Gene: S1PR5

53637
EDG8|Edg-8|S1P5|SPPR-1|SPPR-2
sphingosine-1-phosphate receptor 5
protein-coding
19p13.2
Ensembl:ENSG00000180739 MIM:605146 Vega:OTTHUMG00000180581 UniprotKB:Q9H228
NC_000019.10
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.659e-1 (AD)  9.848e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PPP1R14A0.922
NKX6-20.9
ST180.887
GALNT60.875
ERMN0.873
FOLH10.872
NINJ20.869
GJB10.869
SH3TC20.868
RBP70.868

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CUX2-0.478
NEUROD1-0.468
OLFM4-0.435
CNGB1-0.426
PCDH8-0.423
GRB14-0.422
LTK-0.42
NHS-0.402
EPHA6-0.398
SPRY1-0.398

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB08868FingolimodSmall Molecule162359-55-9Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of S1PR5 mRNA]"19467301
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of S1PR5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of S1PR5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of S1PR5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of S1PR5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of S1PR5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of S1PR5 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of S1PR5 mRNA17562736
D000643Ammonium ChlorideAmmonium Chloride affects the expression of S1PR5 mRNA16483693
D001151ArsenicArsenic results in increased methylation of S1PR5 promoter21291286
C006632arsenic trioxidearsenic trioxide results in decreased expression of S1PR5 mRNA26705709
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of S1PR5 mRNA26377693
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of S1PR5 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of S1PR5 mRNA19770486|2156981
D004958EstradiolEstradiol results in decreased expression of S1PR5 mRNA23019147
C006780bisphenol Abisphenol A results in decreased expression of S1PR5 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of S1PR5 gene28505145
D001761BleomycinS1PR5 protein affects the reaction [Bleomycin results in increased expression of COL1A1 mRNA]29033951
D001761BleomycinS1PR5 protein affects the reaction [Bleomycin results in increased expression of GATA3 mRNA]29033951
D001761BleomycinS1PR5 protein affects the reaction [Bleomycin results in increased expression of S1PR3 mRNA]29033951
D001761BleomycinS1PR5 protein affects the reaction [Bleomycin results in increased expression of SMAD7 mRNA]29033951
D001761BleomycinS1PR5 protein affects the susceptibility to Bleomycin29033951
D001761Bleomycin[S1PR5 protein affects the susceptibility to Bleomycin] which affects the expression of COMP protein29033951
D001761Bleomycin[S1PR5 protein affects the susceptibility to Bleomycin] which affects the expression of S1PR1 protein29033951
D002737ChloropreneChloroprene results in decreased expression of S1PR5 mRNA23125180
D003300CopperCopper deficiency results in increased expression of S1PR5 mRNA26033743
D003471CuprizoneCuprizone results in decreased expression of S1PR5 mRNA26577399|2752363
C014347decitabinedecitabine affects the expression of S1PR5 mRNA23300844
D002945CisplatinCisplatin affects the expression of S1PR5 mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of S1PR5 mRNA27392435
D002945CisplatinCisplatin results in increased expression of S1PR5 mRNA27392435
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of S1PR5 mRNA]"19467301
D004041Dietary FatsDietary Fats affects the expression of S1PR5 mRNA19680557
D004041Dietary FatsDietary Fats results in increased expression of S1PR5 mRNA19467301
C118739entinostatentinostat results in increased expression of S1PR5 mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of S1PR5 mRNA"27188386
D000431EthanolEthanol results in increased expression of S1PR5 mRNA19167417
D000068876Fingolimod HydrochlorideFingolimod Hydrochloride metabolite binds to and results in increased activity of S1PR5 protein26719367
D005557FormaldehydeFormaldehyde results in decreased expression of S1PR5 mRNA20655997
D005947GlucoseGlucose results in increased expression of S1PR5 mRNA22406263
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of S1PR5 mRNA20044591
C492448ICG 001ICG 001 results in decreased expression of S1PR5 mRNA26191083
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of S1PR5 mRNA27392435
C004925methylmercuric chloridemethylmercuric chloride affects the expression of S1PR5 mRNA20864626
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of S1PR5 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of S1PR5 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of S1PR5 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of S1PR5 mRNA"25620056
D000073878Palm OilPalm Oil affects the expression of S1PR5 mRNA19680557
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of S1PR5 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of S1PR5 mRNA26272509
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of S1PR5 mRNA20136073
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of S1PR5 mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of S1PR5 mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of S1PR5 mRNA19482888
C006253pirinixic acidpirinixic acid results in decreased expression of S1PR5 mRNA23811191
D011441PropylthiouracilPropylthiouracil results in decreased expression of S1PR5 mRNA24780913
D013311StreptozocinStreptozocin results in increased expression of S1PR5 mRNA22406263
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of S1PR5 mRNA23152189
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of S1PR5 mRNA26377647
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of S1PR5 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of S1PR5 mRNA26290441
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of S1PR5 mRNA20133372
C012589trichostatin Atrichostatin A results in increased expression of S1PR5 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of S1PR5 mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of S1PR5 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of S1PR5 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of S1PR5 mRNA23179753|2438349
C111237vorinostatvorinostat results in increased expression of S1PR5 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0038036sphingosine-1-phosphate receptor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0003376sphingosine-1-phosphate signaling pathway-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0045664regulation of neuron differentiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-419408Lysosphingolipid and LPA receptorsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26485657Potential Link between the Sphingosine-1-Phosphate (S1P) System and Defective Alveolar Macrophage Phagocytic Function in Chronic Obstructive Pulmonary Disease (COPD). (2015)Barnawi JPLoS One
27144721Pro-phagocytic Effects of Thymoquinone on Cigarette Smoke-exposed Macrophages Occur by Modulation of the Sphingosine-1-phosphate Signalling System. (2016 Oct)Barnawi JCOPD