Gene: PNLIP

5406
PL|PNLIPD|PTL
pancreatic lipase
protein-coding
10q25.3
Ensembl:ENSG00000175535 MIM:246600 Vega:OTTHUMG00000019103 UniprotKB:P16233
NG_023311.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.390e-1 (AD)  8.017e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLPS0.956
CPA10.955
PRSS10.954
CELA3A0.946
CTRB10.941
CPB10.927
CELA3B0.917
PLA2G1B0.911
GP20.909
SYCN0.901

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CYP2A6-0.216
TM4SF20-0.205
CRLF2-0.203
PSG11-0.202
CCL16-0.2
RNASE13-0.197
NPVF-0.195
NPIPB9-0.19
ORC1-0.187
GOLGA8N-0.183

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01083OrlistatSmall Molecule96829-58-2Approved|InvestigationalTarget
DB04233(Hydroxyethyloxy)Tri(Ethyloxy)OctaneSmall MoleculeExperimentalTarget
DB06586CetilistatSmall Molecule282526-98-1InvestigationalTarget
DB08222METHOXYUNDECYLPHOSPHINIC ACIDSmall MoleculeExperimentalTarget
DB08909Glycerol PhenylbutyrateSmall Molecule611168-24-2ApprovedEnzyme
ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PNLIP mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PNLIP mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PNLIP mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PNLIP mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PNLIP mRNA"25510870
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of PNLIP mRNA"18648102
D020106AcrylamideAcrylamide results in increased expression of PNLIP mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PNLIP mRNA16483693
C006780bisphenol Abisphenol A affects the methylation of PNLIP promoter27415467
D002713Chlorine[Ozone co-treated with Chlorine] results in increased expression of PNLIP mRNA18636392
D002922CiguatoxinsCiguatoxins affects the expression of PNLIP mRNA18353800
D002994ClofibrateClofibrate results in decreased expression of PNLIP mRNA22300585
D003300CopperCopper deficiency results in increased expression of PNLIP mRNA26033743
D003471CuprizoneCuprizone results in increased expression of PNLIP mRNA27523638
D003840Deoxycholic AcidDeoxycholic Acid inhibits the reaction [PNLIP protein results in increased hydrolysis of Olive Oil]18362845
D003840Deoxycholic AcidDeoxycholic Acid results in decreased activity of PNLIP protein18362845
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in decreased expression of PNLIP mRNA26924002
D019422Dietary SucroseDietary Sucrose results in increased expression of PNLIP mRNA26033743
D002117CalcitriolCalcitriol results in increased expression of PNLIP mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of PNLIP mRNA21592394
C024629dimethyl phthalatedimethyl phthalate results in decreased expression of PNLIP mRNA26924002
D005230Fatty Acids, Nonesterified"[[orlistat results in decreased abundance of Fatty Acids, Nonesterified] which results in decreased secretion of CCK protein] which results in decreased secretion of PNLIP protein"11408251
D005419FlavonoidsFlavonoids results in decreased expression of PNLIP mRNA18035473
D007501IronIron deficiency results in increased expression of PNLIP mRNA19821111
C008261lead acetatelead acetate results in increased expression of PNLIP mRNA20542052
C008261lead acetatelead acetate results in increased expression of PNLIP mRNA22641619
D008345ManganeseManganese results in increased expression of PNLIP mRNA26745496
C025340manganese chloridemanganese chloride results in increased expression of PNLIP mRNA26745496
D008694MethamphetamineMethamphetamine results in decreased expression of PNLIP mRNA15644446
D008727MethotrexateMethotrexate affects the expression of PNLIP mRNA18502557
C517284monomethyl phthalatemonomethyl phthalate results in decreased expression of PNLIP mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PNLIP mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PNLIP mRNA"25620056
D000069463Olive Oilorlistat inhibits the reaction [[PNLIP protein co-treated with CLPS protein] results in increased hydrolysis of Olive Oil]15158758
D000069463Olive Oil[PNLIP protein co-treated with CLPS protein] results in increased hydrolysis of Olive Oil15158758
D000069463Olive OilOlive Oil analog affects the expression of PNLIP mRNA17349074
D000069463Olive Oil[PNLIP protein co-treated with CLPS protein] results in increased hydrolysis of Olive Oil15158758
D000069463Olive OilDeoxycholic Acid inhibits the reaction [PNLIP protein results in increased hydrolysis of Olive Oil]18362845
D000069463Olive Oilorlistat inhibits the reaction [PNLIP protein results in increased hydrolysis of Olive Oil]18362845
D000069463Olive OilPNLIP protein results in increased hydrolysis of Olive Oil18362845
D000069463Olive OilTaurodeoxycholic Acid inhibits the reaction [PNLIP protein results in increased hydrolysis of Olive Oil]18362845
D009943Organophosphorus CompoundsOrganophosphorus Compounds results in decreased activity of PNLIP protein16449251
C055122orlistatorlistat affects the folding of PNLIP protein19346257
C055122orlistatorlistat inhibits the reaction [[PNLIP protein co-treated with CLPS protein] results in increased hydrolysis of Olive Oil]15158758
C055122orlistat"[[orlistat results in decreased abundance of Fatty Acids, Nonesterified] which results in decreased secretion of CCK protein] which results in decreased secretion of PNLIP protein"11408251
C055122orlistatorlistat results in decreased activity of PNLIP protein11408251|1238133
C055122orlistatorlistat results in decreased secretion of PNLIP protein11408251
C055122orlistatorlistat inhibits the reaction [Taurocholic Acid results in increased activity of PNLIP protein]11668201
C055122orlistatorlistat results in decreased activity of PNLIP protein21438711
C055122orlistatorlistat inhibits the reaction [PNLIP protein results in increased hydrolysis of Olive Oil]18362845
C055122orlistatorlistat results in decreased activity of PNLIP protein18362845
C055122orlistatorlistat results in decreased activity of PNLIP protein10095983
D010126Ozone[Ozone co-treated with Chlorine] results in increased expression of PNLIP mRNA18636392
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PNLIP mRNA"25510870
D010634PhenobarbitalPhenobarbital affects the expression of PNLIP mRNA23091169
C006253pirinixic acidpirinixic acid results in increased expression of PNLIP mRNA17426115
D020442PoloxamerPoloxamer results in decreased activity of PNLIP protein16872557
D011107PolylysinePolylysine results in decreased activity of PNLIP protein16723640
D059808PolyphenolsPolyphenols results in increased expression of PNLIP mRNA16293270
D011441PropylthiouracilPropylthiouracil results in decreased expression of PNLIP mRNA24780913
C089730rosiglitazonerosiglitazone results in decreased expression of PNLIP mRNA21515302
C016104sodium bichromatesodium bichromate results in decreased expression of PNLIP mRNA22155349
C016104sodium bichromatesodium bichromate results in decreased expression of PNLIP mRNA22561333
D012999SomanSoman results in decreased expression of PNLIP mRNA19281266
D013656Taurocholic Acidorlistat inhibits the reaction [Taurocholic Acid results in increased activity of PNLIP protein]11668201
D013656Taurocholic AcidTaurocholic Acid results in increased activity of PNLIP protein11668201
D013657Taurodeoxycholic AcidTaurodeoxycholic Acid affects the folding of PNLIP protein19346257
D013657Taurodeoxycholic AcidTaurodeoxycholic Acid inhibits the reaction [PNLIP protein results in increased hydrolysis of Olive Oil]18362845
D013657Taurodeoxycholic AcidTaurodeoxycholic Acid results in decreased activity of PNLIP protein18362845
C501413tesaglitazartesaglitazar results in decreased expression of PNLIP mRNA21515302
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of PNLIP mRNA21592394
D013739TestosteroneTestosterone results in increased expression of PNLIP mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PNLIP mRNA26377647
C009495titanium dioxidetitanium dioxide results in increased expression of PNLIP mRNA23409001
C005830tributyrinPNLIP protein results in increased hydrolysis of tributyrin18362845
D014280TriglyceridesPNLIP protein affects the hydrolysis of Triglycerides11408251
C057693troglitazonetroglitazone affects the expression of PNLIP mRNA21515302
D014635Valproic AcidValproic Acid affects the expression of PNLIP mRNA17963808
D014635Valproic AcidValproic Acid results in increased expression of PNLIP mRNA23665938

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004806triglyceride lipase activity-ISS-  
GO:0005515protein binding-IPI1522902  7893686  
GO:0016298lipase activity-IDA25862608  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006629lipid metabolic process-IMP24262094  
GO:0016042lipid catabolic process-IEA-  
GO:0030299intestinal cholesterol absorption-IEA-  
GO:0061365positive regulation of triglyceride lipase activity-IDA9631512  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IDA25862608  
KEGG ID KEGG Term
hsa00561Glycerolipid metabolism
hsa01100Metabolic pathways
hsa04972Pancreatic secretion
hsa04975Fat digestion and absorption
hsa04977Vitamin digestion and absorption
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-162582Signal TransductionTAS
R-HSA-192456Digestion of dietary lipidTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-2187338Visual phototransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-6806667Metabolism of fat-soluble vitaminsTAS
R-HSA-8935690DigestionTAS
R-HSA-8963743Digestion and absorptionTAS
R-HSA-975634Retinoid metabolism and transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28101967Host-related factors explaining interindividual variability of carotenoid bioavailability and tissue concentrations in humans. (2017 Jun)Bohn TMol Nutr Food Res