Gene: BCO1

53630
BCDO|BCDO1|BCMO|BCMO1|BCO
beta-carotene oxygenase 1
protein-coding
16q23.2
Ensembl:ENSG00000135697 MIM:605748 Vega:OTTHUMG00000137630 UniprotKB:Q9HAY6
NG_012171.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.049e-2 (AD)  4.741e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4889294chr16:81270154 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of BCO1 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BCO1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BCO1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BCO1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BCO1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BCO1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BCO1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BCO1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BCO1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BCO1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BCO1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of BCO1 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of BCO1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of BCO1 gene27153756
D000393Air PollutantsAir Pollutants analog results in decreased expression of BCO1 mRNA21757418
C103303alitretinoinalitretinoin results in decreased expression of BCO1 mRNA16699835
D000499AllylamineAllylamine affects the expression of BCO1 mRNA15910882
D000638AmiodaroneAmiodarone results in decreased expression of BCO1 mRNA24535564
D000643Ammonium ChlorideAmmonium Chloride affects the expression of BCO1 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in decreased expression of BCO1 mRNA15761015
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [Oxidants inhibits the reaction [BCO1 protein results in increased oxidation of beta Carotene]]9526112
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of BCO1 mRNA20127859
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of BCO1 mRNA19770486
D019207beta Carotenebeta Carotene results in increased expression of and results in increased activity of BCO1 protein16186334
D019207beta Carotenebeta Carotene results in increased expression of BCO1 mRNA16186334
D019207beta CaroteneBCO1 protein affects the susceptibility to beta Carotene24657404
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ACAD9 mRNA24657404
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of AEBP1 mRNA24657404
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of APPBP2 mRNA24657404
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ARHGAP26 mRNA24657404
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ATP8B1 mRNA24657404
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CDCA8 mRNA24657404
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CENPE mRNA24657404
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CLCN3 mRNA24657404
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of COQ7 mRNA24657404
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CTNNAL1 mRNA24657404
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of DHFR mRNA24657404
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of DTWD2 mRNA24657404
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of EDN1 mRNA24657404
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of EIF2S1 mRNA24657404
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of FOXM1 mRNA24657404
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of FZD6 mRNA24657404
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of IRX4 mRNA24657404
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ITM2A mRNA24657404
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of KIF11 mRNA24657404
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of LANCL1 mRNA24657404
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of LMNB2 mRNA24657404
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of METTL21A mRNA24657404
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of METTL9 mRNA24657404
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of MRPL57 mRNA24657404
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of MTCH2 mRNA24657404
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of NCKAP1 mRNA24657404
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of NOM1 mRNA24657404
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PARD6A mRNA24657404
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PCDH1 mRNA24657404
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PLAT mRNA24657404
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of RPP14 mRNA24657404
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of RRM1 mRNA24657404
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TFCP2 mRNA24657404
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of THOC7 mRNA24657404
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TMEM209 mRNA24657404
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TTC21B mRNA24657404
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TWF1 mRNA24657404
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TYMP mRNA24657404
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of YTHDC2 mRNA24657404
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ZDHHC3 mRNA24657404
D019207beta CaroteneAscorbic Acid inhibits the reaction [Oxidants inhibits the reaction [BCO1 protein results in increased oxidation of beta Carotene]]9526112
D019207beta CaroteneBCO1 protein results in increased oxidation of beta Carotene9526112
D019207beta CaroteneOxidants inhibits the reaction [BCO1 protein results in increased oxidation of beta Carotene]9526112
D019207beta CaroteneVitamin E inhibits the reaction [Oxidants inhibits the reaction [BCO1 protein results in increased oxidation of beta Carotene]]9526112
D019207beta CaroteneBCO1 protein results in increased cleavage of beta Carotene16711651
D019207beta Carotene[BCO1 protein results in increased metabolism of beta Carotene] which results in increased abundance of Vitamin A25344780
C006780bisphenol Abisphenol A results in decreased methylation of BCO1 gene22576693
C006780bisphenol Abisphenol A results in increased expression of BCO1 mRNA22576693
C006780bisphenol Abisphenol A results in increased expression of BCO1 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of BCO1 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of BCO1 mRNA26079696
D002104CadmiumCadmium results in increased expression of BCO1 mRNA19556237
D019256Cadmium ChlorideCadmium Chloride results in increased expression of BCO1 mRNA23741332
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of BCO1 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of BCO1 mRNA27339419
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of BCO1 mRNA26272509
D004041Dietary FatsDietary Fats results in decreased expression of BCO1 mRNA18457598
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of BCO1 mRNA24535843
D004147DioxinsDioxins affects the expression of BCO1 mRNA20463971
C118739entinostatentinostat results in decreased expression of BCO1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BCO1 mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of BCO1 mRNA17606305
D005419FlavonoidsFlavonoids results in increased expression of BCO1 mRNA18035473
C069837fullerene C60fullerene C60 results in decreased expression of BCO1 mRNA19167457
C039281furanfuran results in increased expression of BCO1 mRNA24183702
C039281furanfuran results in increased methylation of BCO1 gene22079235
D017313FenretinideFenretinide results in decreased expression of BCO1 mRNA28973697
D007213IndomethacinIndomethacin results in increased expression of BCO1 mRNA28201806
C015329lycopeneBCO1 affects the reaction [lycopene results in decreased abundance of Testosterone]21935922
C042720mercuric bromidemercuric bromide results in decreased expression of BCO1 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BCO1 mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of BCO1 mRNA26272509
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of BCO1 mRNA"25620056
C028007nickel monoxidenickel monoxide results in decreased expression of BCO1 mRNA19167457
C007350nitrofennitrofen results in increased expression of BCO1 protein25344780
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of BCO1 mRNA25729387
D016877OxidantsAscorbic Acid inhibits the reaction [Oxidants inhibits the reaction [BCO1 protein results in increased oxidation of beta Carotene]]9526112
D016877OxidantsOxidants inhibits the reaction [BCO1 protein results in increased oxidation of beta Carotene]9526112
D016877OxidantsVitamin E inhibits the reaction [Oxidants inhibits the reaction [BCO1 protein results in increased oxidation of beta Carotene]]9526112
D010634PhenobarbitalPhenobarbital affects the expression of BCO1 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BCO1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of BCO1 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of BCO1 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of BCO1 mRNA20813756|2381119
D028321Plant PreparationsBCO1 affects the reaction [Plant Preparations results in decreased abundance of Testosterone]21935922
D012172RetinaldehydeBCO1 protein results in increased chemical synthesis of Retinaldehyde16711651
C084904Ro 41-5253Ro 41-5253 results in increased expression of BCO1 mRNA16186334
C084904Ro 41-5253Ro 41-5253 results in increased expression of BCO1 protein16186334
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of BCO1 mRNA25895662
C016104sodium bichromatesodium bichromate results in decreased expression of BCO1 mRNA24612858
D013739TestosteroneBCO1 affects the reaction [lycopene results in decreased abundance of Testosterone]21935922
D013739TestosteroneBCO1 affects the reaction [Plant Preparations results in decreased abundance of Testosterone]21935922
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BCO1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BCO1 mRNA26377647
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of BCO1 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of BCO1 mRNA18230668
D014212TretinoinTretinoin results in increased expression of BCO1 mRNA20530235
D014212TretinoinTretinoin affects the expression of BCO1 mRNA16186334
D014212TretinoinTretinoin results in decreased expression of BCO1 mRNA16699835
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BCO1 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of BCO1 mRNA24935251|2627250
C057693troglitazonetroglitazone results in decreased expression of BCO1 mRNA28973697
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BCO1 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of BCO1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of BCO1 gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of BCO1 mRNA24535564
D014801Vitamin A[BCO1 protein results in increased metabolism of beta Carotene] which results in increased abundance of Vitamin A25344780
D014810Vitamin EVitamin E inhibits the reaction [Oxidants inhibits the reaction [BCO1 protein results in increased oxidation of beta Carotene]]9526112

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003834beta-carotene 15,15'-monooxygenase activity-IBA21873635  
GO:0003834beta-carotene 15,15'-monooxygenase activity-IDA11401432  
GO:0003834beta-carotene 15,15'-monooxygenase activity-TAS-  
GO:0004744retinal isomerase activity-IBA21873635  
GO:0010436carotenoid dioxygenase activity-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001523retinoid metabolic process-IDA11401432  
GO:0001523retinoid metabolic process-TAS-  
GO:0016121carotene catabolic process-IBA21873635  
GO:0035238vitamin A biosynthetic process-NAS15983114  
GO:0042572retinol metabolic process-IEA-  
GO:0042574retinal metabolic process-IBA21873635  
GO:0042574retinal metabolic process-NAS15983114  
GO:0055114oxidation-reduction process-IEA-  
GO:1901810beta-carotene metabolic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00830Retinol metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-162582Signal TransductionTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-2187338Visual phototransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-6806667Metabolism of fat-soluble vitaminsTAS
R-HSA-975634Retinoid metabolism and transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28101967Host-related factors explaining interindividual variability of carotenoid bioavailability and tissue concentrations in humans. (2017 Jun)Bohn TMol Nutr Food Res