Gene: SNTG1

54212
G1SYN|SYN4
syntrophin gamma 1
protein-coding
8q11.21
Ensembl:ENSG00000147481 MIM:608714 Vega:OTTHUMG00000164257 UniprotKB:Q9NSN8
NC_000008.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.509e-2 (AD)  6.185e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs713179chr8:50700923 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg04172771chr8:50892702SNTG18.630e-10Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AAK10.856
FRY0.854
OPCML0.854
RASAL20.852
NEGR10.852
LRFN50.85
CERS60.849
ZFPM20.848
MAGI30.848
MYCBP20.848

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEY2-0.497
ROM1-0.468
BCL7C-0.467
AQP5-0.465
RAI14-0.461
RAB13-0.455
ASB4-0.453
GRTP1-0.453
YES1-0.447
COPZ2-0.446

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SNTG1 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SNTG1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SNTG1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SNTG1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SNTG1 mRNA"25510870
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of SNTG1 mRNA"18648102
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of SNTG1 mRNA22129741
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SNTG1 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of SNTG1 mRNA21298039
D001151ArsenicArsenic affects the methylation of SNTG1 gene25304211
C015001arsenitearsenite results in increased expression of SNTG1 mRNA18929588
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of SNTG1 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of SNTG1 mRNA26496021
D003471CuprizoneCuprizone results in decreased expression of SNTG1 mRNA26577399
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of SNTG1 mRNA22129741
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of SNTG1 mRNA22129741
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of SNTG1 mRNA"20188158
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SNTG1 mRNA"25510870
D011441PropylthiouracilPropylthiouracil results in decreased expression of SNTG1 mRNA24780913
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SNTG1 mRNA16611356
C009495titanium dioxidetitanium dioxide results in increased expression of SNTG1 mRNA23557971
D014635Valproic AcidValproic Acid affects the expression of SNTG1 mRNA17963808

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-IEA-  
GO:0005198structural molecule activity-IEA-  
GO:0008022protein C-terminus binding-IPI15485858  
GO ID GO Term Qualifier Evidence PubMed
GO:0007154cell communication-TAS10747910  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005737cytoplasm-IDA15485858  
GO:0005856cytoskeleton-IDA-  
GO:0016013syntrophin complex-TAS10747910  
GO:0032587ruffle membrane-IDA15485858  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal