Gene info: ID 54106

Gene: TLR9

GENE ID: 54106

Synonyms: CD289

Description: toll like receptor 9

Gene type: protein-coding

Location: 3p21.2

dbXrefs: Ensembl:ENSG00000239732 MIM:605474 Vega:OTTHUMG00000158106 UniprotKB:Q9NR96

RefSeq: NG_033933.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|OD|ND|AD

# Publications: 18

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.178e-1 (AD) 4.001e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SLFNL1	0.84
NPC1L1	0.829
KLK14	0.792
CELSR1	0.792
CCNA2	0.787
JMJD6	0.777
CNTD2	0.774
PSPN	0.757
TDRG1	0.756
FGFR4	0.751

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CCT6B	-0.518
RBM3	-0.464
CTSO	-0.442
PBLD	-0.434
STARD6	-0.429
HSD17B8	-0.427
PRSS27	-0.427
CDNF	-0.414
RMDN1	-0.388
DPH6	-0.379

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00608	Chloroquine	Small Molecule	54-05-7	Approved\|Investigational	Target
DB01611	Hydroxychloroquine	Small Molecule	118-42-3	Approved	Target
DB05463	ISS-1018	Small Molecule	-	Investigational	Target
DB05475	Golotimod	Small Molecule	229305-39-9	Investigational	Target
DB05530	CPG 10101	BiotechDrug	957255-05-9	Investigational	Target

