Gene info: ID 5426

Gene: POLE

GENE ID: 5426

Synonyms: CRCS12|FILS|POLE1

Description: DNA polymerase epsilon, catalytic subunit

Gene type: protein-coding

Location: 12q24.33

dbXrefs: Ensembl:ENSG00000177084 MIM:174762 Vega:OTTHUMG00000168045 UniprotKB:Q07864

RefSeq: NG_033840.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|ND|AD

# Publications: 6

Sherlock p-value : 1.020e-2 (AD) 8.626e-1 (ND) (Frontal_Cortex)

Pascal p-value : 1.633e-3 (AD) 5.634e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
STK36	0.771
CCDC180	0.766
ABCC10	0.764
MAPKBP1	0.757
EP400	0.757
USP28	0.752
NEIL1	0.75
SEC31B	0.749
AP1G2	0.747
PTCH2	0.745

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
LRAT	-0.342
BCL7C	-0.325
ZNF114	-0.295
AQP5	-0.287
RBP1	-0.282
OR4F5	-0.28
S100A1	-0.279
KLRC2	-0.278
COPZ2	-0.274
MDFI	-0.267

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00242	Cladribine	Small Molecule	4291-63-8	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in increased expression of POLE mRNA"	26377693
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of POLE mRNA"	22698814\|2890350
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of POLE mRNA"	25510870
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of POLE mRNA"	19167446
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of POLE mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of POLE mRNA"	25510870
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of POLE mRNA"	25510870
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of POLE mRNA"	25510870
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in increased expression of POLE mRNA	19191707
D000082	Acetaminophen	Acetaminophen results in increased expression of POLE mRNA	22230336
D020106	Acrylamide	Acrylamide results in increased expression of POLE mRNA	28959563
C059765	amphotericin B, deoxycholate drug combination	"amphotericin B, deoxycholate drug combination results in increased expression of POLE mRNA"	22863853
D016590	Aphidicolin	Aphidicolin results in decreased activity of POLE protein	14975937
C015001	arsenite	arsenite results in decreased expression of POLE mRNA	18929588
D001280	Atrazine	Atrazine results in decreased expression of POLE mRNA	22378314
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of POLE mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of POLE mRNA	20713471
C006780	bisphenol A	bisphenol A results in decreased expression of POLE mRNA	25181051
C584509	C646 compound	C646 compound results in decreased expression of POLE mRNA	26191083
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of POLE mRNA	17484886
D002509	Cephaloridine	Cephaloridine results in increased expression of POLE mRNA	18500788
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of POLE mRNA"	19167446
D003375	Coumestrol	Coumestrol results in increased expression of POLE mRNA	19167446
C408982	CPG-oligonucleotide	CPG-oligonucleotide results in decreased expression of POLE mRNA	21878529
C408982	CPG-oligonucleotide	CPG-oligonucleotide results in increased expression of POLE mRNA	21878529
D003474	Curcumin	Curcumin results in decreased expression of POLE mRNA	18299980
D013759	Dronabinol	Dronabinol results in decreased expression of POLE mRNA	16616335
D003703	Demecolcine	Demecolcine results in decreased expression of POLE mRNA	23649840
D003976	Diazinon	Diazinon results in increased methylation of POLE gene	22964155
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of POLE mRNA	21266533
C000944	dicrotophos	dicrotophos results in increased expression of POLE mRNA	28302478
D000431	Ethanol	Ethanol results in decreased expression of POLE protein	20621659
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of POLE mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of POLE mRNA	17942748
C039281	furan	furan results in increased expression of POLE mRNA	20194422
C039281	furan	furan results in increased expression of POLE mRNA	22079235
D019833	Genistein	Genistein results in increased expression of POLE protein	24552547
C014026	hexamethylene bisacetamide	hexamethylene bisacetamide results in decreased expression of POLE mRNA	26941288
D017313	Fenretinide	Fenretinide results in decreased expression of POLE mRNA	28973697
C056493	imiquimod	imiquimod results in decreased expression of POLE mRNA	21878529
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of POLE mRNA	25613284
C544151	jinfukang	jinfukang results in increased expression of POLE mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of POLE mRNA	26941288
C008261	lead acetate	lead acetate results in increased expression of POLE mRNA	22609695
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of POLE mRNA	26011545
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of POLE mRNA"	26251327
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of POLE mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of POLE mRNA"	25554681
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of POLE mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in decreased expression of POLE mRNA	25729387
D010126	Ozone	[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of POLE mRNA	25658374
D010126	Ozone	TTPA protein affects the reaction [Ozone results in increased expression of POLE mRNA]	19555225
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of POLE mRNA"	25510870
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate results in decreased expression of POLE mRNA	26678675
D010634	Phenobarbital	Phenobarbital results in increased expression of POLE mRNA	23091169
C006253	pirinixic acid	pirinixic acid results in increased expression of POLE mRNA	17950772\|2381119
C006253	pirinixic acid	PPARA protein promotes the reaction [pirinixic acid results in increased expression of POLE mRNA]	17950772
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls affects the expression of POLE mRNA	21334430
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of POLE mRNA	23608068
D011441	Propylthiouracil	Propylthiouracil results in increased expression of POLE mRNA	24780913
D011794	Quercetin	Quercetin results in increased expression of POLE mRNA	21632981
C017947	sodium arsenite	sodium arsenite results in decreased expression of POLE mRNA	12377979
C017947	sodium arsenite	sodium arsenite results in increased expression of POLE mRNA	28595984
C016104	sodium bichromate	sodium bichromate results in increased expression of POLE mRNA	22110744
D053260	Soot	Soot results in increased expression of POLE mRNA	26551751
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of POLE mRNA	22574217
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of POLE mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of POLE mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of POLE mRNA	19465110
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of POLE mRNA	25613284
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of POLE mRNA	25729387
D019772	Topotecan	Topotecan results in decreased expression of POLE mRNA	25729387
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of POLE mRNA	19042947
C057693	troglitazone	troglitazone results in decreased expression of POLE mRNA	19140230
D014635	Valproic Acid	Valproic Acid results in increased methylation of POLE gene	29154799
D014635	Valproic Acid	Valproic Acid affects the expression of POLE mRNA	17292431
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of POLE gene	25560391
C029297	vinylidene chloride	vinylidene chloride results in increased expression of POLE mRNA	26682919

