Gene: SLC38A2

54407
ATA2|PRO1068|SAT2|SNAT2
solute carrier family 38 member 2
protein-coding
12q13.11
Ensembl:ENSG00000134294 MIM:605180 Vega:OTTHUMG00000169471 UniprotKB:Q96QD8
NC_000012.12
PubMed
0   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.636e-1 (AD)  2.344e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg27491190chr12:46767943SLC38A24.400e-8Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PPP4R20.868
TIAL10.849
PDS5A0.839
CGGBP10.838
MBNL10.828
DHX150.827
GOLPH30.826
RYBP0.82
CNOT20.813
ZBTB380.811

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.585
OR4F29-0.554
HES5-0.316
NXNL1-0.285
HKDC1-0.276
HOGA1-0.272
TLCD1-0.259
ENDOU-0.256
C16orf74-0.256
C22orf31-0.254

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of SLC38A2 mRNA"21354444
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of SLC38A2 mRNA28329830
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of SLC38A2 mRNA19933214
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of SLC38A2 mRNA"25614096
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of SLC38A2 mRNA"21920950
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SLC38A2 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SLC38A2 mRNA"21346803
C0179112-(methylamino)isobutyric acidSLC38A2 mutant form inhibits the reaction [arsenite results in increased transport of 2-(methylamino)isobutyric acid]22215663
C0261142-xylene2-xylene results in increased expression of SLC38A2 mRNA20359517
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of SLC38A2 mRNA]"19467301
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SLC38A2 mRNA"23196670
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of SLC38A2 mRNA16788091
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [arsenite results in increased expression of SLC38A2 mRNA]22215663
D000082AcetaminophenAcetaminophen affects the expression of SLC38A2 mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of SLC38A2 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SLC38A2 mRNA]17585979
D000111AcetylcysteineAcetylcysteine inhibits the reaction [arsenite results in increased expression of SLC38A2 mRNA]22215663
D020106AcrylamideAcrylamide results in increased expression of SLC38A2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SLC38A2 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC38A2 mRNA16483693
C058317arsenic disulfidearsenic disulfide results in increased expression of SLC38A2 mRNA16918137
C006632arsenic trioxidearsenic trioxide results in increased expression of SLC38A2 mRNA23892647
C006632arsenic trioxidesalubrinal promotes the reaction [arsenic trioxide results in increased expression of SLC38A2 mRNA]23892647
C006632arsenic trioxideThioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of SLC38A2 mRNA]23892647
C015001arsenitearsenite results in increased expression of SLC38A2 mRNA22215663
C015001arseniteATF4 mutant form inhibits the reaction [arsenite results in increased expression of SLC38A2 mRNA]22215663
C015001arseniteATF4 mutant form inhibits the reaction [arsenite results in increased expression of SLC38A2 protein]22215663
C015001arseniteSLC38A2 mutant form inhibits the reaction [arsenite results in increased expression of DDIT3 mRNA]22215663
C015001arseniteSLC38A2 mutant form inhibits the reaction [arsenite results in increased expression of DDIT3 protein]22215663
C015001arseniteSLC38A2 mutant form inhibits the reaction [arsenite results in increased phosphorylation of RPS6KB1 protein]22215663
C015001arseniteSLC38A2 mutant form inhibits the reaction [arsenite results in increased splicing of XBP1 mRNA]22215663
C015001arsenite4-phenylbutyric acid inhibits the reaction [arsenite results in increased expression of SLC38A2 mRNA]22215663
C015001arseniteAcetylcysteine inhibits the reaction [arsenite results in increased expression of SLC38A2 mRNA]22215663
C015001arsenitearsenite results in increased expression of and results in increased activity of SLC38A2 protein22215663
C015001arsenitearsenite results in increased expression of SLC38A2 mRNA22215663
C015001arseniteSLC38A2 mutant form inhibits the reaction [arsenite results in increased transport of 2-(methylamino)isobutyric acid]22215663
D001554BenzeneBenzene results in increased expression of SLC38A2 mRNA20036648|2035951
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of SLC38A2 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SLC38A2 mRNA21569818|2222880
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of SLC38A2 mRNA"20382639
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SLC38A2 mRNA"17944540|1915039
D004958EstradiolEstradiol affects the expression of SLC38A2 mRNA22574217
D004958EstradiolEstradiol results in increased expression of SLC38A2 mRNA18556351
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of SLC38A2 mRNA18556351
C006780bisphenol Abisphenol A affects the expression of SLC38A2 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of SLC38A2 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SLC38A2 mRNA28628672
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SLC38A2 mRNA20360939
C010063carbonyl sulfidecarbonyl sulfide results in decreased expression of SLC38A2 mRNA19395590
C100187chloropicrinchloropicrin affects the expression of SLC38A2 mRNA26352163
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of SLC38A2 mRNA28472532
D002922CiguatoxinsCiguatoxins affects the expression of SLC38A2 mRNA18353800
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of SLC38A2 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SLC38A2 mRNA]17585979
D019327Copper SulfateCopper Sulfate results in increased expression of SLC38A2 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of SLC38A2 mRNA27523638
C009160cyclonitecyclonite results in increased expression of SLC38A2 mRNA25559034
D016572CyclosporineCyclosporine results in decreased expression of SLC38A2 mRNA25562108
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SLC38A2 mRNA28628672
D002945CisplatinCisplatin results in increased expression of SLC38A2 mRNA27594783
D004004DichlororibofuranosylbenzimidazoleDichlororibofuranosylbenzimidazole affects the expression of SLC38A2 protein15581851
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of SLC38A2 mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of SLC38A2 mRNA19467301
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of SLC38A2 mRNA18164116
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SLC38A2 mRNA20360939
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of SLC38A2 mRNA"22485181
C012301domoic aciddomoic acid results in decreased expression of SLC38A2 mRNA18936300
D004317DoxorubicinSLC38A2 mRNA affects the susceptibility to Doxorubicin16044152
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of SLC38A2 mRNA"23811387
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of SLC38A2 mRNA20064776
D004918Erythromycin EstolateErythromycin Estolate results in decreased expression of SLC38A2 mRNA24412560
C004912ethylbenzeneethylbenzene results in increased expression of SLC38A2 mRNA20359517
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of SLC38A2 mRNA23649840
C017690fenvaleratefenvalerate results in decreased expression of SLC38A2 mRNA28369636
D005419FlavonoidsFlavonoids results in decreased expression of SLC38A2 mRNA18035473
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of SLC38A2 mRNA28329830
C061365flusilazoleflusilazole results in increased expression of SLC38A2 mRNA28263823
D005557FormaldehydeFormaldehyde results in increased expression of SLC38A2 mRNA23649840
D005839GentamicinsGentamicins results in increased expression of SLC38A2 mRNA22061828
D017313FenretinideFenretinide results in increased expression of SLC38A2 mRNA28973697
C492448ICG 001ICG 001 results in increased expression of SLC38A2 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SLC38A2 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SLC38A2 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SLC38A2 mRNA28628672
C544151jinfukangjinfukang results in decreased expression of SLC38A2 mRNA27392435
C410337K 7174K 7174 results in increased expression of SLC38A2 mRNA24086573
C008261lead acetatelead acetate results in decreased expression of SLC38A2 mRNA21829687
C045463leflunomideleflunomide results in increased expression of SLC38A2 mRNA28988120
D064704LevofloxacinLevofloxacin results in increased expression of SLC38A2 mRNA24136188
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of SLC38A2 mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of SLC38A2 mRNA16415329
D008070LipopolysaccharidesRanitidine promotes the reaction [Lipopolysaccharides results in increased expression of SLC38A2 mRNA]16415329
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of SLC38A2 mRNA21641980|2308674
D008345ManganeseManganese results in decreased expression of SLC38A2 protein20737472
C013598methoxyacetic acidmethoxyacetic acid results in increased expression of SLC38A2 mRNA18199887
D008752Methylene ChlorideMethylene Chloride results in increased expression of SLC38A2 mRNA20359517
C002950methylformamidemethylformamide analog results in increased expression of SLC38A2 mRNA17040096
C002950methylformamidemethylformamide results in increased expression of SLC38A2 mRNA17040096
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SLC38A2 mRNA28001369
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of SLC38A2 protein26558463
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of SLC38A2 mRNA"20188158
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of SLC38A2 protein26558463
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of SLC38A2 protein24625837
C437683motexafin gadoliniummotexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of SLC38A2 mRNA]16357179
C437683motexafin gadoliniummotexafin gadolinium results in increased expression of SLC38A2 mRNA16357179
C437683motexafin gadoliniumZinc Acetate affects the reaction [motexafin gadolinium results in increased expression of SLC38A2 mRNA]16357179
D009151Mustard GasMustard Gas affects the expression of SLC38A2 mRNA15651846
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of SLC38A2 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SLC38A2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SLC38A2 mRNA"25554681
D009285NaphthoquinonesNaphthoquinones results in increased expression of SLC38A2 mRNA23811387
D009532NickelNickel affects the expression of SLC38A2 mRNA14575637
D009532Nickeltrichostatin A inhibits the reaction [Nickel affects the expression of SLC38A2 mRNA]14575637
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of SLC38A2 mRNA18593933
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of SLC38A2 mRNA28973697
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SLC38A2 mRNA16221955
D010634PhenobarbitalPhenobarbital results in decreased expression of SLC38A2 mRNA19270015
C018637phoronephorone affects the expression of SLC38A2 mRNA18198479
C049032pinosylvinpinosylvin results in increased expression of SLC38A2 mRNA23333577
C006253pirinixic acidpirinixic acid results in decreased expression of SLC38A2 mRNA23811191
C006253pirinixic acidpirinixic acid results in increased expression of SLC38A2 mRNA18445702
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of SLC38A2 mRNA28903501
D011374ProgesteroneProgesterone results in increased expression of SLC38A2 mRNA18037150
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of SLC38A2 mRNA18556351
C045950propiconazolepropiconazole results in increased expression of SLC38A2 mRNA21278054
D011794QuercetinQuercetin results in decreased expression of SLC38A2 mRNA21632981
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of SLC38A2 mRNA16497877
D011899RanitidineRanitidine promotes the reaction [Lipopolysaccharides results in increased expression of SLC38A2 mRNA]16415329
D012293RifampinRifampin results in decreased expression of SLC38A2 mRNA27199754
C496827salubrinalsalubrinal promotes the reaction [arsenic trioxide results in increased expression of SLC38A2 mRNA]23892647
C009250sevofluranesevoflurane affects the expression of SLC38A2 mRNA15967596
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of SLC38A2 mRNA25895662
C009277sodium arsenatesodium arsenate results in decreased expression of SLC38A2 mRNA23922661
C017947sodium arsenitesodium arsenite results in decreased expression of SLC38A2 mRNA28595984
D053260SootSoot results in increased expression of SLC38A2 mRNA26551751
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of SLC38A2 mRNA21641980|2308674
D013467SulindacSulindac results in increased expression of SLC38A2 mRNA11906190
D013629TamoxifenTamoxifen affects the expression of SLC38A2 mRNA20937368
D013739TestosteroneTestosterone results in increased expression of SLC38A2 mRNA20403060
D013739TestosteroneTestosterone results in decreased expression of SLC38A2 mRNA21812961
D013739TestosteroneTestosterone results in decreased expression of SLC38A2 protein21812961
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC38A2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SLC38A2 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC38A2 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SLC38A2 mRNA25613284
D008063Thioctic AcidThioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of SLC38A2 mRNA]23892647
C009495titanium dioxidetitanium dioxide affects the expression of SLC38A2 mRNA17656681|2355797
C009495titanium dioxidetitanium dioxide analog results in increased expression of SLC38A2 mRNA25111187
D014050TolueneToluene results in increased expression of SLC38A2 mRNA20359517
D014050TolueneToluene affects the expression of SLC38A2 mRNA18653662
D014241TrichloroethyleneTrichloroethylene results in increased expression of SLC38A2 mRNA20359517
C012589trichostatin Atrichostatin A inhibits the reaction [Nickel affects the expression of SLC38A2 mRNA]14575637
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SLC38A2 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of SLC38A2 mRNA28973697
D014520UrethaneUrethane results in increased expression of SLC38A2 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of SLC38A2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of SLC38A2 mRNA23179753
D014635Valproic AcidValproic Acid results in decreased methylation of SLC38A2 gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of SLC38A2 mRNA20546886
D014640VancomycinVancomycin results in decreased expression of SLC38A2 mRNA18930951
D015215ZidovudineZidovudine results in decreased expression of SLC38A2 mRNA24292225
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of SLC38A2 mRNA18593933
D019345Zinc Acetatemotexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of SLC38A2 mRNA]16357179
D019345Zinc AcetateZinc Acetate affects the reaction [motexafin gadolinium results in increased expression of SLC38A2 mRNA]16357179
D019345Zinc AcetateZinc Acetate results in increased expression of SLC38A2 mRNA16357179

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25759021  
GO:0015171amino acid transmembrane transporter activity-IBA21873635  
GO:0015171amino acid transmembrane transporter activity-TAS-  
GO:0015186L-glutamine transmembrane transporter activity-IEA-  
GO:0015293symporter activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0003333amino acid transmembrane transport-IBA21873635  
GO:0006814sodium ion transport-IEA-  
GO:0006865amino acid transport-TAS-  
GO:0006868glutamine transport-IEA-  
GO:0007565female pregnancy-IEA-  
GO:0014047glutamate secretion-TAS-  
GO:0021987cerebral cortex development-IEA-  
GO:0031460glycine betaine transport-IEA-  
GO:0032328alanine transport-IEA-  
GO:0034198cellular response to amino acid starvation-IEA-  
GO:0071260cellular response to mechanical stimulus-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005903brush border-IEA-  
GO:0030424axon-IEA-  
GO:0030425dendrite-IEA-  
GO:0042383sarcolemma-IEA-  
GO:0043025neuronal cell body-IEA-  
KEGG ID KEGG Term
hsa04974Protein digestion and absorption
Reactome ID Reactome Term Evidence
R-HSA-112310Neurotransmitter release cycleTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-210500Glutamate Neurotransmitter Release CycleTAS
R-HSA-352230Amino acid transport across the plasma membraneTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-425393Transport of inorganic cations/anions and amino acids/oligopeptidesTAS
R-HSA-425407SLC-mediated transmembrane transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal