Gene: DUOX1

53905
LNOX1|NOXEF1|THOX1
dual oxidase 1
protein-coding
15q21.1
Ensembl:ENSG00000137857 MIM:606758 Vega:OTTHUMG00000171987 UniprotKB:Q9NRD9
NC_000015.10
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.975e-1 (AD)  4.010e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg23413924chr15:45427734DUOX17.700e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LDLRAP10.726
MYO1D0.725
DNAH170.724
DYSF0.716
TJAP10.714
DUOXA10.712
PRIMA10.704
LRP20.704
KEL0.7
ZNF6520.698

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
VIP-0.379
ABCD2-0.366
CALB2-0.354
SLC29A4-0.351
DLX2-0.334
PAH-0.331
TAC3-0.329
SHISA8-0.323
CHRNA2-0.319
DLX1-0.317

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of DUOX1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of DUOX1 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of DUOX1 mRNA16483693
D000966Antimony Potassium TartrateAntimony Potassium Tartrate inhibits the reaction [IL4 protein results in increased expression of DUOX1 mRNA]29031483
D000966Antimony Potassium TartrateAntimony Potassium Tartrate results in decreased expression of DUOX1 mRNA29031483
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of DUOX1 mRNA24449571
D047310ApigeninApigenin results in decreased expression of DUOX1 mRNA22359648
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DUOX1 mRNA22316170
C006780bisphenol Abisphenol A results in decreased expression of DUOX1 mRNA20678512
C006780bisphenol Abisphenol A affects the methylation of DUOX1 promoter27334623
C006780bisphenol A[bisphenol A co-treated with Genistein] results in increased methylation of DUOX1 gene28505145
C006780bisphenol Abisphenol A results in decreased expression of DUOX1 mRNA25181051
C026690cerous chloride[cerous chloride co-treated with lanthanum chloride] results in increased expression of DUOX1 mRNA28954213
C026690cerous chloridecerous chloride results in decreased expression of DUOX1 mRNA28954213
D019327Copper SulfateCopper Sulfate inhibits the reaction [IL4 protein results in increased expression of DUOX1 mRNA]29031483
D019327Copper SulfateCopper Sulfate results in decreased expression of DUOX1 mRNA29031483
C017160cypermethrincypermethrin results in increased expression of DUOX1 mRNA21142847
D003676DeferoxamineDeferoxamine inhibits the reaction [Particulate Matter results in increased expression of DUOX1 mRNA]21703343
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of DUOX1 mRNA26924002
D002117CalcitriolCalcitriol results in increased expression of DUOX1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of DUOX1 mRNA21592394
D000431EthanolEthanol results in increased expression of DUOX1 mRNA20026259
C039281furanfuran results in increased expression of DUOX1 mRNA27387713
D019833Genistein[bisphenol A co-treated with Genistein] results in increased methylation of DUOX1 gene28505145
D006046Gold[Polyethyleneimine binds to Gold] which results in decreased expression of DUOX1 mRNA28433809
C006552kaempferolkaempferol inhibits the reaction [Paraquat results in increased expression of DUOX1 mRNA]25177032
C028521lanthanum chloride[cerous chloride co-treated with lanthanum chloride] results in increased expression of DUOX1 mRNA28954213
C028521lanthanum chloridelanthanum chloride results in increased expression of DUOX1 mRNA28954213
C517284monomethyl phthalatemonomethyl phthalate affects the expression of DUOX1 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of DUOX1 mRNA"25554681
D009532NickelNickel results in increased expression of DUOX1 mRNA25583101
C028007nickel monoxidenickel monoxide results in increased expression of DUOX1 mRNA19167457
D010269Paraquatkaempferol inhibits the reaction [Paraquat results in increased expression of DUOX1 mRNA]25177032
D010269ParaquatParaquat results in increased expression of DUOX1 mRNA25177032
D010269ParaquatAPOD protein affects the reaction [Paraquat results in increased expression of DUOX1 mRNA]21688324
D010269ParaquatParaquat results in increased expression of DUOX1 mRNA21688324
D052638Particulate MatterDeferoxamine inhibits the reaction [Particulate Matter results in increased expression of DUOX1 mRNA]21703343
D052638Particulate MatterParticulate Matter results in increased expression of DUOX1 mRNA21703343
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of DUOX1 mRNA19710929
D010936Plant ExtractsPlant Extracts results in decreased expression of DUOX1 mRNA23557933
D011094Polyethyleneimine[Polyethyleneimine binds to Gold] which results in decreased expression of DUOX1 mRNA28433809
D011374ProgesteroneProgesterone results in decreased expression of DUOX1 mRNA21540246
D011441PropylthiouracilPropylthiouracil results in increased expression of DUOX1 mRNA24780913
D012643SeleniumSelenium results in increased expression of DUOX1 mRNA19244175
D012822Silicon DioxideSilicon Dioxide results in increased expression of DUOX1 mRNA22431001
D012834SilverSilver results in decreased expression of DUOX1 mRNA19429238|2257657
C017947sodium arseniteDUOX1 protein affects the reaction [sodium arsenite results in increased secretion of CXCL8 protein]27427241
C017947sodium arseniteDUOX1 protein affects the reaction [sodium arsenite results in increased secretion of IL6 protein]27427241
C017947sodium arsenitesodium arsenite affects the methylation of DUOX1 gene28589171
C017947sodium arsenitesodium arsenite inhibits the reaction [IL4 protein results in increased expression of DUOX1 mRNA]29031483
C017947sodium arsenitesodium arsenite results in decreased expression of DUOX1 mRNA29031483
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of DUOX1 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of DUOX1 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DUOX1 mRNA26377647
D013974ThyroxineThyroxine results in decreased expression of DUOX1 protein17332529
D014212TretinoinTretinoin results in increased expression of DUOX1 mRNA16249480
D014638VanadatesVanadates results in decreased expression of DUOX1 mRNA29031483
C016837zinc chlorideDUOX1 protein affects the reaction [zinc chloride results in increased secretion of CXCL8 protein]27427241

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004601peroxidase activity-IEA-  
GO:0005509calcium ion binding-IEA-  
GO:0016174NAD(P)H oxidase activity-NAS10806195  
GO:0016174NAD(P)H oxidase activity-TAS-  
GO:0020037heme binding-IEA-  
GO:0050661NADP binding-NAS10806195  
GO ID GO Term Qualifier Evidence PubMed
GO:0006590thyroid hormone generation-IEA-  
GO:0006590thyroid hormone generation-TAS-  
GO:0006979response to oxidative stress-IEA-  
GO:0019221cytokine-mediated signaling pathway-IDA16111680  
GO:0042335cuticle development-IMP11514595  
GO:0042446hormone biosynthetic process-IEA-  
GO:0042554superoxide anion generation-NAS10806195  
GO:0042744hydrogen peroxide catabolic process-IEA-  
GO:0050665hydrogen peroxide biosynthetic process-NAS10806195  
GO:0051591response to cAMP-IDA15062544  
GO:0051591response to cAMP-ISS-  
GO:0055114oxidation-reduction process-TAS10601291  
GO:0098869cellular oxidant detoxification-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0016324apical plasma membrane-NAS10806195  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-209776Amine-derived hormonesTAS
R-HSA-209968Thyroxine biosynthesisTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24180474NADPH oxidases in vascular pathology. (2014 Jun 10)Konior AAntioxid Redox Signal
27612966Acrolein and thiol-reactive electrophiles suppress allergen-induced innate airway epithelial responses by inhibition of DUOX1 and EGFR. (2016 Nov 1)Danyal KAm J Physiol Lung Cell Mol Physiol
18177232Dual oxidase 1 and 2 expression in airway epithelium of smokers and patients with mild/moderate chronic obstructive pulmonary disease. (2008 Apr)Nagai KAntioxid Redox Signal