Gene: PLXNB1

5364
PLEXIN-B1|PLXN5|SEP
plexin B1
protein-coding
3p21.31
Ensembl:ENSG00000164050 MIM:601053 Vega:OTTHUMG00000133527 UniprotKB:O43157
NC_000003.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.584e-1 (AD)  7.250e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4858818chr3:48408675 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg08534147chr3:48471771PLXNB11.100e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GPRC5B0.918
LLGL10.908
DDR10.906
SLC27A10.904
RAPGEF30.884
PHLPP10.876
KIAA17550.874
PHGDH0.871
CRB20.862
CSRP10.857

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.469
OR4F29-0.452
SCARA5-0.404
LGI2-0.384
FER1L6-0.368
MCHR1-0.364
PRSS12-0.362
LBH-0.359
PNOC-0.358
SERTM1-0.355

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of PLXNB1 mRNA"28903501
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of PLXNB1 mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of PLXNB1 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of PLXNB1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PLXNB1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PLXNB1 mRNA19770486
D001280AtrazineAtrazine results in decreased expression of PLXNB1 mRNA22378314
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of PLXNB1 mRNA26377693
C044887beta-methylcholinebeta-methylcholine affects the expression of PLXNB1 mRNA21179406
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PLXNB1 mRNA28628672
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PLXNB1 mRNA28628672
C013418bromfenacoumbromfenacoum results in increased expression of PLXNB1 protein28903499
C018475butyraldehydebutyraldehyde results in decreased expression of PLXNB1 mRNA26079696
D002220Carbamazepine[Fluoxetine co-treated with Venlafaxine Hydrochloride co-treated with Carbamazepine] results in decreased expression of PLXNB1 mRNA22701549
D002994ClofibrateClofibrate results in decreased expression of PLXNB1 mRNA23811191
C018021cobaltous chloridecobaltous chloride results in decreased expression of PLXNB1 mRNA19320972
D019327Copper SulfateCopper Sulfate results in decreased expression of PLXNB1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of PLXNB1 mRNA20106945
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PLXNB1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PLXNB1 mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of PLXNB1 mRNA27392435
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of PLXNB1 mRNA24535843
D004237DiuronDiuron results in decreased expression of PLXNB1 mRNA21551480
D005473Fluoxetine[Fluoxetine co-treated with Venlafaxine Hydrochloride co-treated with Carbamazepine] results in decreased expression of PLXNB1 mRNA22701549
C039281furanfuran results in increased expression of PLXNB1 mRNA24183702
D019833GenisteinGenistein results in decreased expression of PLXNB1 mRNA16705744
D005839GentamicinsGentamicins results in decreased expression of PLXNB1 mRNA22061828
D005897GlafenineGlafenine results in increased expression of PLXNB1 mRNA24136188
D017313FenretinideFenretinide results in increased expression of PLXNB1 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PLXNB1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PLXNB1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PLXNB1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PLXNB1 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of PLXNB1 mRNA27392435
D008727MethotrexateMethotrexate results in increased expression of PLXNB1 mRNA17400583|2167806
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium affects the expression of PLXNB1 mRNA25234470
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of PLXNB1 mRNA25234470
C523799MRK 003PLXNB1 results in decreased susceptibility to MRK 00319903844
C028007nickel monoxidenickel monoxide results in increased expression of PLXNB1 mRNA19167457
D010634PhenobarbitalPhenobarbital affects the expression of PLXNB1 mRNA19159669
D010634PhenobarbitalPhenobarbital affects the expression of PLXNB1 mRNA23091169
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PLXNB1 mRNA19710929
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of PLXNB1 mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of PLXNB1 mRNA20813756|2381119
C045950propiconazolepropiconazole results in decreased expression of PLXNB1 mRNA21278054
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PLXNB1 mRNA25895662
D012906SmokeSmoke results in decreased expression of PLXNB1 mRNA21095227
D012999SomanSoman results in decreased expression of PLXNB1 mRNA19281266
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of PLXNB1 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PLXNB1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of PLXNB1 mRNA25975270
D013792ThalidomideThalidomide results in increased expression of PLXNB1 mRNA28892372
C009495titanium dioxidetitanium dioxide results in increased expression of PLXNB1 mRNA23557971
D014635Valproic AcidValproic Acid results in decreased expression of PLXNB1 mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of PLXNB1 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PLXNB1 gene25560391
D000069470Venlafaxine Hydrochloride[Fluoxetine co-treated with Venlafaxine Hydrochloride co-treated with Carbamazepine] results in decreased expression of PLXNB1 mRNA22701549
C025643vinclozolinvinclozolin affects the expression of PLXNB1 mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of PLXNB1 mRNA23034163
C029297vinylidene chloridevinylidene chloride results in decreased expression of PLXNB1 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004888transmembrane signaling receptor activity-NAS10520995  
GO:0005096GTPase activator activity-TAS-  
GO:0005515protein binding-IPI12198496  12730235  14732713  15184888  15218527  19843518  
20877282  22404908  
GO:0017154semaphorin receptor activity-IBA21873635  
GO:0017154semaphorin receptor activity-IDA19843518  
GO:0017154semaphorin receptor activity-TAS10520995  
GO:0030215semaphorin receptor binding-TAS10520995  
GO:0032794GTPase activating protein binding-ISS-  
GO:0038023signaling receptor activity-TAS8570614  
GO ID GO Term Qualifier Evidence PubMed
GO:0007162negative regulation of cell adhesion-IBA21873635  
GO:0007162negative regulation of cell adhesion-IDA15218527  
GO:0007165signal transduction-TAS8570614  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0008360regulation of cell shape-IBA21873635  
GO:0008360regulation of cell shape-IDA19843518  
GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling-ISS-  
GO:0016477cell migration-NAS10520995  
GO:0030334regulation of cell migration-IBA21873635  
GO:0033689negative regulation of osteoblast proliferation-ISS-  
GO:0035556intracellular signal transduction-NAS10520995  
GO:0043087regulation of GTPase activity-IBA21873635  
GO:0043547positive regulation of GTPase activity-ISS-  
GO:0043931ossification involved in bone maturation-ISS-  
GO:0048675axon extension-IBA21873635  
GO:0048812neuron projection morphogenesis-ISS-  
GO:0050772positive regulation of axonogenesis-IBA21873635  
GO:0051493regulation of cytoskeleton organization-IDA19843518  
GO:0071526semaphorin-plexin signaling pathway-IDA15218527  19843518  
GO:1900220semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis-ISS-  
GO:1902287semaphorin-plexin signaling pathway involved in axon guidance-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0002116semaphorin receptor complex-IBA21873635  
GO:0002116semaphorin receptor complex-IDA19843518  
GO:0002116semaphorin receptor complex-TAS19909241  
GO:0005576extracellular region-IEA-  
GO:0005622intracellular-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IDA19843518  
GO:0005887integral component of plasma membrane-NAS10520995  
KEGG ID KEGG Term
hsa04360Axon guidance
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373755Semaphorin interactionsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-400685Sema4D in semaphorin signalingTAS
R-HSA-416482G alpha (12/13) signalling eventsTAS
R-HSA-416550Sema4D mediated inhibition of cell attachment and migrationTAS
R-HSA-416572Sema4D induced cell migration and growth-cone collapseTAS
R-HSA-422475Axon guidanceTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal