Gene info: ID 5340

Gene: PLG

GENE ID: 5340

Synonyms: -

Description: plasminogen

Gene type: protein-coding

Location: 6q26

dbXrefs: Ensembl:ENSG00000122194 MIM:173350 Vega:OTTHUMG00000015957 UniprotKB:P00747

RefSeq: NG_016200.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: OD|ND|AD

# Publications: 8

Sherlock p-value : 6.223e-1 (AD) 1.890e-1 (ND) (Frontal_Cortex)

Pascal p-value : 3.832e-1 (AD) 2.869e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
C9orf163	0.531
ZNF831	0.496
ZNF781	0.491
ZNF549	0.485
HIC2	0.484
SPEF2	0.478
TPX2	0.477
ANKRD30B	0.477
TRIP13	0.476
ZNF285	0.476

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ASB12	-0.296
GRTP1	-0.284
C9orf153	-0.262
ZIC2	-0.262
MAPKAPK3	-0.261
SLC2A4	-0.25
CTF1	-0.242
ISG20	-0.242
COPZ2	-0.24
CD4	-0.239

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00009	Alteplase	BiotechDrug	105857-23-6	Approved	Target
DB00013	Urokinase	BiotechDrug	9039-53-6	Approved\|Investigational\|Withdrawn	Target
DB00015	Reteplase	BiotechDrug	133652-38-7	Approved\|Investigational	Target
DB00029	Anistreplase	BiotechDrug	81669-57-0	Approved	Target
DB00031	Tenecteplase	BiotechDrug	191588-94-0	Approved	Target
DB00086	Streptokinase	BiotechDrug	9002-01-1	Approved\|Investigational	Target
DB00302	Tranexamic Acid	Small Molecule	1197-18-8	Approved	Target
DB00513	Aminocaproic Acid	Small Molecule	60-32-2	Approved\|Investigational	Target
DB03709	Bicine	Small Molecule		Experimental	Target
DB04925	Desmoteplase	BiotechDrug	145137-38-8	Investigational	Target
DB06692	Aprotinin	BiotechDrug	9087-70-1	Approved\|Investigational\|Withdrawn	Target
DB09130	Copper	Small Molecule	7440-50-8	Approved\|Investigational	Target
DB12831	Gabexate	Small Molecule	39492-01-8	Investigational	Target

