Gene: PLN

5350
CMD1P|CMH18|PLB
phospholamban
protein-coding
6q22.31
Ensembl:ENSG00000198523 MIM:172405 Vega:OTTHUMG00000015462 UniprotKB:P26678
NG_009082.1
PubMed
0   ANCO-SNPs
ND|AD
7   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.238e-1 (AD)  9.662e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OGN0.879
ACTA20.872
COL8A10.867
CASQ20.867
MYOCD0.865
ITIH30.855
AOC30.85
TRABD2B0.849
TBX180.846
MYH110.842

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HAGHL-0.415
ASPDH-0.406
BAIAP2L2-0.371
FAM43B-0.365
SAC3D1-0.361
NAT14-0.357
ZNF835-0.355
CCDC24-0.353
PNPLA7-0.353
FGF22-0.353

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D0140131,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt"1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Ditiocarb results in increased phosphorylation of PLN protein]"16288776
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PLN mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PLN mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PLN mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PLN mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PLN mRNA"25510870
C0065932-anthramine2-anthramine results in increased expression of PLN mRNA23038007
C5562954-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol"4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol inhibits the reaction [bis(4-hydroxyphenyl)sulfone results in increased phosphorylation of PLN protein]"25723814
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of PLN mRNA22484513
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PLN gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PLN mRNA19770486
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PLN mRNA22484513|2363061
D000493AllopurinolAllopurinol affects the expression of PLN mRNA17071724
D000493AllopurinolAllopurinol affects the expression of PLN protein17071724
D000493AllopurinolAllopurinol affects the expression of PLN protein modified form17071724
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PLN mRNA16483693
C052064astragaloside Aastragaloside A inhibits the reaction [Isoproterenol results in decreased phosphorylation of PLN protein]17509559
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PLN mRNA22228805|2261060
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PLN mRNA21839799
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PLN mRNA25566086
C543008bis(4-hydroxyphenyl)sulfone"4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol inhibits the reaction [bis(4-hydroxyphenyl)sulfone results in increased phosphorylation of PLN protein]"25723814
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased phosphorylation of PLN protein25723814
C006780bisphenol Abisphenol A results in increased expression of PLN protein23418087
C006780bisphenol Abisphenol A affects the expression of PLN mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PLN gene28505145
C006780bisphenol Abisphenol A results in increased phosphorylation of PLN protein24140712|2832406
C006780bisphenol AMifepristone inhibits the reaction [progesterone-11-bovine serum albumin inhibits the reaction [bisphenol A results in increased phosphorylation of PLN protein]]28324061
C006780bisphenol AMifepristone inhibits the reaction [Progesterone inhibits the reaction [bisphenol A results in increased phosphorylation of PLN protein]]28324061
C006780bisphenol APertussis Toxin inhibits the reaction [Progesterone inhibits the reaction [bisphenol A results in increased phosphorylation of PLN protein]]28324061
C006780bisphenol Aprogesterone-11-bovine serum albumin inhibits the reaction [bisphenol A results in increased phosphorylation of PLN protein]28324061
C006780bisphenol AProgesterone inhibits the reaction [bisphenol A results in increased phosphorylation of PLN protein]28324061
C006780bisphenol Awortmannin inhibits the reaction [Progesterone inhibits the reaction [bisphenol A results in increased phosphorylation of PLN protein]]28324061
D002104CadmiumCadmium results in decreased expression of PLN mRNA21694771
C081643candesartancandesartan inhibits the reaction [Isoproterenol results in decreased phosphorylation of PLN protein]16723803
