Gene: FXYD6

53826
-
FXYD domain containing ion transport regulator 6
protein-coding
11q23.3
Ensembl:ENSG00000137726 MIM:606683 Vega:OTTHUMG00000166991 UniprotKB:Q9H0Q3
NG_013071.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.377e-1 (AD)  9.616e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SYP0.966
ENO20.961
C16orf450.961
RTN10.96
GNG30.96
EHD30.96
C1orf2160.957
ATCAY0.957
RAB6B0.956
SULT4A10.955

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.553
OR4F29-0.519
REST-0.494
HEY2-0.479
RNF135-0.471
WWTR1-0.459
CSAG1-0.456
YES1-0.454
GNG11-0.451
ASB4-0.449

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of FXYD6 mRNA"22698814
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of FXYD6 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of FXYD6 mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FXYD6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FXYD6 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of FXYD6 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of FXYD6 mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FXYD6 mRNA16483693
C547126AZM551248AZM551248 results in decreased expression of FXYD6 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FXYD6 mRNA27195522
C006780bisphenol Abisphenol A results in increased expression of FXYD6 mRNA25270620
C006780bisphenol Abisphenol A affects the expression of FXYD6 mRNA25181051
D002211CapsaicinCapsaicin results in increased expression of FXYD6 mRNA16278290
D002220CarbamazepineCarbamazepine affects the expression of FXYD6 mRNA25979313
C010063carbonyl sulfidecarbonyl sulfide results in decreased expression of FXYD6 mRNA19395590
D003345CorticosteroneCorticosterone results in decreased expression of FXYD6 mRNA15755911
D003471CuprizoneCuprizone results in increased expression of FXYD6 mRNA27523638
C014347decitabinedecitabine affects the expression of FXYD6 mRNA23300844
C014347decitabine[decitabine co-treated with vorinostat] affects the expression of FXYD6 mRNA17330099
D003907DexamethasoneDexamethasone results in decreased expression of FXYD6 mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of FXYD6 mRNA21266533
D002945CisplatinCisplatin affects the expression of FXYD6 mRNA23300844
D004041Dietary FatsDietary Fats results in decreased expression of FXYD6 mRNA25016146
D004041Dietary FatsDietary Fats results in increased expression of FXYD6 mRNA18042831
D005419FlavonoidsFlavonoids results in decreased expression of FXYD6 mRNA18035473
C039281furanfuran results in increased expression of FXYD6 mRNA26194646
C546771gardiquimodgardiquimod results in increased expression of FXYD6 mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of FXYD6 mRNA]28003376
C010176halofuginonehalofuginone results in increased expression of FXYD6 mRNA17180598
D017313FenretinideFenretinide results in increased expression of FXYD6 mRNA28973697
C016517indole-3-carbinolindole-3-carbinol affects the expression of FXYD6 mRNA21396975
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FXYD6 mRNA25613284
D007854LeadLead affects the expression of FXYD6 mRNA28903495
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of FXYD6 mRNA25613284
D008344Maneb[Paraquat co-treated with Maneb] results in decreased expression of FXYD6 mRNA18386188
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of FXYD6 mRNA28001369
D008777MethyltestosteroneMethyltestosterone results in increased expression of FXYD6 mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of FXYD6 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of FXYD6 mRNA"25620056
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of FXYD6 mRNA25380136
D009532NickelNickel results in decreased expression of FXYD6 mRNA24768652|2558310
D000073878Palm OilPalm Oil results in increased expression of FXYD6 mRNA18042831
D010269Paraquat[Paraquat co-treated with Maneb] results in decreased expression of FXYD6 mRNA18386188
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FXYD6 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of FXYD6 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FXYD6 mRNA19710929
D011374ProgesteroneProgesterone results in decreased expression of FXYD6 mRNA20726854
D011441PropylthiouracilPropylthiouracil results in increased expression of FXYD6 mRNA24780913
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of FXYD6 mRNA]28003376
D012715Sesame OilSesame Oil results in decreased expression of FXYD6 mRNA29191790
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of FXYD6 mRNA25895662
C017947sodium arsenitesodium arsenite affects the methylation of FXYD6 gene28589171
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FXYD6 mRNA24680724
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FXYD6 mRNA21354282
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FXYD6 mRNA25613284
D013849ThimerosalThimerosal results in decreased expression of FXYD6 mRNA27188386
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of FXYD6 mRNA19042947
D014303TrinitrotolueneTrinitrotoluene affects the expression of FXYD6 mRNA21346803
D014415TunicamycinTunicamycin results in decreased expression of FXYD6 mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of FXYD6 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of FXYD6 mRNA23179753|2718838
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of FXYD6 gene25560391
D014810Vitamin EVitamin E results in increased expression of FXYD6 mRNA19244175
C111237vorinostat[decitabine co-treated with vorinostat] affects the expression of FXYD6 mRNA17330099

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0005216ion channel activity-IEA-  
GO:0005515protein binding-IPI25416956  
GO:0017080sodium channel regulator activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0008150biological_process-ND-  
GO:0034220ion transmembrane transport-IEA-  
GO:2000649regulation of sodium ion transmembrane transporter activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IDA-  
GO:0005886plasma membrane-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-397014Muscle contractionTAS
R-HSA-5576891Cardiac conductionTAS
R-HSA-5578775Ion homeostasisTAS
R-HSA-936837Ion transport by P-type ATPasesTAS
R-HSA-983712Ion channel transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27980621Analysis of gene expression to predict dynamics of future hypertension incidence in type 2 diabetic patients. (2016)Radkowski PBMC Proc