Gene: PLP1

5354
GPM6C|HLD1|MMPL|PLP|PLP/DM20|PMD|SPG2
proteolipid protein 1
protein-coding
Xq22.2
Ensembl:ENSG00000123560 MIM:300401 Vega:OTTHUMG00000022111 UniprotKB:P60201
NG_008863.2
PubMed
0   ANCO-SNPs
CD|ND|AD
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLDND10.942
SLC44A10.941
ERMN0.93
CNP0.918
ENPP20.917
PIP4K2A0.915
DBNDD20.912
EVI2A0.909
ANLN0.907
MOG0.905

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.494
OR4F5-0.445
NEUROD1-0.359
LTK-0.343
CUX2-0.334
CHRNA2-0.316
PAX2-0.313
SHISA8-0.308
CNGB1-0.305
PCDH8-0.305

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of PLP1 protein"21673325
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PLP1 mRNA"19114083
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PLP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PLP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PLP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PLP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLP1 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 affects the expression of PLP1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PLP1 mRNA21632981
C000188alachloralachlor affects the expression of PLP1 mRNA19425180
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PLP1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PLP1 mRNA24449571
D001151ArsenicArsenic results in decreased expression of PLP1 mRNA19654921
C006632arsenic trioxidearsenic trioxide results in decreased expression of PLP1 mRNA26705709
D001280AtrazineAtrazine results in decreased expression of PLP1 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PLP1 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PLP1 mRNA22228805
D004958Estradiol[Progesterone co-treated with Estradiol] inhibits the reaction [Cuprizone results in decreased expression of PLP1 mRNA]19031445
C006780bisphenol Abisphenol A results in decreased expression of PLP1 mRNA28641223
C006780bisphenol Abisphenol A results in increased methylation of PLP1 promoter27312807
C006780bisphenol Abisphenol A affects the expression of PLP1 mRNA25181051
C006780bisphenol Abisphenol A results in decreased expression of PLP1 mRNA25084756
C006780bisphenol Abisphenol A results in decreased expression of PLP1 protein25084756
D019256Cadmium Chloride[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] affects the expression of PLP1 protein23680456
D002110CaffeineCaffeine results in increased expression of PLP1 mRNA18444173
D002211CapsaicinCapsaicin results in increased expression of PLP1 mRNA20349343
D003024ClozapineClozapine results in decreased expression of PLP1 mRNA18797397
D003024ClozapineClozapine results in increased expression of PLP1 mRNA17266109
D003042CocaineCocaine affects the expression of PLP1 mRNA18357522
D003042CocaineCocaine results in decreased expression of PLP1 mRNA12629581|1500967
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of PLP1 mRNA26033743
D003300CopperCopper deficiency results in increased expression of PLP1 mRNA26033743
D016578Crack CocaineCrack Cocaine results in increased expression of PLP1 mRNA12629581
D003471CuprizoneCuprizone results in decreased expression of PLP1 mRNA19031445
D003471Cuprizone[Progesterone co-treated with Estradiol] inhibits the reaction [Cuprizone results in decreased expression of PLP1 mRNA]19031445
D003471CuprizoneCuprizone results in decreased expression of PLP1 mRNA26577399|2752363
D003513CycloheximideCycloheximide promotes the reaction [Tretinoin results in increased expression of PLP1 mRNA]19450544
D003513CycloheximideCycloheximide results in increased expression of PLP1 mRNA19450544
D003561CytarabineCytarabine results in increased expression of PLP1 mRNA21198554
D013759DronabinolDronabinol results in decreased expression of PLP1 mRNA12237329
D013759DronabinolDronabinol results in increased expression of PLP1 mRNA11015613
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PLP1 mRNA17361019|2126653
D004041Dietary FatsDietary Fats results in increased expression of PLP1 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of PLP1 mRNA8858961
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of PLP1 mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of PLP1 mRNA26033743
D000431EthanolEthanol results in increased expression of PLP1 mRNA28986285
D000431EthanolEthanol results in decreased expression of PLP1 mRNA29018328
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of PLP1 mRNA15834898
D005047EtoposidePLP1 protein affects the susceptibility to Etoposide16217747
C069837fullerene C60fullerene C60 results in decreased expression of PLP1 mRNA19167457
D019833GenisteinGenistein results in decreased expression of PLP1 mRNA18444173
D006220HaloperidolHaloperidol results in decreased expression of PLP1 mRNA17177202|1879739
D017313FenretinideFenretinide results in increased expression of PLP1 mRNA28973697
C029424hydrazinehydrazine results in decreased expression of PLP1 mRNA15282401
C098607JP8 aviation fuelJP8 aviation fuel results in increased expression of PLP1 protein17337753
D007649KetamineKetamine results in increased expression of PLP1 mRNA20080153
C008261lead acetate[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] affects the expression of PLP1 protein23680456
D008383MargarineMargarine affects the expression of PLP1 mRNA12168687
D008466MechlorethamineMechlorethamine results in decreased expression of PLP1 mRNA17107856
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PLP1 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PLP1 mRNA"27188386
D008767Methylmercury CompoundsMethylmercury Compounds affects the splicing of PLP1 mRNA25936639
D016685MitomycinPLP1 protein affects the susceptibility to Mitomycin16217747
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PLP1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PLP1 mRNA"25554681
D009532NickelNickel results in decreased expression of PLP1 mRNA25583101
C028007nickel monoxidenickel monoxide results in decreased expression of PLP1 mRNA19167457
C076029olanzapineolanzapine results in decreased expression of PLP1 mRNA18797397
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of PLP1 mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of PLP1 mRNA24236059
D010100OxygenOxygen deficiency results in increased expression of PLP1 mRNA24205000
D000073878Palm OilPalm Oil results in increased expression of PLP1 mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLP1 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of PLP1 mRNA26272509
D010269ParaquatParaquat results in decreased expression of PLP1 mRNA18198484
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of PLP1 mRNA26705709
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of PLP1 mRNA27294297
D010622PhencyclidinePhencyclidine results in increased expression of PLP1 mRNA17266109
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PLP1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of PLP1 mRNA26272509
D011374Progesterone[Progesterone co-treated with Estradiol] inhibits the reaction [Cuprizone results in decreased expression of PLP1 mRNA]19031445
D011441PropylthiouracilPropylthiouracil results in decreased expression of PLP1 mRNA24780913
C010313pseudocumenepseudocumene results in increased expression of PLP1 protein17337753
D011794QuercetinQuercetin results in decreased expression of PLP1 mRNA21632981
C502851quinocetonequinocetone results in increased expression of PLP1 mRNA27046791
D015125OxyquinolineOxyquinoline results in decreased expression of PLP1 mRNA21632981
D012524SarinSarin results in decreased expression of PLP1 protein25842371
C017947sodium arsenitesodium arsenite affects the methylation of PLP1 gene28589171
C017947sodium arsenite[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] affects the expression of PLP1 protein23680456
D012969Sodium FluorideSodium Fluoride results in increased expression of PLP1 mRNA27862939
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PLP1 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PLP1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PLP1 promoter]19654925
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of PLP1 mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of PLP1 mRNA"19682533
D014212TretinoinTretinoin results in decreased expression of PLP1 mRNA21934132
D014212TretinoinCycloheximide promotes the reaction [Tretinoin results in increased expression of PLP1 mRNA]19450544
D014212TretinoinTretinoin results in increased expression of PLP1 mRNA19450544
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLP1 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of PLP1 mRNA24935251|2627250
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of PLP1 mRNA29024780
C057693troglitazonetroglitazone results in decreased expression of PLP1 mRNA28973697
C022884undecaneundecane results in increased expression of PLP1 protein17337753
D017974Uranium CompoundsUranium Compounds results in increased expression of PLP1 mRNA19654044
D014635Valproic AcidValproic Acid results in decreased expression of PLP1 mRNA24935251|2519280
D014638VanadatesVanadates results in increased expression of PLP1 mRNA22714537