ID	Drug Name	Action	PubMed
C036423	1-aminomethylphosphonic acid	"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of PLG mRNA"	20566314
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [PLG protein results in increased phosphorylation of MAPK1 protein]	17482686
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [PLG protein results in increased phosphorylation of MAPK3 protein]	17482686
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of PLG mRNA"	21346803
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene results in decreased expression of PLG mRNA"	20406850
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of PLG mRNA"	21346803
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl affects the expression of PLG mRNA"	21703328
C095170	4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid	4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Zinc results in increased expression of PLG mRNA]	21615740
C095170	4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid	4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Zinc results in increased expression of PLG protein]	21615740
C010024	4-aminophenylmercuriacetate	4-aminophenylmercuriacetate inhibits the reaction [Zinc results in increased expression of PLG mRNA]	21615740
C010024	4-aminophenylmercuriacetate	4-aminophenylmercuriacetate inhibits the reaction [Zinc results in increased expression of PLG protein]	21615740
D000082	Acetaminophen	Acetaminophen results in decreased expression of PLG mRNA	21420995\|2906747
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of PLG mRNA	17585979
D000082	Acetaminophen	PLG protein affects the susceptibility to Acetaminophen	22507835
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of PLG mRNA]	17585979
C043377	acetochlor	"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of PLG mRNA"	20566314
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of PLG protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of PLG mRNA	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of PLG gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of PLG mRNA	19770486
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of PLG protein	26072098
D024502	alpha-Tocopherol	alpha-Tocopherol inhibits the reaction [Arsenic promotes the reaction [Humic Substances results in decreased activity of PLG protein]]	11419606
D024502	alpha-Tocopherol	alpha-Tocopherol inhibits the reaction [Humic Substances results in decreased activity of PLG protein]	11419606
D000584	Amiloride	Amiloride inhibits the reaction [PLAU protein results in increased degradation of PLG protein]	14644129
D015119	Aminocaproic Acid	Aminocaproic Acid inhibits the reaction [PLG protein results in increased phosphorylation of MAPK1 protein]	17482686
D015119	Aminocaproic Acid	Aminocaproic Acid inhibits the reaction [PLG protein results in increased phosphorylation of MAPK3 protein]	17482686
D000638	Amiodarone	Amiodarone affects the expression of PLG mRNA	19483382
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of PLG mRNA	16483693
D001151	Arsenic	alpha-Tocopherol inhibits the reaction [Arsenic promotes the reaction [Humic Substances results in decreased activity of PLG protein]]	11419606
D001151	Arsenic	Arsenic promotes the reaction [Humic Substances results in decreased activity of PLG protein]	11419606
D001151	Arsenic	Ascorbic Acid inhibits the reaction [Arsenic promotes the reaction [Humic Substances results in decreased activity of PLG protein]]	11419606
D001151	Arsenic	CAT protein inhibits the reaction [Arsenic promotes the reaction [Humic Substances results in decreased activity of PLG protein]]	11419606
C006632	arsenic trioxide	arsenic trioxide results in decreased activity of PLG protein	19781379
D001205	Ascorbic Acid	Ascorbic Acid inhibits the reaction [Arsenic promotes the reaction [Humic Substances results in decreased activity of PLG protein]]	11419606
D001205	Ascorbic Acid	Ascorbic Acid inhibits the reaction [Humic Substances results in decreased activity of PLG protein]	11419606
C487081	belinostat	belinostat results in decreased expression of PLG mRNA	27188386
C044946	benazepril	benazepril results in increased activity of PLG protein	15339989
C044946	benazepril	FR 173657 inhibits the reaction [benazepril results in increased activity of PLG protein]	15339989
D001553	Benzbromarone	Benzbromarone affects the expression of PLG mRNA	19483382
D053119	Benzophenanthridines	Benzophenanthridines analog results in decreased expression of PLG mRNA	22120849
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of PLG mRNA	20106945
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of PLG mRNA	19770486
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PLG mRNA	22610609
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of PLG mRNA	22300585
D004958	Estradiol	Estradiol affects the expression of PLG mRNA	23557687
D004958	Estradiol	Estradiol results in decreased expression of PLG mRNA	20106945
D004958	Estradiol	Estradiol results in increased expression of PLG mRNA	20838740
C006780	bisphenol A	bisphenol A results in increased expression of PLG mRNA	26364221
C006780	bisphenol A	bisphenol A affects the methylation of PLG promoter	27334623
C006780	bisphenol A	bisphenol A results in increased expression of PLG mRNA	22687993
C006780	bisphenol A	bisphenol A affects the expression of PLG mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of PLG gene	28505145
D002104	Cadmium	Cadmium results in increased expression of PLG mRNA	24084258
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of PLG mRNA	22110744
D002110	Caffeine	Caffeine results in decreased expression of PLG mRNA	25868845
D002251	Carbon Tetrachloride	PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of AMY2A5 mRNA]	16006527
D002251	Carbon Tetrachloride	PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of AURKA mRNA]	16006527
D002251	Carbon Tetrachloride	PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of BCL2A1D mRNA]	16006527
D002251	Carbon Tetrachloride	PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of BCL6 mRNA]	16006527
D002251	Carbon Tetrachloride	PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of CCNA2 mRNA]	16006527
D002251	Carbon Tetrachloride	PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of CCNB1 mRNA]	16006527
D002251	Carbon Tetrachloride	PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of CCNB2 mRNA]	16006527
D002251	Carbon Tetrachloride	PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of CDC20 mRNA]	16006527
D002251	Carbon Tetrachloride	PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of CELA2A mRNA]	16006527
D002251	Carbon Tetrachloride	PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of CHIL3 mRNA]	16006527
D002251	Carbon Tetrachloride	PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of CTDSP2 mRNA]	16006527
D002251	Carbon Tetrachloride	PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of DBP mRNA]	16006527
D002251	Carbon Tetrachloride	PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of EGR1 mRNA]	16006527
D002251	Carbon Tetrachloride	PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of ELA1 mRNA]	16006527
D002251	Carbon Tetrachloride	PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of ELOVL6 mRNA]	16006527
D002251	Carbon Tetrachloride	PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of GSTM3 mRNA]	16006527
D002251	Carbon Tetrachloride	PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of KIF22 mRNA]	16006527
D002251	Carbon Tetrachloride	PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of LCN2 mRNA]	16006527
D002251	Carbon Tetrachloride	PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of LPL mRNA]	16006527
D002251	Carbon Tetrachloride	PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of MARCO mRNA]	16006527
D002251	Carbon Tetrachloride	PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of NNMT mRNA]	16006527
D002251	Carbon Tetrachloride	PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of PALD1 mRNA]	16006527
D002251	Carbon Tetrachloride	PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of PLK1 mRNA]	16006527
D002251	Carbon Tetrachloride	PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of PMF1 mRNA]	16006527
D002251	Carbon Tetrachloride	PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of PNLIPRP1 mRNA]	16006527
D002251	Carbon Tetrachloride	PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of PRSS2 mRNA]	16006527
D002251	Carbon Tetrachloride	PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of PTTG1 mRNA]	16006527
D002251	Carbon Tetrachloride	PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of SAA1 mRNA]	16006527
D002251	Carbon Tetrachloride	PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of SLC51A mRNA]	16006527
D002251	Carbon Tetrachloride	PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of STMN1 mRNA]	16006527
D002251	Carbon Tetrachloride	PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of TRY4 mRNA]	16006527
D002251	Carbon Tetrachloride	PLG protein affects the reaction [Carbon Tetrachloride results in increased expression of BCL2L11 protein]	17482686
D002251	Carbon Tetrachloride	PLG protein affects the reaction [Carbon Tetrachloride results in increased phosphorylation of MAPK1 protein]	17482686
D002251	Carbon Tetrachloride	PLG protein affects the reaction [Carbon Tetrachloride results in increased phosphorylation of MAPK3 protein]	17482686
D002251	Carbon Tetrachloride	PLG protein affects the susceptibility to Carbon Tetrachloride	16006527
D002251	Carbon Tetrachloride	PLG protein inhibits the reaction [Carbon Tetrachloride results in increased expression of VWF protein]	14716496
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of PLG mRNA	12734012
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PLG mRNA	20938992
D002994	Clofibrate	Clofibrate affects the expression of PLG protein	131008
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of PLG mRNA	17585979
D002994	Clofibrate	Clofibrate results in decreased expression of PLG mRNA	17585979
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of PLG mRNA]	17585979
D002994	Clofibrate	Clofibrate results in decreased expression of PLG mRNA	22300585
D002994	Clofibrate	Clofibrate affects the expression of PLG mRNA	19483382
D002994	Clofibrate	Clofibrate results in decreased expression of PLG mRNA	12851107
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of PLG mRNA	24386269
D003276	Contraceptives, Oral	"Contraceptives, Oral results in increased expression of PLG"	15185533
D003276	Contraceptives, Oral	"Contraceptives, Oral results in increased expression of PLG protein"	133615\|4180662
D003277	Contraceptives, Oral, Combined	"Contraceptives, Oral, Combined results in increased expression of PLG protein"	754993
D003300	Copper	PLG protein binds to Copper	23896426
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of PLG mRNA	19549813
D016572	Cyclosporine	Cyclosporine results in decreased expression of PLG mRNA	20106945
D003561	Cytarabine	Cytarabine affects the localization of PLG protein	12165291
D015084	2,4-Dichlorophenoxyacetic Acid	"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of PLG mRNA"	20566314
D003613	Danazol	Danazol results in increased expression of PLG protein	8529771
D003907	Dexamethasone	Dexamethasone affects the expression of PLG protein	10485340
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of PLG mRNA	21266533
D002945	Cisplatin	Cisplatin results in increased secretion of PLG protein	28885000
D004026	Dieldrin	Dieldrin results in increased expression of PLG mRNA	20438755
D004041	Dietary Fats	Dietary Fats results in decreased expression of PLG mRNA	25016146
D004147	Dioxins	Dioxins affects the expression of PLG mRNA	20463971
D004298	Dopamine	PLG protein promotes the reaction [Morphine results in increased secretion of Dopamine]	16619846
D004317	Doxorubicin	Doxorubicin results in increased secretion of PLG protein	28885000
D004492	Edetic Acid	Edetic Acid inhibits the reaction [Zinc results in increased expression of PLG mRNA]	21615740
D004492	Edetic Acid	Edetic Acid inhibits the reaction [Zinc results in increased expression of PLG protein]	21615740
C035276	eicosapentaenoic acid ethyl ester	eicosapentaenoic acid ethyl ester results in increased expression of PLG protein	14614217
C118739	entinostat	entinostat results in decreased expression of PLG mRNA	27188386
D004785	Environmental Pollutants	Environmental Pollutants results in decreased expression of PLG protein	22085608
D004785	Environmental Pollutants	Environmental Pollutants results in increased expression of PLG protein	22085608
D004997	Ethinyl Estradiol	[Ethinyl Estradiol binds to Norethindrone] which results in increased expression of PLG protein	14561536
D004997	Ethinyl Estradiol	[Ethinyl Estradiol co-treated with Gestodene] results in increased activity of PLG protein	11720199
D004997	Ethinyl Estradiol	[Ethinyl Estradiol co-treated with Gestodene] results in increased expression of PLG protein	12618251
D004997	Ethinyl Estradiol	[Ethinyl Estradiol co-treated with Levonorgestrel] results in increased expression of PLG protein	12618251\|1515779
D004997	Ethinyl Estradiol	[Ethinyl Estradiol co-treated with norgestimate] results in increased expression of PLG protein	12618251
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of PLG protein	17374706
C442659	ethinyl estradiol-desogestrel combination	ethinyl estradiol-desogestrel combination results in increased activity of PLG protein	15318540
C442659	ethinyl estradiol-desogestrel combination	ethinyl estradiol-desogestrel combination results in increased expression of PLG protein	12618251
D005001	Ethionine	Ethionine affects the expression of PLG mRNA	19483382
D005227	Fatty Acids	Fatty Acids results in decreased activity of PLG protein	14724836
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PLG mRNA	20938992
C105311	FR 173657	FR 173657 inhibits the reaction [benazepril results in increased activity of PLG protein]	15339989
C039281	furan	furan results in decreased expression of PLG mRNA	26194646
D019833	Genistein	Genistein affects the expression of PLG mRNA	18214933
D019833	Genistein	Genistein results in increased expression of PLG mRNA	20838740
C033273	Gestodene	[Ethinyl Estradiol co-treated with Gestodene] results in increased activity of PLG protein	11720199
C033273	Gestodene	[Ethinyl Estradiol co-treated with Gestodene] results in increased expression of PLG protein	12618251
C081021	Go 6976	Go 6976 inhibits the reaction [Zinc results in increased expression of PLG mRNA]	21615740
C081021	Go 6976	Go 6976 inhibits the reaction [Zinc results in increased expression of PLG protein]	21615740
D006493	Heparin	Heparin inhibits the reaction [PLG protein affects the degradation of CCL11 protein]	17384413
D006540	Herbicides	"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of PLG mRNA"	20566314
D006812	Humic Substances	alpha-Tocopherol inhibits the reaction [Arsenic promotes the reaction [Humic Substances results in decreased activity of PLG protein]]	11419606
D006812	Humic Substances	alpha-Tocopherol inhibits the reaction [Humic Substances results in decreased activity of PLG protein]	11419606
D006812	Humic Substances	Arsenic promotes the reaction [Humic Substances results in decreased activity of PLG protein]	11419606
D006812	Humic Substances	Ascorbic Acid inhibits the reaction [Arsenic promotes the reaction [Humic Substances results in decreased activity of PLG protein]]	11419606
D006812	Humic Substances	Ascorbic Acid inhibits the reaction [Humic Substances results in decreased activity of PLG protein]	11419606
D006812	Humic Substances	CAT protein inhibits the reaction [Arsenic promotes the reaction [Humic Substances results in decreased activity of PLG protein]]	11419606
