Gene: POMC

5443
ACTH|CLIP|LPH|MSH|NPP|OBAIRH|POC
proopiomelanocortin
protein-coding
2p23.3
Ensembl:ENSG00000115138 MIM:176830 Vega:OTTHUMG00000094764 UniprotKB:P01189
NG_008997.1
PubMed
0   ANCO-SNPs
CD|OD|ND|AD
43   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.664e-1 (AD)  3.115e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRL0.607
GH10.576
CGA0.562
LHB0.495
TSHB0.463
DLK10.438
C16orf820.415
IRX30.414
HES40.414
CSTA0.405

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SIGLEC6-0.278
PKD2L1-0.262
NEB-0.248
MYPN-0.244
LHX4-0.238
SH2D1B-0.237
ATAD5-0.237
SMYD1-0.237
THEMIS-0.231
SLCO4C1-0.231

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00836LoperamideSmall Molecule53179-11-6ApprovedTarget
DB01497EtorphineSmall Molecule14521-96-1IllicitTarget
DB01565DihydromorphineSmall Molecule509-60-4Experimental|IllicitTarget
ID Drug Name Action PubMed
C5342221-(2-((1-ethoxycarbonyloxyethoxycarbonylmethyl)carbamoyl)-3-phenylpropyldisulfanylmethyl)-3-methylsulfanylpropylamine1-(2-((1-ethoxycarbonyloxyethoxycarbonylmethyl)carbamoyl)-3-phenylpropyldisulfanylmethyl)-3-methylsulfanylpropylamine results in decreased degradation of POMC protein modified form18938155
C5342221-(2-((1-ethoxycarbonyloxyethoxycarbonylmethyl)carbamoyl)-3-phenylpropyldisulfanylmethyl)-3-methylsulfanylpropylamineN-methylnaloxone inhibits the reaction [1-(2-((1-ethoxycarbonyloxyethoxycarbonylmethyl)carbamoyl)-3-phenylpropyldisulfanylmethyl)-3-methylsulfanylpropylamine results in decreased degradation of POMC protein modified form]18938155
C5179431-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone"1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone results in decreased expression of POMC mRNA"29092056
C03368918-hydroxycortisolPOMC protein results in increased abundance of 18-hydroxycortisol3015796
C05598720-hydroxy-5,8,11,14-eicosatetraenoic acid"N-hydroxy-N'-(4-butyl-2-methylphenyl)formamidine inhibits the reaction [POMC protein affects the abundance of 20-hydroxy-5,8,11,14-eicosatetraenoic acid]"19458537
C05598720-hydroxy-5,8,11,14-eicosatetraenoic acid"POMC protein results in increased abundance of 20-hydroxy-5,8,11,14-eicosatetraenoic acid"18067589|1945853
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of POMC mRNA"27291303
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of POMC mRNA"21394737
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of POMC mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of POMC mRNA"21346803
C4118272,5-dihydro-2,4,5-trimethylthiazoline"2,5-dihydro-2,4,5-trimethylthiazoline affects the expression of POMC"19103229
C4118272,5-dihydro-2,4,5-trimethylthiazoline"[2,5-dihydro-2,4,5-trimethylthiazoline co-treated with 3-hexen-1-ol co-treated with 2-hexenal] results in decreased expression of POMC protein"21515296
C4118272,5-dihydro-2,4,5-trimethylthiazoline"2,5-dihydro-2,4,5-trimethylthiazoline results in decreased expression of POMC protein"21515296
C4118272,5-dihydro-2,4,5-trimethylthiazoline"2,5-dihydro-2,4,5-trimethylthiazoline results in increased secretion of POMC protein"15464754
C4118272,5-dihydro-2,4,5-trimethylthiazoline"[3-hexen-1-ol co-treated with 2-hexenal] inhibits the reaction [2,5-dihydro-2,4,5-trimethylthiazoline results in decreased expression of POMC protein]"21515296
C0312782-chloroethyl ethyl sulfide2-chloroethyl ethyl sulfide results in decreased expression of POMC mRNA16289378
C0517502-hexenal"[2,5-dihydro-2,4,5-trimethylthiazoline co-treated with 3-hexen-1-ol co-treated with 2-hexenal] results in decreased expression of POMC protein"21515296
C0517502-hexenal"[3-hexen-1-ol co-treated with 2-hexenal] inhibits the reaction [2,5-dihydro-2,4,5-trimethylthiazoline results in decreased expression of POMC protein]"21515296
C0517502-hexenal[3-hexen-1-ol co-treated with 2-hexenal] results in decreased expression of POMC19103229
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol affects the expression of POMC mRNA"12641731
C0519183-hexen-1-ol"[2,5-dihydro-2,4,5-trimethylthiazoline co-treated with 3-hexen-1-ol co-treated with 2-hexenal] results in decreased expression of POMC protein"21515296
C0519183-hexen-1-ol"[3-hexen-1-ol co-treated with 2-hexenal] inhibits the reaction [2,5-dihydro-2,4,5-trimethylthiazoline results in decreased expression of POMC protein]"21515296
C0519183-hexen-1-ol[3-hexen-1-ol co-treated with 2-hexenal] results in decreased expression of POMC19103229
C4861844,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol"[4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol co-treated with diarylpropionitrile] results in decreased expression of POMC mRNA"29092056
C0278806-deisopropylatrazine6-deisopropylatrazine results in increased secretion of POMC protein modified form19690231|1971036
C0900198-sulfocholecystokinin octapeptide8-sulfocholecystokinin octapeptide results in increased expression of POMC mRNA20688118
D000079AcetaldehydeAcetaldehyde results in increased expression of POMC mRNA7704432
D000079AcetaldehydeAcetaldehyde results in increased expression of POMC protein7704432
D000082AcetaminophenAcetaminophen results in decreased expression of POMC protein16449370
D000082AcetaminophenAcetaminophen inhibits the reaction [POMC protein results in increased abundance of Hydrocortisone]16551645
C056165acetovanilloneacetovanillone inhibits the reaction [POMC protein affects the abundance of F2-Isoprostanes]16053986
D000109AcetylcholineAcetylcholine results in increased expression of POMC mRNA7588217
D000109AcetylcholineAcetylcholine results in increased expression of POMC protein7588217
D000109AcetylcholineAtropine inhibits the reaction [Acetylcholine results in increased expression of POMC protein]7588217
D000109AcetylcholinePentobarbital inhibits the reaction [Acetylcholine results in increased expression of POMC protein]7588217
D000111AcetylcysteineAcetylcysteine inhibits the reaction [POMC protein promotes the reaction [cobaltous chloride results in increased activity of CASP3 protein]]24412703
C033116acetyl methyl tetramethyl tetralin[acetyl methyl tetramethyl tetralin results in increased expression of MC2R mRNA] which affects the susceptibility to POMC protein23084589
D020106AcrylamideAcrylamide results in increased expression of POMC mRNA15003292
D020106AcrylamideAcrylamide results in increased expression of POMC protein15003292
D000242Cyclic AMPPOMC protein modified form results in increased abundance of Cyclic AMP26586997
D000242Cyclic AMPQuercetin analog inhibits the reaction [POMC protein modified form results in increased abundance of Cyclic AMP]26586997
D000242Cyclic AMPINS1 protein inhibits the reaction [[Theophylline co-treated with POMC protein] results in increased abundance of Cyclic AMP]4306506
D000242Cyclic AMP[Theophylline co-treated with POMC protein] results in increased abundance of Cyclic AMP4306506
D000242Cyclic AMP[POMC protein alternative form binds to MC4R protein] which results in increased abundance of Cyclic AMP23251400
D000305Adrenal Cortex HormonesChloroquine inhibits the reaction [POMC protein modified form results in increased chemical synthesis of Adrenal Cortex Hormones]2993719
D000305Adrenal Cortex HormonesCycloheximide inhibits the reaction [POMC protein modified form results in increased chemical synthesis of Adrenal Cortex Hormones]2993719
D000305Adrenal Cortex HormonesDichlorvos inhibits the reaction [POMC protein modified form results in increased chemical synthesis of Adrenal Cortex Hormones]2993719
D000305Adrenal Cortex HormonesW 7 inhibits the reaction [POMC protein modified form results in increased chemical synthesis of Adrenal Cortex Hormones]2993719
D000305Adrenal Cortex HormonesChloroquine inhibits the reaction [POMC protein modified form results in increased chemical synthesis of Adrenal Cortex Hormones]2993719
D000305Adrenal Cortex HormonesCycloheximide inhibits the reaction [POMC protein modified form results in increased chemical synthesis of Adrenal Cortex Hormones]2993719
D000305Adrenal Cortex HormonesDichlorvos inhibits the reaction [POMC protein modified form results in increased chemical synthesis of Adrenal Cortex Hormones]2993719
D000305Adrenal Cortex Hormonesmevastatin inhibits the reaction [POMC protein modified form results in increased chemical synthesis of Adrenal Cortex Hormones]2993719
D000305Adrenal Cortex HormonesChloroquine inhibits the reaction [POMC protein modified form results in increased chemical synthesis of Adrenal Cortex Hormones]2993719
D000305Adrenal Cortex HormonesCycloheximide inhibits the reaction [POMC protein modified form results in increased chemical synthesis of Adrenal Cortex Hormones]2993719
D000305Adrenal Cortex HormonesDichlorvos inhibits the reaction [POMC protein modified form results in increased chemical synthesis of Adrenal Cortex Hormones]2993719
D000305Adrenal Cortex HormonesW 7 inhibits the reaction [POMC protein modified form results in increased chemical synthesis of Adrenal Cortex Hormones]2993719
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of POMC mRNA23630614
D000450AldosteronePOMC protein results in increased abundance of Aldosterone2831029
D000450AldosteroneDexamethasone inhibits the reaction [POMC protein results in increased abundance of Aldosterone]3015796
D000450AldosteronePOMC protein results in decreased abundance of Aldosterone2551692
D000450AldosteronePOMC protein results in increased abundance of Aldosterone3015796
D000450AldosteronePOMC results in increased secretion of Aldosterone1659878
D00409220-alpha-DihydroprogesteroneCadmium Chloride inhibits the reaction [POMC protein results in increased secretion of 20-alpha-Dihydroprogesterone]8299002
D00409220-alpha-DihydroprogesteronePOMC protein results in increased secretion of 20-alpha-Dihydroprogesterone8299002
C011512alpha-naphthoflavonealpha-naphthoflavone results in decreased activity of POMC protein15635147
C011512alpha-naphthoflavone[beta-Naphthoflavone co-treated with alpha-naphthoflavone] results in decreased activity of POMC protein15635147
C011512alpha-naphthoflavone[beta-Naphthoflavone co-treated with alpha-naphthoflavone] results in increased expression of POMC protein15635147
C010845aluminum chloridealuminum chloride results in increased expression of POMC protein27476752
D006710HomocysteineHomocysteine results in increased expression of POMC mRNA17326132
D000643Ammonium ChlorideAmmonium Chloride affects the expression of POMC mRNA16483693
C103016antalarminantalarmin affects the reaction [CRH protein results in increased expression of POMC protein alternative form]14997174
D001218AspartameAspartame results in increased expression of POMC protein alternative form1805284
C528574astressin-2Bastressin-2B results in increased secretion of POMC protein alternative form12746300
C120841astressin Bastressin B inhibits the reaction [CRH protein results in increased expression of POMC protein alternative form]14997174
C120841astressin Bastressin B inhibits the reaction [CARTPT protein results in increased secretion of POMC protein alternative form]15271883
C120841astressin Bastressin B inhibits the reaction [CRH protein results in increased secretion of POMC protein alternative form]10447963
C120841astressin Bastressin B inhibits the reaction [Ethanol results in decreased secretion of POMC protein alternative form]12746300
C120841astressin Bastressin B inhibits the reaction [Lipopolysaccharides results in decreased secretion of POMC protein alternative form]12746300
C120841astressin Bastressin B inhibits the reaction [Lipopolysaccharides results in increased expression of POMC protein alternative form]12207160
C120841astressin Bastressin B inhibits the reaction [Turpentine results in increased expression of POMC protein alternative form]12207160
D001280AtrazineAtrazine results in increased expression of POMC mRNA27495953
D001280AtrazineAtrazine results in decreased expression of POMC mRNA25929836
D001280AtrazineAtrazine results in increased secretion of POMC protein modified form19690231|1971036
D001280Atrazinelycopene inhibits the reaction [Atrazine results in increased secretion of POMC protein modified form]27102619
D001285AtropineAtropine inhibits the reaction [Acetylcholine results in increased expression of POMC protein]7588217
D019324beta-Naphthoflavone[beta-Naphthoflavone co-treated with alpha-naphthoflavone] results in decreased activity of POMC protein15635147
D019324beta-Naphthoflavone[beta-Naphthoflavone co-treated with alpha-naphthoflavone] results in increased expression of POMC protein15635147
D019324beta-Naphthoflavonebeta-Naphthoflavone results in decreased activity of POMC protein15635147
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of POMC mRNA21839799
C475503benzylphosphonic acidbenzylphosphonic acid results in decreased activity of POMC protein12530643
C475503benzylphosphonic acid[benzylphosphonic acid results in decreased activity of POMC protein] which results in decreased chemical synthesis of Progesterone12530643
D004958EstradiolEstradiol affects the reaction [Dieldrin results in decreased expression of POMC mRNA]23041725
D004958EstradiolEstradiol results in decreased expression of POMC mRNA29092056
D004958EstradiolEstradiol affects the reaction [Dronabinol results in increased expression of POMC mRNA]11528220
D004958EstradiolEstradiol inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in decreased activity of HTR1A protein] which results in increased expression of POMC protein modified form]22265196
C023888beta-hexachlorocyclohexane[Dichlorodiphenyl Dichloroethylene co-treated with beta-hexachlorocyclohexane] results in decreased expression of POMC mRNA16758953
C095105bexarotenebexarotene analog results in decreased expression of POMC mRNA28689802
D001629BezafibrateBezafibrate results in decreased expression of POMC mRNA18787029
C006780bisphenol Abisphenol A results in decreased expression of POMC mRNA29092056
C006780bisphenol Abisphenol A affects the expression of POMC mRNA24323913|2485795
C006780bisphenol Abisphenol A results in decreased expression of POMC mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of POMC protein25812946|2606044
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [Cadmium Chloride inhibits the reaction [POMC protein results in increased abundance of Hydrocortisone]]21396343
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [Cadmium Chloride inhibits the reaction [POMC results in increased expression of CYP11A1 mRNA]]21396343
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [Cadmium Chloride inhibits the reaction [POMC results in increased expression of MC2R mRNA]]21396343
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [Cadmium Chloride inhibits the reaction [POMC results in increased expression of STAR mRNA]]21396343
D001971BromocriptineBromocriptine results in increased expression of POMC mRNA1325994
D001971BromocriptineBromocriptine results in increased expression of POMC protein modified form1325994
D001971BromocriptineBromocriptine inhibits the reaction [POMC protein results in decreased secretion of Corticosterone]12742521
D001971BromocriptineBromocriptine results in decreased expression of POMC protein alternative form6274577
D002065BuspironeBuspirone results in increased expression of POMC protein19762159
D002065BuspironeImipramine inhibits the reaction [Buspirone results in increased expression of POMC protein]19762159
D002079Butter[Butter co-treated with Dietary Fats] results in increased expression of POMC mRNA23038630
D002104CadmiumCadmium inhibits the reaction [POMC protein results in increased secretion of Hydrocortisone]15019247
D002104CadmiumCadmium inhibits the reaction [POMC protein results in increased secretion of Hydrocortisone]15019247
D019256Cadmium ChlorideCadmium Chloride inhibits the reaction [POMC protein results in increased secretion of 20-alpha-Dihydroprogesterone]8299002
D019256Cadmium Chloride8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [Cadmium Chloride inhibits the reaction [POMC protein results in increased abundance of Hydrocortisone]]21396343
D019256Cadmium Chloride8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [Cadmium Chloride inhibits the reaction [POMC results in increased expression of CYP11A1 mRNA]]21396343
D019256Cadmium Chloride8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [Cadmium Chloride inhibits the reaction [POMC results in increased expression of MC2R mRNA]]21396343
D019256Cadmium Chloride8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [Cadmium Chloride inhibits the reaction [POMC results in increased expression of STAR mRNA]]21396343
D019256Cadmium ChlorideCadmium Chloride inhibits the reaction [POMC protein results in increased abundance of Hydrocortisone]21396343
D019256Cadmium ChlorideCadmium Chloride inhibits the reaction [POMC results in increased expression of CYP11A1 mRNA]21396343
D019256Cadmium ChlorideCadmium Chloride inhibits the reaction [POMC results in increased expression of MC2R mRNA]21396343
D019256Cadmium ChlorideCadmium Chloride inhibits the reaction [POMC results in increased expression of STAR mRNA]21396343
D019256Cadmium ChlorideCadmium Chloride affects the expression of POMC protein20652474
D002110CaffeineCaffeine results in increased secretion of POMC protein alternative form22959462
D002118CalciumNaloxone inhibits the reaction [POMC protein alternative form results in increased abundance of Calcium]6193972
D002118CalciumPOMC protein alternative form results in increased abundance of Calcium6193972
D002211CapsaicinCapsaicin inhibits the reaction [[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein]2846107
D002211CapsaicinCapsaicin inhibits the reaction [[Morphine co-treated with Naloxone] results in increased secretion of POMC protein]2846107
D002211CapsaicinCapsaicin results in increased expression of POMC protein22150557
D002211CapsaicinCapsaicin results in increased secretion of POMC protein8925284
D002211Capsaicincapsazepine inhibits the reaction [Capsaicin results in increased secretion of POMC protein]8925284
D002211CapsaicinCP 96345 inhibits the reaction [Capsaicin results in increased secretion of POMC protein]8925284
D002211CapsaicinDizocilpine Maleate inhibits the reaction [Capsaicin results in increased secretion of POMC protein]8925284
D002211CapsaicinLidocaine inhibits the reaction [Capsaicin results in increased secretion of POMC protein]8925284
D002211Capsaicin[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of POMC protein]22150557
D002211CapsaicinNaproxen inhibits the reaction [Capsaicin results in increased expression of POMC protein]22150557
D002211CapsaicinSumatriptan inhibits the reaction [Capsaicin results in increased expression of POMC protein]22150557
C071423capsazepinecapsazepine inhibits the reaction [Capsaicin results in increased secretion of POMC protein]8925284
D002220CarbamazepineCarbamazepine affects the expression of POMC mRNA25979313
D002251Carbon TetrachloridePOMC protein inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]16508911
D002251Carbon TetrachloridePOMC protein inhibits the reaction [Carbon Tetrachloride results in increased expression of ICAM1 mRNA]16508911
D002251Carbon TetrachloridePOMC protein inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]16508911
D002251Carbon TetrachloridePOMC protein inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]16508911
D002251Carbon TetrachloridePOMC protein inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 mRNA]16508911
D002251Carbon TetrachloridePOMC protein inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 protein]16508911
D002251Carbon TetrachloridePOMC protein inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP2 mRNA]16508911
D002251Carbon TetrachloridePOMC protein inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]16508911
D002251Carbon TetrachloridePOMC protein inhibits the reaction [Carbon Tetrachloride results in increased expression of VCAM1 mRNA]16508911
D002251Carbon TetrachloridePOMC protein promotes the reaction [Carbon Tetrachloride results in increased activity of MMP2 protein]16508911
D002251Carbon TetrachloridePOMC protein promotes the reaction [Carbon Tetrachloride results in increased expression of MMP1 protein]16508911
D002301Cardiac GlycosidesPOMC protein results in increased abundance of Cardiac Glycosides18487447
D000068579CelecoxibCelecoxib inhibits the reaction [docetaxel results in increased expression of POMC mRNA]22902858
D010133p-Chloroamphetamine[Melatonin co-treated with p-Chloroamphetamine] results in increased expression of POMC protein11478929
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of POMC mRNA15721885
D002738ChloroquineChloroquine inhibits the reaction [POMC protein modified form results in increased chemical synthesis of Adrenal Cortex Hormones]2993719
D002738ChloroquineChloroquine inhibits the reaction [POMC protein modified form results in increased chemical synthesis of Adrenal Cortex Hormones]2993719
D002738ChloroquineChloroquine inhibits the reaction [POMC protein modified form results in increased chemical synthesis of Adrenal Cortex Hormones]2993719
D015283CitalopramCitalopram results in increased expression of POMC protein20414043
D002994ClofibrateClofibrate results in increased expression of POMC mRNA17585979
D003000ClonidineClonidine results in increased expression of POMC protein2455169|6089027
D003000Clonidine[Clonidine results in increased expression of POMC protein] which results in increased susceptibility to Naloxone6089027
D003000ClonidineCapsaicin inhibits the reaction [[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein]2846107
D003000Clonidine[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein2846107
D003000ClonidineClonidine results in decreased expression of POMC protein3039113
D003000ClonidineClonidine results in increased secretion of POMC protein alternative form10898105
D003000ClonidineIndomethacin inhibits the reaction [Clonidine results in increased secretion of POMC protein alternative form]10898105
C018021cobaltous chlorideAcetylcysteine inhibits the reaction [POMC protein promotes the reaction [cobaltous chloride results in increased activity of CASP3 protein]]24412703
C018021cobaltous chloridePOMC protein modified form inhibits the reaction [cobaltous chloride results in decreased expression of NOX4 mRNA]24412703
C018021cobaltous chloridePOMC protein modified form inhibits the reaction [cobaltous chloride results in decreased expression of NOX4 protein]24412703
C018021cobaltous chloridePOMC protein promotes the reaction [cobaltous chloride results in increased activity of CASP3 protein]24412703
D003042CocaineCocaine affects the expression of POMC mRNA11427339
D003042CocaineCocaine results in increased secretion of POMC protein11750770
D003042CocainePOMC results in increased susceptibility to Cocaine18176854
D003042CocaineCocaine results in increased expression of POMC protein17001283|9610951
D003042CocaineCocaine results in increased expression of POMC protein alternative form8301594
D003042Cocaine[CTAP octapeptide binds to and results in decreased activity of OPRM1 protein] inhibits the reaction [POMC protein results in increased susceptibility to Cocaine]19279569
D003042Cocaineeticlopride inhibits the reaction [Cocaine results in increased expression of POMC protein]17001283
D003042CocainePOMC results in increased susceptibility to Cocaine19279569
D003042CocaineCocaine affects the secretion of POMC protein18176854
D003078ColchicineColchicine results in increased secretion of POMC protein2453250
D003345Corticosterone"lipopolysaccharide, Escherichia coli O111 B4 inhibits the reaction [POMC protein modified form results in increased secretion of Corticosterone]"27052214
D003345CorticosteronePOMC protein modified form results in increased secretion of Corticosterone27052214
D003345Corticosterone"resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 inhibits the reaction [POMC protein modified form results in increased secretion of Corticosterone]]"27052214
D003345CorticosteroneBromocriptine inhibits the reaction [POMC protein results in decreased secretion of Corticosterone]12742521
D003345CorticosteroneCorticosterone inhibits the reaction [Nitroprusside results in increased secretion of POMC protein]3015567
D003345CorticosteroneCorticosterone results in decreased secretion of POMC protein3015567
D003345CorticosteroneCromolyn Sodium inhibits the reaction [POMC results in increased secretion of Corticosterone]1659878
D003345Corticosteronefulvestrant inhibits the reaction [nonylphenol promotes the reaction [POMC protein modified form results in increased secretion of Corticosterone]]20837582
D003345CorticosteroneNitroprusside inhibits the reaction [POMC protein modified form results in increased secretion of Corticosterone]20837582
D003345Corticosteronenonylphenol inhibits the reaction [Nitroprusside inhibits the reaction [POMC protein modified form results in increased secretion of Corticosterone]]20837582
D003345Corticosteronenonylphenol promotes the reaction [POMC protein modified form results in increased secretion of Corticosterone]20837582
D003345Corticosteroneoxophenylarsine inhibits the reaction [POMC protein results in increased abundance of Corticosterone]10518784
D003345Corticosteronepervanadate inhibits the reaction [POMC protein results in increased abundance of Corticosterone]10518784
D003345CorticosteronePOMC protein modified form results in increased secretion of Corticosterone20837582
D003345CorticosteronePOMC protein results in decreased abundance of Corticosterone11518849
D003345CorticosteronePOMC protein results in decreased secretion of Corticosterone12742521
D003345CorticosteronePOMC protein results in increased abundance of Corticosterone10518784|7588239
D003345CorticosteronePOMC protein results in increased secretion of Corticosterone11132610
D003345CorticosteronePOMC results in increased secretion of Corticosterone1659878
D003345CorticosteroneSB 203580 inhibits the reaction [POMC protein modified form results in increased secretion of Corticosterone]20837582
C101628CP 154526[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased secretion of POMC protein modified form]24398105
C101628CP 154526[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone results in increased secretion of POMC protein modified form]24398105
C066892CP 96345CP 96345 inhibits the reaction [Capsaicin results in increased secretion of POMC protein]8925284
D016578Crack CocaineCrack Cocaine results in increased secretion of POMC protein10780258
D016578Crack CocaineDexamethasone inhibits the reaction [Crack Cocaine results in increased secretion of POMC protein]10780258
D004205Cromolyn SodiumCromolyn Sodium inhibits the reaction [POMC results in increased secretion of Corticosterone]1659878
C529311CTAP octapeptide[CTAP octapeptide binds to and results in decreased activity of OPRM1 protein] inhibits the reaction [POMC protein results in increased susceptibility to Cocaine]19279569
C029892cupric chloridecupric chloride results in increased expression of POMC mRNA21072851
D003484Cyanamide[Cyanamide co-treated with Ethanol] results in increased expression of POMC mRNA16375214
D003484CyanamideCyanamide results in increased expression of POMC mRNA10978654
D003484Cyanamide[Ethanol co-treated with Cyanamide] results in decreased expression of POMC mRNA16375214
D003484Cyanamide[Ethanol co-treated with Cyanamide] results in increased expression of POMC mRNA11139417
D003513CycloheximideCycloheximide inhibits the reaction [POMC protein modified form results in increased chemical synthesis of Adrenal Cortex Hormones]2993719
D003513CycloheximideCycloheximide inhibits the reaction [POMC protein modified form results in increased chemical synthesis of Adrenal Cortex Hormones]2993719
D003513CycloheximideCycloheximide inhibits the reaction [POMC protein modified form results in increased chemical synthesis of Adrenal Cortex Hormones]2993719
D003520CyclophosphamideCyclophosphamide results in increased expression of POMC protein15276878
D003533CyproheptadineCyproheptadine results in decreased secretion of POMC protein642945
D003634DDT[Lindane co-treated with DDT] results in increased expression of POMC16329587
C446541deethylatrazinedeethylatrazine results in increased secretion of POMC protein modified form19690231
D019314Dehydroepiandrosterone SulfatePOMC results in increased abundance of Dehydroepiandrosterone Sulfate2161262
D013759DronabinolDronabinol affects the expression of POMC mRNA12829401
D013759DronabinolDronabinol results in increased expression of POMC10219981
D013759DronabinolDronabinol results in increased expression of POMC mRNA11528220|9128838
D013759DronabinolEstradiol affects the reaction [Dronabinol results in increased expression of POMC mRNA]11528220
D003907DexamethasoneDexamethasone inhibits the reaction [Crack Cocaine results in increased secretion of POMC protein]10780258
D003907DexamethasoneDexamethasone inhibits the reaction [POMC protein results in increased abundance of Aldosterone]3015796
D003907DexamethasoneDexamethasone results in decreased expression of POMC protein174842
D003907DexamethasoneDexamethasone results in decreased secretion of POMC protein9253312
D003907DexamethasonePOMC affects the susceptibility to Dexamethasone1459535
C492519diarylpropionitrile"[4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol co-treated with diarylpropionitrile] results in decreased expression of POMC mRNA"29092056
D003994BucladesineBucladesine results in increased expression of POMC mRNA1325994
D003994BucladesineBucladesine results in increased expression of POMC protein modified form1325994
D003633Dichlorodiphenyl Dichloroethylene[Dichlorodiphenyl Dichloroethylene co-treated with beta-hexachlorocyclohexane] results in decreased expression of POMC mRNA16758953
D004006DichlorvosDichlorvos inhibits the reaction [POMC protein modified form results in increased chemical synthesis of Adrenal Cortex Hormones]2993719
D004006DichlorvosDichlorvos inhibits the reaction [POMC protein modified form results in increased chemical synthesis of Adrenal Cortex Hormones]2993719
D004006DichlorvosDichlorvos inhibits the reaction [POMC protein modified form results in increased chemical synthesis of Adrenal Cortex Hormones]2993719
D004006DichlorvosDichlorvos results in increased secretion of POMC protein modified form6245657
D004026DieldrinDieldrin results in decreased expression of POMC mRNA23041725
D004026DieldrinEstradiol affects the reaction [Dieldrin results in decreased expression of POMC mRNA]23041725
D004041Dietary Fats[Butter co-treated with Dietary Fats] results in increased expression of POMC mRNA23038630
D004041Dietary Fats[Margarine co-treated with Dietary Fats] results in increased expression of POMC mRNA23038630
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of POMC mRNA28871463
