apical plasma membrane-IDA22797597  
GO:0030139endocytic vesicle-IDA22797597  
GO:0031902late endosome membrane-IEA-  
GO:0035579specific granule membrane-TAS-  
GO:0048471perinuclear region of cytoplasm-IEA-  
GO:0070821tertiary granule membrane-TAS-  
KEGG ID KEGG Term
hsa00564Glycerophospholipid metabolism
hsa00565Ether lipid metabolism
hsa01100Metabolic pathways
hsa04144Endocytosis
hsa04666Fc gamma R-mediated phagocytosis
hsa04912GnRH signaling pathway
hsa05200Pathways in cancer
hsa05212Pancreatic cancer
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1430728MetabolismIEA
R-HSA-1483148Synthesis of PGIEA
R-HSA-1483166Synthesis of PATAS
R-HSA-1483206Glycerophospholipid biosynthesisTAS
R-HSA-1483206Glycerophospholipid biosynthesisIEA
R-HSA-1483257Phospholipid metabolismTAS
R-HSA-1483257Phospholipid metabolismIEA
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosisTAS
R-HSA-2029485Role of phospholipids in phagocytosisTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-556833Metabolism of lipidsIEA
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26173551A New Genomewide Association Meta-Analysis of Alcohol Dependence. (2015 Aug)Zuo LAlcohol Clin Exp Res
26763395Cigarette smoke extract-induced interleukin-6 expression is regulated by phospholipase D1 in human bronchial epithelial cells. (2016 Feb)Koo JBJ Toxicol Sci