Gene: PLK1

5347
PLK|STPK13
polo like kinase 1
protein-coding
16p12.2
Ensembl:ENSG00000166851 MIM:602098 Vega:OTTHUMG00000096984 UniprotKB:P53350
NC_000016.10
PubMed
0   ANCO-SNPs
AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.608e-1 (AD)  2.835e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AOC20.816
GSDMB0.814
HIC20.81
RCE10.809
FGF170.806
BRICD50.799
CPT1B0.798
OSBPL70.796
ZGLP10.786
KLK140.782

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KLRB1-0.363
TRDN-0.349
UNC45B-0.34
GZMA-0.337
OR4F5-0.336
CD2-0.333
GSDMC-0.325
GZMK-0.322
KLRF1-0.32
TBX21-0.318

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB068973-[3-chloro-5-(5-{[(1S)-1-phenylethyl]amino}isoxazolo[5,4-c]pyridin-3-yl)phenyl]propan-1-olSmall MoleculeExperimentalTarget
DB069633-[3-(3-methyl-6-{[(1S)-1-phenylethyl]amino}-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl]propanamideSmall MoleculeExperimentalTarget
DB071864-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDESmall MoleculeExperimentalTarget
DB077891-[5-methyl-2-(trifluoromethyl)furan-3-yl]-3-[(2Z)-5-(2-{[6-(1H-1,2,4-triazol-3-ylamino)pyrimidin-4-yl]amino}ethyl)-1,3-thiazol-2(3H)-ylidene]ureaSmall MoleculeExperimentalTarget
DB08059(1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATESmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of PLK1 mRNA"26377693
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of PLK1 mRNA"28903501
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PLK1 mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of PLK1 mRNA"27291303
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PLK1 mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of PLK1 mRNA"19167446
C0630022,3-dimethoxy-1,4-naphthoquinone"2,3-dimethoxy-1,4-naphthoquinone results in increased expression of PLK1 mRNA"19031421
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PLK1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PLK1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PLK1 mRNA"25510870
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PLK1 mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PLK1 mRNA"25510870
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PLK1 mRNA"23196670
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of PLK1 mRNA22841810
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of PLK1 mRNA19191707
C0821644-methoxycinnamate methyl ester[Thapsigargin co-treated with 4-methoxycinnamate methyl ester] results in increased expression of PLK1 mRNA19442820
C5241355-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-((2-(trifluoromethyl)benzyl)oxy)thiophene-2-carboxamide"[5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-((2-(trifluoromethyl)benzyl)oxy)thiophene-2-carboxamide co-treated with Chromium] results in increased activity of PLK1 protein"20089605
C5241355-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-((2-(trifluoromethyl)benzyl)oxy)thiophene-2-carboxamide"5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-((2-(trifluoromethyl)benzyl)oxy)thiophene-2-carboxamide inhibits the reaction [Chromium results in decreased localization of PLK1 protein]"20089605
C5241355-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-((2-(trifluoromethyl)benzyl)oxy)thiophene-2-carboxamide"5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-((2-(trifluoromethyl)benzyl)oxy)thiophene-2-carboxamide inhibits the reaction [PLK1 protein results in decreased susceptibility to Chromium]"20089605
D000082AcetaminophenAcetaminophen affects the expression of PLK1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PLK1 mRNA23630614
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PLK1 mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of PLK1 mRNA"22863853
C015001arsenitearsenite results in decreased expression of PLK1 mRNA18929588
D001205Ascorbic Acid[Quercetin co-treated with Ascorbic Acid] results in increased expression of PLK1 mRNA17639512
D001280AtrazineAtrazine results in increased expression of PLK1 mRNA22378314
C547126AZM551248AZM551248 results in increased expression of PLK1 mRNA22323515
C004456beauvericinbeauvericin results in decreased expression of PLK1 mRNA29203277
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of PLK1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PLK1 mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PLK1 protein29126329
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PLK1 mRNA"19150397|2001819
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehyde[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of PLK1 mRNA25566086
D004958EstradiolEstradiol results in increased expression of PLK1 protein20208560
D004958Estradiolfulvestrant inhibits the reaction [Estradiol results in increased expression of PLK1 protein]20208560
D004958EstradiolTamoxifen inhibits the reaction [Estradiol results in increased expression of PLK1 protein]20208560
D004958EstradiolESR1 protein promotes the reaction [Estradiol results in increased expression of PLK1 mRNA]25210133
D004958EstradiolEstradiol affects the expression of PLK1 mRNA15598610
D004958EstradiolEstradiol results in increased expression of PLK1 mRNA25210133
C518477BI 2536BI 2536 results in decreased activity of PLK1 protein24748653
C006780bisphenol Abisphenol A affects the expression of PLK1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of PLK1 mRNA29027980
C006780bisphenol Abisphenol A results in decreased expression of PLK1 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of PLK1 mRNA25181051
C006780bisphenol Abisphenol A results in decreased expression of PLK1 mRNA26982218
C515564bromovaninbromovanin results in increased expression of PLK1 protein modified form21419150
D002083Butylated Hydroxyanisole[propylparaben co-treated with Butylated Hydroxyanisole] results in decreased expression of PLK1 mRNA25086368
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of PLK1 mRNA12414654
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of PLK1 mRNA15003993
C584509C646 compoundC646 compound results in increased expression of PLK1 mRNA26191083
D002104CadmiumCadmium results in decreased expression of PLK1 mRNA21120746
C040048caffeic acid[Thapsigargin co-treated with caffeic acid] results in increased expression of PLK1 mRNA19442820
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of PLK1 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of PLK1 mRNA27339419
D002251Carbon TetrachloridePLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of PLK1 mRNA]16006527
C577235CBB2001CBB2001 results in increased expression of PLK1 protein22890557
C577235CBB2001CBB2001 binds to and results in decreased activity of PLK1 protein22890557
D002509CephaloridineCephaloridine results in decreased expression of PLK1 mRNA18500788
D002706ChlordanChlordan results in increased expression of PLK1 mRNA20403969
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLK1 mRNA20938992
D002857Chromium"[5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-((2-(trifluoromethyl)benzyl)oxy)thiophene-2-carboxamide co-treated with Chromium] results in increased activity of PLK1 protein"20089605
D002857Chromium"5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-((2-(trifluoromethyl)benzyl)oxy)thiophene-2-carboxamide inhibits the reaction [Chromium results in decreased localization of PLK1 protein]"20089605
D002857Chromium"5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-((2-(trifluoromethyl)benzyl)oxy)thiophene-2-carboxamide inhibits the reaction [PLK1 protein results in decreased susceptibility to Chromium]"20089605
D002857ChromiumChromium results in decreased expression of and results in decreased localization of PLK1 protein20089605
D002857ChromiumPLK1 protein results in decreased susceptibility to Chromium20089605
D002939CiprofloxacinCiprofloxacin results in increased expression of PLK1 protein18512786
D002994ClofibrateClofibrate results in decreased expression of PLK1 mRNA17585979
D002994ClofibrateClofibrate results in increased expression of PLK1 mRNA15033592
C018021cobaltous chloridecobaltous chloride results in decreased expression of PLK1 mRNA19320972|1937684
C018021cobaltous chloridecobaltous chloride results in decreased expression of PLK1 mRNA24386269
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of PLK1 mRNA20971185
D003300CopperCopper results in increased expression of PLK1 mRNA22465980
D019327Copper SulfateCopper Sulfate results in decreased expression of PLK1 mRNA19549813
D003345CorticosteroneCorticosterone results in decreased expression of PLK1 mRNA15755911
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of PLK1 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with ESR1 protein] results in increased expression of PLK1 mRNA18310284
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of PLK1 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of PLK1 mRNA19167446
D003375CoumestrolESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of PLK1 mRNA]18310284
D003471CuprizoneCuprizone results in increased expression of PLK1 mRNA26577399
D003474CurcuminCurcumin analog results in decreased expression of PLK1 mRNA26409325
C057862cyanoginosin LRcyanoginosin LR results in increased phosphorylation of PLK1 protein26506538
D016572CyclosporineCyclosporine results in decreased expression of PLK1 mRNA20106945|2163298
D000069439DasatinibDasatinib results in decreased expression of PLK1 mRNA20579391
D003976DiazinonDiazinon results in increased methylation of PLK1 gene22964155
D003976DiazinonDiazinon affects the expression of PLK1 mRNA22546817
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PLK1 mRNA17361019
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PLK1 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of PLK1 mRNA27594783
D002945CisplatinCisplatin results in increased localization of PLK1 protein20655883
D002945CisplatinCisplatin results in increased localization of [PLK1 protein co-treated with TP73 protein]20655883
D002945CisplatinPLK1 protein inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]20655883
D002945CisplatinPLK1 protein inhibits the reaction [Cisplatin results in increased expression of BAX mRNA]20655883
D002945CisplatinPLK1 protein inhibits the reaction [Cisplatin results in increased expression of GADD45A mRNA]20655883
D002945CisplatinPLK1 protein inhibits the reaction [Cisplatin results in increased expression of TP73 protein]20655883
D002945CisplatinPLK1 protein results in decreased susceptibility to Cisplatin20655883
D002945CisplatinPLK1 results in decreased susceptibility to Cisplatin22000864
D002945CisplatinCisplatin results in decreased expression of PLK1 mRNA25270620
D002945CisplatinCisplatin results in increased expression of PLK1 mRNA21151649
D002945CisplatinPLK1 results in decreased susceptibility to Cisplatin22006019
C000944dicrotophosdicrotophos results in increased expression of PLK1 mRNA28302478
D004026DieldrinDieldrin affects the expression of PLK1 mRNA22546817
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of PLK1 mRNA17854601
D004052DiethylnitrosamineRB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of PLK1 mRNA]17854601
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of PLK1 mRNA25242409
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of PLK1 mRNA22129741
D002117CalcitriolCalcitriol results in decreased expression of PLK1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of PLK1 mRNA21592394
D004317DoxorubicinDoxorubicin results in decreased expression of PLK1 mRNA15205334
D004365Drugs, Chinese Herbal"[Thapsigargin co-treated with Drugs, Chinese Herbal] results in increased expression of PLK1 mRNA"19442820
D005047EtoposideEtoposide results in decreased expression of PLK1 mRNA25270620
D005472FluorouracilFluorouracil results in decreased expression of PLK1 mRNA15205334
D005472FluorouracilFluorouracil results in increased expression of PLK1 protein15016801
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of PLK1 mRNA]15016801
D005472FluorouracilTP53 protein inhibits the reaction [Fluorouracil results in increased expression of PLK1 protein]15016801
D005492Folic Acid[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of PLK1 mRNA24657277
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLK1 mRNA20938992
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol results in increased expression of PLK1 protein]20208560
C070081fulvestrantfulvestrant promotes the reaction [RB1 protein binds to PLK1 promoter]21367843
C070081fulvestrantfulvestrant promotes the reaction [SIN3B protein binds to PLK1 promoter]21367843
C070081fulvestrantRB1 mutant form inhibits the reaction [fulvestrant promotes the reaction [SIN3B protein binds to PLK1 promoter]]21367843
C039281furanfuran results in increased expression of PLK1 mRNA25539665
C056507gemcitabinegemcitabine results in decreased expression of PLK120103597
C056507gemcitabinegemcitabine results in decreased expression of PLK1 mRNA20103597
C056507gemcitabine[gemcitabine results in decreased expression of PLK1] which results in increased susceptibility to gemcitabine20103597
C056507gemcitabineON 01910 promotes the reaction [PLK1 protein affects the susceptibility to gemcitabine]20103597
C056507gemcitabinePLK1 protein affects the susceptibility to gemcitabine20103597
D019833GenisteinGenistein results in decreased expression of PLK1 mRNA26865667