C045645cilostazolcilostazol affects the expression of PLN mRNA18088389
C045645cilostazolcilostazol affects the expression of PLN protein18088389
D003471CuprizoneCuprizone results in decreased expression of PLN mRNA26577399|2752363
D003513CycloheximideCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of PLN mRNA]11007951
D000069439DasatinibDasatinib results in increased expression of PLN mRNA20579391
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of PLN mRNA23914054
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PLN mRNA21266533
D002945CisplatinCisplatin results in increased expression of PLN mRNA22023808
D004041Dietary FatsDietary Fats results in increased expression of PLN mRNA18042831
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of PLN mRNA20920545
D0198131,2-Dimethylhydrazine"1,2-Dimethylhydrazine results in increased expression of PLN mRNA"27840820
D004050Ditiocarb"1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Ditiocarb results in increased phosphorylation of PLN protein]"16288776
D004050DitiocarbDitiocarb results in increased phosphorylation of PLN protein16288776
D004237DiuronDiuron results in increased expression of PLN mRNA21551480
D004280DobutaminePLN protein affects the susceptibility to Dobutamine14991071
D004317DoxorubicinDoxorubicin affects the expression of PLN protein29385562
D004317DoxorubicinDoxorubicin results in decreased expression of PLN mRNA16243910
D004317DoxorubicinDoxorubicin results in increased phosphorylation of PLN protein20668052
D004317DoxorubicinN-benzyladriamycin-14-valerate inhibits the reaction [Doxorubicin results in increased phosphorylation of PLN protein]20668052
D000431EthanolEthanol results in increased expression of and results in decreased phosphorylation of PLN protein23448468
D000431EthanolPRKAA2 protein affects the reaction [Ethanol results in increased expression of PLN protein]23448468
D005419FlavonoidsFlavonoids results in increased expression of PLN mRNA18035473
D007545Isoproterenolastragaloside A inhibits the reaction [Isoproterenol results in decreased phosphorylation of PLN protein]17509559
D007545Isoproterenolcandesartan inhibits the reaction [Isoproterenol results in decreased phosphorylation of PLN protein]16723803
D007545IsoproterenolIsoproterenol results in decreased expression of and results in decreased phosphorylation of PLN protein10997724
D007545IsoproterenolIsoproterenol results in decreased phosphorylation of PLN protein16723803|1750955
D007545IsoproterenolIsoproterenol results in increased phosphorylation of PLN protein21268078
D007545IsoproterenolPropranolol inhibits the reaction [Isoproterenol results in decreased expression of and results in decreased phosphorylation of PLN protein]10997724
C008261lead acetatelead acetate results in increased expression of PLN mRNA22641619
D008345ManganeseManganese results in decreased expression of PLN mRNA17175027
C025340manganese chloridemanganese chloride results in decreased expression of PLN mRNA17175027
D008627Mercuric ChlorideMercuric Chloride results in decreased phosphorylation of PLN protein21723307
D008627Mercuric ChlorideMercuric Chloride results in increased expression of PLN protein21723307
D008727MethotrexateMethotrexate affects the expression of PLN mRNA18502557
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of PLN mRNA"20188158
D015735MifepristoneMifepristone inhibits the reaction [progesterone-11-bovine serum albumin inhibits the reaction [bisphenol A results in increased phosphorylation of PLN protein]]28324061
D015735MifepristoneMifepristone inhibits the reaction [Progesterone inhibits the reaction [bisphenol A results in increased phosphorylation of PLN protein]]28324061
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased phosphorylation of PLN protein27495954
C046808N-benzyladriamycin-14-valerateN-benzyladriamycin-14-valerate inhibits the reaction [Doxorubicin results in increased phosphorylation of PLN protein]20668052
D009532NickelNickel results in decreased expression of PLN mRNA24768652|2558310
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of PLN mRNA17616710
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of PLN mRNA27935865