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005198structural molecule activity-TAS2479017  
GO:0005515protein binding-IPI25416956  26871637  
GO:0019911structural constituent of myelin sheath-IBA21873635  
GO:0019911structural constituent of myelin sheath-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006954inflammatory response-IEA-  
GO:0007229integrin-mediated signaling pathway-IEA-  
GO:0007268chemical synaptic transmission-TAS2479017  
GO:0008366axon ensheathment-TAS2479017  
GO:0010001glial cell differentiation-IBA21873635  
GO:0010628positive regulation of gene expression-IEA-  
GO:0014002astrocyte development-IEA-  
GO:0021762substantia nigra development-HEP22926577  
GO:0022010central nervous system myelination-IBA21873635  
GO:0022010central nervous system myelination-IEA-  
GO:0031175neuron projection development-IBA21873635  
GO:0042552myelination-IBA21873635  
GO:0042759long-chain fatty acid biosynthetic process-IEA-  
GO:0048469cell maturation-IEA-  
GO:0061564axon development-IBA21873635  
GO:0061564axon development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA24103481  
GO:0016021integral component of membrane-IEA-  
GO:0043209myelin sheath-IBA21873635  
GO:0043209myelin sheath-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17291372Oligodendroglial abnormalities in schizophrenia, mood disorders and substance abuse. Comorbidity, shared traits, or molecular phenocopies? (2007 Aug)Sokolov BPInt J Neuropsychopharmacol
22712019Forced Abstinence from Cocaine Self-Administration is Associated with DNA Methylation Changes in Myelin Genes in the Corpus Callosum: a Preliminary Study. (2012)Nielsen DAFront Psychiatry
23897225Skin gene expression correlates of severity of interstitial lung disease in systemic sclerosis. (2013 Nov)Assassi SArthritis Rheum
28130959Evidence of altered brain regulatory gene expression in tobacco-exposed fetuses. (2017 Dec 20)Salihu HMJ Perinat Med
18357522Expression of transcripts for myelin related genes in postmortem brain from cocaine abusers. (2009 Jan)Kristiansen LVNeurochem Res