D005944GlucosamineGlucosamine results in increased expression of PLK1 mRNA17178593
D005944GlucosamineGlucosamine results in decreased expression of PLK1 mRNA17109745
D005947GlucoseGlucose results in increased expression of PLK1 mRNA17178593
C568713GSK1210151AGSK1210151A results in decreased expression of PLK1 mRNA26877780
C568713GSK1210151AGSK1210151A results in decreased expression of PLK1 protein26877780
D017313FenretinideFenretinide results in increased expression of PLK1 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of PLK1 mRNA12414654
D000068877Imatinib MesylatePLK1 mutant form results in increased susceptibility to Imatinib Mesylate26008977
D000068877Imatinib Mesylate[PLK1 mutant form results in increased susceptibility to Imatinib Mesylate] which results in increased cleavage of PARP1 protein26008977
D000068877Imatinib MesylatePLK1 protein affects the reaction [Imatinib Mesylate results in increased cleavage of PARP1 protein]26008977
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of PLK1 mRNA22129741
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of PLK1 mRNA25613284
C051890irinotecanirinotecan metabolite results in decreased expression of PLK1 mRNA15956246
C051890irinotecanirinotecan results in decreased expression of PLK1 mRNA15956246
C544151jinfukangjinfukang results in increased expression of PLK1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PLK1 mRNA24796395|2687778
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PLK1 protein26877780
C045463leflunomideleflunomide results in decreased expression of PLK1 mRNA28988120
C045463leflunomideleflunomide results in decreased expression of PLK1 mRNA24136188
D008154LucanthoneLucanthone results in decreased expression of PLK1 mRNA21148553
D047311LuteolinLuteolin results in decreased expression of PLK1 protein22926442
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLK1 mRNA20938992
D008727Methotrexate[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of PLK1 mRNA24657277
D008727MethotrexateMethotrexate results in decreased expression of PLK1 mRNA24657277
C013598methoxyacetic acidmethoxyacetic acid results in decreased expression of PLK1 mRNA9681501
C005219methyl cellosolvemethyl cellosolve results in decreased expression of PLK1 mRNA9681501
C005223methyleugenolmethyleugenol affects the expression of PLK1 mRNA26011634
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PLK1 mRNA26011545
C008493methylselenic acidmethylselenic acid affects the expression of PLK1 mRNA14617803
C008493methylselenic acidmethylselenic acid results in decreased expression of PLK1 mRNA11830524
D016685MitomycinMitomycin results in decreased expression of PLK1 mRNA25270620
D009151Mustard GasMustard Gas results in decreased expression of PLK1 mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PLK1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PLK1 mRNA"25554681
D009532NickelNickel results in increased expression of PLK1 mRNA19031421
C022838nickel chloridenickel chloride affects the expression of PLK1 mRNA22546817
C028007nickel monoxidenickel monoxide results in increased expression of PLK1 mRNA19167457
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of PLK1 mRNA20971185
C025589ochratoxin Aochratoxin A results in increased expression of PLK1 mRNA25636497
C025589ochratoxin ATRP53 gene mutant form promotes the reaction [ochratoxin A results in increased expression of PLK1 mRNA]25636497
C025589ochratoxin Aochratoxin A results in increased expression of PLK1 mRNA16251485|1923760
C507134ON 01910ON 01910 promotes the reaction [PLK1 protein affects the susceptibility to gemcitabine]20103597
C507134ON 01910ON 01910 results in decreased activity of PLK1 protein26008977
C507134ON 01910ON 01910 results in decreased phosphorylation of PLK1 protein25472472
C507134ON 01910ON 01910 results in decreased activity of PLK1 protein23658603
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of PLK1 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of PLK1 mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of PLK1 mRNA26516004
D010100OxygenOxygen results in decreased expression of PLK1 mRNA27103661
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of PLK1 mRNA25658374
D017239Paclitaxel[pifithrin co-treated with Paclitaxel] results in increased expression of PLK1 protein18516295
C500026palbociclibpalbociclib inhibits the reaction [RBL1 protein binds to PLK1 promoter]20100483