ID	Drug Name	Action	PubMed
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of TLR9 mRNA"	25614096
C003898	2-anisidine	2-anisidine affects the expression of TLR9 mRNA	28089782
C034343	4-aminobenzhydrazide	4-aminobenzhydrazide inhibits the reaction [hydroxyhydroquinone results in decreased expression of TLR9 mRNA]	24530881
D000082	Acetaminophen	Acetaminophen affects the expression of TLR9 mRNA	17562736
D000082	Acetaminophen	TLR9 protein affects the reaction [Acetaminophen results in increased expression of IL1B mRNA]	19164858
D000082	Acetaminophen	TLR9 protein results in increased susceptibility to Acetaminophen	19164858
D020106	Acrylamide	Acrylamide results in decreased expression of TLR9 mRNA	28959563
C547126	AZM551248	AZM551248 results in decreased expression of TLR9 mRNA	22323515
C012768	benzanthrone	benzanthrone results in increased expression of TLR9 mRNA	28495615
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased mutagenesis of TLR9 gene	25435355
D004958	Estradiol	Estradiol results in increased expression of TLR9 mRNA	28811679
C006780	bisphenol A	bisphenol A results in decreased methylation of TLR9 promoter	27312807
C006780	bisphenol A	bisphenol A results in decreased expression of TLR9 mRNA	25181051
D019328	Buthionine Sulfoximine	[Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of TLR9 mRNA	23986454
D002738	Chloroquine	Chloroquine results in decreased activity of TLR9 protein	17727805
C423449	CpG ODN 1826	[CpG ODN 1826 binds to and results in increased activity of TLR9 protein] results in increased secretion of [IL12A protein binds to IL12B protein]	21097750
C423449	CpG ODN 1826	[CpG ODN 1826 binds to and results in increased activity of TLR9 protein] which results in increased activity of NFKB1 protein	21097750
C423449	CpG ODN 1826	[CpG ODN 1826 binds to and results in increased activity of TLR9 protein] which results in increased activity of NFKB2 protein	21097750
C423449	CpG ODN 1826	[CpG ODN 1826 binds to and results in increased activity of TLR9 protein] which results in increased activity of RELA protein	21097750
C423449	CpG ODN 1826	[CpG ODN 1826 binds to and results in increased activity of TLR9 protein] which results in increased expression of CD86 protein	21097750
C423449	CpG ODN 1826	[CpG ODN 1826 binds to and results in increased activity of TLR9 protein] which results in increased expression of ICAM1 protein	21097750
C423449	CpG ODN 1826	[CpG ODN 1826 binds to and results in increased activity of TLR9 protein] which results in increased expression of ITGAX protein	21097750
C423449	CpG ODN 1826	[CpG ODN 1826 binds to and results in increased activity of TLR9 protein] which results in increased secretion of IL10 protein	21097750
C423449	CpG ODN 1826	[CpG ODN 1826 binds to and results in increased activity of TLR9 protein] which results in increased secretion of IL6 protein	21097750
C423449	CpG ODN 1826	[CpG ODN 1826 binds to and results in increased activity of TLR9 protein] which results in increased secretion of TNF protein	21097750
C423449	CpG ODN 1826	Tetrachlorodibenzodioxin inhibits the reaction [[CpG ODN 1826 binds to and results in increased activity of TLR9 protein] results in increased secretion of [IL12A protein binds to IL12B protein]]	21097750
C423449	CpG ODN 1826	Tetrachlorodibenzodioxin inhibits the reaction [[CpG ODN 1826 binds to and results in increased activity of TLR9 protein] which results in increased activity of NFKB1 protein]	21097750
C423449	CpG ODN 1826	Tetrachlorodibenzodioxin inhibits the reaction [[CpG ODN 1826 binds to and results in increased activity of TLR9 protein] which results in increased activity of RELA protein]	21097750
C423449	CpG ODN 1826	Tetrachlorodibenzodioxin inhibits the reaction [[CpG ODN 1826 binds to and results in increased activity of TLR9 protein] which results in increased expression of ITGAX protein]	21097750
C423449	CpG ODN 1826	Tetrachlorodibenzodioxin inhibits the reaction [[CpG ODN 1826 binds to and results in increased activity of TLR9 protein] which results in increased secretion of IL10 protein]	21097750
C423449	CpG ODN 1826	Tetrachlorodibenzodioxin inhibits the reaction [[CpG ODN 1826 binds to and results in increased activity of TLR9 protein] which results in increased secretion of IL6 protein]	21097750
C423449	CpG ODN 1826	Tetrachlorodibenzodioxin inhibits the reaction [[CpG ODN 1826 binds to and results in increased activity of TLR9 protein] which results in increased secretion of TNF protein]	21097750
C423449	CpG ODN 1826	Tetrachlorodibenzodioxin promotes the reaction [[CpG ODN 1826 binds to and results in increased activity of TLR9 protein] which results in increased expression of CD86 protein]	21097750
C423449	CpG ODN 1826	Tetrachlorodibenzodioxin promotes the reaction [[CpG ODN 1826 binds to and results in increased activity of TLR9 protein] which results in increased expression of ICAM1 protein]	21097750
C423449	CpG ODN 1826	CpG ODN 1826 binds to and results in increased activity of TLR9 protein	21097750
C513533	CpG ODN 2006	CpG ODN 2006 binds to and results in increased activity of TLR9 protein	23266719
C526902	CpG ODN 2216	CpG ODN 2216 results in increased activity of TLR9 protein	28003376
C408982	CPG-oligonucleotide	CPG-oligonucleotide promotes the reaction [[TLR9 co-treated with MYD88] results in increased expression of HSPA1B protein]	17046822
C408982	CPG-oligonucleotide	CPG-oligonucleotide results in decreased expression of TLR9 mRNA	21823020
C408982	CPG-oligonucleotide	[CPG-oligonucleotide results in decreased expression of TLR9 mRNA] which results in decreased susceptibility to Cisplatin	21823020
C408982	CPG-oligonucleotide	CPG-oligonucleotide results in increased expression of TLR9 mRNA	21823020
C408982	CPG-oligonucleotide	CPG-oligonucleotide binds to and results in increased activity of TLR9 protein	21878529
C408982	CPG-oligonucleotide	TLR9 protein affects the reaction [CPG-oligonucleotide results in increased expression of HSP70 protein]	17727805
C408982	CPG-oligonucleotide	TLR9 protein affects the reaction [CPG-oligonucleotide results in increased expression of HSPD1 protein]	17727805
C408982	CPG-oligonucleotide	CPG-oligonucleotide binds to and results in increased activity of TLR9 protein	29319822
C408982	CPG-oligonucleotide	CPG-oligonucleotide results in increased activity of TLR9	21823020
C408982	CPG-oligonucleotide	[CPG-oligonucleotide results in increased activity of TLR9] which results in increased susceptibility to Cisplatin	21823020
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of TLR9 mRNA	21266533
D002945	Cisplatin	[CPG-oligonucleotide results in decreased expression of TLR9 mRNA] which results in decreased susceptibility to Cisplatin	21823020
D002945	Cisplatin	[CPG-oligonucleotide results in increased activity of TLR9] which results in increased susceptibility to Cisplatin	21823020
D003633	Dichlorodiphenyl Dichloroethylene	Dichlorodiphenyl Dichloroethylene results in increased expression of TLR9 protein	18757214
C045651	epigallocatechin gallate	epigallocatechin gallate inhibits the reaction [Paraquat results in increased expression of TLR9 protein]	27890776
C045651	epigallocatechin gallate	epigallocatechin gallate inhibits the reaction [Paraquat results in increased expression of TLR9 protein]	27890776
D005038	Ethylnitrosourea	Ethylnitrosourea results in increased mutagenesis of TLR9 gene	16724327
C070081	fulvestrant	fulvestrant results in decreased expression of TLR9 mRNA	28811679
C013038	hydroxyhydroquinone	4-aminobenzhydrazide inhibits the reaction [hydroxyhydroquinone results in decreased expression of TLR9 mRNA]	24530881
C013038	hydroxyhydroquinone	hydroxyhydroquinone results in decreased expression of TLR9 mRNA	24530881
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TLR9 mRNA	25613284
C008261	lead acetate	lead acetate results in increased expression of TLR9 mRNA	20542052
D001556	Lindane	Lindane results in increased expression of TLR9 protein	18757214
C433788	lipopolysaccharide, E. coli O26-B6	"lipopolysaccharide, E. coli O26-B6 results in increased expression of TLR9 mRNA"	23090859
C440499	lipopolysaccharide, Escherichia coli O111 B4	"lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of TLR9 mRNA"	23840549
C440499	lipopolysaccharide, Escherichia coli O111 B4	"[Pam(3)CSK(4) peptide co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in decreased expression of TLR9 mRNA"	23840549
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of TLR9 mRNA	22130863
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of TLR9 mRNA	25613284
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with Titanium] results in decreased expression of TLR9 mRNA	21308757
C013592	mangiferin	mangiferin results in decreased expression of TLR9 mRNA	15135318
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of TLR9 mRNA	23103053
C508075	Pam(3)CSK(4) peptide	"[Pam(3)CSK(4) peptide co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in decreased expression of TLR9 mRNA"	23840549
C508075	Pam(3)CSK(4) peptide	Pam(3)CSK(4) peptide results in decreased expression of TLR9 mRNA	23840549
D010269	Paraquat	epigallocatechin gallate inhibits the reaction [Paraquat results in increased expression of TLR9 protein]	27890776
D010269	Paraquat	Paraquat results in increased expression of TLR9 mRNA	28363843
D010269	Paraquat	Paraquat results in increased expression of TLR9 protein	27890776\|2836384
D010269	Paraquat	TLR9 protein promotes the reaction [Paraquat results in increased expression of and results in increased secretion of IL1B protein]	28363843
D010269	Paraquat	TLR9 protein promotes the reaction [Paraquat results in increased expression of and results in increased secretion of TNF protein]	28363843
D010269	Paraquat	TLR9 protein promotes the reaction [Paraquat results in increased expression of CASP3 protein modified form]	28363843
D010269	Paraquat	TLR9 protein promotes the reaction [Paraquat results in increased expression of IL1B mRNA]	28363843
D010269	Paraquat	TLR9 protein promotes the reaction [Paraquat results in increased expression of RELA protein modified form]	28363843
D010269	Paraquat	TLR9 protein promotes the reaction [Paraquat results in increased expression of TNF mRNA]	28363843
D010269	Paraquat	epigallocatechin gallate inhibits the reaction [Paraquat results in increased expression of TLR9 protein]	27890776
D010269	Paraquat	Paraquat results in increased expression of TLR9 mRNA	25304964\|2836384
D010269	Paraquat	Paraquat results in increased expression of TLR9 protein	25304964\|2789077
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of TLR9 mRNA	23892564
D010672	Phenytoin	[Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of TLR9 mRNA	23986454
D010672	Phenytoin	Phenytoin results in decreased expression of TLR9 mRNA	23986454
C006253	pirinixic acid	pirinixic acid results in decreased expression of TLR9 mRNA	23811191
D011070	Poly I-C	Poly I-C results in increased expression of TLR9 mRNA	17087994
D011374	Progesterone	Progesterone results in increased expression of TLR9 mRNA	21549006
D011374	Progesterone	Progesterone results in increased expression of TLR9 protein	21549006
D013629	Tamoxifen	Tamoxifen results in decreased expression of TLR9 mRNA	28811679
C000591600	tetrachlorobenzoquinone	tetrachlorobenzoquinone promotes the reaction [HMGB1 protein binds to TLR9 protein]	27413111
C000591600	tetrachlorobenzoquinone	tetrachlorobenzoquinone results in increased expression of TLR9 mRNA	27413111
C000591600	tetrachlorobenzoquinone	tetrachlorobenzoquinone results in increased expression of TLR9 protein	27413111
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [[CpG ODN 1826 binds to and results in increased activity of TLR9 protein] results in increased secretion of [IL12A protein binds to IL12B protein]]	21097750
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [[CpG ODN 1826 binds to and results in increased activity of TLR9 protein] which results in increased activity of NFKB1 protein]	21097750
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [[CpG ODN 1826 binds to and results in increased activity of TLR9 protein] which results in increased activity of RELA protein]	21097750
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [[CpG ODN 1826 binds to and results in increased activity of TLR9 protein] which results in increased expression of ITGAX protein]	21097750
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [[CpG ODN 1826 binds to and results in increased activity of TLR9 protein] which results in increased secretion of IL10 protein]	21097750
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [[CpG ODN 1826 binds to and results in increased activity of TLR9 protein] which results in increased secretion of IL6 protein]	21097750
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [[CpG ODN 1826 binds to and results in increased activity of TLR9 protein] which results in increased secretion of TNF protein]	21097750
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [[CpG ODN 1826 binds to and results in increased activity of TLR9 protein] which results in increased expression of CD86 protein]	21097750
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [[CpG ODN 1826 binds to and results in increased activity of TLR9 protein] which results in increased expression of ICAM1 protein]	21097750
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TLR9 mRNA	25613284
D014025	Titanium	[Lipopolysaccharides co-treated with Titanium] results in decreased expression of TLR9 mRNA	21308757
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of TLR9 mRNA"	26743178
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of TLR9 gene	25560391
C025643	vinclozolin	vinclozolin results in increased expression of TLR9 mRNA	18629315
D015054	Zymosan	Zymosan results in increased expression of TLR9 protein	17321468

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004888	transmembrane signaling receptor activity	-	IEA	-
GO:0005149	interleukin-1 receptor binding	-	IPI	12925853
GO:0008329	signaling pattern recognition receptor activity	-	IBA	21873635
GO:0016303	1-phosphatidylinositol-3-kinase activity	-	TAS	-
GO:0035197	siRNA binding	-	IMP	15723075
GO:0042803	protein homodimerization activity	-	ISS	-
GO:0045322	unmethylated CpG binding	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002224	toll-like receptor signaling pathway	-	IBA	21873635
GO:0002224	toll-like receptor signaling pathway	-	TAS	-
GO:0002237	response to molecule of bacterial origin	-	IBA	21873635
GO:0002237	response to molecule of bacterial origin	-	TAS	15356140
GO:0002639	positive regulation of immunoglobulin production	-	IDA	23857366
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	-	IEA	-
GO:0006954	inflammatory response	-	IEA	-
GO:0006955	immune response	-	IBA	21873635
GO:0007249	I-kappaB kinase/NF-kappaB signaling	-	IBA	21873635
GO:0007252	I-kappaB phosphorylation	-	IDA	19740627
GO:0010628	positive regulation of gene expression	-	IDA	24409285
GO:0030277	maintenance of gastrointestinal epithelium	-	ISS	-
GO:0030890	positive regulation of B cell proliferation	-	IDA	23857366
GO:0032088	negative regulation of NF-kappaB transcription factor activity	-	IDA	17128265
GO:0032640	tumor necrosis factor production	-	IBA	21873635
GO:0032640	tumor necrosis factor production	-	IDA	23826189
GO:0032715	negative regulation of interleukin-6 production	-	ISS	-
GO:0032717	negative regulation of interleukin-8 production	-	IDA	17128265
GO:0032722	positive regulation of chemokine production	-	IDA	19740627
GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production	-	IDA	24409285
GO:0032728	positive regulation of interferon-beta production	-	ISS	-
GO:0032733	positive regulation of interleukin-10 production	-	ISS	-
GO:0032735	positive regulation of interleukin-12 production	-	ISS	-
GO:0032741	positive regulation of interleukin-18 production	-	ISS	-
GO:0032755	positive regulation of interleukin-6 production	-	IBA	21873635
GO:0032755	positive regulation of interleukin-6 production	-	IDA	19740627 24409285
GO:0032757	positive regulation of interleukin-8 production	-	IDA	17128265 19740627 24409285
GO:0032760	positive regulation of tumor necrosis factor production	-	ISS	-
GO:0034122	negative regulation of toll-like receptor signaling pathway	-	IDA	17128265
GO:0034123	positive regulation of toll-like receptor signaling pathway	-	IDA	17128265
GO:0034162	toll-like receptor 9 signaling pathway	-	TAS	-
GO:0034163	regulation of toll-like receptor 9 signaling pathway	-	IDA	23857366
GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	-	IEA	-
GO:0042742	defense response to bacterium	-	NAS	11130078
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	-	IDA	17128265
GO:0043410	positive regulation of MAPK cascade	-	IDA	23857366
GO:0043507	positive regulation of JUN kinase activity	-	IDA	17128265
GO:0045078	positive regulation of interferon-gamma biosynthetic process	-	IBA	21873635
GO:0045078	positive regulation of interferon-gamma biosynthetic process	-	IDA	16286015
GO:0045087	innate immune response	-	TAS	15356140
GO:0045356	positive regulation of interferon-alpha biosynthetic process	-	IDA	16286015
GO:0045359	positive regulation of interferon-beta biosynthetic process	-	IBA	21873635
GO:0045359	positive regulation of interferon-beta biosynthetic process	-	IDA	16286015
GO:0045416	positive regulation of interleukin-8 biosynthetic process	-	IBA	21873635
GO:0045577	regulation of B cell differentiation	-	IDA	23857366
GO:0045944	positive regulation of transcription by RNA polymerase II	-	ISS	-
GO:0046330	positive regulation of JNK cascade	-	IC	17128265
GO:0050707	regulation of cytokine secretion	-	IEA	-
GO:0050729	positive regulation of inflammatory response	-	IC	19740627
GO:0050829	defense response to Gram-negative bacterium	-	IMP	22427638
GO:0050871	positive regulation of B cell activation	-	IDA	23857366
GO:0051092	positive regulation of NF-kappaB transcription factor activity	-	IBA	21873635
GO:0051092	positive regulation of NF-kappaB transcription factor activity	-	IDA	17128265
GO:0051607	defense response to virus	-	IBA	21873635
GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	-	ISS	-
GO:1901224	positive regulation of NIK/NF-kappaB signaling	-	IDA	19740627
GO:1901895	negative regulation of calcium-transporting ATPase activity	-	IDA	24610369

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000139	Golgi membrane	-	TAS	-
GO:0005576	extracellular region	-	NAS	11130078
GO:0005737	cytoplasm	-	IDA	19740627
GO:0005764	lysosome	-	ISS	-
GO:0005768	endosome	-	ISS	-
GO:0005783	endoplasmic reticulum	-	ISS	-
GO:0005789	endoplasmic reticulum membrane	-	TAS	-
GO:0005886	plasma membrane	-	IBA	21873635
GO:0005886	plasma membrane	-	IDA	19740627
GO:0010008	endosome membrane	-	TAS	-
GO:0016021	integral component of membrane	-	IEA	-
GO:0016323	basolateral plasma membrane	-	IDA	17128265
GO:0016324	apical plasma membrane	-	IDA	17128265
GO:0032009	early phagosome	-	ISS	-
GO:0036020	endolysosome membrane	-	TAS	-

KEGG ID	KEGG Term
hsa04620	Toll-like receptor signaling pathway
hsa05142	Chagas disease (American trypanosomiasis)
hsa05143	African trypanosomiasis
hsa05144	Malaria

Reactome ID	Reactome Term	Evidence
R-HSA-109704	PI3K Cascade	TAS
R-HSA-112399	IRS-mediated signalling	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-1679131	Trafficking and processing of endosomal TLR	TAS
R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	TAS
R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-168898	Toll-Like Receptors Cascades	TAS
R-HSA-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	TAS
R-HSA-2428924	IGF1R signaling cascade	TAS
R-HSA-2428928	IRS-related events triggered by IGF1R	TAS
R-HSA-74751	Insulin receptor signalling cascade	TAS
R-HSA-74752	Signaling by Insulin receptor	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS
R-HSA-975110	TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	TAS
R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	TAS
R-HSA-975155	MyD88 dependent cascade initiated on endosome	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25737198	Molecular attributes of conjugate antigen influence function of antibodies induced by anti-nicotine vaccine in mice and non-human primates. (2015 Apr)	McCluskie MJ	Int Immunopharmacol
22714906	Involvement of Toll-like Receptor 9 polymorphism in cervical cancer development. (2012 Aug)	Roszak A	Mol Biol Rep
25346143	Expression of nucleic acid-sensing Toll-like receptors predicts HPV16 clearance associated with an E6-directed cell-mediated response. (2015 May 15)	Scott ME	Int J Cancer
23497334	Smoking decreases the response of human lung macrophages to double-stranded RNA by reducing TLR3 expression. (2013 Mar 9)	Todt JC	Respir Res
20559037	Pneumococcal conjugate vaccination in persons with HIV: the effect of highly active antiretroviral therapy. (2010 Jun 1)	Sogaard OS	AIDS
23562759	Enhancing immunogenicity of a 3'aminomethylnicotine-DT-conjugate anti-nicotine vaccine with CpG adjuvant in mice and non-human primates. (2013 May)	McCluskie MJ	Int Immunopharmacol
26371589	A toll-like receptor 9 (rs352140) variant is associated with placental inflammation in newborn infants. (2016)	Karody V	J Matern Fetal Neonatal Med
18763053	Increased expression of Toll-like receptors 4 and 9 in human lung cancer. (2009 Jul)	Zhang YB	Mol Biol Rep
29132311	Weighted gene co-expression network analysis of expression data of monozygotic twins identifies specific modules and hub genes related to BMI. (2017 Nov 13)	Wang W	BMC Genomics
24098532	Selection of a novel anti-nicotine vaccine: influence of antigen design on antibody function in mice. (2013)	Pryde DC	PLoS One
22103307	Breastfeeding modulates neonatal innate immune responses: a prospective birth cohort study. (2012 Feb)	Belderbos ME	Pediatr Allergy Immunol
21425908	Toll-like receptor expression and activation in astroglia: differential regulation by HIV-1 Tat, gp120, and morphine. (2011)	El-Hage N	Immunol Invest
16870663	Maternal smoking is associated with impaired neonatal toll-like-receptor-mediated immune responses. (2006 Oct)	Noakes PS	Eur Respir J
21684332	Cigarette smoke induces the release of CXCL-8 from human bronchial epithelial cells via TLRs and induction of the inflammasome. (2011 Sep)	Mortaz E	Biochim Biophys Acta
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