Gene: MOV10L1

54456
CHAMP|DJ402G11.8
Mov10 RISC complex RNA helicase like 1
protein-coding
22q13.33
Ensembl:ENSG00000073146 MIM:605794 Vega:OTTHUMG00000044648 UniprotKB:Q9BXT6
NC_000022.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.173e-1 (AD)  2.937e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs138229chr22:50118978 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GOLGA8A0.686
ADAT20.681
CCDC140.661
ZNF1330.658
L3MBTL10.653
GIT20.653
CDRT40.643
TCERG10.642
AMY2B0.642
PIGZ0.639

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRAT-0.296
CCDC102A-0.296
OR4F5-0.281
ZNF114-0.279
EVC2-0.277
LHFPL1-0.275
P2RY2-0.274
PGF-0.271
TBX5-0.269
TSLP-0.268

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of MOV10L1 mRNA22129741
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of MOV10L1 gene27153756
D001374AzacitidineAzacitidine results in increased expression of MOV10L1 mRNA20823114
C547126AZM551248AZM551248 results in decreased expression of MOV10L1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MOV10L1 mRNA22228805
C018021cobaltous chloridecobaltous chloride results in decreased expression of MOV10L1 mRNA19320972
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of MOV10L1 mRNA28123099
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of MOV10L1 mRNA22129741
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MOV10L1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MOV10L1 mRNA17942748
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of MOV10L1 mRNA22129741
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of MOV10L1 mRNA22401849
D010656PhenylephrineMOV10L1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]12754203
D010656PhenylephrineMOV10L1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]11854500
D010656PhenylephrineMOV10L1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]11854500
C005556propionaldehydepropionaldehyde results in decreased expression of MOV10L1 mRNA26079696
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MOV10L1 mRNA16962184
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MOV10L1 mRNA17942748
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of MOV10L1 mRNA28111298
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of MOV10L1 mRNA"26179874
D001335Vehicle EmissionsVehicle Emissions affects the methylation of MOV10L1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-TAS11839499  
GO:0003723RNA binding-IBA21873635  
GO:0003723RNA binding-TAS11839499  
GO:0004004ATP-dependent RNA helicase activity-ISS-  
GO:0004004ATP-dependent RNA helicase activity-NAS11279525  
GO:0005524ATP binding-TAS11839499  
GO ID GO Term Qualifier Evidence PubMed
GO:0007141male meiosis I-ISS-  
GO:0007275multicellular organism development-IEA-  
GO:0007281germ cell development-IEP11279525  
GO:0007283spermatogenesis-IEP11279525  
GO:0007283spermatogenesis-ISS-  
GO:0034587piRNA metabolic process-ISS-  
GO:0035194posttranscriptional gene silencing by RNA-IBA21873635  
GO:0043046DNA methylation involved in gamete generation-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IBA21873635  
GO:0043186P granule-IBA21873635  
GO:0043186P granule-ISS-  
GO:0071546pi-body-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-211000Gene Silencing by RNAIEA
R-HSA-5601884PIWI-interacting RNA (piRNA) biogenesisIEA
R-HSA-74160Gene expression (Transcription)IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal