Gene: POLB

5423
-
DNA polymerase beta
protein-coding
8p11.21
Ensembl:ENSG00000070501 MIM:174760 Vega:OTTHUMG00000164093 UniprotKB:P06746
NC_000008.11
PubMed
0   ANCO-SNPs
ND
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.501e-1 (AD)  9.191e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TAF90.938
ZNHIT30.934
VPS290.931
SNAPC50.928
RSL24D10.924
MRPS230.924
PSMA10.924
MRPS350.924
DNAJC190.923
SUMO10.92

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.639
OR4F29-0.597
P2RY14-0.343
MTRNR2L6-0.312
MTRNR2L10-0.299
VNN3-0.293
CXCR2-0.288
MAGEA12-0.288
ZBTB20-0.285
MTRNR2L9-0.283

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00987CytarabineSmall Molecule147-94-4Approved|InvestigationalTarget
DB01592IronSmall Molecule7439-89-6ApprovedTarget
DB03222dATPSmall Molecule1927-31-7ExperimentalTarget
DB07479(1S)-1,2,3,4-TETRAHYDRO-BENZO[C]PHENANTHRENE-2,3,4-TRIOLSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0389831,3-dimethylthiourea"1,3-dimethylthiourea inhibits the reaction [Puromycin Aminonucleoside results in increased expression of POLB protein]"17035936
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of POLB mRNA"21346803
C0581182'-deoxyadenosine[erythritol anhydride binds to 2'-deoxyadenosine] which results in decreased activity of POLB protein26098310
C0166172-nitropropane2-nitropropane results in increased expression of and results in increased activity of POLB protein12189182
C0166172-nitropropanePOLB protein inhibits the reaction [2-nitropropane results in increased expression of TRP53 protein]12189182
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of POLB mRNA21983209
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of POLB mRNA12419474
C0108895-chlorouracilPOLB protein affects the metabolism of 5-chlorouracil20104909
C1056915-formyl-2'-deoxyuridine 5'-triphosphatePOLB protein binds to and results in increased metabolism of 5-formyl-2'-deoxyuridine 5'-triphosphate28862449
C0006256425-formyldeoxycytosine-5'-triphosphatePOLB protein binds to and results in increased metabolism of 5-formyldeoxycytosine-5'-triphosphate28862449
C0006256416-thio-2'-deoxyguanosine-5'-triphosphatePOLB protein binds to and results in increased metabolism of 6-thio-2'-deoxyguanosine-5'-triphosphate28862449
D000082AcetaminophenAcetaminophen results in increased expression of POLB mRNA16751229
D000499AllylamineAllylamine results in increased expression of POLB mRNA15910882
D000643Ammonium ChlorideAmmonium Chloride affects the expression of POLB mRNA16483693
D001151ArsenicArsenic results in decreased expression of POLB mRNA21332098
D001151ArsenicArsenic results in decreased expression of POLB protein21332098
D001151ArsenicCurcumin inhibits the reaction [Arsenic results in decreased expression of POLB mRNA]21332098
D001151ArsenicCurcumin inhibits the reaction [Arsenic results in decreased expression of POLB protein]21332098
C015001arsenitearsenite affects the expression of POLB mRNA18252256
C015001arsenitearsenite results in increased expression of POLB protein15996700
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of POLB mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of POLB mRNA22641617
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of POLB mRNA22228805|2365215
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of POLB protein23652152
D001564Benzo(a)pyrenePOLB protein promotes the reaction [Benzo(a)pyrene results in increased mutagenesis of HPRT gene]23652152
D001564Benzo(a)pyrenePOLB protein affects the susceptibility to Benzo(a)pyrene20364579|2235751
C044887beta-methylcholinebeta-methylcholine affects the expression of POLB mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of POLB mRNA29275510
C006780bisphenol Abisphenol A affects the expression of POLB mRNA25181051
D001761BleomycinPOLB results in decreased susceptibility to Bleomycin21251944
C584509C646 compoundC646 compound results in increased expression of POLB mRNA26191083
D002104CadmiumCadmium results in decreased activity of POLB protein16677676
C028031cadmium acetatecadmium acetate affects the expression of POLB mRNA16249259
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of POLB promoter22457795
D002211CapsaicinCapsaicin results in decreased expression of POLB mRNA16278290
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of POLB mRNA23288052
D002251Carbon TetrachlorideDiethylnitrosamine promotes the reaction [Carbon Tetrachloride results in decreased expression of POLB mRNA]23288052
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of POLB mRNA16239168
D002857ChromiumChromium results in increased activity of POLB protein9649318
C408982CPG-oligonucleotideCPG-oligonucleotide results in increased expression of POLB mRNA21878529
D003474CurcuminCurcumin inhibits the reaction [Arsenic results in decreased expression of POLB mRNA]21332098
D003474CurcuminCurcumin inhibits the reaction [Arsenic results in decreased expression of POLB protein]21332098
D003474CurcuminCurcumin results in decreased expression of POLB protein19401701
D016572CyclosporineCyclosporine results in decreased expression of POLB mRNA27989131
C089595cylindrospermopsincylindrospermopsin results in decreased expression of POLB mRNA23726867
D003976DiazinonDiazinon affects the expression of POLB mRNA22546817
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of POLB mRNA21266533
D002945CisplatinPOLB results in increased susceptibility to Cisplatin21357694
C000944dicrotophosdicrotophos results in decreased expression of POLB mRNA28302478
D004052DiethylnitrosamineDiethylnitrosamine promotes the reaction [Carbon Tetrachloride results in decreased expression of POLB mRNA]23288052
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of POLB mRNA18164116
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of POLB mRNA"22485181
C095351epolactaeneepolactaene binds to and results in decreased activity of POLB protein15656580
C007366erythritol anhydride[erythritol anhydride binds to 2'-deoxyadenosine] which results in decreased activity of POLB protein26098310
C036216ethyleneethylene results in increased expression of POLB protein16051529
D005027Ethylene OxideEthylene Oxide results in increased expression of POLB protein16051529
C522804fluorodeoxyuridine triphosphatePOLB protein binds to and results in increased metabolism of fluorodeoxyuridine triphosphate28862449
D005485FlutamideFlutamide results in increased expression of POLB mRNA24136188
C005499honokiolhonokiol results in decreased activity of POLB protein28067485
D017313FenretinideFenretinide results in increased expression of POLB mRNA28973697
D007501IronIron binds to and inhibits the reaction [NEIL1 protein binds to POLB protein]20622253
D008095Lithocholic AcidLithocholic Acid analog binds to and results in decreased activity of POLB protein15311928
D008095Lithocholic AcidLithocholic Acid binds to and results in decreased activity of POLB protein15311928|1565658
D008095Lithocholic AcidLithocholic Acid binds to and results in decreased activity of POLB protein mutant form16996474
D008095Lithocholic AcidLithocholic Acid results in decreased activity of POLB protein20028873
D008713MethimazoleMethimazole results in increased expression of POLB mRNA17403546
C005214methoxyaminePOLB protein inhibits the reaction [MPG protein promotes the reaction [methoxyamine results in increased susceptibility to temozolomide]]21377995
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of POLB mRNA21527772|2364984
D008770MethylnitrosoureaPOLB gene mutant form results in increased susceptibility to Methylnitrosourea17166880
D016685MitomycinPOLB results in decreased susceptibility to Mitomycin21357694
C455139myrtucommulone Amyrtucommulone A results in increased expression of POLB mRNA26032814
C000598755N6-(2-hydroxy-3-buten-1-yl)-2'-deoxyadenosineN6-(2-hydroxy-3-buten-1-yl)-2'-deoxyadenosine results in decreased activity of POLB protein26098310
C013147nervonic acidnervonic acid binds to and results in decreased activity of POLB protein16996474
C013147nervonic acidnervonic acid binds to and results in decreased activity of POLB protein mutant form16996474
C025589ochratoxin Aochratoxin A results in increased expression of POLB mRNA19562491
C016340o,p'-DDT"o,p'-DDT analog results in decreased expression of POLB mRNA"22937105
C016340o,p'-DDT"o,p'-DDT results in increased expression of POLB mRNA"22937105
D010100OxygenOxygen deficiency results in decreased expression of POLB protein25030372
D010269ParaquatParaquat results in increased expression of POLB protein28428137
D010269ParaquatParaquat results in increased expression of POLB28428137
C494474perchlorateperchlorate results in increased expression of POLB mRNA17403546
C011272perfosfamideperfosfamide results in decreased expression of POLB mRNA11754170
C006253pirinixic acidpirinixic acid results in decreased expression of POLB mRNA18445702
C006253pirinixic acidpirinixic acid results in decreased expression of POLB mRNA19162173
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of POLB mRNA19162173
D011441PropylthiouracilPropylthiouracil results in increased expression of POLB mRNA17403546
D011692Puromycin Aminonucleoside"1,3-dimethylthiourea inhibits the reaction [Puromycin Aminonucleoside results in increased expression of POLB protein]"17035936
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in increased expression of POLB protein17035936
D011794QuercetinQuercetin results in increased expression of POLB protein19207037
D011794QuercetinQuercetin results in increased expression of POLB mRNA25862958
D012402RotenoneRotenone results in decreased expression of POLB mRNA19013527
C017947sodium arsenite[HAX1 protein affects the susceptibility to sodium arsenite] which affects the expression of POLB mRNA23164465
C017947sodium arsenite[sodium arsenite results in increased activity of [MAPK3 protein co-treated with MAPK1 protein]] which results in decreased expression of POLB22634503
C017947sodium arsenitesodium arsenite results in decreased expression of POLB mRNA17558810
C017947sodium arsenitesodium arsenite results in increased expression of POLB mRNA20643705
C016104sodium bichromatesodium bichromate results in increased expression of POLB mRNA12325037
D012969Sodium FluorideSodium Fluoride results in increased expression of POLB protein28918527
D012999SomanSoman results in increased expression of POLB mRNA19281266
C013694sulfoquinovosyl diglyceridesulfoquinovosyl diglyceride binds to and results in decreased activity of POLB protein15656580
D013629TamoxifenTamoxifen results in decreased expression of POLB protein17219426
D013654TaurineTaurine results in increased expression of POLB mRNA16579726
D013662TeaTea results in increased expression of POLB mRNA22181980
D013662TeaTea results in increased expression of POLB protein22181980
C047246temozolomidePOLB protein inhibits the reaction [MPG protein promotes the reaction [methoxyamine results in increased susceptibility to temozolomide]]21377995
C047246temozolomidePOLB protein results in decreased susceptibility to temozolomide16024643
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of POLB mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of POLB mRNA19520675
D019284ThapsigarginThapsigargin results in decreased expression of POLB protein24648495
D013853ThioacetamideThioacetamide results in increased expression of POLB mRNA23411599
C034697transplatinPOLB results in decreased susceptibility to transplatin21357694
C012589trichostatin Atrichostatin A affects the expression of POLB mRNA28542535
C012589trichostatin Atrichostatin A results in decreased expression of POLB mRNA15901671
D017974Uranium CompoundsUranium Compounds results in increased expression of POLB mRNA19654044
D014527Uric AcidNLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of POLB mRNA]23619996
D014527Uric AcidUric Acid results in decreased expression of POLB mRNA23619996
D014635Valproic AcidValproic Acid affects the expression of POLB mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of POLB mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased expression of POLB mRNA29154799
D014635Valproic AcidValproic Acid results in decreased expression of POLB mRNA15901671

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IBA21873635  
GO:0003684damaged DNA binding-IEA-  
GO:0003887DNA-directed DNA polymerase activity-IBA21873635  
GO:0003887DNA-directed DNA polymerase activity-IDA9207062  16600869  
GO:0003887DNA-directed DNA polymerase activity-TAS-  
GO:0003906DNA-(apurinic or apyrimidinic site) endonuclease activity-TAS-  
GO:0005515protein binding-IPI9207062  15520167  25260657  25416956  25910212  
GO:0008017microtubule binding-IDA15725623  
GO:0016829lyase activity-IBA21873635  
GO:0016829lyase activity-IDA16600869  
GO:0019899enzyme binding-IPI16600869  19713937  21362556  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006261DNA-dependent DNA replication-TAS8168825  
GO:0006281DNA repair-TAS8168825  
GO:0006284base-excision repair-IDA16600869  
GO:0006284base-excision repair-IMP21362556  
GO:0006286base-excision repair, base-free sugar-phosphate removal-TAS-  
GO:0006287base-excision repair, gap-filling-IEA-  
GO:0006288base-excision repair, DNA ligation-TAS-  
GO:0006290pyrimidine dimer repair-IEA-  
GO:0006297nucleotide-excision repair, DNA gap fillingNOTIMP20227374  
GO:0006954inflammatory response-IEA-  
GO:0006974cellular response to DNA damage stimulus-IMP21362556  
GO:0007435salivary gland morphogenesis-IEA-  
GO:0007568aging-IEA-  
GO:0008630intrinsic apoptotic signaling pathway in response to DNA damage-IEA-  
GO:0010332response to gamma radiation-IEA-  
GO:0016446somatic hypermutation of immunoglobulin genes-IEA-  
GO:0016579protein deubiquitination-TAS-  
GO:0045471response to ethanol-IEA-  
GO:0048535lymph node development-IEA-  
GO:0048536spleen development-IEA-  
GO:0048872homeostasis of number of cells-IEA-  
GO:0051402neuron apoptotic process-IEA-  
GO:0055093response to hyperoxia-IEA-  
GO:0071707immunoglobulin heavy chain V-D-J recombination-IEA-  
GO:0071897DNA biosynthetic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA19713937  21362556  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA15725623  19713937  21362556  
GO:0005874microtubule-IDA15725623  
GO:0005876spindle microtubule-IDA15725623  
GO:0032991protein-containing complex-IDA25378300  
KEGG ID KEGG Term
hsa03410Base excision repair
Reactome ID Reactome Term Evidence
R-HSA-110362POLB-Dependent Long Patch Base Excision RepairTAS
R-HSA-110373Resolution of AP sites via the multiple-nucleotide patch replacement pathwayTAS
R-HSA-110381Resolution of AP sites via the single-nucleotide replacement pathwayTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5649702APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement PathwayTAS
R-HSA-5651801PCNA-Dependent Long Patch Base Excision RepairTAS
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689880Ub-specific processing proteasesTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-73884Base Excision RepairTAS
R-HSA-73894DNA RepairTAS
R-HSA-73930Abasic sugar-phosphate removal via the single-nucleotide replacement pathwayTAS
R-HSA-73933Resolution of Abasic Sites (AP sites)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24595271NEIL2 protects against oxidative DNA damage induced by sidestream smoke in human cells. (2014)Sarker AHPLoS One
22382497Lung cancer and DNA repair genes: multilevel association analysis from the International Lung Cancer Consortium. (2012 May)Kazma RCarcinogenesis
23462851Thirdhand smoke causes DNA damage in human cells. (2013 Jul)Hang BMutagenesis
19147782DNA repair gene polymorphisms and risk of pancreatic cancer. (2009 Jan 15)Li DClin Cancer Res
17203305Genetic variation in the base excision repair pathway and bladder cancer risk. (2007 Apr)Figueroa JDHum Genet
24382701Comprehensive analyses of DNA repair pathways, smoking and bladder cancer risk in Los Angeles and Shanghai. (2014 Jul 15)Corral RInt J Cancer