Gene: TREM2

54209
TREM-2|Trem2a|Trem2b|Trem2c
triggering receptor expressed on myeloid cells 2
protein-coding
6p21.1
Ensembl:ENSG00000095970 MIM:605086 Vega:OTTHUMG00000014671 UniprotKB:Q9NZC2
NG_011561.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.287e-1 (AD)  5.790e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LAPTM50.927
TYROBP0.925
AIF10.913
LPAR50.902
C3AR10.902
TNFAIP8L20.9
TMEM1190.898
ITGB20.898
ADORA30.895
CSF1R0.892

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATP2C2-0.341
TMEM191C-0.338
MARCH4-0.335
ZSCAN1-0.324
KCNB2-0.307
YBX2-0.304
HES5-0.303
ABCC12-0.303
ZNF835-0.302
SPRN-0.302

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in increased expression of TREM2 mRNA"26377693
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of TREM2 mRNA"20406850
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of TREM2 mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of TREM2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of TREM2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TREM2 mRNA21632981|2164198
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of TREM2 mRNA"21730038
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of TREM2 protein"21730038
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of TREM2 mRNA21298039
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of TREM2 mRNA"23917077
C547126AZM551248AZM551248 results in increased expression of TREM2 mRNA22323515
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of TREM2 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TREM2 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TREM2 mRNA15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TREM2 mRNA22228805|2261060
D004958EstradiolEstradiol results in increased expression of TREM2 mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of TREM2 mRNA25594700
C006780bisphenol A[bisphenol A co-treated with Genistein] results in increased methylation of TREM2 gene28505145
C006780bisphenol Abisphenol A results in decreased expression of TREM2 mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of TREM2 mRNA27339419
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TREM2 mRNA20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of TREM2 mRNA28472532
D003471CuprizoneCuprizone results in increased expression of TREM2 mRNA27523638
D002945CisplatinCisplatin results in increased expression of TREM2 mRNA19561079
D004041Dietary FatsDietary Fats results in increased expression of TREM2 mRNA22609946
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of TREM2 mRNA28943392
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of TREM2 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TREM2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TREM2 mRNA17942748
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TREM2 mRNA20938992
C039281furanfuran results in increased expression of TREM2 mRNA27387713
D019833Genistein[bisphenol A co-treated with Genistein] results in increased methylation of TREM2 gene28505145
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TREM2 mRNA25613284
D007649KetamineKetamine results in increased expression of TREM2 mRNA20080153
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of TREM2 mRNA20453108
D008694MethamphetamineMethamphetamine results in decreased expression of TREM2 mRNA19564919
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TREM2 mRNA20938992
C523799MRK 003TREM2 results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TREM2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TREM2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TREM2 mRNA"19836432|2491129
C028007nickel monoxidenickel monoxide results in increased expression of TREM2 mRNA19167457
D010795Phthalic AcidsPhthalic Acids results in decreased expression of TREM2 mRNA21061450
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in increased expression of TREM2 mRNA27989595
C513428pyrachlostrobinpyrachlostrobin results in increased expression of TREM2 mRNA27029645
D011791QuartzQuartz results in increased expression of TREM2 mRNA19836432
D011794QuercetinQuercetin results in increased expression of TREM2 mRNA21632981
D012822Silicon DioxideSilicon Dioxide results in increased expression of TREM2 mRNA22431001
C009277sodium arsenatesodium arsenate results in decreased expression of TREM2 mRNA21795629
D012999SomanSoman results in increased expression of TREM2 mRNA19281266
D053260SootSoot results in increased expression of TREM2 mRNA22461453|2655175
D013629TamoxifenTamoxifen affects the expression of TREM2 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TREM2 mRNA24680724
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TREM2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TREM2 mRNA15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TREM2 mRNA26232522
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TREM2 mRNA25613284
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of TREM2 mRNA28943392
C009495titanium dioxidetitanium dioxide results in increased expression of TREM2 mRNA19464567|2125934
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of TREM2 mRNA20133372
D014635Valproic AcidValproic Acid results in increased methylation of TREM2 gene29154799
D014635Valproic AcidValproic Acid affects the expression of TREM2 mRNA17963808
C029297vinylidene chloridevinylidene chloride results in increased expression of TREM2 mRNA26682919
D024483Vitamin K 3Vitamin K 3 affects the expression of TREM2 mRNA20829426

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001530lipopolysaccharide binding-IEA-  
GO:0005543phospholipid binding-IDA27995897  
GO:0038023signaling receptor activity-TAS10799849  
GO:0042834peptidoglycan binding-IEA-  
GO:0070891lipoteichoic acid binding-IEA-  
GO:0097110scaffold protein binding-IPI11602640  
GO ID GO Term Qualifier Evidence PubMed
GO:0002588positive regulation of antigen processing and presentation of peptide antigen via MHC class II-IDA11602640  
GO:0006911phagocytosis, engulfment-IEA-  
GO:0006959humoral immune response-TAS10799849  
GO:0007165signal transduction-IEA-  
GO:0030316osteoclast differentiation-IMP21841309  
GO:0032497detection of lipopolysaccharide-IEA-  
GO:0032499detection of peptidoglycan-IEA-  
GO:0045087innate immune response-TAS-  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-IDA11602640  
GO:0050776regulation of immune response-TAS-  
GO:0050850positive regulation of calcium-mediated signaling-IDA11602640  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IDA11602640  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IMP27995897  
GO:0070392detection of lipoteichoic acid-IEA-  
GO:0071223cellular response to lipoteichoic acid-IEA-  
GO:0071224cellular response to peptidoglycan-IEA-  
GO:0097028dendritic cell differentiation-IDA11602640  
GO:1903078positive regulation of protein localization to plasma membrane-IDA11602640  
GO:1903082positive regulation of C-C chemokine receptor CCR7 signaling pathway-IDA11602640  
GO:2000350positive regulation of CD40 signaling pathway-IDA11602640  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005886plasma membrane-IDA27995897  
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IDA11602640  
KEGG ID KEGG Term
hsa04380Osteoclast differentiation
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168249Innate Immune SystemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellTAS
R-HSA-2172127DAP12 interactionsTAS
R-HSA-2172127DAP12 interactionsIEA
R-HSA-2424491DAP12 signalingTAS
R-HSA-2424491DAP12 signalingIEA
R-HSA-373755Semaphorin interactionsTAS
R-HSA-416700Other semaphorin interactionsTAS
R-HSA-422475Axon guidanceTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20421649DAP12 is required for macrophage recruitment to the lung in response to cigarette smoke and chemotaxis toward CCL2. (2010 Jun 1)Koth LLJ Immunol