Gene: DCUN1D1

54165
DCNL1|DCUN1L1|RP42|SCCRO|SCRO|Tes3
defective in cullin neddylation 1 domain containing 1
protein-coding
3q26.33
Ensembl:ENSG00000043093 MIM:605905 Vega:OTTHUMG00000158314 UniprotKB:Q96GG9
NC_000003.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.902e-1 (AD)  9.859e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLCN30.903
FBXL30.902
CLIP40.899
MEGF90.893
RNF1700.883
APPBP20.878
SLC35A50.878
SNX130.877
USP80.875
GNAQ0.873

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.636
OR4F29-0.609
CSAG1-0.305
TFPI2-0.291
NCCRP1-0.28
MTRNR2L3-0.279
FCER2-0.275
MTRNR2L10-0.273
PDE6G-0.27
PGF-0.266

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of DCUN1D1 mRNA"19114083
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of DCUN1D1 mRNA16788091
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of DCUN1D1 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of DCUN1D1 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of DCUN1D1 mRNA24449571
D001280AtrazineAtrazine results in decreased expression of DCUN1D1 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to DCUN1D1 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DCUN1D1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DCUN1D1 mRNA"19150397|2001819
C044887beta-methylcholinebeta-methylcholine affects the expression of DCUN1D1 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of DCUN1D1 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of DCUN1D1 mRNA25181051
D019327Copper SulfateCopper Sulfate results in decreased expression of DCUN1D1 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of DCUN1D1 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of DCUN1D1 mRNA19770486
D003703DemecolcineDemecolcine results in increased expression of DCUN1D1 mRNA23649840
C000944dicrotophosdicrotophos results in decreased expression of DCUN1D1 mRNA28302478
D011345FenofibrateFenofibrate results in increased expression of DCUN1D1 mRNA21318169
D005485FlutamideFlutamide results in increased expression of DCUN1D1 mRNA24136188
C039281furanfuran results in decreased expression of DCUN1D1 mRNA25539665
D005839GentamicinsGentamicins results in decreased expression of DCUN1D1 mRNA22061828
C016517indole-3-carbinolindole-3-carbinol affects the expression of DCUN1D1 mRNA21396975
C544151jinfukangjinfukang results in decreased expression of DCUN1D1 mRNA27392435
D048628KetolidesKetolides analog results in decreased expression of DCUN1D1 mRNA24967691
C008261lead acetate[lead acetate co-treated with zinc protoporphyrin] results in increased expression of DCUN1D1 mRNA22839698
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of DCUN1D1 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased methylation of DCUN1D1 promoter"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of DCUN1D1 mRNA"26251327
D015741MetriboloneMetribolone results in decreased expression of DCUN1D1 protein17152098
D010100OxygenOxygen deficiency results in increased expression of DCUN1D1 mRNA22629407
D010100OxygenOxygen inhibits the reaction [Oxygen deficiency results in increased expression of DCUN1D1 mRNA]22629407
C006253pirinixic acidpirinixic acid results in decreased expression of DCUN1D1 mRNA18445702
D012822Silicon DioxideSilicon Dioxide results in decreased expression of DCUN1D1 mRNA19073995
C009277sodium arsenatesodium arsenate results in increased expression of DCUN1D1 mRNA21795629
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DCUN1D1 mRNA19465110|1977048
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DCUN1D1 mRNA21215274
D013849ThimerosalThimerosal results in increased expression of DCUN1D1 mRNA27188386
C057693troglitazonetroglitazone results in decreased expression of DCUN1D1 mRNA28973697
D014520UrethaneUrethane results in increased expression of DCUN1D1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of DCUN1D1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of DCUN1D1 mRNA23179753|2718838
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of DCUN1D1 gene25560391
C025643vinclozolinvinclozolin results in increased expression of DCUN1D1 mRNA23555832
D014750VincristineVincristine results in increased expression of DCUN1D1 mRNA23649840
C017803zinc protoporphyrin[lead acetate co-treated with zinc protoporphyrin] results in increased expression of DCUN1D1 mRNA22839698

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16189514  18826954  25416956  27107012  28581483  
GO:0031624ubiquitin conjugating enzyme binding-IBA21873635  
GO:0032182ubiquitin-like protein binding-IBA21873635  
GO:0097602cullin family protein binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0043687post-translational protein modification-TAS-  
GO:0045116protein neddylation-IBA21873635  
GO:0051443positive regulation of ubiquitin-protein transferase activity-IBA21873635  
GO:2000436positive regulation of protein neddylation-IMP28581483  
GO ID GO Term Qualifier Evidence PubMed
GO:0000151ubiquitin ligase complex-IBA21873635  
GO:0000151ubiquitin ligase complex-IDA18826954  
GO:0005634nucleus-IDA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8951664NeddylationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24278325Distinct effects of alcohol consumption and smoking on genetic alterations in head and neck carcinoma. (2013)Urashima MPLoS One