C500026palbociclibpalbociclib results in decreased expression of PLK1 mRNA22869556
C500026palbociclibRB1 protein affects the reaction [palbociclib inhibits the reaction [RBL1 protein binds to PLK1 promoter]]20100483
D052638Particulate MatterParticulate Matter results in decreased expression of PLK1 mRNA28366736
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PLK1 mRNA"25510870
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of PLK1 mRNA26678675
D010634PhenobarbitalPhenobarbital results in increased expression of PLK1 mRNA20403969|2309116
C121565pifithrin[pifithrin co-treated with Paclitaxel] results in increased expression of PLK1 protein18516295
C006253pirinixic acidpirinixic acid results in decreased expression of PLK1 mRNA17426115
C006253pirinixic acidpirinixic acid results in increased expression of PLK1 mRNA17950772|2381119
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of PLK1 mRNA]17950772
C006253pirinixic acidpirinixic acid results in increased expression of PLK1 mRNA19162173
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of PLK1 mRNA22698814
D011398PromethazinePromethazine results in decreased expression of PLK1 mRNA26011634
C005556propionaldehydepropionaldehyde results in decreased expression of PLK1 mRNA26079696
C006068propylparaben[propylparaben co-treated with Butylated Hydroxyanisole] results in decreased expression of PLK1 mRNA25086368
D011441PropylthiouracilPropylthiouracil results in increased expression of PLK1 mRNA24780913
C014175pyrazolo(3,4-d)pyrimidine"pyrazolo(3,4-d)pyrimidine analog affects the expression of PLK1 mRNA"21152443
C014175pyrazolo(3,4-d)pyrimidine"pyrazolo(3,4-d)pyrimidine analog affects the expression of PLK1 mRNA"21152443
D011794Quercetin[Quercetin co-treated with Ascorbic Acid] results in increased expression of PLK1 mRNA17639512
D011794QuercetinQuercetin results in decreased expression of PLK1 mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of PLK1 mRNA19167446
C059514resveratrolresveratrol results in decreased expression of PLK1 mRNA15767336
C104586roscovitineroscovitine results in decreased expression of PLK1 protein20100483
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of PLK1 mRNA"24160326
D012834SilverSilver results in decreased expression of PLK1 mRNA27131904
D012835Silver NitrateSilver Nitrate analog results in decreased expression of PLK1 mRNA22831968
C017947sodium arsenitesodium arsenite results in increased expression of PLK1 mRNA28595984
C017947sodium arsenitesodium arsenite results in decreased expression of PLK1 mRNA16014739
C075117squalestatin 1squalestatin 1 results in decreased expression of PLK1 mRNA27225895
C075117squalestatin 1squalestatin 1 results in decreased expression of PLK1 mRNA27225895
D013629TamoxifenTamoxifen inhibits the reaction [Estradiol results in increased expression of PLK1 protein]20208560
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of PLK1 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of PLK1 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PLK1 mRNA16714409
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PLK1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PLK1 mRNA15667827
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of PLK1 mRNA19031421
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of PLK1 mRNA25613284
D019284Thapsigargin[Thapsigargin co-treated with 4-methoxycinnamate methyl ester] results in increased expression of PLK1 mRNA19442820
D019284Thapsigargin[Thapsigargin co-treated with caffeic acid] results in increased expression of PLK1 mRNA19442820
D019284Thapsigargin"[Thapsigargin co-treated with Drugs, Chinese Herbal] results in increased expression of PLK1 mRNA"19442820
D019284ThapsigarginThapsigargin results in increased expression of PLK1 mRNA19442820
D013853ThioacetamideThioacetamide affects the expression of PLK1 mRNA26011634
D013853ThioacetamideThioacetamide results in increased expression of PLK1 mRNA22659510|2341159
C009495titanium dioxidetitanium dioxide affects the activity of PLK1 protein19695278
C009495titanium dioxidetitanium dioxide results in increased expression of PLK1 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PLK1 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of PLK1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of PLK1 mRNA25729387
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in decreased expression of PLK1 mRNA"17951470