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of PLN mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of PLN mRNA25729387
D000073878Palm OilPalm Oil results in increased expression of PLN mRNA18042831
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PLN mRNA"25510870
D037342Pertussis ToxinPertussis Toxin inhibits the reaction [Progesterone inhibits the reaction [bisphenol A results in increased phosphorylation of PLN protein]]28324061
D010795Phthalic AcidsPhthalic Acids results in decreased expression of PLN mRNA21061450
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of PLN mRNA27935865
D011374ProgesteroneMifepristone inhibits the reaction [Progesterone inhibits the reaction [bisphenol A results in increased phosphorylation of PLN protein]]28324061
D011374ProgesteronePertussis Toxin inhibits the reaction [Progesterone inhibits the reaction [bisphenol A results in increased phosphorylation of PLN protein]]28324061
D011374ProgesteroneProgesterone inhibits the reaction [bisphenol A results in increased phosphorylation of PLN protein]28324061
D011374ProgesteroneProgesterone results in increased expression of PLN mRNA16376865
D011374Progesteronewortmannin inhibits the reaction [Progesterone inhibits the reaction [bisphenol A results in increased phosphorylation of PLN protein]]28324061
C068561progesterone-11-bovine serum albuminMifepristone inhibits the reaction [progesterone-11-bovine serum albumin inhibits the reaction [bisphenol A results in increased phosphorylation of PLN protein]]28324061
C068561progesterone-11-bovine serum albuminprogesterone-11-bovine serum albumin inhibits the reaction [bisphenol A results in increased phosphorylation of PLN protein]28324061
D015742PropofolPropofol results in decreased phosphorylation of PLN protein27495954
D011433PropranololPropranolol inhibits the reaction [Isoproterenol results in decreased expression of and results in decreased phosphorylation of PLN protein]10997724
D011441PropylthiouracilPropylthiouracil results in decreased expression of PLN mRNA24780913
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in increased expression of PLN mRNA17457379
C059514resveratrolresveratrol results in decreased expression of PLN mRNA22610192
C059514resveratrolresveratrol results in increased phosphorylation of PLN protein25425099
C064294sarpogrelatesarpogrelate affects the expression of PLN mRNA18088389
C064294sarpogrelatesarpogrelate affects the expression of PLN protein18088389
D013311StreptozocinStreptozocin results in decreased phosphorylation of PLN protein19561140
D013311StreptozocinUCF 101 inhibits the reaction [Streptozocin results in decreased phosphorylation of PLN protein]19561140
D013629TamoxifenTamoxifen results in decreased expression of PLN mRNA17555576
D013749TetrachlorodibenzodioxinCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of PLN mRNA]11007951
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PLN mRNA11007951
D013853ThioacetamideThioacetamide results in increased expression of PLN mRNA23411599
C009495titanium dioxidetitanium dioxide results in decreased expression of PLN mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of PLN mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of PLN mRNA25729387
D019772TopotecanTopotecan results in increased expression of PLN mRNA25729387
D014212TretinoinTretinoin results in increased expression of PLN mRNA21934132
D014241TrichloroethyleneTrichloroethylene results in increased expression of PLN mRNA25847060
C501517UCF 101UCF 101 inhibits the reaction [Streptozocin results in decreased phosphorylation of PLN protein]19561140
D014635Valproic AcidValproic Acid affects the expression of PLN mRNA25979313
D014635Valproic AcidValproic Acid affects the expression of PLN mRNA17292431
D001335Vehicle EmissionsVehicle Emissions affects the methylation of PLN gene25560391
C025643vinclozolinvinclozolin results in increased expression of PLN mRNA23034163
C009687wortmanninwortmannin inhibits the reaction [Progesterone inhibits the reaction [bisphenol A results in increased phosphorylation of PLN protein]]28324061

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004857enzyme inhibitor activity-ISS12032137  
GO:0005246calcium channel regulator activity-IEA-  
GO:0005515protein binding-IPI15598648  25416956  25910212  