C034504digoxin-like factorsPOMC protein results in increased abundance of digoxin-like factors8136112
D0151279,10-Dimethyl-1,2-benzanthracene"POMC protein promotes the reaction [CYP1B1 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene]"7588239
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in decreased expression of POMC protein15680486
D004221DisulfiramDisulfiram results in decreased expression of POMC protein alternative form8246921
D004050DitiocarbDitiocarb promotes the reaction [Sodium Selenite inhibits the reaction [POMC protein results in increased secretion of Hydrocortisone]]21466817
D016291Dizocilpine MaleateDizocilpine Maleate inhibits the reaction [Capsaicin results in increased secretion of POMC protein]8925284
C067311docetaxelCelecoxib inhibits the reaction [docetaxel results in increased expression of POMC mRNA]22902858
C067311docetaxeldocetaxel results in increased expression of POMC mRNA22902858
C067311docetaxelN-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [docetaxel results in increased expression of POMC mRNA]22902858
D007980LevodopaLevodopa promotes the reaction [Oxidopamine results in increased expression of POMC protein]16325000
C001123dopachrome[POMC protein modified form results in increased activity of TYR protein] which results in increased chemical synthesis of dopachrome26586997
C001123dopachromeQuercetin analog inhibits the reaction [[POMC protein modified form results in increased activity of TYR protein] which results in increased chemical synthesis of dopachrome]26586997
D004298DopaminePOMC protein affects the reaction [Nicotine results in increased abundance of Dopamine]15689546
D004785Environmental Pollutants"[[Phytochemicals co-treated with Environmental Pollutants co-treated with Food Preservatives co-treated with Plasticizers co-treated with Sunscreening Agents co-treated with Insecticides co-treated with Fungicides, Industrial co-treated with Herbicides] affects the susceptibility to perfluorononanoic acid] which results in decreased expression of POMC protein modified form"25588985
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of POMC mRNA20706672
D000431EthanolEthanol results in decreased expression of POMC mRNA17934066
D000431Ethanolfomepizole inhibits the reaction [Ethanol results in decreased expression of POMC mRNA]17934066
D000431Ethanolastressin B inhibits the reaction [Ethanol results in decreased secretion of POMC protein alternative form]12746300
D000431Ethanol[Cyanamide co-treated with Ethanol] results in increased expression of POMC mRNA16375214
D000431Ethanol[Ethanol co-treated with Cyanamide] results in decreased expression of POMC mRNA16375214
D000431Ethanol[Ethanol co-treated with Cyanamide] results in increased expression of POMC mRNA11139417
D000431EthanolEthanol results in decreased secretion of POMC protein alternative form12746300
D000431EthanolEthanol results in increased expression of and results in increased secretion of POMC protein20021565
D000431EthanolEthanol results in increased expression of POMC mRNA16925589|7704432
D000431EthanolEthanol results in increased expression of POMC protein16925589|7704432
D000431EthanolPOMC protein affects the reaction [Ethanol results in increased abundance of Steroids]20021565
D000431EthanolPOMC protein affects the susceptibility to Ethanol20021565
D000431EthanolR 121919 inhibits the reaction [Ethanol results in decreased secretion of POMC protein alternative form]12746300
D004986EtherEther results in increased secretion of POMC protein2846107
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of POMC mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of POMC mRNA17942748
C045989eticloprideeticlopride inhibits the reaction [Cocaine results in increased expression of POMC protein]17001283
D028441F2-Isoprostanesacetovanillone inhibits the reaction [POMC protein affects the abundance of F2-Isoprostanes]16053986
D028441F2-IsoprostanesPOMC protein results in increased abundance of F2-Isoprostanes12872045|1605398
D005283Fentanyl[Fentanyl co-treated with Morphine] results in decreased expression of POMC protein alternative form20084599
D005283FentanylFentanyl results in decreased expression of POMC protein alternative form20084599
D018120Finasteride[Finasteride results in increased susceptibility to IL1B protein] which results in increased secretion of POMC protein19458216
D005411Flame RetardantsFlame Retardants results in increased expression of POMC mRNA29112739
D005438Fludrocortisone[Fludrocortisone binds to and results in increased activity of NR3C2 protein] which results in decreased expression of POMC protein16566900
D005473FluoxetineFluoxetine results in increased expression of POMC protein22374755
D005473FluoxetineFluoxetine results in decreased expression of POMC mRNA15936043|1604208
D005473FluoxetineFluoxetine results in increased expression of POMC mRNA18359080
D005473FluoxetineFluoxetine results in increased expression of POMC protein18359080
C010238fomepizolefomepizole inhibits the reaction [Ethanol results in decreased expression of POMC mRNA]17934066
D005520Food Preservatives"[[Phytochemicals co-treated with Environmental Pollutants co-treated with Food Preservatives co-treated with Plasticizers co-treated with Sunscreening Agents co-treated with Insecticides co-treated with Fungicides, Industrial co-treated with Herbicides] affects the susceptibility to perfluorononanoic acid] which results in decreased expression of POMC protein modified form"25588985
D005557FormaldehydeFormaldehyde results in increased expression of POMC mRNA15196973|1580573
D005557FormaldehydeFormaldehyde results in increased expression of POMC protein15196973|1580573
D005632FructoseFructose results in decreased expression of POMC mRNA18627777
C070081fulvestrantfulvestrant inhibits the reaction [nonylphenol promotes the reaction [POMC protein modified form results in increased secretion of Corticosterone]]20837582
D005659Fungicides, Industrial"[[Phytochemicals co-treated with Environmental Pollutants co-treated with Food Preservatives co-treated with Plasticizers co-treated with Sunscreening Agents co-treated with Insecticides co-treated with Fungicides, Industrial co-treated with Herbicides] affects the susceptibility to perfluorononanoic acid] which results in decreased expression of POMC protein modified form"25588985
D019833GenisteinGenistein results in decreased expression of POMC mRNA20706672
D005947GlucoseGlucose results in increased susceptibility to POMC protein19489000
D005947GlucosePOMC inhibits the reaction [INS1 results in increased uptake of Glucose]18310442
D005947GlucoseGlucose results in decreased expression of POMC mRNA18627777
D005990GlycerolPOMC protein alternative form results in increased secretion of Glycerol8429757
D006152Cyclic GMPPOMC protein affects the abundance of Cyclic GMP11193135
D006153Guanosine Diphosphate[Guanosine Diphosphate co-treated with Sodium Chloride] results in decreased activity of POMC protein modified form2550106
D006160Guanosine Triphosphate[Guanosine Triphosphate co-treated with Lithium] results in decreased activity of POMC protein modified form2550106
D006160Guanosine Triphosphate[Guanosine Triphosphate co-treated with Potassium] results in decreased activity of POMC protein modified form2550106
D006160Guanosine Triphosphate[Guanosine Triphosphate co-treated with Sodium Chloride] results in decreased activity of POMC protein modified form2550106
D006160Guanosine Triphosphate[Guanosine Triphosphate co-treated with Sodium Chloride] results in decreased activity of POMC protein modified form2550106
D006165Guanylyl Imidodiphosphate[Guanylyl Imidodiphosphate co-treated with Sodium Chloride] results in decreased activity of POMC protein modified form2550106
D006165Guanylyl Imidodiphosphate[Guanylyl Imidodiphosphate co-treated with Sodium Chloride] results in decreased activity of POMC protein modified form2550106
D006221HalothaneHalothane results in increased secretion of POMC protein2846107
D006540Herbicides"[[Phytochemicals co-treated with Environmental Pollutants co-treated with Food Preservatives co-treated with Plasticizers co-treated with Sunscreening Agents co-treated with Insecticides co-treated with Fungicides, Industrial co-treated with Herbicides] affects the susceptibility to perfluorononanoic acid] which results in decreased expression of POMC protein modified form"25588985
C018959hexadecafluoro-nonanoic acidhexadecafluoro-nonanoic acid results in increased secretion of POMC protein alternative form18583369
D006854HydrocortisonePOMC protein results in increased abundance of Hydrocortisone2831029
D006854HydrocortisoneLead inhibits the reaction [POMC protein modified form results in increased secretion of Hydrocortisone]22112310
D006854HydrocortisoneMelatonin inhibits the reaction [POMC protein results in increased abundance of Hydrocortisone]21332028
D006854HydrocortisonePOMC protein results in increased abundance of Hydrocortisone21332028|9881897
D006854HydrocortisonePOMC protein results in increased secretion of Hydrocortisone11082157|1321309
D006854HydrocortisonePOMC protein results in increased susceptibility to Hydrocortisone3015460
D006854Hydrocortisone8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [Cadmium Chloride inhibits the reaction [POMC protein results in increased abundance of Hydrocortisone]]21396343
D006854HydrocortisoneAcetaminophen inhibits the reaction [POMC protein results in increased abundance of Hydrocortisone]16551645
D006854HydrocortisoneCadmium Chloride inhibits the reaction [POMC protein results in increased abundance of Hydrocortisone]21396343
D006854HydrocortisoneCadmium inhibits the reaction [POMC protein results in increased secretion of Hydrocortisone]15019247
D006854HydrocortisoneIbuprofen inhibits the reaction [POMC protein results in increased abundance of Hydrocortisone]16551645
D006854HydrocortisonePOMC protein results in increased abundance of Hydrocortisone16551645|2139634
D006854HydrocortisonePOMC protein results in increased secretion of Hydrocortisone15019247
D006854HydrocortisoneSalicylic Acid inhibits the reaction [POMC protein results in increased abundance of Hydrocortisone]16551645
D006854HydrocortisonePOMC protein results in increased abundance of Hydrocortisone21466837
D006854HydrocortisoneCadmium inhibits the reaction [POMC protein results in increased secretion of Hydrocortisone]15019247
D006854HydrocortisonePOMC protein results in increased secretion of Hydrocortisone15019247
D006854HydrocortisoneDitiocarb promotes the reaction [Sodium Selenite inhibits the reaction [POMC protein results in increased secretion of Hydrocortisone]]21466817
D006854HydrocortisonePOMC protein alternative form results in increased abundance of Hydrocortisone1666317
D006854HydrocortisonePOMC protein results in increased secretion of Hydrocortisone21466817|2210084
D006854HydrocortisoneSodium Selenite inhibits the reaction [POMC protein results in increased secretion of Hydrocortisone]21466817
D003900DesoxycorticosteronePOMC protein results in increased abundance of Desoxycorticosterone3015796
D007052IbuprofenIbuprofen inhibits the reaction [POMC protein results in increased abundance of Hydrocortisone]16551645
D007099ImipramineImipramine inhibits the reaction [Buspirone results in increased expression of POMC protein]19762159
D007213IndomethacinIndomethacin inhibits the reaction [Clonidine results in increased secretion of POMC protein alternative form]10898105
D007213IndomethacinIndomethacin inhibits the reaction [Phenylephrine results in increased secretion of POMC protein alternative form]10898105
D007306Insecticides"[[Phytochemicals co-treated with Environmental Pollutants co-treated with Food Preservatives co-treated with Plasticizers co-treated with Sunscreening Agents co-treated with Insecticides co-treated with Fungicides, Industrial co-treated with Herbicides] affects the susceptibility to perfluorononanoic acid] which results in decreased expression of POMC protein modified form"25588985
D007545IsoproterenolIsoproterenol results in increased secretion of POMC protein alternative form10898105
D007654KetoconazoleKetoconazole results in decreased expression of POMC protein modified form25808816
D064747LansoprazoleLansoprazole results in increased expression of POMC protein16524691
D007854LeadLead inhibits the reaction [POMC protein modified form results in increased secretion of Hydrocortisone]22112310
D008012LidocaineLidocaine inhibits the reaction [Capsaicin results in increased secretion of POMC protein]8925284
D001556Lindane[Lindane co-treated with DDT] results in increased expression of POMC16329587
C002385linsidomineCRH protein affects the reaction [linsidomine results in increased secretion of POMC protein alternative form]10460269
C002385linsidominelinsidomine results in increased secretion of POMC protein alternative form10460269
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 inhibits the reaction [POMC protein modified form results in increased secretion of Corticosterone]"27052214
C440499lipopolysaccharide, Escherichia coli O111 B4"resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 inhibits the reaction [POMC protein modified form results in increased secretion of Corticosterone]]"27052214
D008070LipopolysaccharidesLipopolysaccharides affects the expression of POMC mRNA15667454
D008070Lipopolysaccharidesastressin B inhibits the reaction [Lipopolysaccharides results in decreased secretion of POMC protein alternative form]12746300
D008070Lipopolysaccharidesastressin B inhibits the reaction [Lipopolysaccharides results in increased expression of POMC protein alternative form]12207160
D008070LipopolysaccharidesLipopolysaccharides results in decreased secretion of POMC protein alternative form12746300
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of POMC protein16522730
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of POMC protein alternative form12207160
D008070LipopolysaccharidesR 121919 inhibits the reaction [Lipopolysaccharides results in decreased secretion of POMC protein alternative form]12746300
D008094Lithium[Guanosine Triphosphate co-treated with Lithium] results in decreased activity of POMC protein modified form2550106
C015329lycopenelycopene inhibits the reaction [Atrazine results in increased secretion of POMC protein modified form]27102619
D008274MagnesiumPhentolamine inhibits the reaction [POMC results in increased uptake of Magnesium]191614
D008274MagnesiumPOMC modified form results in decreased uptake of Magnesium191614
D008274MagnesiumPOMC results in increased uptake of Magnesium191614
D008383Margarine[Margarine co-treated with Dietary Fats] results in increased expression of POMC mRNA23038630
D008543MelaninsPOMC protein modified form results in increased chemical synthesis of Melanins26586997
D008543MelaninsQuercetin analog inhibits the reaction [POMC protein modified form results in increased chemical synthesis of Melanins]26586997
D008550MelatoninMelatonin inhibits the reaction [POMC protein results in increased abundance of Hydrocortisone]21332028
D008550MelatoninMelatonin inhibits the reaction [POMC protein results in increased abundance of Progesterone]21332028
D008550MelatoninMelatonin results in decreased susceptibility to POMC protein19301769
D008550Melatonin[Melatonin co-treated with p-Chloroamphetamine] results in increased expression of POMC protein11478929
C014655methamidophosmethamidophos results in increased expression of POMC protein alternative form11048668
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of POMC mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"naltrindole inhibits the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of POMC mRNA]"19523041
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of POMC mRNA"19523041
D008797MetyraponeMetyrapone results in increased expression of POMC protein16566900
D008797MetyraponeMetyrapone results in increased expression of POMC protein15265784
D008797MetyraponeMetyrapone results in increased expression of POMC638031
C012258mevastatinmevastatin inhibits the reaction [POMC protein modified form results in increased chemical synthesis of Adrenal Cortex Hormones]2993719
D009020Morphine[Fentanyl co-treated with Morphine] results in decreased expression of POMC protein alternative form20084599
D009020MorphineMorphine results in increased expression of POMC mRNA20144693
D009020Morphine[Zymosan co-treated with Morphine] results in increased expression of POMC mRNA15979727
D009020MorphineCapsaicin inhibits the reaction [[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein]2846107
D009020MorphineCapsaicin inhibits the reaction [[Morphine co-treated with Naloxone] results in increased secretion of POMC protein]2846107
D009020Morphine[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein2846107
D009020Morphine[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased secretion of POMC protein modified form]24398105
D009020Morphine[Morphine co-treated with Naloxone] results in increased secretion of POMC protein2846107
D009020MorphineMorphine deficiency results in increased secretion of POMC protein modified form24398105
D009020MorphineMorphine affects the susceptibility to POMC protein7127082
D009020MorphinePOMC results in decreased susceptibility to Morphine3421781
D009118MuscimolMuscimol promotes the reaction [Pentobarbital results in decreased expression of POMC mRNA]7937335
D009118MuscimolMuscimol results in decreased expression of POMC mRNA7937335
D009151Mustard GasMustard Gas results in increased expression of POMC protein alternative form8299707
C080955N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamideN-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [docetaxel results in increased expression of POMC mRNA]22902858
C038981nalmefenenalmefene results in increased expression of POMC protein alternative form3026683
D009270NaloxoneNaloxone results in increased expression of POMC protein8277081
D009270Naloxone[Clonidine results in increased expression of POMC protein] which results in increased susceptibility to Naloxone6089027
D009270NaloxoneNaloxone binds to and results in increased activity of POMC protein alternative form3157294
D009270NaloxoneNaloxone results in increased expression of POMC protein alternative form2255747
D009270NaloxoneCapsaicin inhibits the reaction [[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein]2846107
D009270NaloxoneCapsaicin inhibits the reaction [[Morphine co-treated with Naloxone] results in increased secretion of POMC protein]2846107
D009270Naloxone[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein2846107
D009270Naloxone[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone results in increased secretion of POMC protein modified form]24398105
D009270Naloxone[Morphine co-treated with Naloxone] results in increased secretion of POMC protein2846107
D009270NaloxoneNaloxone results in increased secretion of POMC protein modified form24398105
D009270NaloxoneNaloxone inhibits the reaction [POMC protein alternative form inhibits the reaction [AGT protein alternative form results in increased expression of AVP protein]]6262492
D009270NaloxoneNaloxone inhibits the reaction [POMC protein alternative form results in increased abundance of Calcium]6193972
D009270NaloxoneNaloxone results in decreased susceptibility to POMC protein6329457
C055382naltrindole"naltrindole inhibits the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of POMC mRNA]"19523041
D009288Naproxen[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of POMC protein]22150557
D009288NaproxenNaproxen inhibits the reaction [Capsaicin results in increased expression of POMC protein]22150557
C007548n-dodecanen-dodecane results in increased expression of POMC protein modified form19152832
C433446N-hydroxy-N'-(4-butyl-2-methylphenyl)formamidine"N-hydroxy-N'-(4-butyl-2-methylphenyl)formamidine inhibits the reaction [POMC protein affects the abundance of 20-hydroxy-5,8,11,14-eicosatetraenoic acid]"19458537
D009532NickelNickel results in increased expression of POMC mRNA20682304
D009538NicotinePOMC protein affects the reaction [Nicotine results in increased abundance of Dopamine]15689546
D009538NicotinePOMC protein affects the susceptibility to Nicotine19376143
D009538NicotineNicotine affects the expression of POMC protein22975262
D009538NicotineNicotine results in increased expression of POMC protein alternative form23623838
C012655nimesulidenimesulide results in decreased secretion of POMC protein18450957
