Gene info: ID 5441

Gene: POLR2L

GENE ID: 5441

Description: RNA polymerase II subunit L

Gene type: protein-coding

Location: 11p15.5

dbXrefs: Ensembl:ENSG00000177700 MIM:601189 Vega:OTTHUMG00000133316 UniprotKB:P62875

RefSeq: NC_000011.10

Retrived from: SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: AD

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.690e-1 (AD) 3.849e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs11246327	chr11:840034 (GRCh38.p7)	C>A	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ROMO1	0.925
UQCR11	0.915
MRPL52	0.912
NDUFA3	0.905
COX8A	0.904
NDUFA1	0.9
UQCRQ	0.898
NDUFA13	0.894
BLOC1S1	0.894
OST4	0.894

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.778
OR4F29	-0.769
ZC3H11B	-0.247
XIRP2	-0.242
TPH1	-0.229
C1orf146	-0.22
PZP	-0.212
KRT73	-0.209
WFDC12	-0.204
LY75	-0.204

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of POLR2L mRNA"	28973690
D020106	Acrylamide	Acrylamide results in increased expression of POLR2L mRNA	28959563
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in decreased expression of POLR2L mRNA	21298039
D004958	Estradiol	Estradiol affects the expression of POLR2L mRNA	15598610
C006780	bisphenol A	bisphenol A results in decreased methylation of POLR2L promoter	27312807
C006780	bisphenol A	bisphenol A results in increased expression of POLR2L mRNA	25181051
D002104	Cadmium	Cadmium results in decreased expression of POLR2L mRNA	23256528
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of POLR2L mRNA	28472532
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of POLR2L mRNA	19376846
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of POLR2L mRNA	24386269
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of POLR2L mRNA	19549813
D016572	Cyclosporine	Cyclosporine results in decreased expression of POLR2L mRNA	25562108
C089595	cylindrospermopsin	cylindrospermopsin results in increased expression of POLR2L mRNA	24921660
C014347	decitabine	decitabine affects the expression of POLR2L mRNA	23300844
D003907	Dexamethasone	Dexamethasone results in increased expression of POLR2L mRNA	25047013
D003976	Diazinon	Diazinon results in increased methylation of POLR2L gene	22964155
D002945	Cisplatin	Cisplatin affects the expression of POLR2L mRNA	23300844
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of POLR2L mRNA	28085963
D004785	Environmental Pollutants	Environmental Pollutants results in decreased expression of POLR2L mRNA	20064776
D005485	Flutamide	Flutamide results in increased expression of POLR2L mRNA	24136188
D005897	Glafenine	Glafenine results in increased expression of POLR2L mRNA	24136188
D006830	Hydralazine	[Hydralazine co-treated with Valproic Acid] results in increased expression of POLR2L mRNA	17183730
C410337	K 7174	K 7174 results in decreased expression of POLR2L mRNA	24086573
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of POLR2L mRNA	26011545
C568376	MT19c compound	MT19c compound results in decreased expression of POLR2L mRNA	21781307
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of POLR2L mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of POLR2L mRNA"	25554681
D052638	Particulate Matter	Particulate Matter results in decreased expression of POLR2L mRNA	24769257
D010578	Petroleum	Petroleum affects the expression of POLR2L mRNA	25208076
D010634	Phenobarbital	Phenobarbital affects the expression of POLR2L mRNA	19159669
D010936	Plant Extracts	Plant Extracts results in decreased expression of POLR2L mRNA	23557933
C017947	sodium arsenite	sodium arsenite results in increased expression of POLR2L mRNA	28595984
D018038	Sodium Selenite	Sodium Selenite results in increased expression of POLR2L mRNA	18175754
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of POLR2L mRNA	19465110
D013750	Tetrachloroethylene	Tetrachloroethylene results in decreased expression of POLR2L mRNA	28973375
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of POLR2L mRNA"	26179874
D014635	Valproic Acid	[Hydralazine co-treated with Valproic Acid] results in increased expression of POLR2L mRNA	17183730
D014635	Valproic Acid	Valproic Acid affects the expression of POLR2L mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of POLR2L mRNA	23179753\|2718838
D014635	Valproic Acid	Valproic Acid results in increased methylation of POLR2L gene	29154799
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical affects the expression of POLR2L mRNA"	25208076

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001054	RNA polymerase I activity	CONTRIBUTES_TO	IBA	21873635
GO:0001055	RNA polymerase II activity	CONTRIBUTES_TO	IBA	21873635
GO:0001056	RNA polymerase III activity	CONTRIBUTES_TO	IBA	21873635
GO:0003677	DNA binding	-	IEA	-
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	CONTRIBUTES_TO	IBA	21873635
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	-	TAS	8524256
GO:0005515	protein binding	-	IPI	25416956
GO:0008270	zinc ion binding	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000398	mRNA splicing, via spliceosome	-	TAS	-
GO:0006283	transcription-coupled nucleotide-excision repair	-	TAS	-
GO:0006356	regulation of transcription by RNA polymerase I	-	TAS	8786124
GO:0006361	transcription initiation from RNA polymerase I promoter	-	TAS	-
GO:0006363	termination of RNA polymerase I transcription	-	TAS	-
GO:0006366	transcription by RNA polymerase II	-	IDA	9852112
GO:0006366	transcription by RNA polymerase II	-	TAS	-
GO:0006367	transcription initiation from RNA polymerase II promoter	-	TAS	-
GO:0006368	transcription elongation from RNA polymerase II promoter	-	TAS	-
GO:0006370	7-methylguanosine mRNA capping	-	TAS	-
GO:0006383	transcription by RNA polymerase III	-	IEA	-
GO:0008543	fibroblast growth factor receptor signaling pathway	-	TAS	-
GO:0016070	RNA metabolic process	-	TAS	-
GO:0042795	snRNA transcription by RNA polymerase II	-	TAS	-
GO:0045815	positive regulation of gene expression, epigenetic	-	TAS	-
GO:0060964	regulation of gene silencing by miRNA	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000428	DNA-directed RNA polymerase complex	-	IBA	21873635
GO:0005634	nucleus	-	IDA	9852112
GO:0005654	nucleoplasm	-	TAS	-
GO:0005665	DNA-directed RNA polymerase II, core complex	-	IBA	21873635
GO:0005665	DNA-directed RNA polymerase II, core complex	-	IDA	9852112
GO:0005666	DNA-directed RNA polymerase III complex	-	IBA	21873635
GO:0005736	DNA-directed RNA polymerase I complex	-	IBA	21873635
GO:0005829	cytosol	-	TAS	-

KEGG ID	KEGG Term
hsa00230	Purine metabolism
hsa00240	Pyrimidine metabolism
hsa01100	Metabolic pathways
hsa03020	RNA polymerase
hsa05016	Huntington's disease

Reactome ID	Reactome Term	Evidence
R-HSA-112382	Formation of RNA Pol II elongation complex	TAS
R-HSA-113418	Formation of the Early Elongation Complex	TAS
R-HSA-1226099	Signaling by FGFR in disease	IEA
R-HSA-1266738	Developmental Biology	TAS
R-HSA-1266738	Developmental Biology	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-162587	HIV Life Cycle	IEA
R-HSA-162587	HIV Life Cycle	TAS
R-HSA-162599	Late Phase of HIV Life Cycle	IEA
R-HSA-162599	Late Phase of HIV Life Cycle	TAS
R-HSA-162906	HIV Infection	IEA
R-HSA-162906	HIV Infection	TAS
R-HSA-1643685	Disease	IEA
R-HSA-1643685	Disease	TAS
R-HSA-167152	Formation of HIV elongation complex in the absence of HIV Tat	IEA
R-HSA-167158	Formation of the HIV-1 Early Elongation Complex	IEA
R-HSA-167160	RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	IEA
R-HSA-167161	HIV Transcription Initiation	IEA
R-HSA-167162	RNA Polymerase II HIV Promoter Escape	IEA
R-HSA-167169	HIV Transcription Elongation	IEA
R-HSA-167169	HIV Transcription Elongation	TAS
R-HSA-167172	Transcription of the HIV genome	IEA
R-HSA-167172	Transcription of the HIV genome	TAS
R-HSA-167200	Formation of HIV-1 elongation complex containing HIV-1 Tat	IEA
R-HSA-167200	Formation of HIV-1 elongation complex containing HIV-1 Tat	TAS
R-HSA-167238	Pausing and recovery of Tat-mediated HIV elongation	IEA
R-HSA-167242	Abortive elongation of HIV-1 transcript in the absence of Tat	IEA
R-HSA-167243	Tat-mediated HIV elongation arrest and recovery	IEA
R-HSA-167246	Tat-mediated elongation of the HIV-1 transcript	IEA
R-HSA-167246	Tat-mediated elongation of the HIV-1 transcript	TAS
R-HSA-167287	HIV elongation arrest and recovery	IEA
R-HSA-167290	Pausing and recovery of HIV elongation	IEA
R-HSA-168249	Innate Immune System	TAS
R-HSA-168254	Influenza Infection	TAS
R-HSA-168255	Influenza Life Cycle	TAS
R-HSA-168256	Immune System	TAS
R-HSA-168273	Influenza Viral RNA Transcription and Replication	TAS
R-HSA-168325	Viral Messenger RNA Synthesis	TAS
R-HSA-1834949	Cytosolic sensors of pathogen-associated DNA	TAS
R-HSA-1839126	FGFR2 mutant receptor activation	IEA
R-HSA-190236	Signaling by FGFR	TAS
R-HSA-203927	MicroRNA (miRNA) biogenesis	TAS
R-HSA-211000	Gene Silencing by RNA	TAS
R-HSA-211000	Gene Silencing by RNA	IEA
R-HSA-212165	Epigenetic regulation of gene expression	TAS
R-HSA-212165	Epigenetic regulation of gene expression	IEA
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-3700989	Transcriptional Regulation by TP53	TAS
R-HSA-427413	NoRC negatively regulates rRNA expression	IEA
R-HSA-452723	Transcriptional regulation of pluripotent stem cells	TAS
R-HSA-5250913	Positive epigenetic regulation of rRNA expression	TAS
R-HSA-5250924	B-WICH complex positively regulates rRNA expression	TAS
R-HSA-5250941	Negative epigenetic regulation of rRNA expression	IEA
R-HSA-5578749	Transcriptional regulation by small RNAs	TAS
R-HSA-5601884	PIWI-interacting RNA (piRNA) biogenesis	IEA
R-HSA-5617472	Activation of anterior HOX genes in hindbrain development during early embryogenesis	IEA
R-HSA-5619507	Activation of HOX genes during differentiation	IEA
R-HSA-5654738	Signaling by FGFR2	TAS
R-HSA-5655253	Signaling by FGFR2 in disease	IEA
R-HSA-5663202	Diseases of signal transduction	IEA
R-HSA-5663205	Infectious disease	IEA
R-HSA-5663205	Infectious disease	TAS
R-HSA-5696398	Nucleotide Excision Repair	TAS
R-HSA-674695	RNA Polymerase II Pre-transcription Events	TAS
R-HSA-6781823	Formation of TC-NER Pre-Incision Complex	TAS
R-HSA-6781827	Transcription-Coupled Nucleotide Excision Repair (TC-NER)	TAS
R-HSA-6782135	Dual incision in TC-NER	TAS
R-HSA-6782210	Gap-filling DNA repair synthesis and ligation in TC-NER	TAS
R-HSA-6796648	TP53 Regulates Transcription of DNA Repair Genes	TAS
R-HSA-6803529	FGFR2 alternative splicing	TAS
R-HSA-6807505	RNA polymerase II transcribes snRNA genes	TAS
R-HSA-6807505	RNA polymerase II transcribes snRNA genes	IEA
R-HSA-72086	mRNA Capping	TAS
R-HSA-72163	mRNA Splicing - Major Pathway	TAS
R-HSA-72165	mRNA Splicing - Minor Pathway	TAS
R-HSA-72172	mRNA Splicing	TAS
R-HSA-72203	Processing of Capped Intron-Containing Pre-mRNA	TAS
R-HSA-73762	RNA Polymerase I Transcription Initiation	TAS
R-HSA-73762	RNA Polymerase I Transcription Initiation	IEA
R-HSA-73772	RNA Polymerase I Promoter Escape	TAS
R-HSA-73776	RNA Polymerase II Promoter Escape	TAS
R-HSA-73777	RNA Polymerase I Chain Elongation	TAS
R-HSA-73779	RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	TAS
R-HSA-73780	RNA Polymerase III Chain Elongation	IEA
R-HSA-73854	RNA Polymerase I Promoter Clearance	TAS
R-HSA-73854	RNA Polymerase I Promoter Clearance	IEA
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-73857	RNA Polymerase II Transcription	IEA
R-HSA-73863	RNA Polymerase I Transcription Termination	TAS
R-HSA-73864	RNA Polymerase I Transcription	TAS
R-HSA-73864	RNA Polymerase I Transcription	IEA
R-HSA-73894	DNA Repair	TAS
R-HSA-73980	RNA Polymerase III Transcription Termination	IEA
R-HSA-74158	RNA Polymerase III Transcription	IEA
R-HSA-74158	RNA Polymerase III Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-74160	Gene expression (Transcription)	IEA
R-HSA-749476	RNA Polymerase III Abortive And Retractive Initiation	IEA
R-HSA-75953	RNA Polymerase II Transcription Initiation	TAS
R-HSA-75955	RNA Polymerase II Transcription Elongation	TAS
R-HSA-76042	RNA Polymerase II Transcription Initiation And Promoter Clearance	TAS
R-HSA-76046	RNA Polymerase III Transcription Initiation	IEA
R-HSA-76046	RNA Polymerase III Transcription Initiation	TAS
R-HSA-76061	RNA Polymerase III Transcription Initiation From Type 1 Promoter	IEA
R-HSA-76061	RNA Polymerase III Transcription Initiation From Type 1 Promoter	TAS
R-HSA-76066	RNA Polymerase III Transcription Initiation From Type 2 Promoter	IEA
R-HSA-76066	RNA Polymerase III Transcription Initiation From Type 2 Promoter	TAS
R-HSA-76071	RNA Polymerase III Transcription Initiation From Type 3 Promoter	IEA
R-HSA-76071	RNA Polymerase III Transcription Initiation From Type 3 Promoter	TAS
R-HSA-77075	RNA Pol II CTD phosphorylation and interaction with CE	TAS
R-HSA-8851708	Signaling by FGFR2 IIIa TM	IEA
R-HSA-8939211	ESR-mediated signaling	TAS
R-HSA-8953854	Metabolism of RNA	TAS
R-HSA-9006931	Signaling by Nuclear Receptors	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS
R-HSA-9018519	Estrogen-dependent gene expression	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal