Gene: RAB4B

53916
-
RAB4B, member RAS oncogene family
protein-coding
19q13.2
Ensembl:ENSG00000167578 MIM:612945 Vega:OTTHUMG00000182694 UniprotKB:P61018
NC_000019.10
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GPS10.945
TRAPPC10.943
CUTA0.939
CFL10.938
GIPC10.938
RAB11B0.935
MRPL280.933
TBCB0.933
CLTA0.933
PEX160.932

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.777
OR4F29-0.751
MTRNR2L9-0.393
MTRNR2L6-0.391
PABPC4L-0.357
MTRNR2L10-0.352
SIX1-0.33
CCDC36-0.326
KCNJ15-0.32
EBF1-0.318

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0652504-hydroxy-equilenin4-hydroxy-equilenin results in decreased expression of RAB4B mRNA15135645
D000082AcetaminophenAcetaminophen results in increased expression of RAB4B mRNA26690555
D020106AcrylamideAcrylamide results in increased expression of RAB4B mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RAB4B mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of RAB4B mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to RAB4B promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RAB4B mRNA22228805
D004958EstradiolEstradiol results in decreased expression of RAB4B mRNA23019147
C006780bisphenol Abisphenol A results in decreased expression of RAB4B mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of RAB4B gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of RAB4B mRNA28628672
D002994ClofibrateClofibrate results in decreased expression of RAB4B mRNA17585979|2381119
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of RAB4B mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of RAB4B mRNA21266533
D002117CalcitriolCalcitriol results in increased expression of RAB4B mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of RAB4B mRNA21592394
D005419FlavonoidsFlavonoids results in decreased expression of RAB4B mRNA18035473
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of RAB4B mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of RAB4B mRNA28628672
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of RAB4B mRNA"24972896
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of RAB4B mRNA"20188158|2625132
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of RAB4B mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of RAB4B mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of RAB4B mRNA"25554681
D010634PhenobarbitalPhenobarbital results in increased expression of RAB4B mRNA12832660
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of RAB4B mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of RAB4B mRNA23811191
C059514resveratrolresveratrol results in increased expression of RAB4B protein25505154
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of RAB4B mRNA25895662
D012969Sodium FluorideSodium Fluoride results in increased expression of RAB4B protein27548804
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of RAB4B mRNA21592394
D013739TestosteroneTestosterone results in increased expression of RAB4B mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RAB4B mRNA21570461
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of RAB4B gene25560391
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in increased expression of RAB4B mRNA25423262
C025643vinclozolinvinclozolin results in increased expression of RAB4B mRNA15686871
D015032ZincZinc results in decreased expression of RAB4B mRNA20932299

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0003924GTPase activity-IBA21873635  
GO:0003924GTPase activity-IEA-  
GO:0005515protein binding-IPI25416956  
GO:0005525GTP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006886intracellular protein transport-IBA21873635  
GO:0015031protein transport-IEA-  
GO:0030100regulation of endocytosis-IBA21873635  
GO:0032482Rab protein signal transduction-IBA21873635  
GO:0043312neutrophil degranulation-TAS-  
GO:0046323glucose import-IMP19590752  
GO ID GO Term Qualifier Evidence PubMed
GO:0005768endosome-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0012505endomembrane system-IBA21873635  
GO:0030667secretory granule membrane-TAS-  
GO:0032593insulin-responsive compartment-IBA21873635  
GO:0032593insulin-responsive compartment-IDA19590752  
GO:0048471perinuclear region of cytoplasm-IDA19590752  
GO:0055037recycling endosome-IDA19590752  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-6806834Signaling by METTAS
R-HSA-8873719RAB geranylgeranylationTAS
R-HSA-8875656MET receptor recyclingTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29092026COPD GWAS variant at 19q13.2 in relation with DNA methylation and gene expression. (2018 Jan 15)Nedeljkovic IHum Mol Genet
22080838A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. (2012 Feb 15)Cho MHHum Mol Genet