D009569Nitric OxideCRH protein affects the reaction [Nitric Oxide results in increased secretion of POMC protein alternative form]10460269
D009569Nitric OxideNitric Oxide results in increased secretion of POMC protein alternative form10460269
D009569Nitric OxidePOMC protein results in decreased abundance of Nitric Oxide11193135|1170338
D020030Nitric Oxide DonorsCRH protein affects the reaction [Nitric Oxide Donors results in increased secretion of POMC protein alternative form]10460269
D020030Nitric Oxide DonorsNitric Oxide Donors results in increased secretion of POMC protein alternative form10460269
D009599NitroprussideNitroprusside results in increased expression of POMC protein2831029
D009599NitroprussideCorticosterone inhibits the reaction [Nitroprusside results in increased secretion of POMC protein]3015567
D009599NitroprussideNitroprusside inhibits the reaction [POMC protein modified form results in increased secretion of Corticosterone]20837582
D009599NitroprussideNitroprusside results in increased secretion of POMC protein3015567
D009599Nitroprussidenonylphenol inhibits the reaction [Nitroprusside inhibits the reaction [POMC protein modified form results in increased secretion of Corticosterone]]20837582
D009609Nitrous OxideNitrous Oxide results in increased secretion of POMC protein2846107
C041269N-methylnaloxoneN-methylnaloxone inhibits the reaction [1-(2-((1-ethoxycarbonyloxyethoxycarbonylmethyl)carbamoyl)-3-phenylpropyldisulfanylmethyl)-3-methylsulfanylpropylamine results in decreased degradation of POMC protein modified form]18938155
C017573nonanenonane results in increased expression of POMC protein modified form19152832
C025256nonylphenolfulvestrant inhibits the reaction [nonylphenol promotes the reaction [POMC protein modified form results in increased secretion of Corticosterone]]20837582
C025256nonylphenolnonylphenol inhibits the reaction [Nitroprusside inhibits the reaction [POMC protein modified form results in increased secretion of Corticosterone]]20837582
C025256nonylphenolnonylphenol promotes the reaction [POMC protein modified form results in increased secretion of Corticosterone]20837582
C025256nonylphenolnonylphenol results in increased expression of POMC protein22765982
D009638NorepinephrinePOMC protein results in increased susceptibility to Norepinephrine6279499
D016627OxidopamineLevodopa promotes the reaction [Oxidopamine results in increased expression of POMC protein]16325000
D016627OxidopamineOxidopamine results in increased expression of POMC protein16325000
D0173718-Hydroxy-2-(di-n-propylamino)tetralin[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in decreased activity of HTR1A protein] which results in increased expression of POMC protein modified form22265196
D0173718-Hydroxy-2-(di-n-propylamino)tetralinEstradiol inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in decreased activity of HTR1A protein] which results in increased expression of POMC protein modified form]22265196
C076029olanzapineolanzapine results in decreased expression of POMC protein21695181
C108709oleoyl-estroneoleoyl-estrone results in increased expression of POMC protein modified form10485330
D008939MitotaneMitotane results in increased expression of POMC protein alternative form8453685
C485800osajinosajin results in decreased expression of POMC mRNA20706672
C029341oxophenylarsineoxophenylarsine results in decreased activity of POMC protein12530643
C029341oxophenylarsine[oxophenylarsine results in decreased activity of POMC protein] which results in decreased chemical synthesis of Progesterone12530643
C029341oxophenylarsineoxophenylarsine inhibits the reaction [POMC protein results in increased abundance of Corticosterone]10518784
D010100OxygenOxygen results in increased secretion of POMC protein2846107
D010418PentagastrinPentagastrin results in increased expression of POMC protein alternative form10481831
D010418PentagastrinPentagastrin affects the expression of POMC protein alternative form18222546
D010424PentobarbitalMuscimol promotes the reaction [Pentobarbital results in decreased expression of POMC mRNA]7937335
D010424PentobarbitalPentobarbital inhibits the reaction [Acetylcholine results in increased expression of POMC protein]7588217
D010424PentobarbitalPentobarbital results in decreased expression of POMC mRNA7937335
C584865perfluorononanoic acid"[[Phytochemicals co-treated with Environmental Pollutants co-treated with Food Preservatives co-treated with Plasticizers co-treated with Sunscreening Agents co-treated with Insecticides co-treated with Fungicides, Industrial co-treated with Herbicides] affects the susceptibility to perfluorononanoic acid] which results in decreased expression of POMC protein modified form"25588985
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased secretion of POMC protein24440345
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of POMC mRNA24440345
C076715pervanadatepervanadate inhibits the reaction [POMC protein results in increased abundance of Corticosterone]10518784
D010646PhentolaminePhentolamine inhibits the reaction [POMC results in increased uptake of Magnesium]191614
D010656PhenylephrinePOMC protein results in increased susceptibility to Phenylephrine2822310|3015460
D010656PhenylephrineIndomethacin inhibits the reaction [Phenylephrine results in increased secretion of POMC protein alternative form]10898105
D010656PhenylephrinePhenylephrine results in increased secretion of POMC protein alternative form10898105
D010665PhenylpropanolaminePhenylpropanolamine results in increased expression of POMC mRNA17684035|2479232
D010665PhenylpropanolaminePhenylpropanolamine results in increased expression of POMC protein17684035
D010665PhenylpropanolamineS-ethyl glutathione inhibits the reaction [Phenylpropanolamine results in increased expression of POMC mRNA]24792324
D010665PhenylpropanolamineSTAT3 mRNA promotes the reaction [Phenylpropanolamine results in increased expression of POMC mRNA]24792324
D064209Phytochemicals"[[Phytochemicals co-treated with Environmental Pollutants co-treated with Food Preservatives co-treated with Plasticizers co-treated with Sunscreening Agents co-treated with Insecticides co-treated with Fungicides, Industrial co-treated with Herbicides] affects the susceptibility to perfluorononanoic acid] which results in decreased expression of POMC protein modified form"25588985
D010968Plasticizers"[[Phytochemicals co-treated with Environmental Pollutants co-treated with Food Preservatives co-treated with Plasticizers co-treated with Sunscreening Agents co-treated with Insecticides co-treated with Fungicides, Industrial co-treated with Herbicides] affects the susceptibility to perfluorononanoic acid] which results in decreased expression of POMC protein modified form"25588985
C474837pomiferinpomiferin results in decreased expression of POMC mRNA20706672
D011188Potassium[Guanosine Triphosphate co-treated with Potassium] results in decreased activity of POMC protein modified form2550106
D011188PotassiumPOMC protein affects the abundance of Potassium2157753|9535146
D011188PotassiumPOMC protein modified form results in decreased abundance of Potassium10100081
D011188PotassiumSpironolactone inhibits the reaction [POMC protein modified form results in decreased abundance of Potassium]10100081
D011239PrednisolonePrednisolone results in decreased expression of POMC protein modified form9625448
D011239Prednisolonesairei-to inhibits the reaction [Prednisolone results in decreased expression of POMC protein modified form]9625448
D011241PrednisonePrednisone results in decreased expression of POMC protein modified form1977371
D011374ProgesteroneProgesterone results in increased expression of POMC mRNA23012394
D011374ProgesteroneMelatonin inhibits the reaction [POMC protein results in increased abundance of Progesterone]21332028
D011374ProgesteronePOMC protein results in increased abundance of Progesterone21332028
D011374Progesterone[benzylphosphonic acid results in decreased activity of POMC protein] which results in decreased chemical synthesis of Progesterone12530643
D011374ProgesteroneHMOX1 protein inhibits the reaction [POMC protein results in increased abundance of Progesterone]19489000
D011374Progesterone[oxophenylarsine results in decreased activity of POMC protein] which results in decreased chemical synthesis of Progesterone12530643
D011374ProgesteronePOMC protein results in increased abundance of Progesterone19489000
D011374ProgesteronePOMC protein affects the abundance of Progesterone21466837
D011374ProgesteronePOMC protein results in increased secretion of Progesterone22100847
C100043propazinepropazine results in increased secretion of POMC protein modified form19690231
D011441PropylthiouracilPropylthiouracil results in decreased expression of POMC mRNA24780913
D011732Pyridoxal PhosphatePyridoxal Phosphate results in decreased secretion of POMC protein16690808
D011794QuercetinQuercetin analog inhibits the reaction [POMC protein modified form results in increased abundance of Cyclic AMP]26586997
D011794QuercetinQuercetin analog inhibits the reaction [[POMC protein modified form results in increased activity of TYR protein] which results in increased chemical synthesis of dopachrome]26586997
D011794QuercetinQuercetin analog inhibits the reaction [POMC protein modified form results in increased chemical synthesis of Melanins]26586997
D011794QuercetinQuercetin analog inhibits the reaction [POMC protein modified form results in increased expression of and results in increased activity of TYR protein]26586997
D011794QuercetinQuercetin analog inhibits the reaction [POMC protein modified form results in increased expression of DCT protein]26586997
D011794QuercetinQuercetin analog inhibits the reaction [POMC protein modified form results in increased expression of MITF protein]26586997
D011794QuercetinQuercetin analog inhibits the reaction [POMC protein modified form results in increased expression of TYRP1 protein]26586997
D011794QuercetinQuercetin analog inhibits the reaction [POMC protein modified form results in increased phosphorylation of CREB1 protein]26586997
D011794QuercetinQuercetin inhibits the reaction [POMC protein results in increased expression of and results in increased activity of TYR protein]21290442
D011794QuercetinQuercetin inhibits the reaction [POMC protein results in increased phosphorylation of PRKAR2A protein]21290442
C412383R 121919R 121919 inhibits the reaction [Ethanol results in decreased secretion of POMC protein alternative form]12746300
C412383R 121919R 121919 inhibits the reaction [Lipopolysaccharides results in decreased secretion of POMC protein alternative form]12746300
D064750RabeprazoleRabeprazole results in increased expression of POMC protein16524691
D026361Reactive Nitrogen SpeciesPOMC protein results in increased abundance of Reactive Nitrogen Species15554453
D012110ReserpinePOMC protein alternative form inhibits the reaction [Reserpine results in decreased expression of PNMT mRNA]20504635
D012110ReserpineReserpine results in increased expression of POMC mRNA20504635
D012110ReserpineReserpine results in increased expression of POMC protein alternative form8479280
C059514resveratrol"resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 inhibits the reaction [POMC protein modified form results in increased secretion of Corticosterone]]"27052214
C529148rosavinrosavin results in decreased expression of POMC mRNA20706672
C025759saikosaponinsaikosaponin results in increased expression of POMC mRNA8552307
C025759saikosaponinsaikosaponin results in increased expression of POMC protein8552307
C080903sairei-toCRH protein affects the reaction [sairei-to results in increased expression of POMC protein]8247339
C080903sairei-tosairei-to inhibits the reaction [Prednisolone results in decreased expression of POMC protein modified form]9625448
C080903sairei-to[sairei-to results in increased expression of CRH protein] which results in increased expression of POMC mRNA8233027
C080903sairei-to[sairei-to results in increased expression of CRH protein] which results in increased expression of POMC protein8233027
C080903sairei-tosairei-to results in increased expression of POMC mRNA8247339
C080903sairei-tosairei-to results in increased expression of POMC protein8247339
D020156Salicylic AcidSalicylic Acid inhibits the reaction [POMC protein results in increased abundance of Hydrocortisone]16551645
D012524SarinSarin results in decreased expression of POMC protein17301067
C093642SB 203580SB 203580 inhibits the reaction [POMC protein modified form results in increased secretion of Corticosterone]20837582
C042431S-ethyl glutathioneS-ethyl glutathione inhibits the reaction [Phenylpropanolamine results in increased expression of POMC mRNA]24792324
D012839SimazineSimazine results in increased secretion of POMC protein modified form19690231
D012964SodiumPOMC protein affects the abundance of Sodium2157753|9535146
D012964SodiumPOMC protein modified form results in increased abundance of Sodium10100081
D012964SodiumSpironolactone inhibits the reaction [POMC protein modified form results in increased abundance of Sodium]10100081
D012965Sodium Chloride[Guanosine Triphosphate co-treated with Sodium Chloride] results in decreased activity of POMC protein modified form2550106
D012965Sodium Chloride[Guanylyl Imidodiphosphate co-treated with Sodium Chloride] results in decreased activity of POMC protein modified form2550106
D012965Sodium Chloride[Guanosine Triphosphate co-treated with Sodium Chloride] results in decreased activity of POMC protein modified form2550106
D012965Sodium Chloride[Guanylyl Imidodiphosphate co-treated with Sodium Chloride] results in decreased activity of POMC protein modified form2550106
D012965Sodium Chloride[Guanosine Diphosphate co-treated with Sodium Chloride] results in decreased activity of POMC protein modified form2550106
D018038Sodium SeleniteDitiocarb promotes the reaction [Sodium Selenite inhibits the reaction [POMC protein results in increased secretion of Hydrocortisone]]21466817
D018038Sodium SeleniteSodium Selenite inhibits the reaction [POMC protein results in increased secretion of Hydrocortisone]21466817
D013148SpironolactoneSpironolactone inhibits the reaction [POMC protein modified form results in decreased abundance of Potassium]10100081
D013148SpironolactoneSpironolactone inhibits the reaction [POMC protein modified form results in increased abundance of Sodium]10100081
D013256SteroidsPOMC protein affects the reaction [Ethanol results in increased abundance of Steroids]20021565
D013256SteroidsPOMC protein alternative form affects the abundance of Steroids1668613
D013311StreptozocinINS protein inhibits the reaction [Streptozocin results in decreased expression of POMC mRNA]20219977
D013311StreptozocinStreptozocin results in decreased expression of POMC mRNA20219977
D017409SufentanilSufentanil results in decreased expression of POMC protein modified form15714323
D018170SumatriptanSumatriptan results in decreased expression of POMC protein modified form7640145
D018170Sumatriptan[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of POMC protein]22150557
D018170SumatriptanSumatriptan inhibits the reaction [Capsaicin results in increased expression of POMC protein]22150557
D013473Sunscreening Agents"[[Phytochemicals co-treated with Environmental Pollutants co-treated with Food Preservatives co-treated with Plasticizers co-treated with Sunscreening Agents co-treated with Insecticides co-treated with Fungicides, Industrial co-treated with Herbicides] affects the susceptibility to perfluorononanoic acid] which results in decreased expression of POMC protein modified form"25588985
D013481SuperoxidesPOMC protein results in increased abundance of Superoxides16620303
D013549Sweetening AgentsSweetening Agents results in decreased expression of POMC mRNA18627777
D013739Testosterone[Testosterone co-treated with Water deficiency] results in decreased expression of POMC mRNA20850559
D013739TestosteroneTestosterone results in decreased expression of POMC mRNA20850559
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of POMC mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of POMC mRNA12520768
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of POMC protein12520768
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of POMC mRNA15977195
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of POMC mRNA15093705|1882401
D013752TetracyclineTetracycline results in increased expression of POMC mRNA16917069
D013806TheophyllineINS1 protein inhibits the reaction [[Theophylline co-treated with POMC protein] results in increased abundance of Cyclic AMP]4306506
D013806Theophylline[Theophylline co-treated with POMC protein] results in increased abundance of Cyclic AMP4306506
D013849ThimerosalThimerosal results in increased expression of POMC mRNA24675092
D013849ThimerosalThimerosal results in increased expression of POMC protein24675092
D013853ThioacetamidePOMC protein alternative form inhibits the reaction [Thioacetamide results in increased degradation of NFKBIA protein]15313186
D013853ThioacetamidePOMC protein alternative form inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein]16511523
D013853ThioacetamidePOMC protein alternative form inhibits the reaction [Thioacetamide results in increased expression of and results in increased activity of TIMP1 protein]16511523
D013853ThioacetamidePOMC protein alternative form inhibits the reaction [Thioacetamide results in increased expression of COL1A1 mRNA]16511523
D013853ThioacetamidePOMC protein alternative form inhibits the reaction [Thioacetamide results in increased expression of ICAM1 mRNA]16511523
D013853ThioacetamidePOMC protein alternative form inhibits the reaction [Thioacetamide results in increased expression of NOS2 mRNA]15313186
D013853ThioacetamidePOMC protein alternative form inhibits the reaction [Thioacetamide results in increased expression of PCNA protein]16511523
D013853ThioacetamidePOMC protein alternative form inhibits the reaction [Thioacetamide results in increased expression of PTGS2 protein]16511523
D013853ThioacetamidePOMC protein alternative form inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]16511523
D013853ThioacetamidePOMC protein alternative form inhibits the reaction [Thioacetamide results in increased expression of TIMP1 mRNA]16511523
D013853ThioacetamidePOMC protein alternative form inhibits the reaction [Thioacetamide results in increased expression of TNF mRNA]15313186|1651152
D013853ThioacetamidePOMC protein alternative form inhibits the reaction [Thioacetamide results in increased expression of VCAM1 mRNA]16511523
D013853ThioacetamidePOMC protein alternative form promotes the reaction [Thioacetamide results in increased activity of MMP2 protein]16511523
D013853ThioacetamidePOMC protein alternative form promotes the reaction [Thioacetamide results in increased expression of MMP1 mRNA]16511523
D013853ThioacetamidePOMC protein alternative form promotes the reaction [Thioacetamide results in increased expression of MMP8 mRNA]16511523
D013875ThiophanateThiophanate results in decreased expression of POMC protein17549544
D014050TolueneToluene results in increased expression of POMC protein15707876
D014212TretinoinTretinoin results in decreased expression of POMC protein19526345
D014221TriamcinoloneTriamcinolone results in decreased susceptibility to POMC protein modified form7788158
C009954trilostanetrilostane results in decreased expression of POMC protein19117688
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in decreased expression of POMC mRNA25307695
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of POMC protein11959675
C005445triphenyl phosphate"[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of POMC mRNA"29112739
C016805tris(1,3-dichloro-2-propyl)phosphate"[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of POMC mRNA"29112739
D014317Tritolyl Phosphates"[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of POMC mRNA"29112739
D014425Turpentineastressin B inhibits the reaction [Turpentine results in increased expression of POMC protein alternative form]12207160
D014425TurpentineTurpentine results in increased expression of POMC protein alternative form12207160
D014520UrethaneUrethane results in increased secretion of POMC protein2846107
D014635Valproic AcidValproic Acid affects the expression of POMC protein7816191
D001335Vehicle EmissionsVehicle Emissions affects the methylation of POMC gene25560391
C025643vinclozolinvinclozolin results in decreased expression of POMC mRNA21570938
D014801Vitamin AVitamin A results in increased expression of POMC protein17373634
C017967W 7W 7 inhibits the reaction [POMC protein modified form results in increased chemical synthesis of Adrenal Cortex Hormones]2993719
C017967W 7W 7 inhibits the reaction [POMC protein modified form results in increased chemical synthesis of Adrenal Cortex Hormones]2993719
D014867Water[Testosterone co-treated with Water deficiency] results in decreased expression of POMC mRNA20850559
D014867WaterWater deficiency results in decreased expression of POMC mRNA20850559
D015054Zymosan[Zymosan co-treated with Morphine] results in increased expression of POMC mRNA15979727

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001664G-protein coupled receptor binding-IBA21873635  
GO:0001664G-protein coupled receptor binding-IDA19452503  
GO:0005102signaling receptor binding-IMP9620771  
GO:0005179hormone activity-IMP9620771  
GO:0005179hormone activity-ISS-  
GO:0005184neuropeptide hormone activity-IBA21873635  
GO:0031781type 3 melanocortin receptor binding-IPI19743876  
GO:0031782type 4 melanocortin receptor binding-IPI19743876  
GO:0070996type 1 melanocortin receptor binding-IDA18292087  
GO:0070996type 1 melanocortin receptor binding-IPI19743876  
GO ID GO Term Qualifier Evidence PubMed
GO:0006091generation of precursor metabolites and energy-IMP9620771  
GO:0007165signal transduction-IMP9620771  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007218neuropeptide signaling pathway-IBA21873635  
GO:0007267cell-cell signaling-IMP9620771  
GO:0008217regulation of blood pressure-ISS-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0032098regulation of appetite-IMP9620771  
GO:0032720negative regulation of tumor necrosis factor production-IDA10233018  
GO:0033059cellular pigmentation-IMP9620771  
GO:0042593glucose homeostasis-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA18292087  
GO:0070873regulation of glycogen metabolic process-IEA-  
GO:2000852regulation of corticosterone secretion-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IDA9620771  
GO:0005737cytoplasm-ISS-  
GO:0030141secretory granule-IBA21873635  
GO:0030141secretory granule-ISS-  
GO:0034774secretory granule lumen-TAS-  
KEGG ID KEGG Term
hsa04916Melanogenesis
hsa04920Adipocytokine signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-111885Opioid SignallingTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1430728MetabolismTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-168256Immune SystemTAS
R-HSA-193048Androgen biosynthesisTAS
R-HSA-194002Glucocorticoid biosynthesisTAS
R-HSA-196071Metabolism of steroid hormonesTAS
R-HSA-202040G-protein activationTAS
R-HSA-209952Peptide hormone biosynthesisTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211897Cytochrome P450 - arranged by substrate typeTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-211976Endogenous sterolsTAS
R-HSA-2980736Peptide hormone metabolismTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-418555G alpha (s) signalling eventsTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-500792GPCR ligand bindingTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-5579029Metabolic disorders of biological oxidation enzymesTAS
R-HSA-5579031Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)TAS
R-HSA-5668914Diseases of metabolismTAS
R-HSA-6785807Interleukin-4 and 13 signalingTAS
R-HSA-8957322Metabolism of steroidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
2854897Human corticotropin releasing hormone: clinical studies in patients with affective disorders, alcoholism, panic disorder and in normal controls. (1988)von Bardeleben UProg Neuropsychopharmacol Biol Psychiatry
2969250Beta-endorphin genetics in the etiology of alcoholism. (1988 Mar-Apr)Topel HAlcohol
25446223Individual differences in gene expression of vasopressin, D2 receptor, POMC and orexin: vulnerability to relapse to heroin-seeking in rats. (2015 Feb)Zhou YPhysiol Behav
22398003Smoking, but not malnutrition, influences promoter-specific DNA methylation of the proopiomelanocortin gene in patients with and without anorexia nervosa. (2012 Mar)Ehrlich SCan J Psychiatry
18589403The opioid peptides enkephalin and beta-endorphin in alcohol dependence. (2008 Dec 1)Racz IBiol Psychiatry
18034691Alcoholism, craving, and hormones: the role of leptin, ghrelin, prolactin, and the pro-opiomelanocortin system in modulating ethanol intake. (2007 Dec)Wurst FMAlcohol Clin Exp Res
16046320Association between common polymorphisms of the proopiomelanocortin gene and body fat distribution: a family study. (2005 Aug)Baker MDiabetes
24929109Alcohol: a stimulant activating brain stress responsive systems with persistent neuroadaptation. (2014 Dec)Zhou YNeuropharmacology
24035285Opioid system genes in alcoholism: a case-control study in Croatian population. (2013 Oct)Cupic BNeuropeptides
8519440Effect of S(-)- and R(+)-salsolinol on the POMC gene expression and ACTH release of an anterior pituitary cell line. (1995 Sep-Oct)Putscher IAlcohol
9665316The effect of an acute ethanol exposure on the rat brain POMC opiopeptide system. (1998 Aug)Popp RLAlcohol
24189487The biology of Nociceptin/Orphanin FQ (N/OFQ) related to obesity, stress, anxiety, mood, and drug dependence. (2014 Mar)Witkin JMPharmacol Ther
27490364High Resolution Genomic Scans Reveal Genetic Architecture Controlling Alcohol Preference in Bidirectionally Selected Rat Model. (2016 Aug)Lo CLPLoS Genet
20872312Appetite- and volume-regulating neuropeptides: Role in treating alcohol dependence. (2010 Oct)Hillemacher TCurr Opin Investig Drugs
8883945Effect of morphine on proopiomelanocortin gene expression and peptide levels in the hypothalamus. (1996 Sep 5)Wardlaw SLBrain Res Mol Brain Res
22848202Cigarette smoking and brain regulation of energy homeostasis. (2012)Chen HFront Pharmacol
2598523Value of plasma NH2-terminal fragment of pro-opiomelanocortin in marking human lung cancer in various clinical settings. (1989 Oct)Gilbert FClin Invest Med
1346939Rationale for maintenance pharmacotherapy of opiate dependence. (1992)Kreek MJRes Publ Assoc Res Nerv Ment Dis
11981131Chronic daily ethanol and withdrawal: 3. Forebrain pro-opiomelanocortin gene expression and implications for dependence, relapse, and deprivation effect. (2002 Apr)Rasmussen DDAlcohol Clin Exp Res
22622000Male germline transmits fetal alcohol adverse effect on hypothalamic proopiomelanocortin gene across generations. (2012 Sep 1)Govorko DBiol Psychiatry
26903543Combination of Levo-Tetrahydropalmatine and Low Dose Naltrexone: A Promising Treatment for Prevention of Cocaine Relapse. (2016 May)Sushchyk SJ Pharmacol Exp Ther
21659607Nicotine decreases food intake through activation of POMC neurons. (2011 Jun 10)Mineur YSScience
26806779Neuroscience of opiates for addiction medicine: From stress-responsive systems to behavior. (2016)Zhou YProg Brain Res
12576179Alterations in hypothalamic-pituitary-adrenal axis activity and in levels of proopiomelanocortin and corticotropin-releasing hormone-receptor 1 mRNAs in the pituitary and hypothalamus of the rat during chronic 'binge' cocaine and withdrawal. (2003 Feb 28)Zhou YBrain Res
29510398Epigenetic Effects of Intravenous Diacetylmorphine on the Methylation of POMC and NR3C1. (2017)Groh ANeuropsychobiology
29694503Neonatal tobacco smoke reduces thermogenesis capacity in brown adipose tissue in adult rats. (2018)Peixoto TCBraz J Med Biol Res
9512064Effect of mu opioid receptor blockade on alcohol intake in rats bred for high alcohol drinking. (1998 Mar)Krishnan-Sarin SPharmacol Biochem Behav
25595971Persistent increases in rat hypothalamic POMC gene expression following chronic withdrawal from chronic "binge" pattern escalating-dose, but not steady-dose, cocaine. (2015 Mar 19)Zhou YNeuroscience
11141043Chronic daily ethanol and withdrawal: 1. Long-term changes in the hypothalamo-pituitary-adrenal axis. (2000 Dec)Rasmussen DDAlcohol Clin Exp Res
19217079Pro-opiomelanocortin gene variation related to alcohol or drug dependence: evidence and replications across family- and population-based studies. (2009 Jul 15)Zhang HBiol Psychiatry
11701716Chronic maternal nicotine exposure alters neuronal systems in the arcuate nucleus that regulate feeding behavior in the newborn rhesus macaque. (2001 Nov)Grove KLJ Clin Endocrinol Metab
20191296DNA methylation of the POMC gene promoter is associated with craving in alcohol dependence. (2010 Apr)Muschler MAJ Neural Transm (Vienna)
17443794Nicotine regulates mRNA expression of feeding peptides in the arcuate nucleus in neonatal rat pups. (2007 Feb 15)Huang LZDev Neurobiol
24271034CAGn repeat of the androgen receptor is linked to proopiomelanocortin promoter methylation-relevance for craving of male alcohol-dependent patients? (2014 May)Muschler MAPsychopharmacology (Berl)
25072633Modulation of proopiomelanocortin gene expression by ethanol in mouse anterior pituitary corticotrope tumor cell AtT20. (2014 Jun-Aug)Zhou YRegul Pept
22924764Array-based profiling of DNA methylation changes associated with alcohol dependence. (2013 Jan)Zhang HAlcohol Clin Exp Res
21677651Persistent increase in hypothalamic arginine vasopressin gene expression during protracted withdrawal from chronic escalating-dose cocaine in rodents. (2011 Sep)Zhou YNeuropsychopharmacology
7662043Effects of voluntary ethanol ingestion on the POMC gene expression in the rat pituitary and on the plasma beta-endorphin content. (1995 Mar)Winkler AAlcohol Alcohol
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample. (2011 May)Kendler KSAlcohol Clin Exp Res
17503481The opioid system in alcohol and drug dependence: family-based association study. (2007 Oct 5)Xuei XAm J Med Genet B Neuropsychiatr Genet
23050949Decreased immunoreactivity of the polypeptide precursor pro-opiomelanocortin (POMC) and the prohormone convertase pc1/3 after chronic ethanol exposure in Sprague-Dawley rats. (2013 Mar)Navarro MAlcohol Clin Exp Res
9695129Effects of chronic nicotine treatment and withdrawal on hypothalamic proopiomelanocortin gene expression and neuroendocrine regulation. (1998 Apr)Rasmussen DDPsychoneuroendocrinology
21653710Nicotine excites hypothalamic arcuate anorexigenic proopiomelanocortin neurons and orexigenic neuropeptide Y neurons: similarities and differences. (2011 Sep)Huang HJ Neurophysiol