Gene: WNT4

54361
SERKAL|WNT-4
Wnt family member 4
protein-coding
1p36.12
Ensembl:ENSG00000162552 MIM:603490 Vega:OTTHUMG00000002894 UniprotKB:P56705
NG_008974.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.258e-1 (AD)  8.433e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZCCHC120.692
GLRA20.691
CBLN10.665
FSTL50.665
ACAT20.627
TBC1D90.627
NXPH10.626
GRIK10.623
BTBD110.622
ARL4C0.621

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PPBP-0.367
HIF3A-0.363
CLEC4E-0.358
CDA-0.344
OTOS-0.341
P2RY14-0.33
ANPEP-0.324
NPIPB6-0.316
REST-0.31
STON2-0.308

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in increased expression of WNT4 mRNA"20826375
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran results in decreased expression of WNT4 mRNA"21724226
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of WNT4 mRNA"21346803
C0299552-nitrotoluene2-nitrotoluene results in increased expression of WNT4 mRNA16460773
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of WNT4 mRNA24140754
C4861844,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol"4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol results in increased expression of WNT4 mRNA"22445810
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WNT4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WNT4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WNT4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WNT4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WNT4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WNT4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WNT4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WNT4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WNT4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WNT4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WNT4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WNT4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WNT4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WNT4 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of WNT4 mRNA29067470
D020106AcrylamideAcrylamide results in increased expression of WNT4 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of WNT4 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of WNT4 mRNA19770486
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of WNT4 mRNA23630614
D000393Air PollutantsAir Pollutants results in decreased expression of WNT4 mRNA23649983
D000643Ammonium ChlorideAmmonium Chloride affects the expression of WNT4 mRNA16483693
C487081belinostatbelinostat results in increased expression of WNT4 mRNA23671600|2627250
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WNT4 mRNA"27188386
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of WNT4 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to WNT4 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of WNT4 mRNA19770486|2171566
C020711beryllium sulfateberyllium sulfate results in increased expression of WNT4 mRNA16314022
D004958EstradiolNR3C1 protein promotes the reaction [[Progesterone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with Estradiol] results in increased expression of WNT4 mRNA]23275455
D004958Estradiol[Progesterone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with Estradiol] results in increased expression of WNT4 mRNA23275455
D004958EstradiolEstradiol affects the expression of WNT4 mRNA15598610
D004958EstradiolEstradiol results in increased expression of WNT4 mRNA19164167|2082637
C006780bisphenol Abisphenol A promotes the reaction [Progesterone results in increased expression of WNT4 mRNA]21903720
C006780bisphenol Abisphenol A results in increased expression of WNT4 mRNA20826375|2273214
C006780bisphenol Abisphenol A results in increased expression of WNT4 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of WNT4 protein24552547
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of WNT4 mRNA22079614
D0151248-Bromo Cyclic Adenosine MonophosphateNR3C1 protein promotes the reaction [[Progesterone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with Estradiol] results in increased expression of WNT4 mRNA]23275455
D0151248-Bromo Cyclic Adenosine Monophosphate[Progesterone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with Estradiol] results in increased expression of WNT4 mRNA23275455
C099813bromochloroacetic acidbromochloroacetic acid results in increased expression of WNT4 mRNA16460773
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of WNT4 mRNA15003993
C037123cadmium sulfate[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in decreased expression of WNT4 mRNA18654764
D002110CaffeineCaffeine affects the expression of WNT4 mRNA20864626
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of WNT4 mRNA16780995
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of WNT4 mRNA24763279
C084597chlorcyclizinechlorcyclizine results in increased expression of WNT4 mRNA21058326
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of WNT4 mRNA25270620
D004390ChlorpyrifosChlorpyrifos affects the expression of WNT4 mRNA26775027
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of WNT4 mRNA20938992
D002994ClofibrateClofibrate results in decreased expression of WNT4 mRNA25270620
C018021cobaltous chloride[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in decreased expression of WNT4 mRNA18654764
D019327Copper SulfateCopper Sulfate results in increased expression of WNT4 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of WNT4 mRNA19770486
D003907DexamethasoneDexamethasone results in decreased expression of WNT4 mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of WNT4 mRNA]20032058
D003976DiazinonDiazinon affects the expression of WNT4 mRNA19130878
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of WNT4 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of WNT4 mRNA27392435
D002945CisplatinCisplatin results in increased expression of WNT4 mRNA23956100|2739243
D004026DieldrinDieldrin affects the expression of WNT4 mRNA19130878
D004041Dietary FatsDietary Fats results in increased expression of WNT4 mRNA18042831
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of WNT4 mRNA26219507|2749589
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of WNT4 protein27495896
D004052Diethylnitrosamine[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of WNT4 gene23968726
D004054DiethylstilbestrolDiethylstilbestrol affects the expression of WNT4 mRNA15070830
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of WNT4 mRNA22445810
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of WNT4 protein22445810
D004054Diethylstilbestrolfulvestrant inhibits the reaction [Diethylstilbestrol results in increased expression of WNT4 mRNA]22445810
D004237DiuronDiuron results in decreased expression of WNT4 mRNA21551480
D004317DoxorubicinDoxorubicin results in increased expression of WNT4 mRNA23956100
C118739entinostatentinostat results in increased expression of WNT4 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WNT4 mRNA"27188386
D004967Estrogens[Progesterone co-treated with Estrogens] results in increased expression of WNT4 mRNA21258428
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of WNT4 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of WNT4 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of WNT4 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of WNT4 mRNA16551644|1735126
D005492Folic Acid[Folic Acid co-treated with sodium arsenite] results in decreased methylation of WNT4 mRNA22959928
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of WNT4 mRNA20938992
D005557FormaldehydeFormaldehyde results in decreased expression of WNT4 mRNA27664576
C070081fulvestrantfulvestrant inhibits the reaction [Diethylstilbestrol results in increased expression of WNT4 mRNA]22445810
D019833GenisteinGenistein results in increased expression of WNT4 mRNA24365114
D005947GlucoseGlucose results in decreased expression of WNT4 mRNA18004065
D005947GlucoseSimvastatin inhibits the reaction [Glucose results in decreased expression of WNT4 mRNA]18004065
C508665gold (III) porphyrin 1agold (III) porphyrin 1a results in decreased expression of WNT4 mRNA16206274
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of WNT4 mRNA24763279
D017313FenretinideFenretinide results in increased expression of WNT4 mRNA28973697
C475919hydroxytamoxifenhydroxytamoxifen results in increased expression of WNT4 mRNA16849584
C016517indole-3-carbinolindole-3-carbinol affects the expression of WNT4 mRNA21396975
D007213IndomethacinIndomethacin results in decreased expression of WNT4 mRNA25972201
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of WNT4 mRNA27392435
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of WNT4 protein17337753
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of WNT4 mRNA26644586
D007854LeadLead affects the expression of WNT4 mRNA28903495
C029891lead chloride[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in decreased expression of WNT4 mRNA18654764
C017461lead nitratelead nitrate affects the reaction [WNT4 affects the expression of MT1 mRNA]11891201
C017461lead nitratelead nitrate affects the reaction [WNT4 affects the expression of MT2 mRNA]11891201
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of WNT4 mRNA"24972896
D018021Lithium ChlorideLithium Chloride results in increased expression of WNT4 mRNA17506889
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of WNT4 mRNA20938992
D009532NickelNickel results in decreased expression of WNT4 mRNA24768652|2558310
D009532NickelNickel affects the expression of WNT4 mRNA19130878