D006812	Humic Substances	CAT protein inhibits the reaction [Humic Substances results in decreased activity of PLG protein]	11419606
D006812	Humic Substances	Humic Substances results in decreased activity of PLG protein	11419606
D007531	Isoflurophate	Isoflurophate inhibits the reaction [PLG protein results in increased phosphorylation of MAPK1 protein]	17482686
D007531	Isoflurophate	Isoflurophate inhibits the reaction [PLG protein results in increased phosphorylation of MAPK3 protein]	17482686
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of PLG mRNA	22802445
C008261	lead acetate	lead acetate affects the activity of PLG protein modified form	2143947
C008340	mecoprop	"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of PLG mRNA"	20566314
D017258	Medroxyprogesterone Acetate	Medroxyprogesterone Acetate results in increased expression of PLG	1828463
D008713	Methimazole	Methimazole results in increased expression of PLG mRNA	22504374
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PLG mRNA	20938992
C043243	methyl tert-butyl ether	methyl tert-butyl ether affects the expression of PLG mRNA	24128854
D009020	Morphine	PLG protein affects the susceptibility to Morphine	16619846
D009020	Morphine	PLG protein promotes the reaction [Morphine results in increased secretion of Dopamine]	16619846
C078131	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Zinc results in increased expression of PLG mRNA]	21615740
C078131	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Zinc results in increased expression of PLG protein]	21615740
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of PLG mRNA"	25554681
C051752	nefazodone	nefazodone results in decreased expression of PLG mRNA	24136188
D009532	Nickel	PLG protein binds to Nickel	23896426
D009532	Nickel	Nickel analog results in decreased expression of PLG protein alternative form	25144474
D009532	Nickel	Nickel results in increased expression of PLG mRNA	24084258
C022838	nickel chloride	nickel chloride affects the expression of PLG mRNA	22546817
D009599	Nitroprusside	PLG protein results in decreased susceptibility to Nitroprusside	9710261
D009599	Nitroprusside	PLG protein results in decreased susceptibility to Nitroprusside	9710261
D009640	Norethindrone	[Ethinyl Estradiol binds to Norethindrone] which results in increased expression of PLG protein	14561536
C017576	norgestimate	[Ethinyl Estradiol co-treated with norgestimate] results in increased expression of PLG protein	12618251
D016912	Levonorgestrel	[Ethinyl Estradiol co-treated with Levonorgestrel] results in increased expression of PLG protein	12618251\|1515779
C516519	NuvaRing	NuvaRing results in increased expression of PLG protein	15157790
C025589	ochratoxin A	ochratoxin A results in decreased expression of PLG mRNA	29274910
D009853	Omeprazole	Omeprazole affects the expression of PLG mRNA	19483382
D010100	Oxygen	Oxygen deficiency promotes the reaction [PLAU protein results in increased activity of PLG protein]	12485432
D052638	Particulate Matter	Particulate Matter results in decreased expression of PLG protein alternative form	25144474
C101816	perfluoro-n-nonanoic acid	perfluoro-n-nonanoic acid results in decreased expression of PLG mRNA	21984479
C101814	perfluoro-n-undecanoic acid	perfluoro-n-undecanoic acid results in decreased expression of PLG mRNA	23602845
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of PLG mRNA	25868421
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PLG mRNA	19710929
C006253	pirinixic acid	[pirinixic acid co-treated with PPARA] results in decreased expression of PLG mRNA	20813756
C006253	pirinixic acid	pirinixic acid results in decreased expression of PLG mRNA	20813756
C006253	pirinixic acid	pirinixic acid affects the expression of PLG mRNA	19483382
D011192	Potassium Dichromate	Potassium Dichromate affects the expression of PLG mRNA	23608068
D011441	Propylthiouracil	Propylthiouracil affects the expression of PLG mRNA	19483382
D011441	Propylthiouracil	Propylthiouracil results in increased expression of PLG mRNA	22504374
D012406	Roxarsone	Roxarsone results in decreased expression of PLG mRNA	18414637
D012645	Selenomethionine	Selenomethionine affects the expression of PLG mRNA	17222674
C017947	sodium arsenite	sodium arsenite affects the expression of PLG mRNA	19590694
C017947	sodium arsenite	sodium arsenite affects the expression of PLG mRNA	17450228
C016104	sodium bichromate	sodium bichromate results in decreased expression of PLG mRNA	24612858
C016104	sodium bichromate	sodium bichromate affects the expression of PLG mRNA	22110744
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of PLG protein	28918527
C049985	staurosporine aglycone	staurosporine aglycone inhibits the reaction [Zinc results in increased expression of PLG mRNA]	21615740
C049985	staurosporine aglycone	staurosporine aglycone inhibits the reaction [Zinc results in increased expression of PLG protein]	21615740
D013629	Tamoxifen	Tamoxifen results in increased expression of PLG protein	8200368
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of PLG mRNA	20106945
D013752	Tetracycline	Tetracycline results in increased expression of PLG mRNA	16917069
D013756	Tetraethyl Lead	Tetraethyl Lead affects the activity of PLG protein modified form	2143947
D013853	Thioacetamide	Thioacetamide affects the expression of PLG mRNA	19483382
D014148	Tranexamic Acid	Tranexamic Acid results in decreased activity of PLG protein	22507835
C012589	trichostatin A	trichostatin A results in decreased expression of PLG mRNA	15901671
D014260	Triclosan	Triclosan inhibits the reaction [TNF protein results in increased metabolism of PLG protein]	19874453
D014520	Urethane	Urethane results in decreased expression of PLG mRNA	28818685
D014635	Valproic Acid	Valproic Acid results in decreased expression of PLG mRNA	15901671
D014635	Valproic Acid	Valproic Acid results in decreased expression of PLG mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in decreased methylation of PLG gene	29154799
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of PLG gene	25560391
C111237	vorinostat	vorinostat results in decreased expression of PLG mRNA	27188386
D015032	Zinc	PLG protein binds to Zinc	23896426
D015032	Zinc	4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Zinc results in increased expression of PLG mRNA]	21615740
D015032	Zinc	4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Zinc results in increased expression of PLG protein]	21615740
D015032	Zinc	4-aminophenylmercuriacetate inhibits the reaction [Zinc results in increased expression of PLG mRNA]	21615740
D015032	Zinc	4-aminophenylmercuriacetate inhibits the reaction [Zinc results in increased expression of PLG protein]	21615740
D015032	Zinc	BDNF protein affects the reaction [Zinc results in increased expression of PLG mRNA]	21615740
D015032	Zinc	BDNF protein affects the reaction [Zinc results in increased expression of PLG protein]	21615740
D015032	Zinc	Edetic Acid inhibits the reaction [Zinc results in increased expression of PLG mRNA]	21615740
D015032	Zinc	Edetic Acid inhibits the reaction [Zinc results in increased expression of PLG protein]	21615740
D015032	Zinc	Go 6976 inhibits the reaction [Zinc results in increased expression of PLG mRNA]	21615740
D015032	Zinc	Go 6976 inhibits the reaction [Zinc results in increased expression of PLG protein]	21615740
D015032	Zinc	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Zinc results in increased expression of PLG mRNA]	21615740
D015032	Zinc	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Zinc results in increased expression of PLG protein]	21615740
D015032	Zinc	staurosporine aglycone inhibits the reaction [Zinc results in increased expression of PLG mRNA]	21615740
D015032	Zinc	staurosporine aglycone inhibits the reaction [Zinc results in increased expression of PLG protein]	21615740
D015032	Zinc	Zinc results in increased expression of PLG mRNA	21615740
D015032	Zinc	Zinc results in increased expression of PLG protein	21615740

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004175	endopeptidase activity	-	IDA	9603964
GO:0004252	serine-type endopeptidase activity	-	IBA	21873635
GO:0004252	serine-type endopeptidase activity	-	IDA	14688145 14699093 17307854
GO:0004252	serine-type endopeptidase activity	-	IMP	18070902 19270100 20727989
GO:0004252	serine-type endopeptidase activity	-	TAS	-
GO:0005102	signaling receptor binding	-	IPI	20028034
GO:0005515	protein binding	-	IPI	134998 6438154 9092705 9102401 9603964 10077593 11257124 12456874 12622818 16319056 16480936 17557824 17653767 17849409 19712047 21949403 22087329 22321644 23197176 25978044 26627825 26667841 26822058
GO:0008236	serine-type peptidase activity	-	TAS	24263861
GO:0019899	enzyme binding	-	IPI	12666133 12818429 12867553 14688145 17307854 17849409 17892475 17964283 18070902 19270100 19433310 19574304 20727989 22025510 22087329
GO:0019900	kinase binding	-	IPI	24196407
GO:0019904	protein domain specific binding	-	IPI	9786936 20028034
GO:0034185	apolipoprotein binding	-	IPI	16480936
GO:0051087	chaperone binding	-	IPI	17307854 17849409 19574304
GO:1904854	proteasome core complex binding	-	IPI	17849409
GO:1990405	protein antigen binding	-	IPI	17849409

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002576	platelet degranulation	-	TAS	-
GO:0006508	proteolysis	-	IDA	9603964
GO:0006508	proteolysis	-	IMP	18070902 19270100
GO:0007596	blood coagulation	-	IMP	1986355
GO:0008285	negative regulation of cell proliferation	-	TAS	8910613
GO:0010812	negative regulation of cell-substrate adhesion	-	IDA	14699093
GO:0022617	extracellular matrix disassembly	-	IDA	14699093
GO:0022617	extracellular matrix disassembly	-	TAS	-
GO:0042730	fibrinolysis	-	IDA	14688145 17307854 22025510
GO:0042730	fibrinolysis	-	TAS	-
GO:0044267	cellular protein metabolic process	-	TAS	-
GO:0048771	tissue remodeling	-	IEA	-
GO:0051702	interaction with symbiont	-	IDA	12818429
GO:0051918	negative regulation of fibrinolysis	-	IDA	14726399
GO:0051919	positive regulation of fibrinolysis	-	IDA	6438154 26667841
GO:0052182	modification by host of symbiont morphology or physiology via secreted substance	-	IDA	14688145 17307854
GO:0052182	modification by host of symbiont morphology or physiology via secreted substance	-	IMP	18070902 20727989
GO:0052213	interaction with symbiont via secreted substance involved in symbiotic interaction	-	IDA	19270100 22025510 22087329
GO:2000048	negative regulation of cell-cell adhesion mediated by cadherin	-	TAS	17203182

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	HDA	16502470
GO:0005615	extracellular space	-	IDA	6216475 6980881 14688145 17307854
GO:0005886	plasma membrane	-	TAS	-
GO:0009986	cell surface	-	IDA	14699093
GO:0031093	platelet alpha granule lumen	-	TAS	-
GO:0031232	extrinsic component of external side of plasma membrane	-	IDA	14699093
GO:0044218	other organism cell membrane	-	IDA	17307854
GO:0070062	extracellular exosome	-	HDA	19199708 23533145
GO:0072562	blood microparticle	-	HDA	22516433

KEGG ID	KEGG Term
hsa04080	Neuroactive ligand-receptor interaction
hsa04610	Complement and coagulation cascades
hsa05150	Staphylococcus aureus infection

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	TAS
R-HSA-114608	Platelet degranulation	TAS
R-HSA-1474228	Degradation of the extracellular matrix	IEA
R-HSA-1474228	Degradation of the extracellular matrix	TAS
R-HSA-1474244	Extracellular matrix organization	IEA
R-HSA-1474244	Extracellular matrix organization	TAS
R-HSA-1592389	Activation of Matrix Metalloproteinases	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-186797	Signaling by PDGF	TAS
R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-75205	Dissolution of Fibrin Clot	TAS
R-HSA-76002	Platelet activation, signaling and aggregation	TAS
R-HSA-76005	Response to elevated platelet cytosolic Ca2+	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26315791	Risk Factors for Thrombosis Development in Mexican Patients. (2015 Nov)	Zavala-Hernandez C	Ann Vasc Surg
1455395	Plasminogen levels in healthy volunteers--influence of age, sex, smoking and oral contraceptives. (1992 Nov 10)	Tait RC	Thromb Haemost
25466412	Genetic evidence for PLASMINOGEN as a shared genetic risk factor of coronary artery disease and periodontitis. (2015 Feb)	Schaefer AS	Circ Cardiovasc Genet
28546848	Estimation of Maximal Oxygen Consumption and Heart Rate Recovery Using the Tecumseh Sub-Maximal Step Test and their Relationship to Cardiovascular Risk Factors. (2017 Jun)	Hughes AD	Artery Res
19212904	Cardiovascular risk factors in non-diabetic hemodialysis patients: a comparative study. (2009)	Tzanatos HA	Ren Fail
18374997	Cardiovascular diseases (CVD) risk factors, physical activity (PA) and plasma plasminogen (Plg) in a random sample of community-dwelling elderly. (2009 May-Jun)	Kostka T	Arch Gerontol Geriatr
28548211	A haplotype block downstream of plasminogen is associated with chronic and aggressive periodontitis. (2017 Oct)	Munz M	J Clin Periodontol
15569605	The preclinical development of Medisorb Naltrexone, a once a month long acting injection, for the treatment of alcohol dependence. (2005 Jan 1)	Dean RL	Front Biosci