Gene: SERPINF2

5345
A2AP|AAP|ALPHA-2-PI|API|PLI
serpin family F member 2
protein-coding
17p13.3
Ensembl:ENSG00000167711 MIM:613168 Vega:OTTHUMG00000090552 UniprotKB:P08697
NG_013215.1
PubMed
0   ANCO-SNPs
ND|AD
1   
7.382e-1 (AD)  9.747e-1 (ND)   (Frontal_Cortex)
5.981e-1 (AD)  6.923e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCNA20.703
CLDN150.679
SRRM50.678
SLFNL10.677
PLOD30.674
CLDN90.665
SAP250.663
KLK140.655
TLR90.654
NPIPB60.647

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABCD2-0.451
LYPD6-0.411
HES5-0.404
HPDL-0.393
HAPLN1-0.391
CYS1-0.369
CRH-0.362
TTC30A-0.347
ALDH1L1-AS2-0.346
ERBB4-0.346

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB08888OcriplasminBiotechDrug1048016-09-6ApprovedTarget
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0364231-aminomethylphosphonic acid[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of SERPINF2 mRNA20566314
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of SERPINF2 mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of SERPINF2 mRNA29067470
D020106AcrylamideAcrylamide affects the expression of SERPINF2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SERPINF2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SERPINF2 mRNA27153756
D000638AmiodaroneAmiodarone affects the expression of SERPINF2 mRNA19483382
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SERPINF2 mRNA24449571
D001149Arsenates[Atrazine co-treated with Arsenates] results in increased expression of SERPINF2 mRNA18585445
C006632arsenic trioxidearsenic trioxide results in increased expression of SERPINF2 protein11775254
D001280Atrazine[Atrazine co-treated with Arsenates] results in increased expression of SERPINF2 mRNA18585445
D001553BenzbromaroneBenzbromarone affects the expression of SERPINF2 mRNA19483382
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SERPINF2 mRNA19770486
D004958EstradiolEstradiol results in decreased expression of SERPINF2 mRNA20106945
C006780bisphenol Abisphenol A results in increased expression of SERPINF2 mRNA27104808
C006780bisphenol Abisphenol A results in decreased expression of SERPINF2 mRNA25181051
D002793Cholic Acids[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of SERPINF2 mRNA27344345
D002793Cholic Acids[Cyclosporine co-treated with Cholic Acids] affects the expression of SERPINF2 mRNA27344345
D002994ClofibrateClofibrate affects the expression of SERPINF2 mRNA19483382
D003042CocaineCocaine results in increased expression of SERPINF2 mRNA27899881
D003300CopperSERPINF2 protein binds to Copper23896426
D019327Copper SulfateCopper Sulfate results in decreased expression of SERPINF2 mRNA19549813
D016572Cyclosporine[Cyclosporine co-treated with Cholic Acids] affects the expression of SERPINF2 mRNA27344345
D016572CyclosporineCyclosporine results in decreased expression of SERPINF2 mRNA20106945|2556210
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of SERPINF2 mRNA23914054
D002945CisplatinCisplatin results in decreased expression of SERPINF2 mRNA27392435
D004008DiclofenacDiclofenac results in increased expression of SERPINF2 mRNA26934552
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in decreased expression of SERPINF2 mRNA26924002
C024629dimethyl phthalatedimethyl phthalate results in decreased expression of SERPINF2 mRNA26924002
C035276eicosapentaenoic acid ethyl estereicosapentaenoic acid ethyl ester results in decreased expression of SERPINF2 protein14614217
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SERPINF2 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SERPINF2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SERPINF2 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SERPINF2 mRNA17108234
D005001EthionineEthionine affects the expression of SERPINF2 mRNA19483382
D005485FlutamideFlutamide results in decreased expression of SERPINF2 mRNA24136188|2479361
C069837fullerene C60fullerene C60 results in increased expression of SERPINF2 mRNA19167457
C039281furanfuran results in increased methylation of SERPINF2 gene22079235
D005897GlafenineGlafenine results in increased expression of SERPINF2 mRNA24136188
C412815GW 4064GW 4064 results in increased expression of SERPINF2 mRNA26655953
D006540Herbicides[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of SERPINF2 mRNA20566314
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SERPINF2 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SERPINF2 mRNA26752646
C410337K 7174K 7174 results in decreased expression of SERPINF2 mRNA24086573
D007854LeadLead results in decreased expression of SERPINF2 mRNA19921347
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of SERPINF2 mRNA"24972896
C517284monomethyl phthalatemonomethyl phthalate results in decreased expression of SERPINF2 mRNA26924002
D0150581-Naphthylisothiocyanate[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of SERPINF2 mRNA27344345
C051752nefazodonenefazodone results in decreased expression of SERPINF2 mRNA24136188
D009532NickelSERPINF2 protein binds to Nickel23896426
C028007nickel monoxidenickel monoxide results in increased expression of SERPINF2 mRNA19167457
D009853OmeprazoleOmeprazole affects the expression of SERPINF2 mRNA19483382
C036567perfluorodecanoic acidperfluorodecanoic acid results in decreased expression of SERPINF2 mRNA23567314
