Gene: PMS2

5395
HNPCC4|MLH4|PMS2CL|PMSL2
PMS1 homolog 2, mismatch repair system component
protein-coding
7p22.1
Ensembl:ENSG00000122512 MIM:600259 Vega:OTTHUMG00000023135 UniprotKB:P54278
NG_008466.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.459e-1 (AD)  3.677e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CEP680.933
MCM40.924
RNMT0.922
TUBGCP50.912
DPP80.912
C17orf750.911
ANAPC10.911
MTMR70.91
HEATR5B0.91
SLC35B40.91

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MTRNR2L6-0.495
MTRNR2L10-0.481
MTRNR2L9-0.468
CSAG1-0.444
RAB13-0.437
MTRNR2L8-0.424
CCDC102A-0.419
MTRNR2L2-0.413
PGF-0.412
HEY2-0.412

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB02930Adenosine 5'-[gamma-thio]triphosphateSmall Molecule35094-46-3ExperimentalTarget
ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of PMS2 mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of PMS2 mRNA17562736
C006632arsenic trioxidearsenic trioxide results in increased expression of PMS2 mRNA22521957
C547126AZM551248AZM551248 results in decreased expression of PMS2 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PMS2 mRNA28461126
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PMS2 mRNA22228805
D004958EstradiolEstradiol results in decreased expression of PMS2 mRNA22082530
C006780bisphenol Abisphenol A affects the expression of PMS2 mRNA21786754
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PMS2 mRNA11958953
D019256Cadmium ChlorideMT1 affects the reaction [Cadmium Chloride results in increased expression of PMS2 mRNA]11958953
D019256Cadmium ChlorideMT2 affects the reaction [Cadmium Chloride results in increased expression of PMS2 mRNA]11958953
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of PMS2 mRNA11566570
C074702chromium hexavalent ionPMS2 protein results in increased susceptibility to chromium hexavalent ion15831465
C408982CPG-oligonucleotideCPG-oligonucleotide results in increased expression of PMS2 mRNA21878529
D003520CyclophosphamideCyclophosphamide results in decreased expression of PMS2 mRNA11056294
C089595cylindrospermopsincylindrospermopsin results in increased expression of PMS2 mRNA24921660
C014347decitabinedecitabine results in increased expression of PMS2 mRNA22082530
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PMS2 mRNA17361019|2126653
D002945CisplatinCisplatin affects the localization of PMS2 protein21064154
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of PMS2 mRNA27392435
D002945CisplatinCisplatin results in increased expression of PMS2 mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of PMS2 mRNA25016146
D000431EthanolEthanol results in decreased expression of PMS2 mRNA11566570
C039281furanfuran results in increased expression of PMS2 mRNA22079235
C071834glycidamideglycidamide affects the expression of PMS2 protein21978862
C056493imiquimodimiquimod results in decreased expression of PMS2 mRNA21878529
D007213IndomethacinIndomethacin results in increased expression of PMS2 mRNA28201806
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of PMS2 mRNA27392435
C005223methyleugenolmethyleugenol results in decreased expression of PMS2 mRNA21659616
D008770MethylnitrosoureaMethylnitrosourea promotes the reaction [MSH2 protein binds to MLH1 protein binds to PMS2 protein]16204460
D008770MethylnitrosoureaPMS2 protein results in increased susceptibility to Methylnitrosourea16426742
D008770MethylnitrosoureaPMS2 protein affects the susceptibility to Methylnitrosourea12967659
C008493methylselenic acidmethylselenic acid results in increased expression of PMS2 mRNA12517777
C005246myristicinmyristicin results in decreased expression of PMS2 mRNA24792648
D009569Nitric OxideNitric Oxide deficiency results in increased expression of PMS2 mRNA15878706
C064976O(6)-benzylguanine[temozolomide co-treated with O(6)-benzylguanine] affects the expression of PMS2 protein20980775
D052638Particulate MatterParticulate Matter results in decreased expression of PMS2 mRNA24769257
C011272perfosfamideperfosfamide results in decreased expression of PMS2 mRNA11754170
D010936Plant ExtractsPlant Extracts results in increased expression of PMS2 mRNA23557933
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of PMS2 mRNA16202921
C547185riccardin Driccardin D results in increased expression of PMS2 mRNA24069304
C017947sodium arsenitesodium arsenite results in increased expression of PMS2 mRNA11353140
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of PMS2 mRNA"26680231
C047246temozolomide[temozolomide co-treated with O(6)-benzylguanine] affects the expression of PMS2 protein20980775
C047246temozolomidePMS2 protein affects the susceptibility to temozolomide12967659
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PMS2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of PMS2 mRNA25975270

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IDA10871409  
GO:0003697single-stranded DNA binding-IBA21873635  
GO:0003697single-stranded DNA bindingcontributes_toIDA11809883  
GO:0004519endonuclease activity-TAS-  
GO:0005515protein binding-IPI11793469  17581638  20603073  20706999  26496610  
GO:0005524ATP binding-IEA-  
GO:0016887ATPase activity-IBA21873635  
GO:0032138single base insertion or deletion binding-IDA10871409  
GO:0032407MutSalpha complex bindingcontributes_toIDA16403449  
GO ID GO Term Qualifier Evidence PubMed
GO:0006298mismatch repair-IBA21873635  
GO:0006298mismatch repair-IDA10871409  23709753  
GO:0006298mismatch repair-IMP9618520  
GO:0006298mismatch repair-TAS-  
GO:0016446somatic hypermutation of immunoglobulin genes-IBA21873635  
GO:0042493response to drug-IEA-  
GO:0090305nucleic acid phosphodiester bond hydrolysis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IC10871409  
GO:0005634nucleus-IDA23709753  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005829cytosol-IDA-  
GO:0005886plasma membrane-IDA-  
GO:0015630microtubule cytoskeleton-IDA-  
GO:0032300mismatch repair complex-IBA21873635  
GO:0032389MutLalpha complex-IBA21873635  
GO:0036464cytoplasmic ribonucleoprotein granule-IDA-  
KEGG ID KEGG Term
hsa03430Mismatch repair
Reactome ID Reactome Term Evidence
R-HSA-1643685DiseaseTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-5358508Mismatch RepairTAS
R-HSA-5358508Mismatch RepairIEA
R-HSA-5358565Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)TAS
R-HSA-5358606Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)IEA
R-HSA-5423599Diseases of Mismatch Repair (MMR)TAS
R-HSA-5545483Defective Mismatch Repair Associated With MLH1TAS
R-HSA-5632987Defective Mismatch Repair Associated With PMS2TAS
R-HSA-6796648TP53 Regulates Transcription of DNA Repair GenesTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73894DNA RepairTAS
R-HSA-73894DNA RepairIEA
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20301390Lynch Syndrome (1993)Kohlmann W-
29775861Screening methylation of DNA repair genes in the oral mucosa of chronic smokers. (2018 May 1)Carta CFLArch Oral Biol
21559014Body mass index in early adulthood and colorectal cancer risk for carriers and non-carriers of germline mutations in DNA mismatch repair genes. (2011 Jun 28)Win AKBr J Cancer