Gene info: ID 5424

Gene: POLD1

GENE ID: 5424

Synonyms: CDC2|CRCS10|MDPL|POLD

Description: DNA polymerase delta 1, catalytic subunit

Gene type: protein-coding

Location: 19q13.33

dbXrefs: Ensembl:ENSG00000062822 MIM:174761 Vega:OTTHUMG00000183037 UniprotKB:P28340

RefSeq: NG_033800.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.534e-1 (AD) 9.335e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TRABD	0.825
SLC26A6	0.819
IRF3	0.817
RELA	0.813
ABCD4	0.806
COLGALT1	0.797
SHKBP1	0.792
REEP4	0.787
HAUS5	0.784
EHD1	0.779

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.395
OR4F29	-0.379
CRH	-0.366
HAPLN1	-0.319
DIO2	-0.303
EDN3	-0.3
ADAMTS5	-0.291
KIT	-0.279
VIP	-0.279
OSTN	-0.276

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of POLD1 mRNA"	19167446
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of POLD1 mRNA"	23196670
C439024	3,5-dihydroxy-4'-methoxystilbene	"3,5-dihydroxy-4'-methoxystilbene results in decreased activity of POLD1 protein"	11316812
C506282	3,5-dimethoxy-4'-hydroxystilbene	"3,5-dimethoxy-4'-hydroxystilbene results in decreased activity of POLD1 protein"	11316812
C032642	4-aminophenylarsenoxide	4-aminophenylarsenoxide binds to POLD1 protein	26598702
C032642	4-aminophenylarsenoxide	arsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to POLD1 protein]	26598702
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of POLD1 mRNA	12419474
D000082	Acetaminophen	Acetaminophen affects the expression of POLD1 mRNA	17562736
D020106	Acrylamide	Acrylamide results in increased expression of POLD1 mRNA	28959563
C038491	allyl sulfide	[allyl sulfide co-treated with Diethylstilbestrol] results in increased expression of POLD1 mRNA	17125941
C038491	allyl sulfide	allyl sulfide results in increased expression of POLD1 mRNA	17125941
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of POLD1 mRNA	16483693
C059765	amphotericin B, deoxycholate drug combination	"amphotericin B, deoxycholate drug combination results in increased expression of POLD1 mRNA"	22863853
D016590	Aphidicolin	Aphidicolin results in decreased activity of POLD1 protein	14975937
D001151	Arsenic	Arsenic affects the methylation of POLD1 gene	25304211
C006632	arsenic trioxide	arsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to POLD1 protein]	26598702
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of POLD1 mRNA	22228805
C543008	bis(4-hydroxyphenyl)sulfone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of POLD1 mRNA	28628672
C006780	bisphenol A	bisphenol A affects the expression of POLD1 mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of POLD1 mRNA	29275510
C006780	bisphenol A	bisphenol A results in increased expression of POLD1 mRNA	26063408
C006780	bisphenol A	bisphenol A affects the expression of POLD1 mRNA	21786754
C006780	bisphenol A	bisphenol A results in increased methylation of POLD1 gene	28505145
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of POLD1 mRNA	12419474
C584509	C646 compound	C646 compound results in decreased expression of POLD1 mRNA	26191083
D002101	Cacodylic Acid	Cacodylic Acid results in increased expression of POLD1 mRNA	17720352
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of POLD1 mRNA	23644582
C055494	caffeic acid phenethyl ester	caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of POLD1 mRNA]	20360939
D002509	Cephaloridine	Cephaloridine results in increased expression of POLD1 mRNA	18500788
D002994	Clofibrate	Clofibrate results in decreased expression of POLD1 mRNA	16081524
D003300	Copper	Copper results in increased expression of POLD1 mRNA	16391388
D003300	Copper	[NSC 689534 binds to Copper] which results in decreased expression of POLD1 mRNA	20971185
C030123	coumarin	coumarin results in increased expression of POLD1 mRNA	18480146
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of POLD1 mRNA"	19167446
D003375	Coumestrol	[Coumestrol co-treated with resveratrol] results in increased expression of POLD1 mRNA	19167446
D003375	Coumestrol	Coumestrol results in increased expression of POLD1 mRNA	19167446
C408982	CPG-oligonucleotide	CPG-oligonucleotide results in decreased expression of POLD1 mRNA	21878529
D016572	Cyclosporine	Cyclosporine results in decreased expression of POLD1 mRNA	25562108
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of POLD1 mRNA	28628672
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of POLD1 mRNA	21266533
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of POLD1 mRNA	21266533
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate results in increased expression of POLD1 mRNA	26924002
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of POLD1 mRNA	17854601
D004052	Diethylnitrosamine	RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of POLD1 mRNA]	17854601
D004052	Diethylnitrosamine	caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of POLD1 mRNA]	20360939
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of POLD1 mRNA	20360939
D004054	Diethylstilbestrol	[allyl sulfide co-treated with Diethylstilbestrol] results in increased expression of POLD1 mRNA	17125941
D002117	Calcitriol	Calcitriol results in decreased expression of POLD1 mRNA	21592394
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in decreased expression of POLD1 mRNA	21592394
C024629	dimethyl phthalate	dimethyl phthalate results in increased expression of POLD1 mRNA	26924002
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of POLD1 protein	23301498
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of POLD1 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of POLD1 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of POLD1 mRNA	17942748
D005038	Ethylnitrosourea	Ethylnitrosourea results in increased mutagenesis of POLD1 3' UTR	27776689
D005038	Ethylnitrosourea	Ethylnitrosourea results in increased mutagenesis of POLD1 gene	27776689
C039281	furan	furan results in increased expression of POLD1 mRNA	22079235\|2553966
C010974	glyphosate	[Surface-Active Agents co-treated with glyphosate] results in increased expression of POLD1 mRNA	22467014
D006147	Guanine	Guanine metabolite results in decreased activity of POLD1 protein	26010525
D006147	Guanine	Guanine metabolite results in decreased activity of [POLD1 protein binds to POLD2 protein binds to POLD3 protein binds to POLD4 protein]	26010525
D006147	Guanine	Guanine metabolite results in decreased activity of [POLD1 protein binds to POLD2 protein binds to POLD4 protein]	26010525
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of POLD1 mRNA	12419474
D006997	Hypochlorous Acid	Hypochlorous Acid results in decreased expression of POLD1 mRNA	19376150
C492448	ICG 001	ICG 001 results in decreased expression of POLD1 mRNA	26191083
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of POLD1 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of POLD1 mRNA	28628672
C544151	jinfukang	jinfukang results in increased expression of POLD1 mRNA	27392435
D007649	Ketamine	Ketamine results in decreased expression of POLD1 mRNA	20080153
D007854	Lead	Lead affects the expression of POLD1 mRNA	28903495
C008261	lead acetate	lead acetate results in increased expression of POLD1 mRNA	21829687
C017461	lead nitrate	lead nitrate affects the reaction [POLD1 affects the expression of MT1 mRNA]	11891201
C017461	lead nitrate	lead nitrate affects the reaction [POLD1 affects the expression of MT2 mRNA]	11891201
D008825	Miconazole	Miconazole results in increased expression of POLD1 mRNA	22262564
C517284	monomethyl phthalate	monomethyl phthalate results in increased expression of POLD1 mRNA	26924002
D009151	Mustard Gas	Mustard Gas results in decreased expression of POLD1 mRNA	25102026
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of POLD1 mRNA"	25554681
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in decreased expression of POLD1 mRNA	20971185
D010100	Oxygen	Oxygen deficiency results in decreased expression of POLD1 mRNA	26516004
D010126	Ozone	Ozone results in increased expression of POLD1 mRNA	16716893
D052638	Particulate Matter	Particulate Matter results in decreased expression of POLD1 mRNA	24769257
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of POLD1 mRNA	24642059
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of POLD1 mRNA	23427857
C011272	perfosfamide	perfosfamide results in decreased expression of POLD1 mRNA	19429390
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate results in decreased expression of POLD1 mRNA	26678675
D010634	Phenobarbital	Phenobarbital affects the expression of POLD1 mRNA	19159669
C006253	pirinixic acid	pirinixic acid results in increased expression of POLD1 mRNA	19162173
D011374	Progesterone	Progesterone results in decreased expression of POLD1 mRNA	20726854
C059514	resveratrol	resveratrol results in decreased activity of POLD1 protein	11316812
C059514	resveratrol	[Coumestrol co-treated with resveratrol] results in increased expression of POLD1 mRNA	19167446
C017947	sodium arsenite	sodium arsenite results in decreased expression of POLD1 mRNA	12377979\|1276083
C016104	sodium bichromate	sodium bichromate results in increased expression of POLD1 mRNA	22155349
C016104	sodium bichromate	sodium bichromate results in increased expression of POLD1 mRNA	12325037\|2211074
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of POLD1 protein	28918527
D012999	Soman	Soman results in increased expression of POLD1 mRNA	19281266
D013501	Surface-Active Agents	[Surface-Active Agents co-treated with glyphosate] results in increased expression of POLD1 mRNA	22467014
D000952	Antigens, Polyomavirus Transforming	"Antigens, Polyomavirus Transforming results in increased expression of POLD1 mRNA"	26680231
D013654	Taurine	Taurine results in increased expression of POLD1 mRNA	16579726
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in decreased expression of POLD1 mRNA	21592394
D013739	Testosterone	Testosterone results in decreased expression of POLD1 mRNA	21592394
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of POLD1 mRNA	22574217
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of POLD1 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of POLD1 mRNA	17942748
D014212	Tretinoin	Tretinoin results in decreased expression of POLD1 mRNA	18230668
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of POLD1 mRNA	19042947
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of POLD1 mRNA"	26179874
C057693	troglitazone	troglitazone results in decreased expression of POLD1 mRNA	19140230
D014520	Urethane	Urethane results in decreased expression of POLD1 mRNA	28818685
D014635	Valproic Acid	Valproic Acid affects the expression of POLD1 mRNA	17292431
D014640	Vancomycin	Vancomycin results in decreased expression of POLD1 mRNA	18930951

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000166	nucleotide binding	-	IEA	-
GO:0003677	DNA binding	-	IDA	16762037
GO:0003682	chromatin binding	-	IDA	16762037 24939902
GO:0003684	damaged DNA binding	-	IDA	24939902
GO:0003887	DNA-directed DNA polymerase activity	-	IBA	21873635
GO:0003887	DNA-directed DNA polymerase activity	-	IMP	16762037
GO:0003887	DNA-directed DNA polymerase activity	-	TAS	-
GO:0005515	protein binding	-	IPI	12403614 15670210 15805117 16510448 21044950 24939902 26496610
GO:0008296	3'-5'-exodeoxyribonuclease activity	-	IBA	21873635
GO:0046872	metal ion binding	-	IEA	-
GO:0051539	4 iron, 4 sulfur cluster binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000723	telomere maintenance	-	TAS	-
GO:0000731	DNA synthesis involved in DNA repair	-	IDA	3335506
GO:0000731	DNA synthesis involved in DNA repair	-	IMP	1730053
GO:0006260	DNA replication	-	IMP	16762037
GO:0006261	DNA-dependent DNA replication	-	IBA	21873635
GO:0006281	DNA repair	-	TAS	3146346
GO:0006283	transcription-coupled nucleotide-excision repair	-	TAS	-
GO:0006287	base-excision repair, gap-filling	-	IBA	21873635
GO:0006287	base-excision repair, gap-filling	-	IDA	10559260 10559261
GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion	-	TAS	-
GO:0006297	nucleotide-excision repair, DNA gap filling	-	IBA	21873635
GO:0006297	nucleotide-excision repair, DNA gap filling	-	IC	20713449
GO:0006297	nucleotide-excision repair, DNA gap filling	-	IMP	20227374
GO:0006297	nucleotide-excision repair, DNA gap filling	-	TAS	-
GO:0009411	response to UV	-	TAS	3146346
GO:0019985	translesion synthesis	-	TAS	-
GO:0032201	telomere maintenance via semi-conservative replication	-	TAS	-
GO:0033683	nucleotide-excision repair, DNA incision	-	TAS	-
GO:0034644	cellular response to UV	-	IDA	24939902
GO:0042769	DNA damage response, detection of DNA damage	-	TAS	-
GO:0045004	DNA replication proofreading	-	IBA	21873635
GO:0055089	fatty acid homeostasis	-	IMP	23770608

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000109	nucleotide-excision repair complex	-	IDA	20713449
GO:0000784	nuclear chromosome, telomeric region	colocalizes_with	IDA	24270157
GO:0005634	nucleus	-	IDA	16762037
GO:0005654	nucleoplasm	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005829	cytosol	-	IDA	-
GO:0016020	membrane	-	HDA	19946888
GO:0016235	aggresome	-	IDA	-
GO:0043625	delta DNA polymerase complex	-	IBA	21873635

KEGG ID	KEGG Term
hsa00230	Purine metabolism
hsa00240	Pyrimidine metabolism
hsa01100	Metabolic pathways
hsa03030	DNA replication
hsa03410	Base excision repair
hsa03420	Nucleotide excision repair
hsa03430	Mismatch repair
hsa03440	Homologous recombination

Reactome ID	Reactome Term	Evidence
R-HSA-110313	Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	TAS
R-HSA-110314	Recognition of DNA damage by PCNA-containing replication complex	TAS
R-HSA-110373	Resolution of AP sites via the multiple-nucleotide patch replacement pathway	TAS
R-HSA-1430728	Metabolism	IEA
R-HSA-157579	Telomere Maintenance	TAS
R-HSA-1640170	Cell Cycle	TAS
R-HSA-174411	Polymerase switching on the C-strand of the telomere	TAS
R-HSA-174414	Processive synthesis on the C-strand of the telomere	TAS
R-HSA-174417	Telomere C-strand (Lagging Strand) Synthesis	TAS
R-HSA-174437	Removal of the Flap Intermediate from the C-strand	TAS
R-HSA-180786	Extension of Telomeres	TAS
R-HSA-2564830	Cytosolic iron-sulfur cluster assembly	IEA
R-HSA-5358508	Mismatch Repair	TAS
R-HSA-5358565	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	TAS
R-HSA-5358606	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	TAS
R-HSA-5651801	PCNA-Dependent Long Patch Base Excision Repair	TAS
R-HSA-5656169	Termination of translesion DNA synthesis	TAS
R-HSA-5685942	HDR through Homologous Recombination (HRR)	TAS
R-HSA-5693532	DNA Double-Strand Break Repair	TAS
R-HSA-5693538	Homology Directed Repair	TAS
R-HSA-5693567	HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)	TAS
R-HSA-5696397	Gap-filling DNA repair synthesis and ligation in GG-NER	TAS
R-HSA-5696398	Nucleotide Excision Repair	TAS
R-HSA-5696399	Global Genome Nucleotide Excision Repair (GG-NER)	TAS
R-HSA-5696400	Dual Incision in GG-NER	TAS
R-HSA-6781827	Transcription-Coupled Nucleotide Excision Repair (TC-NER)	TAS
R-HSA-6782135	Dual incision in TC-NER	TAS
R-HSA-6782210	Gap-filling DNA repair synthesis and ligation in TC-NER	TAS
R-HSA-69091	Polymerase switching	TAS
R-HSA-69109	Leading Strand Synthesis	TAS
R-HSA-69166	Removal of the Flap Intermediate	TAS
R-HSA-69183	Processive synthesis on the lagging strand	TAS
R-HSA-69186	Lagging Strand Synthesis	TAS
R-HSA-69190	DNA strand elongation	TAS
R-HSA-69239	Synthesis of DNA	TAS
R-HSA-69242	S Phase	TAS
R-HSA-69278	Cell Cycle, Mitotic	TAS
R-HSA-69306	DNA Replication	TAS
R-HSA-73884	Base Excision Repair	TAS
R-HSA-73886	Chromosome Maintenance	TAS
R-HSA-73893	DNA Damage Bypass	TAS
R-HSA-73894	DNA Repair	TAS
R-HSA-73933	Resolution of Abasic Sites (AP sites)	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
17203305	Genetic variation in the base excision repair pathway and bladder cancer risk. (2007 Apr)	Figueroa JD	Hum Genet