Gene: CYTL1

54360
C17|C4orf4
cytokine like 1
protein-coding
4p16.2
Ensembl:ENSG00000170891 MIM:607930 Vega:OTTHUMG00000125479 UniprotKB:Q9NRR1
NC_000004.12
PubMed
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.073e-1 (AD)  1.924e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LY860.765
HLA-DMB0.754
CSF2RA0.742
LST10.742
IL180.739
SYK0.737
RGS180.734
IGSF60.733
TBXAS10.726
RNASE60.725

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FOXP3-0.27
KRTAP5-7-0.265
FSCN2-0.264
KREMEN2-0.254
KLHL25-0.253
ST6GAL2-0.246
NTN5-0.245
YBX2-0.244
NXPH3-0.239
REEP6-0.234

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYTL1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYTL1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYTL1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYTL1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYTL1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYTL1 mRNA"27188386
D020106AcrylamideAcrylamide results in increased expression of CYTL1 mRNA28959563
C006632arsenic trioxidearsenic trioxide inhibits the reaction [SP1 protein binds to CYTL1 promoter]15761015
C006632arsenic trioxidearsenic trioxide results in decreased expression of CYTL1 mRNA15070760|1576101
C006632arsenic trioxide[Tretinoin co-treated with arsenic trioxide] results in decreased expression of CYTL1 mRNA15894607
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of CYTL1 mRNA26377693
D004958EstradiolEstradiol results in increased expression of CYTL1 mRNA25878060
D004958EstradiolEstradiol results in decreased expression of CYTL1 mRNA19484750
C044887beta-methylcholinebeta-methylcholine affects the expression of CYTL1 mRNA21179406
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of CYTL1 mRNA27685785
C006780bisphenol Abisphenol A results in increased expression of CYTL1 mRNA27685785
C006780bisphenol Abisphenol A affects the expression of CYTL1 mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of CYTL1 mRNA25979313
C018021cobaltous chloridecobaltous chloride results in decreased expression of CYTL1 mRNA19320972
D004041Dietary FatsDietary Fats results in increased expression of CYTL1 mRNA18042831|2501614
D004237DiuronDiuron results in increased expression of CYTL1 mRNA21551480
D004397FonofosFonofos results in increased methylation of CYTL1 promoter22847954
C069837fullerene C60fullerene C60 affects the expression of CYTL1 mRNA19167457
C039281furanfuran results in decreased expression of CYTL1 mRNA25539665
D017313FenretinideFenretinide results in decreased expression of CYTL1 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of CYTL1 mRNA15761015
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CYTL1 mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CYTL1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CYTL1 mRNA"25554681
D009532NickelNickel results in decreased expression of CYTL1 mRNA24768652|2558310
D010126OzoneOzone results in increased expression of CYTL1 mRNA28623178
D000073878Palm OilPalm Oil results in increased expression of CYTL1 mRNA18042831
D010278ParathionParathion results in increased methylation of CYTL1 promoter22847954
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of CYTL1 mRNA26705709
D011441PropylthiouracilPropylthiouracil results in decreased expression of CYTL1 mRNA24780913
D017382Reactive Oxygen SpeciesReactive Oxygen Species affects the expression of CYTL1 mRNA15761015
D017632Asbestos, Serpentine"Asbestos, Serpentine results in decreased expression of CYTL1 mRNA"21514415
D053260SootSoot results in decreased expression of CYTL1 mRNA26551751
C012568terbufosterbufos results in increased methylation of CYTL1 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CYTL1 mRNA21998131
C009495titanium dioxidetitanium dioxide affects the expression of CYTL1 mRNA23557971
C009495titanium dioxidetitanium dioxide results in decreased expression of CYTL1 mRNA23409001
D014212Tretinoin[Tretinoin co-treated with arsenic trioxide] results in decreased expression of CYTL1 mRNA15894607
D014212TretinoinTretinoin results in decreased expression of CYTL1 mRNA15894607|1721838
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYTL1 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of CYTL1 mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYTL1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CYTL1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of CYTL1 mRNA23179753|2438349
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYTL1 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of CYTL1 mRNA26272509
D019287Zinc SulfateZinc Sulfate results in increased expression of CYTL1 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-TAS10857752  
GO ID GO Term Qualifier Evidence PubMed
GO:0002062chondrocyte differentiation-IEA-  
GO:0007165signal transduction-TAS10857752  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0048839inner ear development-IEA-  
GO:0050650chondroitin sulfate proteoglycan biosynthetic process-IEA-  
GO:0051091positive regulation of DNA-binding transcription factor activity-IEA-  
GO:1990079cartilage homeostasis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-TAS10857752  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22613542ANKRD7 and CYTL1 are novel risk genes for alcohol drinking behavior. (2012 Mar)Chen XDChin Med J (Engl)
22011669Genome-wide analysis of DNA methylation and the gene expression change in lung cancer. (2012 Jan)Kwon YJJ Thorac Oncol