Gene: PELO

53918
CGI-17|PRO1770
pelota mRNA surveillance and ribosome rescue factor
protein-coding
5q11.2
Ensembl:ENSG00000152684 MIM:605757 Vega:OTTHUMG00000096973 UniprotKB:Q9BRX2
NC_000005.10
PubMed
0   ANCO-SNPs
ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BFAR0.879
ARCN10.879
CCT20.879
LEPROTL10.878
AGFG10.875
KLHL120.874
UBQLN10.873
YME1L10.873
TM9SF20.873
HNRNPA00.871

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.587
OR4F29-0.563
ASB4-0.294
MTRNR2L6-0.262
OLAH-0.262
TBX5-0.261
MYOM1-0.259
MTRNR2L9-0.252
KLF17-0.252
CTNNA3-0.249

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PELO mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PELO mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PELO mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PELO mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PELO mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PELO mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PELO mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PELO mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PELO mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PELO mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PELO mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PELO mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of PELO mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PELO gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PELO mRNA27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PELO mRNA24449571
D001151Arsenic[APOE protein affects the susceptibility to Arsenic] which results in increased expression of PELO mRNA22719926
D001554BenzeneBenzene results in increased expression of PELO mRNA19162166
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of PELO mRNA19737606
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PELO mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PELO mRNA21569818
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of PELO mRNA20660070
D004958EstradiolEstradiol results in increased expression of PELO mRNA20106945
C006780bisphenol Abisphenol A affects the expression of PELO mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of PELO mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of PELO mRNA25181051
D002104CadmiumCadmium results in increased expression of PELO mRNA23369406
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PELO mRNA23741332
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PELO mRNA19010381
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PELO mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of PELO mRNA26272509
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of PELO mRNA28472532
C018021cobaltous chloridecobaltous chloride results in increased expression of PELO mRNA24612858
C018021cobaltous chloridecobaltous chloride results in increased expression of PELO mRNA19376846|2010528
C018021cobaltous chloridecobaltous chloride results in increased expression of PELO mRNA24386269
D003078ColchicineColchicine results in decreased expression of PELO mRNA24211769
D019327Copper SulfateCopper Sulfate results in increased expression of PELO mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of PELO mRNA20106945|2556210
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PELO mRNA21266533
D002945CisplatinCisplatin results in decreased expression of PELO mRNA24211769
D004040Dietary CarbohydratesDietary Carbohydrates results in decreased expression of PELO mRNA17490981
D004147DioxinsDioxins affects the expression of PELO mRNA20463971
C118739entinostatentinostat results in increased expression of PELO mRNA27188386
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PELO mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PELO mRNA20227414
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PELO mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of PELO mRNA24211769
D005047EtoposideEtoposide results in decreased expression of PELO mRNA24211769
D005485FlutamideFlutamide results in increased expression of PELO mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of PELO mRNA20655997
D006918HydroxyureaHydroxyurea results in decreased expression of PELO mRNA24211769
D007854LeadLead affects the expression of PELO mRNA28903495
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PELO mRNA"27188386
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PELO mRNA26011545
D016685MitomycinMitomycin results in decreased expression of PELO mRNA24211769
D009151Mustard GasMustard Gas results in decreased expression of PELO mRNA12884408
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PELO mRNA"25554681
C051752nefazodonenefazodone results in increased expression of PELO mRNA24136188
D009532NickelNickel results in decreased expression of PELO mRNA25583101
C022838nickel chloridenickel chloride results in increased expression of PELO mRNA24612858
C022838nickel chloridenickel chloride affects the expression of PELO mRNA22546817
C029938nickel sulfatenickel sulfate results in decreased expression of PELO mRNA22714537
C012655nimesulidenimesulide results in increased expression of PELO mRNA24136188
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of PELO mRNA25729387
D010416PentachlorophenolPentachlorophenol results in increased expression of PELO mRNA23892564
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of PELO mRNA17560707
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of PELO mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of PELO mRNA19162173
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of PELO mRNA17097637
D010634PhenobarbitalPhenobarbital affects the expression of PELO mRNA19159669
D010634PhenobarbitalPhenobarbital results in increased expression of PELO mRNA19162173
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PELO mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of PELO mRNA26272509
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of PELO mRNA20660070
D011374ProgesteroneProgesterone results in increased expression of PELO mRNA19690047
D011794QuercetinQuercetin results in decreased expression of PELO mRNA21632981
C009277sodium arsenatesodium arsenate results in increased expression of PELO mRNA23922661
C016104sodium bichromatesodium bichromate results in increased expression of PELO mRNA24612858
C016104sodium bichromatesodium bichromate results in increased expression of PELO mRNA25993096
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PELO mRNA21570461|2468072
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PELO mRNA17942748
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of PELO mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of PELO mRNA25729387
D014212TretinoinTretinoin results in increased expression of PELO mRNA17431108|2193413
C012589trichostatin Atrichostatin A results in increased expression of PELO mRNA24935251
D014520UrethaneUrethane results in increased expression of PELO mRNA28818685
C406224valdecoxibvaldecoxib results in increased expression of PELO mRNA24136188
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PELO mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of PELO mRNA24383497|2493525
D014635Valproic AcidValproic Acid affects the expression of PELO mRNA17292431
D014747VinblastinePELO protein affects the susceptibility to Vinblastine16217747
D000225AdenineAdenine results in decreased expression of PELO mRNA24211769
C111237vorinostatvorinostat results in increased expression of PELO mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004519endonuclease activity-IEA-  
GO:0005515protein binding-IPI25416956  
GO:0043022ribosome binding-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006412translation-IBA21873635  
GO:0007049cell cycle-IEA-  
GO:0007492endoderm development-IEA-  
GO:0008283cell proliferation-IEA-  
GO:0019827stem cell population maintenance-IEA-  
GO:0030513positive regulation of BMP signaling pathway-IEA-  
GO:0032790ribosome disassembly-IBA21873635  
GO:0051276chromosome organization-IEA-  
GO:0051301cell division-IEA-  
GO:0060231mesenchymal to epithelial transition-IEA-  
GO:0070481nuclear-transcribed mRNA catabolic process, non-stop decay-IEA-  
GO:0070651nonfunctional rRNA decay-IBA21873635  
GO:0070966nuclear-transcribed mRNA catabolic process, no-go decay-IBA21873635  
GO:0071025RNA surveillance-IEA-  
GO:0090305nucleic acid phosphodiester bond hydrolysis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005737cytoplasm-IBA21873635  
KEGG ID KEGG Term
hsa03015mRNA surveillance pathway
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27305182The Nursing Diagnosis of risk for pressure ulcer: content validation. (2016 Jun 14)Santos CTRev Lat Am Enfermagem
28591252Impact of the Use of Different Diagnostic Criteria in the Prevalence of Dyslipidemia in Pregnant Women. (2017 Jul)Feitosa ACRArq Bras Cardiol
28678924Persistent Depressive Symptoms are Independent Predictors of Low-Grade Inflammation Onset Among Healthy Individuals. (2017 Jun 29)Franco FGMArq Bras Cardiol
27832238Smoking control: challenges and achievements. (2016 Jul-Aug)Silva LCJ Bras Pneumol