Gene: PNOC

5368
N/OFQ|NOP|OFQ|PPNOC|ppN/OFQ
prepronociceptin
protein-coding
8p21.1
Ensembl:ENSG00000168081 MIM:601459 Vega:OTTHUMG00000102125 UniprotKB:Q13519
NC_000008.11
PubMed
0   ANCO-SNPs
OD|ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.341e-1 (AD)  1.037e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GJD20.794
ELFN10.791
PTHLH0.787
CRH0.77
CRHBP0.769
DLX10.768
ARL4C0.764
ZNF385D0.762
SLC10A40.762
IGF10.761

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PDK4-0.526
SLC14A1-0.513
C10orf105-0.512
OTOS-0.51
SYTL4-0.509
DOCK5-0.507
ARHGAP19-0.501
ITGB8-0.498
OTUD7B-0.497
BAZ2B-0.496

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of PNOC mRNA19933214
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PNOC mRNA"19114083
D020106AcrylamideAcrylamide results in decreased expression of PNOC mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PNOC mRNA23630614
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PNOC mRNA16483693
C015001arsenitearsenite results in increased methylation of PNOC promoter23974009
D001280AtrazineAtrazine results in decreased expression of PNOC mRNA25929836
D001285AtropineAtropine inhibits the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein]12007927
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PNOC mRNA18164116
D004958Estradiolnociceptin (1-13) amide inhibits the reaction [PNOC protein inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of LHB protein]]17640482
D004958EstradiolPNOC protein inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of LHB protein]17640482
C006780bisphenol Abisphenol A results in decreased expression of PNOC mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PNOC gene28505145
C018475butyraldehydebutyraldehyde results in increased expression of PNOC mRNA26079696
D002118CalciumPNOC protein results in decreased abundance of Calcium21039959
D004390ChlorpyrifosChlorpyrifos results in increased expression of PNOC mRNA26775027
C066892CP 96345CP 96345 results in decreased activity of PNOC protein10490918
D003471CuprizoneCuprizone results in decreased expression of PNOC mRNA27523638
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PNOC mRNA18164116
D004237DiuronDiuron results in decreased expression of PNOC mRNA25152437
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PNOC mRNA12655037|1583489
D005419FlavonoidsFlavonoids results in decreased expression of PNOC mRNA18035473
D005557FormaldehydeFormaldehyde results in decreased expression of PNOC mRNA23649840
C040029gabapentingabapentin results in decreased expression of PNOC mRNA18281898
D019833GenisteinGenistein results in increased expression of PNOC mRNA22553218
D019833Genistein[Genistein co-treated with Methoxychlor] results in decreased expression of PNOC mRNA21782745
C029424hydrazinehydrazine results in decreased expression of PNOC mRNA15282401
C016517indole-3-carbinolindole-3-carbinol affects the expression of PNOC mRNA21396975
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PNOC mRNA25613284
C402921J 113397J 113397 inhibits the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein]12007927
D007854LeadLead affects the expression of PNOC mRNA28903495
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PNOC mRNA12057914
D008344Maneb[Paraquat co-treated with Maneb] results in increased expression of PNOC24376148
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in decreased expression of PNOC mRNA21782745
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PNOC mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of PNOC mRNA19162046
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of PNOC mRNA19162046
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"PNOC affects the susceptibility to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"16237164
D009020MorphinePNOC protein results in decreased susceptibility to Morphine17303110
D009151Mustard GasMustard Gas results in decreased expression of PNOC mRNA15674843
D009538NicotinePNOC protein alternative form affects the susceptibility to Nicotine19371589
D009569Nitric OxideNitric Oxide deficiency results in decreased activity of PNOC protein10794074
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of PNOC mRNA17616710
C439964nociceptin (1-13) amidenociceptin (1-13) amide affects the reaction [PNOC protein binds to and results in increased activity of OPRL1 protein]12007927
C439964nociceptin (1-13) amidenociceptin (1-13) amide inhibits the reaction [PNOC protein inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of LHB protein]]17640482
D016627OxidopamineOxidopamine results in decreased expression of PNOC mRNA19162046
D016627OxidopamineOxidopamine results in increased expression of PNOC mRNA19162046
D010269Paraquat[Paraquat co-treated with Maneb] results in increased expression of PNOC24376148
D037342Pertussis ToxinPertussis Toxin results in decreased activity of PNOC protein10490918
D010634PhenobarbitalPhenobarbital results in increased expression of PNOC mRNA19162173
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PNOC mRNA19710929
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile affects the expression of PNOC mRNA19162173
D011374Progesteronenociceptin (1-13) amide inhibits the reaction [PNOC protein inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of LHB protein]]17640482
D011374ProgesteronePNOC protein inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of LHB protein]17640482
D011441PropylthiouracilPropylthiouracil affects the expression of PNOC mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in decreased expression of PNOC mRNA27029645
C017947sodium arsenitesodium arsenite affects the methylation of PNOC gene28589171
D012999SomanSoman results in increased expression of PNOC mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PNOC mRNA24680724
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PNOC mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PNOC mRNA15644576
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PNOC mRNA25613284
D014403TubocurarineTubocurarine results in decreased expression of PNOC mRNA19728367
D014750VincristineVincristine results in decreased expression of PNOC mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001515opioid peptide activity-IEA-  
GO:0005184neuropeptide hormone activity-TAS10419552  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-TAS9521323  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007218neuropeptide signaling pathway-IBA21873635  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0007565female pregnancy-IEA-  
GO:0007600sensory perception-IBA21873635  
GO:0007600sensory perception-TAS9521323  
GO:0010469regulation of signaling receptor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005886plasma membrane-IBA21873635  
GO:0030425dendrite-IBA21873635  
GO:0043025neuronal cell body-IBA21873635  
GO:0043679axon terminus-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27430399Repeated nicotine exposure modulates prodynorphin and pronociceptin levels in the reward pathway. (2016 Sep 1)Carboni LDrug Alcohol Depend
17910740Association analysis of genes encoding the nociceptin receptor (OPRL1) and its endogenous ligand (PNOC) with alcohol or illicit drug dependence. (2008 Mar)Xuei XAddict Biol