D014212TretinoinTretinoin results in decreased expression of PLK1 mRNA16249480
D014241TrichloroethyleneTrichloroethylene results in increased expression of PLK1 mRNA25549359
C012589trichostatin Atrichostatin A affects the expression of PLK1 mRNA28542535
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of PLK1 mRNA19042947
C001899triptolidetriptolide results in increased expression of PLK1 mRNA23639586
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PLK1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of PLK1 mRNA19140230
D014635Valproic AcidValproic Acid results in decreased expression of PLK1 mRNA22083351
D014635Valproic AcidValproic Acid affects the expression of PLK1 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PLK1 gene25560391
D024483Vitamin K 3Vitamin K 3 results in decreased expression of PLK1 mRNA12414654
C088658zoledronic acidzoledronic acid results in decreased expression of PLK1 mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-IMP17461553  
GO:0004672protein kinase activity-IDA17146433  19596235  22854038  
GO:0004672protein kinase activity-IMP17461553  
GO:0004674protein serine/threonine kinase activity-EXP18378770  20577264  
GO:0004674protein serine/threonine kinase activity-IDA12524548  12939256  15148369  17351640  18174154  18477460  
19160488  19468300  19468302  
GO:0004674protein serine/threonine kinase activity-IMP19473992  21041660  23455478  
GO:0004674protein serine/threonine kinase activity-TAS-  
GO:0005515protein binding-IPI12493754  12524548  12595692  12939256  14532005  15148369  
15654075  16439210  16753148  16760428  16815967  16864798  
16980960  17146433  17307877  17310276  17351640  17495026  
18174154  18250300  18329369  18331714  18477460  18521620  
18615013  18794143  19160488  19468300  19468302  19473992  
19596235  19597481  19833129  20126263  20360068  20534861  
20577264  20679239  20890306  21041660  21642957  21880710  
21887822  21988832  22609948  22653443  23036704  23455478  
25503564  25852190  25986610  26496610  26638075  27173435  
GO:0005524ATP binding-IMP17461553  
GO:0008017microtubule binding-IDA12939256  
GO:0010997anaphase-promoting complex binding-IPI18662541  
GO:0016301kinase activity-TAS-  
GO:0019901protein kinase binding-IPI12639966  18615013  21041660  
GO:0042802identical protein binding-IPI14532005  21041660  23354166  26192437  
GO ID GO Term Qualifier Evidence PubMed
GO:0000070mitotic sister chromatid segregation-IMP23455478  
GO:0000086G2/M transition of mitotic cell cycle-IDA19160488  
GO:0000086G2/M transition of mitotic cell cycle-TAS-  
GO:0000122negative regulation of transcription by RNA polymerase II-IMP18174154  
GO:0000278mitotic cell cycle-IDA18615013  
GO:0000278mitotic cell cycle-IMP18477460  
GO:0000281mitotic cytokinesis-IDA19468302  
GO:0001578microtubule bundle formation-IDA12939256  
GO:0006468protein phosphorylation-IDA19468300  20679239  22701722  
GO:0006468protein phosphorylation-IMP17461553  
GO:0007062sister chromatid cohesion-TAS-  
GO:0007077mitotic nuclear envelope disassembly-TAS-  
GO:0007094mitotic spindle assembly checkpoint-IMP23455478  
GO:0007098centrosome cycle-IMP8991084  18477460  
GO:0007346regulation of mitotic cell cycle-IMP17495026  
GO:0008283cell proliferation-TAS8127874  
GO:0010389regulation of G2/M transition of mitotic cell cycle-TAS-  
GO:0010800positive regulation of peptidyl-threonine phosphorylation-IMP21041660  
GO:0016321female meiosis chromosome segregation-IEA-  
GO:0016567protein ubiquitination-IDA16885022  
GO:0018105peptidyl-serine phosphorylation-IDA16885022  
GO:0030071regulation of mitotic metaphase/anaphase transition-IMP21041660  
GO:0031145anaphase-promoting complex-dependent catabolic process-TAS-  
GO:0031648protein destabilization-IDA16885022  
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process-IMP19473992  
GO:0032465regulation of cytokinesis-IDA17351640  
GO:0032465regulation of cytokinesis-IMP12939256  
GO:0043066negative regulation of apoptotic process-IMP18174154  
GO:0043393regulation of protein binding-IMP21041660  
GO:0045143homologous chromosome segregation-IEA-  
GO:0045184establishment of protein localization-IMP18331714  
GO:0045736negative regulation of cyclin-dependent protein serine/threonine kinase activity-IMP21041660  
GO:0045862positive regulation of proteolysis-IDA16885022  
GO:0051081nuclear envelope disassembly-IMP20679239  
GO:0051443positive regulation of ubiquitin-protein transferase activity-IMP19473992  
GO:0051726regulation of cell cycle-TAS-  
GO:0070194synaptonemal complex disassembly-IEA-  
GO:0071168protein localization to chromatin-IDA21111234  
GO:0072425signal transduction involved in G2 DNA damage checkpoint-IDA18662541  
GO:0090435protein localization to nuclear envelope-IMP20679239  
GO:0097711ciliary basal body-plasma membrane docking-TAS-  
GO:1900182positive regulation of protein localization to nucleus-TAS-  
GO:1901673regulation of mitotic spindle assembly-IDA22621898  
GO:1902749regulation of cell cycle G2/M phase transition-TAS-  
GO:1904668positive regulation of ubiquitin protein ligase activity-IDA15148369  
GO:1904668positive regulation of ubiquitin protein ligase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000776kinetochore-IDA17617734  18477460  18615013  21041660  23455478  24157919  25395579  
GO:0000785chromatin-IEA-  
GO:0000795synaptonemal complex-IEA-  
GO:0000922spindle pole-IDA18331714  21041660  
GO:0000942condensed nuclear chromosome outer kinetochore-IDA18195732  
GO:0005634nucleus-IDA18615013  
GO:0005654nucleoplasm-TAS-  
GO:0005813centrosome-IDA8991084  12524548  18477460  18615013  21041660  21399614  23455478  24157919  
GO:0005819spindle-IDA12939256  17351640  
GO:0005829cytosol-TAS-  
GO:0005876spindle microtubulecolocalizes_withIDA21041660  
GO:0015630microtubule cytoskeleton-IDA21041660  
GO:0030496midbody-IDA19468300  
GO:0051233spindle midzone-IDA19468302  21041660  
KEGG ID KEGG Term
hsa04110Cell cycle
hsa04114Oocyte meiosis
hsa04914Progesterone-mediated oocyte maturation
Reactome ID Reactome Term Evidence
R-HSA-141424Amplification of signal from the kinetochoresTAS
R-HSA-141444Amplification of signal from unattached kinetochores via a MAD2 inhibitory signalTAS
R-HSA-156711Polo-like kinase mediated eventsTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162658Golgi Cisternae Pericentriolar Stack ReorganizationTAS
R-HSA-162658Golgi Cisternae Pericentriolar Stack ReorganizationIEA
R-HSA-1640170Cell CycleTAS
R-HSA-1640170Cell CycleIEA
R-HSA-174143APC/C-mediated degradation of cell cycle proteinsTAS
R-HSA-174178APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1TAS
R-HSA-176408Regulation of APC/C activators between G1/S and early anaphaseTAS
R-HSA-176412Phosphorylation of the APC/CTAS
R-HSA-176417Phosphorylation of Emi1TAS
R-HSA-176814Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteinsTAS
R-HSA-1852241Organelle biogenesis and maintenanceTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-2299718Condensation of Prophase ChromosomesTAS
R-HSA-2467813Separation of Sister ChromatidsTAS
R-HSA-2500257Resolution of Sister Chromatid CohesionTAS
R-HSA-2555396Mitotic Metaphase and AnaphaseTAS
R-HSA-2565942Regulation of PLK1 Activity at G2/M TransitionTAS
R-HSA-2980766Nuclear Envelope BreakdownTAS
R-HSA-2980767Activation of NIMA Kinases NEK9, NEK6, NEK7TAS
R-HSA-380259Loss of Nlp from mitotic centrosomesTAS
R-HSA-380270Recruitment of mitotic centrosome proteins and complexesTAS
R-HSA-380284Loss of proteins required for interphase microtubule organization from the centrosomeTAS
R-HSA-380287Centrosome maturationTAS
R-HSA-380320Recruitment of NuMA to mitotic centrosomesTAS
R-HSA-453274Mitotic G2-G2/M phasesTAS
R-HSA-453276Regulation of mitotic cell cycleTAS
R-HSA-5617833Cilium AssemblyTAS
R-HSA-5620912Anchoring of the basal body to the plasma membraneTAS
R-HSA-5663220RHO GTPases Activate ForminsTAS
R-HSA-68875Mitotic ProphaseTAS
R-HSA-68875Mitotic ProphaseIEA
R-HSA-68877Mitotic PrometaphaseTAS
R-HSA-68881Mitotic Metaphase/Anaphase TransitionTAS
R-HSA-68882Mitotic AnaphaseTAS
R-HSA-68884Mitotic Telophase/CytokinesisTAS
R-HSA-68886M PhaseTAS
R-HSA-68886M PhaseIEA
R-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionTAS
R-HSA-69275G2/M TransitionTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69278Cell Cycle, MitoticIEA
R-HSA-69618Mitotic Spindle CheckpointTAS
R-HSA-69620Cell Cycle CheckpointsTAS
R-HSA-8852276The role of GTSE1 in G2/M progression after G2 checkpointTAS
R-HSA-8854518AURKA Activation by TPX2TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23047041Disulfiram, a drug widely used to control alcoholism, suppresses the self-renewal of glioblastoma and over-rides resistance to temozolomide. (2012 Oct)Triscott JOncotarget
21324136Aberrant methylation of Polo-like kinase CpG islands in Plk4 heterozygous mice. (2011 Feb 15)Ward ABMC Cancer