Gene: CNTN5

53942
HNB-2s|NB-2
contactin 5
protein-coding
11q22.1
Ensembl:ENSG00000149972 MIM:607219 Vega:OTTHUMG00000167579 UniprotKB:O94779
NG_047156.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.428e-1 (AD)  5.405e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs117557854chr11:100268439 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FAM19A20.91
IGSF30.907
CBLN40.902
PCDH190.899
VSTM2A0.894
KITLG0.894
SERTM10.892
SMIM170.889
B4GALT60.889
CDH180.886

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CPM-0.581
ROM1-0.578
TGFB3-0.578
HEY2-0.576
RAB13-0.545
CSAG1-0.538
SNHG18-0.537
ZHX2-0.534
HVCN1-0.531
MYL3-0.528

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CNTN5 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of CNTN5 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CNTN5 mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CNTN5 mRNA22316170
D004958EstradiolEstradiol results in increased expression of CNTN5 mRNA20106945
C006780bisphenol Abisphenol A results in decreased expression of CNTN5 mRNA26364221
C006780bisphenol Abisphenol A results in decreased expression of CNTN5 mRNA25181051
C009160cyclonitecyclonite results in increased expression of CNTN5 mRNA25559034
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of CNTN5 mRNA21889194
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of CNTN5 mRNA"24972896
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of CNTN5 mRNA24810058
D010936Plant ExtractsPlant Extracts results in decreased expression of CNTN5 mRNA23557933
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of CNTN5 mRNA22698814
D011441PropylthiouracilPropylthiouracil results in increased expression of CNTN5 mRNA24780913
D014403TubocurarineTubocurarine results in increased expression of CNTN5 mRNA19728367

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-IEA-  
GO:0007605sensory perception of sound-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005829cytosol-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0031225anchored component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-163125Post-translational modification: synthesis of GPI-anchored proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28631723Pharmacogenetic biomarkers of response in Crohn's disease. (2018 Jan)Linares-Pineda TMPharmacogenomics J