Gene: PON2

5445
-
paraoxonase 2
protein-coding
7q21.3
Ensembl:ENSG00000105854 MIM:602447 Vega:OTTHUMG00000153948 UniprotKB:Q15165
NG_008725.1
PubMed
0   ANCO-SNPs
ND
13   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.502e-1 (AD)  9.155e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACAA20.934
HADHB0.927
PSAT10.924
TP53BP20.924
GPR137B0.921
HSDL20.919
METTL7A0.918
SLC25A200.916
RAB310.912
AGT0.91

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.538
OR4F29-0.531
KCNH1-0.451
CALHM1-0.45
KCNH5-0.449
COL19A1-0.448
RTP1-0.446
GABRG3-0.445
OPRD1-0.444
IL12RB2-0.443

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of PON2 mRNA"22653878
C0630022,3-dimethoxy-1,4-naphthoquinone"PON2 protein results in decreased susceptibility to 2,3-dimethoxy-1,4-naphthoquinone"21354197
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PON2 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of PON2 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of PON2 mRNA"22653878
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of PON2 mRNA"23196670
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PON2 mRNA"26006071
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of PON2 mRNA21983209
C0473683-methylquercetin3-methylquercetin results in increased expression of PON2 mRNA19865538
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of PON2 mRNA"18648102
C5509955,6,7,8-tetrahydroxy-4-oxooctanal"[PON2 protein results in increased metabolism of [Acrolein binds to Ascorbic Acid]] which results in increased chemical synthesis of 5,6,7,8-tetrahydroxy-4-oxooctanal"20353174
C0476515-hydroxyeicosatetraenoic acid lactonePON2 protein affects the metabolism of 5-hydroxyeicosatetraenoic acid lactone15772423
C0106436-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of PON2 protein]"17916643
C0106436-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of PON2 protein]"17916643
C0030017-ketocholesterol7-ketocholesterol results in increased activity of PON2 protein12615656
C0030017-ketocholesterol7-ketocholesterol results in increased expression of PON2 mRNA12615656
D000082AcetaminophenAcetaminophen results in decreased expression of PON2 mRNA29067470
D000111AcetylcysteineAcetylcysteine inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of PON2 protein]17916643
D000111AcetylcysteineAcetylcysteine inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of PON2 protein]17916643
D000117AcetylglucosamineAcetylglucosamine results in increased expression of PON2 mRNA18047607
D000171AcroleinPON2 protein results in increased metabolism of [Acrolein binds to Ascorbic Acid]20353174
D000171Acrolein"[PON2 protein results in increased metabolism of [Acrolein binds to Ascorbic Acid]] which results in increased chemical synthesis of 5,6,7,8-tetrahydroxy-4-oxooctanal"20353174
D020106AcrylamideAcrylamide results in decreased expression of PON2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PON2 gene27153756
C038491allyl sulfideallyl sulfide results in decreased expression of PON2 mRNA22653878
C068073Am 580Am 580 results in decreased expression of PON2 mRNA16982809
D000638AmiodaroneAmiodarone affects the expression of PON2 mRNA19483382
D001151ArsenicPON2 gene SNP affects the susceptibility to Arsenic19152805
D001205Ascorbic AcidPON2 protein results in increased metabolism of [Acrolein binds to Ascorbic Acid]20353174
D001205Ascorbic Acid"[PON2 protein results in increased metabolism of [Acrolein binds to Ascorbic Acid]] which results in increased chemical synthesis of 5,6,7,8-tetrahydroxy-4-oxooctanal"20353174
D000069059Atorvastatin CalciumAtorvastatin Calcium results in increased activity of PON2 protein14592851
D000069059Atorvastatin CalciumAtorvastatin Calcium results in increased expression of PON2 mRNA14592851
D001280AtrazineAtrazine results in increased expression of PON2 mRNA25929836
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PON2 mRNA27858113
D001553BenzbromaroneBenzbromarone affects the expression of PON2 mRNA19483382
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PON2 mRNA27858113
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PON2 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PON2 mRNA21839799
D003374CoumarinsPON2 protein results in increased hydrolysis of Coumarins20353174
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of PON2 mRNA26496021
D001663BilirubinBilirubin results in decreased expression of PON2 mRNA20196124
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of PON2 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of PON2 mRNA25181051
D001786Blood GlucosePON2 gene polymorphism affects the abundance of Blood Glucose9329371
D002084Butylated HydroxytolueneButylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of PON2 protein]17916643
D002084Butylated HydroxytolueneButylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of PON2 protein]17916643
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of PON2 mRNA15336504
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of PON2 mRNA14729362
D002104CadmiumCadmium results in decreased expression of PON2 mRNA16624402
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PON2 mRNA16624402
D002118CalciumPON2 gene polymorphism affects the abundance of Calcium16141008
D002241CarbohydratesCarbohydrates results in decreased activity of PON2 protein16332370
D002241CarbohydratesCarbohydrates results in increased activity of PON2 protein16332370
D004390ChlorpyrifosChlorpyrifos results in increased activity of PON2 protein24979751
D004390ChlorpyrifosChlorpyrifos results in increased expression of PON2 mRNA24979751
D004390ChlorpyrifosPlicamycin inhibits the reaction [Chlorpyrifos results in increased expression of PON2 mRNA]24979751
D008076Cholesterol, HDL"PON2 gene polymorphism affects the abundance of Cholesterol, HDL"16030523|9699900
D008078Cholesterol, LDL"PON2 gene mutant form affects the abundance of Cholesterol, LDL"14996478
D008078Cholesterol, LDL"PON2 gene polymorphism affects the abundance of Cholesterol, LDL"9842991
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PON2 mRNA27858113
C019304ciprofibrateciprofibrate results in decreased expression of PON2 mRNA22653878
D002994ClofibrateClofibrate affects the expression of PON2 mRNA19483382
D002995Clofibric AcidClofibric Acid results in decreased expression of PON2 mRNA22653878
C018021cobaltous chloridecobaltous chloride results in decreased expression of PON2 mRNA24612858
C018021cobaltous chloridecobaltous chloride results in decreased expression of PON2 mRNA19376846
D019327Copper SulfateCopper Sulfate results in decreased expression of PON2 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of PON2 mRNA20106945|2556210
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PON2 mRNA21266533
C000944dicrotophosdicrotophos results in decreased expression of PON2 mRNA28302478
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of PON2 mRNA"22485181
D004281Docosahexaenoic AcidsPON2 protein affects the metabolism of Docosahexaenoic Acids analog15772423
D005001EthionineEthionine affects the expression of PON2 mRNA19483382
D005839GentamicinsGentamicins results in increased expression of PON2 mRNA22061828
D005897GlafenineGlafenine results in decreased expression of PON2 mRNA24136188
D005947GlucosePON2 gene polymorphism affects the abundance of Glucose16185677
D017313FenretinideFenretinide results in decreased expression of PON2 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of PON2 mRNA20044591
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of PON2 mRNA24979751
D006861Hydrogen PeroxidePON2 protein results in decreased susceptibility to Hydrogen Peroxide11579088
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of PON2 mRNA14729362
D006861Hydrogen PeroxidePON2 protein results in decreased susceptibility to Hydrogen Peroxide21354197
D007213IndomethacinIndomethacin results in increased expression of PON2 mRNA28201806
C051140iron(II)-ascorbic acid complex"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of PON2 protein]"17916643
C051140iron(II)-ascorbic acid complexAcetylcysteine inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of PON2 protein]17916643
C051140iron(II)-ascorbic acid complexButylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of PON2 protein]17916643
C051140iron(II)-ascorbic acid complexiron(II)-ascorbic acid complex results in increased expression of PON2 protein17916643
C051140iron(II)-ascorbic acid complex"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of PON2 protein]"17916643
C051140iron(II)-ascorbic acid complexAcetylcysteine inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of PON2 protein]17916643
C051140iron(II)-ascorbic acid complexButylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of PON2 protein]17916643
C051140iron(II)-ascorbic acid complexiron(II)-ascorbic acid complex results in increased expression of PON2 protein17916643
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PON2 mRNA23430699|2479639
D007783LactonesPON2 protein results in increased hydrolysis of Lactones analog15772423
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PON2 mRNA23649840
D008825MiconazoleMiconazole results in decreased expression of PON2 mRNA22262564
C109860N-(3-oxododecanoyl)homoserine lactonePON2 protein results in increased susceptibility to N-(3-oxododecanoyl)homoserine lactone25627690
C022838nickel chloridenickel chloride results in decreased expression of PON2 mRNA24612858
D009538NicotineNicotine results in increased expression of PON2 mRNA16949557
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of PON2 mRNA"12888634
D009853OmeprazoleOmeprazole affects the expression of PON2 mRNA19483382
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 gene polymorphism affects the susceptibility to [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of PON2 mRNA]"21673326
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of PON2 mRNA"21673326
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 protein affects the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of PON2 mRNA]"21673326
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of PON2 mRNA20118188
C023036perfluorooctanoic acidPPARA promotes the reaction [perfluorooctanoic acid results in increased expression of PON2 mRNA]20118188
D010634PhenobarbitalPhenobarbital affects the expression of PON2 mRNA19159669
D010634PhenobarbitalPhenobarbital results in decreased expression of PON2 mRNA22653878
C570634phenyl acetatePON2 gene SNP affects the hydrolysis of phenyl acetate20839225
C025136phenylacetic acidPON2 protein results in increased hydrolysis of phenylacetic acid16117861
C025136phenylacetic acidPON2 protein SNP results in decreased hydrolysis of phenylacetic acid16117861
D010713PhosphatidylcholinesPhosphatidylcholines results in increased activity of PON2 protein12615656
D010713PhosphatidylcholinesPhosphatidylcholines results in increased expression of PON2 mRNA12615656
C006253pirinixic acidpirinixic acid affects the expression of PON2 mRNA19483382
D010936Plant ExtractsPlant Extracts results in increased expression of PON2 mRNA23557933
D008926PlicamycinPlicamycin inhibits the reaction [Chlorpyrifos results in increased expression of PON2 mRNA]24979751
D059808PolyphenolsPolyphenols results in decreased activity of PON2 protein16332370
C045950propiconazolepropiconazole results in decreased expression of PON2 mRNA21278054
D011441PropylthiouracilPropylthiouracil affects the expression of PON2 mRNA19483382
C432165pyrazolanthronepyrazolanthrone results in decreased expression of PON2 protein15544923
D011794QuercetinQuercetin results in increased expression of PON2 mRNA19865538
D011794QuercetinQuercetin results in increased expression of PON2 protein19865538
C089730rosiglitazonerosiglitazone results in decreased expression of PON2 mRNA16982809
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of PON2 mRNA21427059
D012643SeleniumSelenium results in decreased expression of PON2 mRNA19244175
D012822Silicon DioxideSilicon Dioxide results in decreased expression of PON2 mRNA19073995
C016104sodium bichromatesodium bichromate results in decreased expression of PON2 mRNA24612858
D018038Sodium SeleniteSodium Selenite results in decreased expression of PON2 mRNA18175754
D012999SomanSoman results in increased expression of PON2 mRNA19281266
D013481SuperoxidesSuperoxides results in increased expression of PON2 protein15544923
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PON2 mRNA21570461
D019284ThapsigarginThapsigargin results in decreased expression of PON2 mRNA22378314
D013853ThioacetamideThioacetamide affects the expression of PON2 mRNA19483382
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PON2 mRNA28065790
D014212Tretinoin[Tretinoin co-treated with zoledronic acid] results in increased expression of PON2 protein20349282
D014212TretinoinTretinoin results in decreased expression of PON2 mRNA23724009
D014415TunicamycinTunicamycin results in decreased expression of PON2 mRNA22378314
D017974Uranium CompoundsUranium Compounds results in decreased expression of PON2 mRNA19654044
D014635Valproic AcidValproic Acid affects the expression of PON2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of PON2 mRNA24935251
D014635Valproic AcidValproic Acid results in decreased methylation of PON2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of PON2 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in decreased expression of PON2 mRNA21427059
D014810Vitamin EVitamin E results in decreased expression of PON2 mRNA19244175
D014810Vitamin EVitamin E results in decreased expression of and results in decreased activity of PON2 protein15544923
D014810Vitamin EVitamin E results in decreased expression of PON2 mRNA15544923
C111237vorinostatvorinostat results in decreased expression of PON2 mRNA27188386
C088658zoledronic acid[Tretinoin co-treated with zoledronic acid] results in increased expression of PON2 protein20349282

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004064arylesterase activity-IBA21873635  
GO:0016788hydrolase activity, acting on ester bonds-IBA21873635  
GO:0042802identical protein binding-IDA15772423  
GO:0046872metal ion binding-IEA-  
GO:0102007acyl-L-homoserine-lactone lactonohydrolase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006979response to oxidative stress-IEA-  
GO:0009636response to toxic substance-IBA21873635  
GO:0019372lipoxygenase pathway-TAS-  
GO:0019439aromatic compound catabolic process-IDA15772423  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005634nucleus-IEA-  
GO:0005739mitochondrion-IEA-  
GO:0005764lysosome-IEA-  
GO:0005886plasma membrane-IDA15772423  
KEGG ID KEGG Term
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-2142688Synthesis of 5-eicosatetraenoic acidsTAS
R-HSA-2142753Arachidonic acid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8978868Fatty acid metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
16239632Evaluation of the paraoxonases as candidate genes for stroke: Gln192Arg polymorphism in the paraoxonase 1 gene is associated with increased risk of stroke. (2005 Nov)Ranade KStroke
17309646Interactions and associations of paraoxonase gene cluster polymorphisms with myocardial infarction in a Pakistani population. (2007 Mar)Saeed MClin Genet
14984433Interaction between smoking and PON2 Ser311Cys polymorphism as a determinant of the risk of myocardial infarction. (2004 Jan)Martinelli NEur J Clin Invest
14996478PON1 M/L55 mutation protects high-risk patients against coronary artery disease. (2004 Mar)Oliveira SAInt J Cardiol
14636952Human paraoxonase gene cluster polymorphisms as predictors of coronary heart disease risk in the prospective Northwick Park Heart Study II. (2003 Nov 20)Robertson KSBiochim Biophys Acta
17137217Association of sixty-one non-synonymous polymorphisms in forty-one hypertension candidate genes with blood pressure variation and hypertension. (2006 Aug)Kokubo YHypertens Res
20536507Independent predictive roles of eotaxin Ala23Thr, paraoxonase 2 Ser311Cys and beta-adrenergic receptor Trp64Arg polymorphisms on cardiac disease in Type 2 Diabetes--an 8-year prospective cohort analysis of 1297 patients. (2010 Apr)Wang YDiabet Med
25606379Effect of PON1 gene polymorphisms in Turkish patients with hepatocellular carcinoma. (2013 Dec)Akkiz HMeta Gene
24845160Gene-environment interaction among GSTT1, PON2 polymorphisms and organic solvents on gestational age in a Chinese women cohort. (2014 Jul)Li SJ Assist Reprod Genet
16614106GSTP1 genetic polymorphism is associated with a higher risk of DNA damage in pesticide-exposed fruit growers. (2006 Apr)Liu YJCancer Epidemiol Biomarkers Prev
21231776C-reactive protein levels are associated with paraoxonase polymorphism L55M in patients undergoing cardiac SPECT imaging. (2011 May)Acampa WScand J Clin Lab Invest
18635682Genetic analysis of 56 polymorphisms in 17 genes involved in methionine metabolism in patients with abdominal aortic aneurysm. (2008 Nov)Giusti BJ Med Genet
15345661Paraoxonase and superoxide dismutase gene polymorphisms and noise-induced hearing loss. (2004 Nov)Fortunato GClin Chem