Gene: GSAP

54103
PION
gamma-secretase activating protein
protein-coding
7q11.23
Ensembl:ENSG00000186088 MIM:613552 Vega:OTTHUMG00000150504 UniprotKB:A4D1B5
NC_000007.14
PubMed
0   ANCO-SNPs
ND
1   
7.631e-1 (AD)  9.865e-1 (ND)   (Frontal_Cortex)
2.241e-1 (AD)  1.184e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DNAJC100.798
ZNF4490.796
NAA400.793
GOLGA8A0.791
HGSNAT0.788
YTHDC20.784
UGGT20.78
SNRK0.777
NFATC2IP0.777
ALG130.775

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.454
C7orf61-0.442
OR4F29-0.417
MIA-0.365
CCDC102A-0.307
HSPB9-0.306
CELSR1-0.297
NPC1L1-0.296
VHLL-0.291
CYP39A1-0.286

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of GSAP mRNA"22698814
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GSAP mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GSAP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GSAP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GSAP mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of GSAP mRNA21420995
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of GSAP mRNA24449571
D001507BeclomethasoneBeclomethasone results in increased expression of GSAP mRNA23656298
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of GSAP mRNA26377693
D004958EstradiolEstradiol results in decreased expression of GSAP mRNA25321415
C006780bisphenol Abisphenol A affects the expression of GSAP mRNA20170705
C006780bisphenol Abisphenol A results in decreased expression of GSAP mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of GSAP mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of GSAP gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of GSAP mRNA26079696
D002737ChloropreneChloroprene results in decreased expression of GSAP mRNA23125180
C018021cobaltous chloridecobaltous chloride results in decreased expression of GSAP mRNA19376846
D016572CyclosporineCyclosporine results in decreased expression of GSAP mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of GSAP mRNA27989131
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of GSAP mRNA27392435
D002945CisplatinCisplatin results in increased expression of GSAP mRNA27594783
C000944dicrotophosdicrotophos results in decreased expression of GSAP mRNA28302478
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GSAP mRNA22079256
D005557FormaldehydeFormaldehyde results in increased expression of GSAP mRNA23649840
C039281furanfuran results in increased methylation of GSAP gene22079235
D005897GlafenineGlafenine results in increased expression of GSAP mRNA24136188
C010974glyphosateglyphosate results in decreased expression of GSAP mRNA25636363
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GSAP mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of GSAP mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of GSAP mRNA24796395|2675264
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of GSAP mRNA24231268
C045463leflunomideleflunomide results in decreased expression of GSAP mRNA28988120
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of GSAP mRNA21641980
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GSAP mRNA28001369
C523799MRK 003MRK 003 results in decreased expression of GSAP mRNA21169257
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of GSAP mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of GSAP mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of GSAP mRNA"25620056
D010634PhenobarbitalPhenobarbital results in decreased expression of GSAP mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of GSAP mRNA19270015
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GSAP mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of GSAP mRNA20813756|2381119
D010936Plant ExtractsPlant Extracts results in increased expression of GSAP mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GSAP mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of GSAP mRNA22079256
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of GSAP mRNA28903501
D012822Silicon DioxideSilicon Dioxide results in decreased expression of GSAP mRNA19073995
D012999SomanSoman results in increased expression of GSAP mRNA19281266
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of GSAP mRNA21641980
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GSAP mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GSAP mRNA26290441
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GSAP mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of GSAP mRNA20133372
D014212TretinoinTretinoin results in decreased expression of GSAP mRNA15894607
D014212TretinoinTretinoin results in increased expression of GSAP mRNA21934132
C012589trichostatin Atrichostatin A results in decreased expression of GSAP mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of GSAP mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of GSAP mRNA"26179874
D014520UrethaneUrethane results in decreased expression of GSAP mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GSAP mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of GSAP mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of GSAP mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in decreased methylation of GSAP gene29154799
D014635Valproic AcidValproic Acid results in increased expression of GSAP mRNA24935251
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GSAP mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of GSAP mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001540amyloid-beta binding-IDA20811458  
GO:0005515protein binding-IPI20811458  
GO ID GO Term Qualifier Evidence PubMed
GO:0030162regulation of proteolysis-IDA20811458  
GO:1902004positive regulation of amyloid-beta formation-IDA20811458  
GO ID GO Term Qualifier Evidence PubMed
GO:0005802trans-Golgi network-IDA20811458  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27171516Prospective Study of Alcohol Drinking, Smoking, and Pancreatitis: The Multiethnic Cohort. (2016 Jul)Setiawan VWPancreas