GO:0042030ATPase inhibitor activity-IDA19708671  
GO:0042030ATPase inhibitor activity-ISS-  
GO:0042802identical protein binding-ISS-  
GO:0051117ATPase binding-ISS12032137  
GO ID GO Term Qualifier Evidence PubMed
GO:0002026regulation of the force of heart contraction-IC19708671  
GO:0006816calcium ion transport-IEA-  
GO:0007219Notch signaling pathway-IEA-  
GO:0008015blood circulation-NAS8406504  
GO:0008016regulation of heart contraction-IMP16432188  
GO:0010043response to zinc ion-IEA-  
GO:0010459negative regulation of heart rate-IMP16432188  
GO:0010881regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion-IEA-  
GO:0032780negative regulation of ATPase activity-IDA19708671  
GO:0032780negative regulation of ATPase activity-ISS-  
GO:0032868response to insulin-IEA-  
GO:0033574response to testosterone-IEA-  
GO:0043086negative regulation of catalytic activity-ISS12032137  
GO:0048738cardiac muscle tissue development-IEA-  
GO:0051260protein homooligomerization-IEA-  
GO:0051480regulation of cytosolic calcium ion concentration-IC19708671  
GO:0051924regulation of calcium ion transport-IDA22427649  
GO:0051924regulation of calcium ion transport-ISS-  
GO:0051926negative regulation of calcium ion transport-IDA19708671  
GO:0055119relaxation of cardiac muscle-TAS22679139  
GO:0060314regulation of ryanodine-sensitive calcium-release channel activity-IEA-  
GO:0086004regulation of cardiac muscle cell contraction-IC19708671  
GO:0086023adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process-IEA-  
GO:0086036regulation of cardiac muscle cell membrane potential-IC19708671  
GO:0086092regulation of the force of heart contraction by cardiac conduction-IEA-  
GO:0090281negative regulation of calcium ion import-ISS12032137  
GO:1901020negative regulation of calcium ion transmembrane transporter activity-IDA19708671  
GO:1901020negative regulation of calcium ion transmembrane transporter activity-ISS12032137  
GO:1901877negative regulation of calcium ion binding-IDA19708671  
GO:1901877negative regulation of calcium ion binding-ISS12032137  
GO:1901894regulation of calcium-transporting ATPase activity-IDA22427649  
GO:1901895negative regulation of calcium-transporting ATPase activity-IDA19708671  
GO:1901897regulation of relaxation of cardiac muscle-IC19708671  
GO:1902081negative regulation of calcium ion import into sarcoplasmic reticulum-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-HDA20833797  
GO:0005783endoplasmic reticulum-ISS-  
GO:0016020membrane-IDA19708671  
GO:0031966mitochondrial membrane-IEA-  
GO:0031982vesicle-IEA-  
GO:0033017sarcoplasmic reticulum membrane-ISS-  
GO:0033017sarcoplasmic reticulum membrane-TAS-  
GO:0048471perinuclear region of cytoplasm-ISS-  
GO:0090534calcium ion-transporting ATPase complex-IDA19708671  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa05414Dilated cardiomyopathy
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-397014Muscle contractionTAS
R-HSA-5576891Cardiac conductionTAS
R-HSA-5578775Ion homeostasisTAS
R-HSA-936837Ion transport by P-type ATPasesTAS
R-HSA-983712Ion channel transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
16539181[Relationship between disease severity, smoking index age and direct costs of hospital treatment of COPD exacerbations]. (2005)Targowski TPneumonol Alergol Pol
29570212How does the risk of cardiovascular death and cardiovascular risk factor profiles differ between socioeconomic classes in Poland: A country in transition. (2018 Mar 23)Nadrowski PCardiol J
15524028[Retrospective analysis of direct costs of hospital treatment of chronic obstructive pulmonary disease exacerbations]. (2004 May)Jahnz-Rozyk KPol Merkur Lekarski
24037902The genetics of dilated cardiomyopathy: a prioritized candidate gene study of LMNA, TNNT2, TCAP, and PLN. (2013 Oct)Hirtle-Lewis MClin Cardiol
25799855[Risk factors for smoking in persons over 45]. (2014)Jozwiak PPrzegl Lek
29781077Demographic factors determining folic acid supplementation in pregnant and childbearing age women. (2018)Kurzawinska GGinekol Pol
15794248[Active tobacco smoking as determinant of costs of inpatient treatment of COPD exacerbations]. (2004)Targowski TPrzegl Lek