C522391perfluorododecanoic acidperfluorododecanoic acid results in decreased expression of SERPINF2 mRNA23567314
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of SERPINF2 mRNA20936131
C076994perfluorooctane sulfonic acidPPARA protein promotes the reaction [perfluorooctane sulfonic acid results in decreased expression of SERPINF2 mRNA]20936131
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SERPINF2 mRNA18467677
C023036perfluorooctanoic acidPPARA protein promotes the reaction [perfluorooctanoic acid results in decreased expression of SERPINF2 mRNA]18467677
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of SERPINF2 mRNA17097637
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of SERPINF2 mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of SERPINF2 mRNA16221962|1795077
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of SERPINF2 mRNA]17950772|2005976
C006253pirinixic acidpirinixic acid affects the expression of SERPINF2 mRNA19483382
D011192Potassium DichromatePotassium Dichromate affects the expression of SERPINF2 mRNA23608068
D011441PropylthiouracilPropylthiouracil affects the expression of SERPINF2 mRNA19483382
D011794QuercetinQuercetin results in decreased expression of SERPINF2 mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SERPINF2 mRNA25895662
D012969Sodium FluorideSodium Fluoride results in increased expression of SERPINF2 protein28918527
D013629TamoxifenTamoxifen results in decreased expression of SERPINF2 protein8200368
D013629TamoxifenTamoxifen affects the expression of SERPINF2 mRNA17555576
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SERPINF2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SERPINF2 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SERPINF2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SERPINF2 mRNA22298810
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of SERPINF2 mRNA28973375
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SERPINF2 mRNA25613284
D013853ThioacetamideThioacetamide affects the expression of SERPINF2 mRNA19483382
D014212TretinoinTretinoin results in decreased expression of SERPINF2 mRNA18230668
D014212TretinoinTretinoin results in increased expression of SERPINF2 protein11775254
D014241TrichloroethyleneTrichloroethylene results in decreased expression of SERPINF2 mRNA19448997
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SERPINF2 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of SERPINF2 mRNA25572481
D014635Valproic AcidValproic Acid results in decreased expression of SERPINF2 mRNA29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SERPINF2 gene25560391
C088658zoledronic acidzoledronic acid results in decreased expression of SERPINF2 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0002020protease binding-IPI134998  6980881  15853774  17317851  
GO:0004866endopeptidase inhibitor activity-TAS2830248  
GO:0004867serine-type endopeptidase inhibitor activity-IBA21873635  
GO:0004867serine-type endopeptidase inhibitor activity-IDA134998  
GO:0004867serine-type endopeptidase inhibitor activity-NAS12878203  
GO:0004867serine-type endopeptidase inhibitor activity-TAS-  
GO:0005515protein binding-IPI12878203  14687906  
GO:0042803protein homodimerization activity-IPI134998  
GO ID GO Term Qualifier Evidence PubMed
GO:0002034regulation of blood vessel diameter by renin-angiotensin-ISS-  
GO:0002576platelet degranulation-TAS-  
GO:0006953acute-phase response-IEA-  
GO:0010033response to organic substance-IEA-  
GO:0010757negative regulation of plasminogen activation-IDA134998  
GO:0010951negative regulation of endopeptidase activity-IBA21873635  
GO:0010951negative regulation of endopeptidase activity-IEA-  
GO:0030199collagen fibril organization-ISS17958745  
GO:0032967positive regulation of collagen biosynthetic process-IDA17958745  
GO:0042730fibrinolysis-TAS-  
GO:0045597positive regulation of cell differentiation-IDA20008146  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA17958745  
GO:0046330positive regulation of JNK cascade-IDA20008146  
GO:0048514blood vessel morphogenesis-ISS-  
GO:0048661positive regulation of smooth muscle cell proliferation-ISS-  
GO:0051496positive regulation of stress fiber assembly-IDA20008146  
GO:0051918negative regulation of fibrinolysis-IDA134998  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IDA20008146  
GO:0071636positive regulation of transforming growth factor beta production-IDA17958745  20008146  
GO:2000049positive regulation of cell-cell adhesion mediated by cadherin-TAS17203182  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-NAS14718574  
GO:0005576extracellular region-TAS-  
GO:0005577fibrinogen complex-IDA17317851  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IDA6980881  
GO:0009986cell surface-IDA17958745  
GO:0031093platelet alpha granule lumen-TAS-  
GO:0070062extracellular exosome-HDA23533145  
GO:0072562blood microparticle-HDA22516433  
KEGG ID KEGG Term
hsa04610Complement and coagulation cascades
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114608Platelet degranulation TAS
R-HSA-75205Dissolution of Fibrin ClotTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27222041A proteomic signature of ovarian cancer tumor fluid identified by highthroughput and verified by targeted proteomics. (2016 Aug 11)Poersch AJ Proteomics