Gene: FXYD1

5348
PLM
FXYD domain containing ion transport regulator 1
protein-coding
19q13.12
Ensembl:ENSG00000266964 MIM:602359 Vega:OTTHUMG00000182359 UniprotKB:O00168
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.349e-1 (AD)  2.611e-2 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg05216501chr19:35632564FXYD1Gene body3.859e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAMP10.918
ALDH20.907
MT30.905
DCXR0.898
SNTA10.892
APOE0.89
CST30.889
PRDX60.883
NDRG20.876
TNFSF130.875

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.593
OR4F5-0.591
ZNF860-0.452
COL19A1-0.451
IL12RB2-0.449
GABRG3-0.448
ARNTL2-0.445
PPM1E-0.443
TYRP1-0.443
ARHGAP20-0.44

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of FXYD1 mRNA"28903501
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FXYD1 mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of FXYD1 mRNA"25614096
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FXYD1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FXYD1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FXYD1 mRNA"25510870
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of FXYD1 mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FXYD1 mRNA"25510870
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of FXYD1 mRNA"28973690
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of FXYD1 mRNA"20959002|2319667
D000082AcetaminophenAcetaminophen results in decreased expression of FXYD1 mRNA26690555
D000082AcetaminophenAcetaminophen results in increased expression of FXYD1 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of FXYD1 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of FXYD1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of FXYD1 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of FXYD1 mRNA19770486
D000638AmiodaroneAmiodarone results in increased expression of FXYD1 mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FXYD1 mRNA16483693
D000667AmpicillinAmpicillin results in increased expression of FXYD1 mRNA21632981
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FXYD1 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to FXYD1 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FXYD1 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FXYD1 mRNA22228805
D004958EstradiolEstradiol results in decreased expression of FXYD1 mRNA20106945|2163298
C006780bisphenol Abisphenol A results in decreased expression of FXYD1 mRNA25181051
D002065BuspironeBuspirone results in increased expression of FXYD1 mRNA24136188
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of FXYD1 mRNA23650126
D002994ClofibrateClofibrate results in decreased expression of FXYD1 mRNA17585979
D019327Copper SulfateCopper Sulfate results in decreased expression of FXYD1 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of FXYD1 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of FXYD1 mRNA20106945|2163298
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in increased expression of FXYD1 mRNA"25908611
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of FXYD1 mRNA19638242
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of FXYD1 mRNA"22485181
D004237DiuronDiuron results in decreased expression of FXYD1 mRNA25152437
D004237DiuronDiuron results in increased expression of FXYD1 mRNA21551480
D004317DoxorubicinDoxorubicin affects the expression of FXYD1 protein29385562
D004317DoxorubicinDoxorubicin results in decreased expression of FXYD1 mRNA19915844
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of FXYD1 mRNA16174780|1755790
D005485FlutamideFlutamide results in decreased expression of FXYD1 mRNA24136188
C039281furanfuran results in decreased expression of FXYD1 mRNA25539665|2619464
D007608Kainic AcidKainic Acid results in decreased expression of FXYD1 mRNA17997037
D007854LeadLead affects the expression of FXYD1 mRNA28903495
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of FXYD1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of FXYD1 mRNA"25554681
D009532NickelNickel results in decreased expression of FXYD1 mRNA25583101
C028007nickel monoxidenickel monoxide results in decreased expression of FXYD1 mRNA19167457
D009538NicotineNicotine results in increased expression of FXYD1 mRNA17997037
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of FXYD1 mRNA27935865
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FXYD1 mRNA"25510870
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of FXYD1 mRNA27935865
D011441PropylthiouracilPropylthiouracil results in decreased expression of FXYD1 mRNA24780913
D011794QuercetinQuercetin affects the expression of FXYD1 mRNA21632981
D015125OxyquinolineOxyquinoline results in increased expression of FXYD1 mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FXYD1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FXYD1 mRNA15358164|1605489
D013853ThioacetamideThioacetamide results in decreased expression of FXYD1 mRNA23411599
D014050TolueneToluene results in decreased expression of FXYD1 mRNA22967744
D014241TrichloroethyleneTrichloroethylene results in decreased expression of FXYD1 mRNA19448997
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of FXYD1 mRNA19042947
C057693troglitazone[troglitazone co-treated with TNF protein] results in decreased expression of FXYD1 mRNA12732648
C022884undecaneundecane results in increased expression of FXYD1 protein17337753
D014520UrethaneUrethane results in decreased expression of FXYD1 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of FXYD1 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of FXYD1 mRNA19101580
D014635Valproic AcidValproic Acid results in increased methylation of FXYD1 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005254chloride channel activity-TAS9169143  
GO:0017080sodium channel regulator activity-IBA21873635  
GO:0017080sodium channel regulator activity-ISS-  
GO:0044325ion channel binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006813potassium ion transport-IEA-  
GO:0006814sodium ion transport-IEA-  
GO:0006821chloride transport-TAS9169143  
GO:0006936muscle contraction-TAS9169143  
GO:0008016regulation of heart contraction-TAS19683723  
GO:0010734negative regulation of protein glutathionylation-ISS-  
GO:0086036regulation of cardiac muscle cell membrane potential-ISS-  
GO:1902476chloride transmembrane transport-IEA-  
GO:1903278positive regulation of sodium ion export across plasma membrane-ISS-  
GO:2000649regulation of sodium ion transmembrane transporter activity-IBA21873635  
GO:2000649regulation of sodium ion transmembrane transporter activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS9169143  
GO:0005890sodium:potassium-exchanging ATPase complex-ISS-  
GO:0005901caveola-ISS-  
GO:0014704intercalated disc-ISS-  
GO:0016324apical plasma membrane-ISS-  
GO:0030315T-tubule-ISS-  
GO:0042383sarcolemma-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-397014Muscle contractionTAS
R-HSA-5576891Cardiac conductionTAS
R-HSA-5578775Ion homeostasisTAS
R-HSA-936837Ion transport by P-type ATPasesTAS
R-HSA-983712Ion channel transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27814717Differential DNA methylation marks and gene comethylation of COPD in African-Americans with COPD exacerbations. (2016 Nov 5)Busch RRespir Res