Gene: A4GALT

53947
A14GALT|A4GALT1|Gb3S|P(k)|P1|P1PK|PK
alpha 1,4-galactosyltransferase (P blood group)
protein-coding
22q13.2
Ensembl:ENSG00000128274 MIM:607922 Vega:OTTHUMG00000150744 UniprotKB:Q9NPC4
NG_007495.2
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.680e-1 (AD)  8.841e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3747193chr22:42692457 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LTBR0.893
TUBB60.867
CLIC10.864
VASP0.848
TEAD20.848
ANXA20.846
TNFRSF1A0.84
IFITM20.836
TAGLN20.833
PLP20.833

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC7A4-0.588
SMIM18-0.588
PPEF1-0.582
MARCH4-0.564
NEUROD6-0.556
CASC15-0.553
ABCC12-0.547
XKR4-0.546
SPHKAP-0.546
SLC1A6-0.536

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5850042-monochloropropanediol2-monochloropropanediol results in increased expression of A4GALT mRNA28522335
D000643Ammonium ChlorideAmmonium Chloride affects the expression of A4GALT mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of A4GALT mRNA19152381|2006483
D001564Benzo(a)pyrenechlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of A4GALT mRNA]19152381
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to A4GALT promoter]19654925
C006780bisphenol Abisphenol A results in decreased expression of A4GALT mRNA25181051
D002235CarbofuranA4GALT gene SNP affects the susceptibility to Carbofuran22919386
C007020chlorophyllinchlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of A4GALT mRNA]19152381
D003300CopperCopper deficiency results in increased expression of A4GALT mRNA26033743
D003474CurcuminCurcumin inhibits the reaction [IL1B protein results in increased expression of A4GALT mRNA]16819191
D003474CurcuminCurcumin inhibits the reaction [TNF protein results in increased expression of A4GALT mRNA]16819191
C014347decitabinedecitabine affects the expression of A4GALT mRNA23300844
D002945CisplatinCisplatin affects the expression of A4GALT mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of A4GALT mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of A4GALT mRNA25016146
D019422Dietary SucroseDietary Sucrose results in increased expression of A4GALT mRNA26033743
D004397FonofosFonofos results in increased methylation of A4GALT promoter22847954
D005557FormaldehydeFormaldehyde results in decreased expression of A4GALT mRNA27664576
C039281furanfuran results in increased expression of A4GALT mRNA27387713
C492448ICG 001ICG 001 results in increased expression of A4GALT mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of A4GALT mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of A4GALT mRNA27392435
C544151jinfukangjinfukang results in increased expression of A4GALT mRNA27392435
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of A4GALT mRNA24810058
D010278ParathionParathion results in increased methylation of A4GALT promoter22847954
D010936Plant ExtractsPlant Extracts results in decreased expression of A4GALT mRNA23557933
D011374ProgesteroneProgesterone results in increased expression of A4GALT mRNA19690047
C524947Scutellaria barbata extractScutellaria barbata extract results in increased expression of A4GALT protein16218664
D012906SmokeSmoke results in decreased expression of A4GALT mRNA21095227
C017947sodium arsenitesodium arsenite affects the methylation of A4GALT gene28589171
C012568terbufosterbufos results in increased methylation of A4GALT promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of A4GALT mRNA20106945|2163298
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of A4GALT mRNA25613284
D014520UrethaneUrethane results in increased expression of A4GALT mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of A4GALT gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of A4GALT gene25560391
C088658zoledronic acidzoledronic acid results in increased expression of A4GALT mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008378galactosyltransferase activity-IDA10747952  10748143  
GO:0015643toxic substance binding-IEA-  
GO:0050512lactosylceramide 4-alpha-galactosyltransferase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001576globoside biosynthetic process-IEA-  
GO:0006486protein glycosylation-IEA-  
GO:0006688glycosphingolipid biosynthetic process-NAS10748143  
GO:0007009plasma membrane organization-IDA10747952  
GO ID GO Term Qualifier Evidence PubMed
GO:0016020membrane-IDA10748143  
GO:0030173integral component of Golgi membrane-NAS10748143  
KEGG ID KEGG Term
hsa00603Glycosphingolipid biosynthesis - globo series
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal