Gene: SOX18

54345
HLTRS|HLTS
SRY-box 18
protein-coding
20q13.33
Ensembl:ENSG00000203883 MIM:601618 Vega:OTTHUMG00000033017 UniprotKB:P35713
NG_008095.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.074e-1 (AD)  1.987e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg21721340chr20:62682309SOX181.750e-8Maternal smoking in pregnancy27040690
cg14391586chr20:62681296SOX188.000e-9Smoking27651444
cg02231404chr20:62679635SOX182.030e-9Alcohol consumption der day27843151
cg14391586chr20:62681296SOX188.810e-8Alcohol consumption der day27843151
cg02231404chr20:62679635SOX184.770e-8Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ID10.773
TMEM880.7
NDUFA4L20.691
FOXF10.664
CD2480.663
KLF20.662
TBX20.66
TINAGL10.651
KLF40.648
KANK30.645

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FSTL5-0.418
EPHA5-0.417
TENM3-0.408
GRM1-0.402
PTPRR-0.398
DACH2-0.393
GLRA2-0.391
MCF2-0.39
HTR5A-0.387
CSRNP3-0.387

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of SOX18 mRNA"18648102
D000082AcetaminophenAcetaminophen results in increased expression of SOX18 mRNA17585979
D001151ArsenicArsenic results in decreased expression of SOX18 mRNA16835338
C006632arsenic trioxidearsenic trioxide results in decreased expression of SOX18 mRNA15761015
D001554BenzeneBenzene results in increased expression of SOX18 mRNA15120971|1512265
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of SOX18 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SOX18 mRNA27195522
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SOX18 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SOX18 mRNA21839799
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of SOX18 mRNA25566086
D004958EstradiolEstradiol results in decreased expression of SOX18 mRNA20106945
D004958EstradiolEstradiol affects the expression of SOX18 mRNA15598610
C006780bisphenol Abisphenol A affects the methylation of SOX18 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of SOX18 mRNA26063408
C006780bisphenol Abisphenol A results in increased methylation of SOX18 promoter27312807
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of SOX18 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of SOX18 mRNA25181051
C584509C646 compoundC646 compound results in increased expression of SOX18 mRNA26191083
D002104CadmiumCadmium results in increased expression of SOX18 mRNA24376830
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of SOX18 mRNA24763279
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of SOX18 mRNA16934159
D004390ChlorpyrifosChlorpyrifos results in increased expression of SOX18 mRNA20691718
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SOX18 gene20938992
D002922CiguatoxinsCiguatoxins affects the expression of SOX18 mRNA18353800
D002994ClofibrateClofibrate results in decreased expression of SOX18 mRNA17585979
D003471CuprizoneCuprizone results in increased expression of SOX18 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of SOX18 mRNA21632981
C014347decitabinedecitabine affects the expression of SOX18 mRNA23300844
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SOX18 mRNA17361019
D002945CisplatinCisplatin affects the expression of SOX18 mRNA23300844
C000944dicrotophosdicrotophos results in increased expression of SOX18 mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of SOX18 mRNA18042831
D005472FluorouracilSOX18 protein affects the susceptibility to Fluorouracil16217747
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SOX18 gene20938992
C069837fullerene C60fullerene C60 results in increased expression of SOX18 mRNA19167457
C004312glycidolglycidol results in increased expression of SOX18 mRNA24915197
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of SOX18 mRNA24763279
C412815GW 4064GW 4064 results in increased expression of SOX18 mRNA26655953
D017313FenretinideFenretinide results in decreased expression of SOX18 mRNA16467112
D017313FenretinideFenretinide results in increased expression of SOX18 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of SOX18 mRNA15761015
C492448ICG 001ICG 001 results in increased expression of SOX18 mRNA26191083
D007213IndomethacinIndomethacin results in increased expression of SOX18 mRNA16984733
C119620kenpaullonekenpaullone results in decreased expression of SOX18 mRNA17993264
C008261lead acetatelead acetate results in decreased expression of SOX18 mRNA22641619
D008628MercuryMercury results in increased expression of SOX18 mRNA16823088
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in decreased expression of SOX18 mRNA19564919
D008694MethamphetamineMethamphetamine results in decreased expression of SOX18 mRNA19564919
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SOX18 gene20938992
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of SOX18 mRNA"26251327
C568376MT19c compoundMT19c compound results in decreased expression of SOX18 mRNA21781307
C058346N-(4-methoxyphenyl)retinamideN-(4-methoxyphenyl)retinamide results in decreased expression of SOX18 mRNA16467112
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SOX18 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SOX18 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SOX18 mRNA"25620056
C022838nickel chloridenickel chloride results in decreased expression of SOX18 mRNA17312168
D009538NicotineNicotine results in decreased expression of SOX18 mRNA17456735
D009966OrphenadrineOrphenadrine affects the expression of SOX18 mRNA23665939
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of SOX18 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of SOX18 mRNA25729387
D000073878Palm OilPalm Oil results in increased expression of SOX18 mRNA18042831
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of SOX18 mRNA17097637
D010705PhosgenePhosgene affects the expression of SOX18 mRNA16300373
D010936Plant ExtractsPlant Extracts results in decreased expression of SOX18 mRNA23557933
D017382Reactive Oxygen SpeciesReactive Oxygen Species affects the expression of SOX18 mRNA15761015
D012402RotenoneRotenone results in increased expression of SOX18 mRNA19013527
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in decreased expression of SOX18 mRNA19564919
D012822Silicon DioxideSilicon Dioxide results in decreased expression of SOX18 mRNA22431001
D012999SomanSoman results in decreased expression of SOX18 mRNA19281266
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of SOX18 mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SOX18 mRNA24058054
D013849ThimerosalThimerosal results in decreased expression of SOX18 mRNA24675092
C009495titanium dioxidetitanium dioxide results in decreased expression of SOX18 mRNA23557971
D014050TolueneToluene results in increased expression of SOX18 mRNA22967744
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of SOX18 mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in increased expression of SOX18 mRNA19448997
D014520UrethaneUrethane results in decreased expression of SOX18 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of SOX18 mRNA17292431
C025643vinclozolinvinclozolin affects the expression of SOX18 mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA22292085  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA22292085  
GO:0044212transcription regulatory region DNA binding-IDA18065521  
GO:0046982protein heterodimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IBA21873635  
GO:0000122negative regulation of transcription by RNA polymerase II-IDA22292085  
GO:0001525angiogenesis-IBA21873635  
GO:0001525angiogenesis-IEP16882943  
GO:0001570vasculogenesis-IBA21873635  
GO:0001570vasculogenesis-ISS-  
GO:0001701in utero embryonic development-IEA-  
GO:0001942hair follicle development-IEA-  
GO:0001944vasculature development-ISS-  
GO:0001946lymphangiogenesis-IBA21873635  
GO:0001946lymphangiogenesis-IMP12740761  
GO:0001947heart looping-ISS-  
GO:0003151outflow tract morphogenesis-ISS-  
GO:0006355regulation of transcription, DNA-templated-IBA21873635  
GO:0009653anatomical structure morphogenesis-IBA21873635  
GO:0022405hair cycle process-IMP12740761  
GO:0030154cell differentiation-IBA21873635  
GO:0035050embryonic heart tube development-ISS-  
GO:0042789mRNA transcription by RNA polymerase II-IDA22292085  
GO:0043534blood vessel endothelial cell migration-IEP16882943  
GO:0045892negative regulation of transcription, DNA-templated-ISS-  
GO:0045893positive regulation of transcription, DNA-templated-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA18065521  22292085  
GO:0048469cell maturation-IEA-  
GO:0048866stem cell fate specification-IEA-  
GO:0060214endocardium formation-ISS-  
GO:0060836lymphatic endothelial cell differentiation-ISS-  
GO:0060840artery development-IBA21873635  
GO:0060956endocardial cell differentiation-ISS-  
GO:0061028establishment of endothelial barrier-IMP18065521  
GO:0072091regulation of stem cell proliferation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000790nuclear chromatin-IDA22292085  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA18065521  
GO:0044798nuclear transcription factor complex-IBA21873635  
GO:0044798nuclear transcription factor complex-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
15911247CpG island methylation and expression of tumour-associated genes in lung carcinoma. (2005 May)Dammann REur J Cancer