Gene: PODXL

5420
Gp200|PC|PCLP|PCLP-1
podocalyxin like
protein-coding
7q32.3
Ensembl:ENSG00000128567 MIM:602632 Vega:OTTHUMG00000154918 UniprotKB:O00592
NG_042104.1
PubMed|SNP Mapped
2   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.988e-2 (AD)  3.054e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7807320chr7:131542152 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs6953894chr7:131538418 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FLT10.87
ITPR30.86
TGM20.843
ESAM0.84
MMRN20.84
TGFBR20.834
STARD80.825
CDH50.823
ABCB10.823
SYNE20.82

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.405
OR4F5-0.373
CRH-0.311
NKX2-8-0.31
ALG1L-0.273
LYPD8-0.271
HES5-0.266
ZSCAN1-0.263
C1orf53-0.249
DRD5-0.248

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of PODXL mRNA"26377693
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in decreased expression of PODXL mRNA25596134
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of PODXL mRNA19933214
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PODXL mRNA"19114083
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of PODXL mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PODXL mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PODXL mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PODXL mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PODXL mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PODXL mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PODXL mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PODXL mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PODXL mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PODXL mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PODXL mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of PODXL mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of PODXL mRNA17562736
D019342Acetic AcidAcetic Acid results in increased expression of PODXL protein21296659
D016604Aflatoxin B1Aflatoxin B1 affects the expression of PODXL protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PODXL mRNA21641981|2210060
D000447AldehydesAldehydes results in increased expression of PODXL mRNA25014914
C526957alisol B 23-acetatealisol B 23-acetate inhibits the reaction [AGT protein results in decreased expression of PODXL protein]28578904
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PODXL mRNA16483693
D001151ArsenicArsenic results in decreased expression of PODXL mRNA19654921
C006632arsenic trioxidearsenic trioxide affects the expression of PODXL mRNA28786057
C006632arsenic trioxidearsenic trioxide results in decreased expression of PODXL mRNA19128835|2670570
C547126AZM551248AZM551248 results in increased expression of PODXL mRNA22323515
C487081belinostatbelinostat results in increased expression of PODXL mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PODXL mRNA"27188386
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of PODXL mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PODXL mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of PODXL gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PODXL mRNA22228805|2261060
C044887beta-methylcholinebeta-methylcholine affects the expression of PODXL mRNA21179406
C002791bismuth tripotassium dicitratebismuth tripotassium dicitrate results in decreased expression of PODXL mRNA15912405
C006780bisphenol Abisphenol A affects the expression of PODXL mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of PODXL mRNA26063408
C006780bisphenol Abisphenol A affects the expression of PODXL mRNA25181051
D001761BleomycinBleomycin results in decreased expression of PODXL protein25933445
C099813bromochloroacetic acidbromochloroacetic acid results in increased expression of PODXL protein21296659
C018475butyraldehydebutyraldehyde results in increased expression of PODXL mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PODXL mRNA25596134
D019256Cadmium Chloride[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of PODXL mRNA19840844
D002220CarbamazepineCarbamazepine affects the expression of PODXL mRNA25979313
C010063carbonyl sulfidecarbonyl sulfide results in increased expression of PODXL mRNA19395590
C026690cerous chloridecerous chloride results in increased expression of PODXL mRNA23573234
C004656chloroacetaldehydechloroacetaldehyde results in decreased expression of PODXL mRNA25596134
C059262cidofovircidofovir results in decreased expression of PODXL mRNA25596134
C018021cobaltous chloridecobaltous chloride results in decreased expression of PODXL mRNA19320972
D019327Copper SulfateCopper Sulfate results in decreased expression of PODXL mRNA19549813
D003345CorticosteroneCorticosterone results in increased expression of PODXL mRNA15755911
C402665CP 31398CP 31398 results in decreased expression of PODXL mRNA15155752
C030973cupric oxidecupric oxide results in decreased expression of PODXL mRNA22077320
D016572CyclosporineCyclosporine results in decreased expression of PODXL mRNA20106945
D003561CytarabineCytarabine results in decreased expression of PODXL mRNA21198554
D003634DDTDDT results in decreased expression of PODXL mRNA25014179
C010902decabromobiphenyl etherdecabromobiphenyl ether analog results in decreased expression of PODXL mRNA26854739
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of PODXL mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of PODXL mRNA27392435
D002945CisplatinCisplatin results in increased expression of PODXL mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of PODXL mRNA18042831
D002117CalcitriolCalcitriol results in decreased expression of PODXL mRNA21592394
D002117CalcitriolCalcitriol results in increased expression of PODXL mRNA16002434
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of PODXL mRNA21592394
C118739entinostatentinostat results in increased expression of PODXL mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PODXL mRNA"27188386
C015860ergosta-4,6,8(14),22-tetraen-3-one"ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of PODXL protein]"28578904
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of PODXL mRNA17557909
D011345FenofibrateFenofibrate results in decreased expression of PODXL mRNA25596134
D011345FenofibrateFenofibrate results in decreased expression of PODXL mRNA25596134
D005472FluorouracilFluorouracil results in decreased expression of PODXL protein21296659
D005492Folic AcidFolic Acid affects the expression of PODXL mRNA17320366
D005620Freund's AdjuvantFreund's Adjuvant results in increased expression of PODXL mRNA20846436
D017313FenretinideFenretinide results in increased expression of PODXL mRNA28973697
D007052IbuprofenIbuprofen results in decreased expression of PODXL mRNA25596134
C492448ICG 001ICG 001 inhibits the reaction [AGT protein results in decreased expression of PODXL protein]28578904
D007069IfosfamideIfosfamide results in decreased expression of PODXL mRNA25596134
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of PODXL mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of PODXL mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of PODXL mRNA27392435
C544151jinfukangjinfukang results in increased expression of PODXL mRNA27392435
D007854LeadLead affects the expression of PODXL mRNA28903495
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PODXL mRNA25613284
D019808LosartanLosartan inhibits the reaction [AGT protein results in decreased expression of PODXL protein]28578904
D008687MetforminMetformin results in increased expression of PODXL mRNA25596134
D008694MethamphetamineMethamphetamine results in decreased expression of PODXL mRNA15644446
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PODXL mRNA23179753|2718838
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PODXL mRNA26272509
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PODXL mRNA"27188386
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of PODXL mRNA19840844
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of PODXL mRNA19840844
D015735MifepristoneMifepristone results in decreased expression of PODXL mRNA25972201
D009151Mustard GasMustard Gas results in increased expression of PODXL mRNA15674844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PODXL mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PODXL mRNA"25554681
C025256nonylphenolnonylphenol results in decreased expression of PODXL mRNA22982499
C558013NSC 689534NSC 689534 results in increased expression of PODXL mRNA20971185
D019319Okadaic Acid[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of PODXL mRNA19840844
C510784ormosil[ormosil binds to Polyethylene Glycols] which results in increased expression of PODXL mRNA24888373
D010100OxygenOxygen deficiency results in decreased expression of PODXL mRNA25596134
C102487pachymic acidpachymic acid analog inhibits the reaction [AGT protein results in decreased expression of PODXL protein]28578904
D000073878Palm OilPalm Oil results in increased expression of PODXL mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PODXL mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of PODXL mRNA26272509
C046012pentanalpentanal results in increased expression of PODXL mRNA26079696
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of PODXL mRNA23602845
D010938Plant OilsPlant Oils results in decreased expression of PODXL mRNA23370395
D011092Polyethylene Glycols[ormosil binds to Polyethylene Glycols] which results in increased expression of PODXL mRNA24888373
D011374ProgesteroneProgesterone results in increased expression of PODXL mRNA20726854
C005556propionaldehydepropionaldehyde results in increased expression of PODXL mRNA26079696
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in increased expression of PODXL mRNA11274237
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in increased expression of PODXL protein11274237
D011692Puromycin AminonucleosidePuromycin Aminonucleoside affects the metabolism of PODXL protein8780404
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of PODXL mRNA14699072
C089730rosiglitazonerosiglitazone results in decreased expression of PODXL mRNA25596134
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of PODXL mRNA25895662
D012999SomanSoman results in increased expression of PODXL mRNA19281266
D014284TriiodothyronineTriiodothyronine results in increased expression of PODXL mRNA15953391
D013629TamoxifenTamoxifen affects the expression of PODXL mRNA14699072
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of PODXL mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of PODXL mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PODXL mRNA26854739
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PODXL mRNA19684285
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PODXL mRNA16704738
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PODXL mRNA19933214|2629044
C009495titanium dioxidetitanium dioxide results in decreased expression of PODXL mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PODXL mRNA28065790
D014050TolueneToluene results in increased expression of PODXL mRNA22967744
D014212TretinoinTretinoin results in decreased expression of PODXL mRNA23724009
D014266TrientineTrientine results in increased expression of PODXL protein19634143
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PODXL mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of PODXL mRNA28973697
C057693troglitazonetroglitazone results in decreased expression of PODXL mRNA25596134
C022884undecaneundecane results in increased expression of PODXL protein17337753
D014520UrethaneUrethane results in increased expression of PODXL mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PODXL mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of PODXL mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PODXL mRNA26272509
C029297vinylidene chloridevinylidene chloride results in decreased expression of PODXL mRNA26682919
D024483Vitamin K 3Vitamin K 3 affects the expression of PODXL mRNA20044591
D015032ZincZinc results in decreased expression of PODXL mRNA20932299

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI22662192  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-IEA-  
GO:0007162negative regulation of cell adhesion-ISS-  
GO:0016477cell migration-ISS-  
GO:0022408negative regulation of cell-cell adhesion-ISS-  
GO:0030335positive regulation of cell migration-IDA18456258  
GO:0032534regulation of microvillus assembly-ISS-  
GO:0033634positive regulation of cell-cell adhesion mediated by integrin-IDA18456258  
GO:0072015glomerular visceral epithelial cell development-ISS-  
GO:0072175epithelial tube formation-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001726ruffle-IDA18456258  
GO:0005615extracellular space-HDA16502470  
GO:0005730nucleolus-IDA-  
GO:0005737cytoplasm-IDA18456258  
GO:0005815microtubule organizing center-IDA-  
GO:0005886plasma membrane-IDA18456258  
GO:0005887integral component of plasma membrane-TAS9188463  
GO:0016324apical plasma membrane-ISS-  
GO:0030027lamellipodium-IDA18456258  
GO:0030175filopodium-IDA18456258  
GO:0031528microvillus membrane-ISS-  
GO:0036057slit diaphragm-ISS-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0045121membrane raft-IEA-  
GO:0070062extracellular exosome-HDA19056867  23533145  
GO:0070062extracellular exosome-IDA15326289  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29321582Serum podocalyxin levels correlate with carotid intima media thickness, implicating its role as a novel biomarker for atherosclerosis. (2018 Jan 10)Shoji MSci Rep