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000166	nucleotide binding	-	IEA	-
GO:0003677	DNA binding	-	IBA	21873635
GO:0003677	DNA binding	-	IDA	16762037
GO:0003682	chromatin binding	-	IDA	16762037
GO:0003887	DNA-directed DNA polymerase activity	-	IBA	21873635
GO:0003887	DNA-directed DNA polymerase activity	-	IMP	16762037
GO:0005515	protein binding	-	IPI	10801849 17314511 17353931
GO:0008270	zinc ion binding	-	IEA	-
GO:0008310	single-stranded DNA 3'-5' exodeoxyribonuclease activity	-	IBA	21873635
GO:0051539	4 iron, 4 sulfur cluster binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000082	G1/S transition of mitotic cell cycle	-	IMP	16762037
GO:0000082	G1/S transition of mitotic cell cycle	-	TAS	-
GO:0000278	mitotic cell cycle	-	IBA	21873635
GO:0000731	DNA synthesis involved in DNA repair	-	IMP	1730053
GO:0006260	DNA replication	-	IMP	16762037
GO:0006272	leading strand elongation	-	IBA	21873635
GO:0006287	base-excision repair, gap-filling	-	IBA	21873635
GO:0006287	base-excision repair, gap-filling	-	IDA	10559260
GO:0006297	nucleotide-excision repair, DNA gap filling	-	IBA	21873635
GO:0006297	nucleotide-excision repair, DNA gap filling	-	IMP	20227374
GO:0045004	DNA replication proofreading	-	IBA	21873635
GO:0048568	embryonic organ development	-	IEA	-
GO:0090305	nucleic acid phosphodiester bond hydrolysis	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	16762037
GO:0005654	nucleoplasm	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005886	plasma membrane	-	IDA	-
GO:0008622	epsilon DNA polymerase complex	-	IBA	21873635
GO:0008622	epsilon DNA polymerase complex	-	IDA	10801849

KEGG ID	KEGG Term
hsa00230	Purine metabolism
hsa00240	Pyrimidine metabolism
hsa01100	Metabolic pathways
hsa03030	DNA replication
hsa03410	Base excision repair
hsa03420	Nucleotide excision repair

Reactome ID	Reactome Term	Evidence
R-HSA-110313	Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	TAS
R-HSA-110314	Recognition of DNA damage by PCNA-containing replication complex	TAS
R-HSA-110373	Resolution of AP sites via the multiple-nucleotide patch replacement pathway	TAS
R-HSA-157579	Telomere Maintenance	TAS
R-HSA-1640170	Cell Cycle	TAS
R-HSA-174417	Telomere C-strand (Lagging Strand) Synthesis	TAS
R-HSA-174430	Telomere C-strand synthesis initiation	TAS
R-HSA-180786	Extension of Telomeres	TAS
R-HSA-453279	Mitotic G1-G1/S phases	TAS
R-HSA-5651801	PCNA-Dependent Long Patch Base Excision Repair	TAS
R-HSA-5656169	Termination of translesion DNA synthesis	TAS
R-HSA-5685942	HDR through Homologous Recombination (HRR)	TAS
R-HSA-5693532	DNA Double-Strand Break Repair	TAS
R-HSA-5693538	Homology Directed Repair	TAS
R-HSA-5693567	HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)	TAS
R-HSA-5696397	Gap-filling DNA repair synthesis and ligation in GG-NER	TAS
R-HSA-5696398	Nucleotide Excision Repair	TAS
R-HSA-5696399	Global Genome Nucleotide Excision Repair (GG-NER)	TAS
R-HSA-5696400	Dual Incision in GG-NER	TAS
R-HSA-6781827	Transcription-Coupled Nucleotide Excision Repair (TC-NER)	TAS
R-HSA-6782135	Dual incision in TC-NER	TAS
R-HSA-6782210	Gap-filling DNA repair synthesis and ligation in TC-NER	TAS
R-HSA-68874	M/G1 Transition	TAS
R-HSA-68952	DNA replication initiation	TAS
R-HSA-68962	Activation of the pre-replicative complex	TAS
R-HSA-69002	DNA Replication Pre-Initiation	TAS
R-HSA-69206	G1/S Transition	TAS
R-HSA-69239	Synthesis of DNA	TAS
R-HSA-69242	S Phase	TAS
R-HSA-69278	Cell Cycle, Mitotic	TAS
R-HSA-69306	DNA Replication	TAS
R-HSA-73884	Base Excision Repair	TAS
R-HSA-73886	Chromosome Maintenance	TAS
R-HSA-73893	DNA Damage Bypass	TAS
R-HSA-73894	DNA Repair	TAS
R-HSA-73933	Resolution of Abasic Sites (AP sites)	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28234207	Effects of dopaminergic genes, prenatal adversities, and their interaction on attention-deficit/hyperactivity disorder and neural correlates of response inhibition. (2017 Mar)	van der Meer D	J Psychiatry Neurosci
24273408	Brain volumes and neuropsychological performance are related to current smoking and alcoholism history. (2013)	Luhar RB	Neuropsychiatr Dis Treat
18361441	Dynorphin and prodynorphin mRNA changes in the striatum during nicotine withdrawal. (2008 Jun)	Isola R	Synapse
10639691	Dopamine transporter and D2-receptor density in late-onset alcoholism. (1999 Dec)	Repo E	Psychopharmacology (Berl)
26806129	Mutational Strand Asymmetries in Cancer Genomes Reveal Mechanisms of DNA Damage and Repair. (2016 Jan 28)	Haradhvala NJ	Cell
24927863	Immediate breast reconstruction with acellular dermal matrix: factors affecting outcome. (2014 Aug)	Lardi AM	J Plast Reconstr Aesthet Surg