C042670N-vinyl-2-pyrrolidinone[N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of WNT4 mRNA22037397
D017239PaclitaxelPaclitaxel results in increased expression of WNT4 mRNA23956100
D000073878Palm OilPalm Oil results in increased expression of WNT4 mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WNT4 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of WNT4 mRNA26272509
D010634PhenobarbitalPhenobarbital results in increased expression of WNT4 mRNA22037397
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WNT4 mRNA"27188386
D010882Piperonyl Butoxide[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of WNT4 gene23968726
C006253pirinixic acidpirinixic acid results in decreased expression of WNT4 mRNA25270620
D011374ProgesteroneNR3C1 protein promotes the reaction [[Progesterone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with Estradiol] results in increased expression of WNT4 mRNA]23275455
D011374Progesterone[Progesterone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with Estradiol] results in increased expression of WNT4 mRNA23275455
D011374Progesteronebisphenol A promotes the reaction [Progesterone results in increased expression of WNT4 mRNA]21903720
D011374ProgesteroneProgesterone affects the expression of WNT4 mRNA17251523
D011374ProgesteroneProgesterone results in decreased expression of WNT4 mRNA22238285
D011374ProgesteroneProgesterone results in increased expression of WNT4 mRNA21903720
D011374ProgesteroneWNT4 protein affects the abundance of Progesterone20371632
D011374Progesterone[Progesterone co-treated with Estrogens] results in increased expression of WNT4 mRNA21258428
D011441PropylthiouracilPropylthiouracil results in decreased expression of WNT4 mRNA24780913
D019821SimvastatinSimvastatin inhibits the reaction [Glucose results in decreased expression of WNT4 mRNA]18004065
D019821SimvastatinSimvastatin results in increased expression of WNT4 protein18004065
D012906SmokeSmoke results in decreased expression of WNT4 mRNA20015843
C017947sodium arsenite[Folic Acid co-treated with sodium arsenite] results in decreased methylation of WNT4 mRNA22959928
C017947sodium arsenitesodium arsenite affects the expression of WNT4 mRNA23137061
D012999SomanSoman results in decreased expression of WNT4 mRNA19281266
D013629TamoxifenTamoxifen affects the expression of WNT4 mRNA17555576
D013739TestosteroneTestosterone results in decreased expression of WNT4 mRNA20403060
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of WNT4 mRNA]20032058
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the reaction [AHR protein binds to WNT4 promoter]19654925
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of WNT4 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of WNT4 mRNA19770486|2527062
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of WNT4 mRNA17035482|1794274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of WNT4 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of WNT4 mRNA21215274|2280813
D014118Toxins, Biological"Toxins, Biological affects the expression of WNT4 mRNA"19682533
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WNT4 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of WNT4 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of WNT4 mRNA"24407104
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WNT4 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of WNT4 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of WNT4 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of WNT4 gene29154799
D014635Valproic AcidValproic Acid affects the expression of WNT4 mRNA17963808
D014635Valproic AcidValproic Acid results in decreased expression of WNT4 mRNA23665938
D002762CholecalciferolCholecalciferol results in increased expression of WNT4 mRNA17170073
D002762CholecalciferolCholecalciferol results in increased expression of WNT4 protein17170073
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WNT4 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of WNT4 mRNA26272509
D019287Zinc SulfateZinc Sulfate results in increased expression of WNT4 mRNA17506889

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003714transcription corepressor activity-ISS-  
GO:0005109frizzled binding-IBA21873635  
GO:0048018receptor ligand activity-IC16959810  
GO ID GO Term Qualifier Evidence PubMed
GO:0001658branching involved in ureteric bud morphogenesis-IEA-  
GO:0001822kidney development-IEP15312687  
GO:0001837epithelial to mesenchymal transition-IEP12841867  
GO:0001838embryonic epithelial tube formation-IEA-  
GO:0001889liver development-IEP15312687  
GO:0006702androgen biosynthetic process-IDA16959810  
GO:0008584male gonad development-IEP17848411  
GO:0008584male gonad development-IMP11283799  
GO:0008585female gonad development-ISS-  
GO:0009267cellular response to starvation-IEA-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0010629negative regulation of gene expression-IDA15317892  
GO:0010894negative regulation of steroid biosynthetic process-IDA15317892  16959810  18182450  
GO:0016055Wnt signaling pathway-IBA21873635  
GO:0016055Wnt signaling pathway-TAS-  
GO:0022407regulation of cell-cell adhesion-IEA-  
GO:0030182neuron differentiation-IBA21873635  
GO:0030237female sex determination-IMP11283799  
GO:0030325adrenal gland development-IEP12844346  
GO:0030336negative regulation of cell migration-IEA-  
GO:0030501positive regulation of bone mineralization-IDA17720811  
GO:0032349positive regulation of aldosterone biosynthetic process-IDA16981135  
GO:0032967positive regulation of collagen biosynthetic process-IDA17720811  
GO:0033080immature T cell proliferation in thymus-IEA-  
GO:0038030non-canonical Wnt signaling pathway via MAPK cascade-IDA17720811  
GO:0040037negative regulation of fibroblast growth factor receptor signaling pathway-IEA-  
GO:0043547positive regulation of GTPase activity-IEA-  
GO:0045165cell fate commitment-IBA21873635  
GO:0045596negative regulation of cell differentiation-IEA-  
GO:0045669positive regulation of osteoblast differentiation-IDA17720811  
GO:0045836positive regulation of meiotic nuclear division-IEA-  
GO:0045892negative regulation of transcription, DNA-templated-IMP12949260  
GO:0045892negative regulation of transcription, DNA-templated-ISS-  
GO:0045893positive regulation of transcription, DNA-templated-IDA16959810  16981135  18182450  
GO:0045893positive regulation of transcription, DNA-templated-ISS11283799  
GO:0048599oocyte development-IEA-  
GO:0051145smooth muscle cell differentiation-IEA-  
GO:0051496positive regulation of stress fiber assembly-IEA-  
GO:0051894positive regulation of focal adhesion assembly-IEA-  
GO:0060070canonical Wnt signaling pathway-IDA15317892  
GO:0060126somatotropin secreting cell differentiation-IEA-  
GO:0060129thyroid-stimulating hormone-secreting cell differentiation-IEA-  
GO:0060231mesenchymal to epithelial transition-IEA-  
GO:0060748tertiary branching involved in mammary gland duct morphogenesis-IEA-  
GO:0061045negative regulation of wound healing-IEA-  
GO:0061180mammary gland epithelium development-IEP8168088  
GO:0061184positive regulation of dermatome development-IDA10654605  
GO:0061205paramesonephric duct development-IMP18182450  
GO:0061369negative regulation of testicular blood vessel morphogenesis-IMP12949260  
GO:0071560cellular response to transforming growth factor beta stimulus-IEP15040835  
GO:0072033renal vesicle formation-IEA-  
GO:0072034renal vesicle induction-IEA-  
GO:0072162metanephric mesenchymal cell differentiation-NAS16368682  
GO:0072174metanephric tubule formation-IEA-  
GO:0072273metanephric nephron morphogenesis-IEA-  
GO:0072659protein localization to plasma membrane-IDA17976063  
GO:0090090negative regulation of canonical Wnt signaling pathway-IDA17976063  
GO:0090263positive regulation of canonical Wnt signaling pathway-IDA16959810  18182450  
GO:2000019negative regulation of male gonad development-IMP11283799  
GO:2000066positive regulation of cortisol biosynthetic process-IDA16981135  
GO:2000225negative regulation of testosterone biosynthetic process-IMP12949260  
GO:2001234negative regulation of apoptotic signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IDA16959810  
GO:0005737cytoplasm-IDA16959810  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0005796Golgi lumen-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0009986cell surface-ISS-  
GO:0030666endocytic vesicle membrane-TAS-  
GO:0070062extracellular exosome-TAS-  
KEGG ID KEGG Term
hsa04310Wnt signaling pathway
hsa04340Hedgehog signaling pathway
hsa04916Melanogenesis
hsa05200Pathways in cancer
hsa05217Basal cell carcinoma
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionIEA
R-HSA-162582Signal TransductionTAS
R-HSA-195721Signaling by WNTIEA
R-HSA-195721Signaling by WNTTAS
R-HSA-201681TCF dependent signaling in response to WNTIEA
R-HSA-3238698WNT ligand biogenesis and traffickingTAS
R-HSA-3238698WNT ligand biogenesis and traffickingIEA
R-HSA-372790Signaling by GPCRIEA
R-HSA-373080Class B/2 (Secretin family receptors)IEA
R-HSA-3772470Negative regulation of TCF-dependent signaling by WNT ligand antagonistsIEA
R-HSA-3858494Beta-catenin independent WNT signalingIEA
R-HSA-3858494Beta-catenin independent WNT signalingTAS
R-HSA-4086400PCP/CE pathwayIEA
R-HSA-4086400PCP/CE pathwayTAS
R-HSA-500792GPCR ligand bindingIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28779169Paternal nicotine exposure defines different behavior in subsequent generation via hyper-methylation of mmu-miR-15b. (2017 Aug 4)Dai JSci Rep