Gene: CLIC6

54102
CLIC1L
chloride intracellular channel 6
protein-coding
21q22.12
Ensembl:ENSG00000159212 MIM:615321 Vega:OTTHUMG00000086237 UniprotKB:Q96NY7
NC_000021.9
SNP Mapped
ND
0   
8.203e-1 (AD)  6.207e-1 (ND)   (Frontal_Cortex)
5.828e-1 (AD)  4.057e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC13A40.811
SLC22A80.809
GATA60.787
SLC22A20.777
CDC20B0.77
TRABD2B0.768
OGN0.762
ALX40.757
OR51E10.739
ESM10.732

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FEZF2-0.36
RHCG-0.282
PNPLA7-0.281
SORCS2-0.254
MYH14-0.244
DOK7-0.235
ASPDH-0.232
NEUROG2-0.229
SERHL2-0.228
DAPK2-0.223

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLIC6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLIC6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLIC6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLIC6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLIC6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLIC6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLIC6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLIC6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLIC6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLIC6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLIC6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLIC6 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CLIC6 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of CLIC6 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CLIC6 mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CLIC6 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CLIC6 mRNA27195522
D004958EstradiolEstradiol results in increased expression of CLIC6 mRNA16474171
C006780bisphenol Abisphenol A results in increased expression of CLIC6 mRNA16474171
C006780bisphenol Abisphenol A results in decreased expression of CLIC6 mRNA26063408
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CLIC6 mRNA20938992
C014347decitabinedecitabine affects the expression of CLIC6 mRNA23300844
C014347decitabinedecitabine inhibits the reaction [Smoke results in decreased expression of CLIC6 mRNA]21095227
D002945CisplatinCisplatin affects the expression of CLIC6 mRNA23300844
D004041Dietary FatsDietary Fats results in increased expression of CLIC6 mRNA25016146
C118739entinostatentinostat results in increased expression of CLIC6 mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLIC6 mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of CLIC6 mRNA29097150
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CLIC6 mRNA20938992
D004397FonofosFonofos results in increased methylation of CLIC6 promoter22847954
D019833GenisteinGenistein results in increased expression of CLIC6 mRNA16474171
D017313FenretinideFenretinide results in increased expression of CLIC6 mRNA28973697
C020758indium trichlorideindium trichloride results in increased expression of CLIC6 protein19539025
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CLIC6 mRNA24796395
C008261lead acetatelead acetate affects the expression of CLIC6 mRNA21864555
D008070LipopolysaccharidesLipopolysaccharides results in decreased methylation of CLIC6 gene21212295
D008070Lipopolysaccharides[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in decreased methylation of CLIC6 gene21212295
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CLIC6 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CLIC6 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLIC6 mRNA"27188386
C028577monobutyl phthalatemonobutyl phthalate results in decreased expression of CLIC6 protein20553848
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLIC6 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of CLIC6 mRNA26272509
D010278ParathionParathion results in increased methylation of CLIC6 promoter22847954
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLIC6 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of CLIC6 mRNA26272509
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in increased expression of CLIC6 mRNA16474171
D011374ProgesteroneProgesterone results in decreased expression of CLIC6 mRNA22238285
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of CLIC6 mRNA21427059
D012906Smokedecitabine inhibits the reaction [Smoke results in decreased expression of CLIC6 mRNA]21095227
C012568terbufosterbufos results in increased methylation of CLIC6 promoter22847954
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in decreased methylation of CLIC6 gene21212295
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CLIC6 promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased methylation of CLIC6 gene21212295
C009495titanium dioxidetitanium dioxide affects the expression of CLIC6 mRNA23557971
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLIC6 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of CLIC6 mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CLIC6 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CLIC6 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of CLIC6 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of CLIC6 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of CLIC6 mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CLIC6 gene25560391
C029297vinylidene chloridevinylidene chloride results in increased expression of CLIC6 mRNA26682919
D015032ZincZinc deficiency results in increased expression of CLIC6 mRNA20857495

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005244voltage-gated ion channel activity-IEA-  
GO:0031749D2 dopamine receptor binding-IBA21873635  
GO:0031750D3 dopamine receptor binding-IBA21873635  
GO:0031751D4 dopamine receptor binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0034765regulation of ion transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IEA-  
GO:0034707chloride channel complex-IEA-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal