Gene: PON3

5446
-
paraoxonase 3
protein-coding
7q21.3
Ensembl:ENSG00000105852 MIM:602720 Vega:OTTHUMG00000153917 UniprotKB:Q15166
NG_008726.1
PubMed
0   ANCO-SNPs
ND
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.141e-1 (AD)  7.927e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
STK330.718
DECR10.713
HOGA10.703
LEPROT0.697
GRAMD1C0.692
NPL0.683
HSDL20.681
TSPAN60.68
RAB340.678
CYBRD10.676

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLSTN2-0.541
IL12RB2-0.525
XKR7-0.515
SSTR2-0.513
USP31-0.51
RXFP1-0.51
TRPV6-0.508
MUM1L1-0.508
FHL2-0.506
GALNT14-0.505

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00227LovastatinSmall Molecule75330-75-5Approved|InvestigationalEnzyme
DB00974Edetic AcidSmall Molecule60-00-4ApprovedEnzyme
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of PON3 mRNA"22653878
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PON3 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PON3 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of PON3 mRNA"22653878
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PON3 mRNA"25530946|2600607
C0476515-hydroxyeicosatetraenoic acid lactonePON3 protein affects the metabolism of 5-hydroxyeicosatetraenoic acid lactone15772423
C0030017-ketocholesterol7-ketocholesterol inhibits the reaction [PON3 protein results in increased metabolism of Lovastatin]12615656
D000082AcetaminophenAcetaminophen results in decreased expression of PON3 mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of PON3 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of PON3 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of PON3 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PON3 gene27153756
C038491allyl sulfideallyl sulfide results in decreased expression of PON3 mRNA22653878
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of PON3 mRNA28522335
C015001arsenitearsenite results in increased methylation of PON3 promoter23974009
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PON3 mRNA22228805
D003374CoumarinsPON3 protein results in increased hydrolysis of Coumarins analog16099434|1613951
C099952bifenthrinbifenthrin results in increased expression of PON3 mRNA26071804
C006780bisphenol Abisphenol A results in decreased expression of PON3 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of PON3 mRNA22079614
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PON3 mRNA24982889
D019256Cadmium ChlorideCadmium Chloride affects the expression of PON3 mRNA22110744
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of PON3 promoter22457795
D002251Carbon TetrachloridePON3 protein inhibits the reaction [Carbon Tetrachloride results in decreased abundance of Glutathione]20079818
D002251Carbon TetrachloridePON3 protein inhibits the reaction [Carbon Tetrachloride results in increased abundance of Malondialdehyde]20079818
D002251Carbon TetrachloridePON3 protein inhibits the reaction [Carbon Tetrachloride results in increased secretion of IL1B protein]20079818
D002251Carbon TetrachloridePON3 protein inhibits the reaction [Carbon Tetrachloride results in increased secretion of TNF protein]20079818
D002251Carbon TetrachloridePON3 protein results in decreased susceptibility to Carbon Tetrachloride20079818
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of PON3 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of PON3 mRNA25478064
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of PON3 protein25478064
D002251Carbon TetrachlorideRutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PON3 mRNA]25478064
D002251Carbon TetrachlorideRutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PON3 protein]25478064
D002994ClofibrateClofibrate results in decreased expression of PON3 mRNA12851107
C018021cobaltous chloridecobaltous chloride results in decreased expression of PON3 mRNA24612858
C018021cobaltous chloridecobaltous chloride results in decreased expression of PON3 mRNA19376846
C018021cobaltous chloridecobaltous chloride results in decreased expression of PON3 mRNA24386269
D016572CyclosporineCyclosporine results in decreased expression of PON3 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in increased expression of PON3 mRNA27989131
C093628cyproconazolecyproconazole results in increased expression of PON3 mRNA22334560
C000944dicrotophosdicrotophos results in decreased expression of PON3 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of PON3 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of PON3 mRNA18042831
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate affects the expression of PON3 mRNA alternative form21636974
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of PON3 mRNA18544905
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with kojic acid] results in increased expression of PON3 mRNA18544905
D004237DiuronDiuron results in decreased expression of PON3 mRNA21551480|2515243
D004281Docosahexaenoic AcidsPON3 protein affects the metabolism of Docosahexaenoic Acids analog15772423
C109476epoxiconazoleepoxiconazole results in increased expression of PON3 mRNA22334560
D018120FinasterideFinasteride results in decreased expression of PON3 mRNA24136188
D005485FlutamideFlutamide results in decreased expression of PON3 mRNA24136188
D005897GlafenineGlafenine results in decreased expression of PON3 mRNA24136188
D005978GlutathionePON3 protein inhibits the reaction [Carbon Tetrachloride results in decreased abundance of Glutathione]20079818
D017313FenretinideFenretinide results in decreased expression of PON3 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PON3 mRNA25613284
C051890irinotecanirinotecan affects the expression of PON3 mRNA20097248
C410337K 7174K 7174 results in decreased expression of PON3 mRNA24086573
C011890kojic acid[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of PON3 mRNA18544905
C011890kojic acid[Diethylnitrosamine co-treated with kojic acid] results in increased expression of PON3 mRNA18544905
D007783LactonesPON3 protein results in increased hydrolysis of Lactones10931838
D008148LovastatinPON3 protein results in increased hydrolysis of Lovastatin15772423
D008148Lovastatin7-ketocholesterol inhibits the reaction [PON3 protein results in increased metabolism of Lovastatin]12615656
D008148LovastatinPhosphatidylcholines inhibits the reaction [PON3 protein results in increased metabolism of Lovastatin]12615656
D008148LovastatinPON3 protein results in increased metabolism of Lovastatin12615656
D008148LovastatinPON3 protein results in increased hydrolysis of Lovastatin10931838
D008315MalondialdehydePON3 protein inhibits the reaction [Carbon Tetrachloride results in increased abundance of Malondialdehyde]20079818
D008748MethylcholanthreneMethylcholanthrene results in increased expression of PON3 mRNA26006071
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PON3 mRNA"25554681
C051752nefazodonenefazodone results in decreased expression of PON3 mRNA24136188
D009532NickelNickel results in decreased expression of PON3 mRNA24768652|2558310
C022838nickel chloridenickel chloride results in decreased expression of PON3 mRNA24612858
C012655nimesulidenimesulide results in decreased expression of PON3 mRNA24136188
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 gene mutant form affects the susceptibility to [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of PON3 mRNA]"21673326
D010100OxygenOxygen deficiency results in increased expression of PON3 mRNA26516004
D000073878Palm OilPalm Oil results in decreased expression of PON3 mRNA18042831
D000073878Palm OilPalm Oil results in increased expression of PON3 mRNA18042831
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of PON3 mRNA28973697
D010578PetroleumPetroleum affects the expression of PON3 mRNA25208076
D010634PhenobarbitalPhenobarbital results in decreased expression of PON3 mRNA22653878
C570634phenyl acetatePON3 gene SNP affects the hydrolysis of phenyl acetate20839225
C025136phenylacetic acidPON3 protein results in increased hydrolysis of phenylacetic acid16099434|1613951
D010713PhosphatidylcholinesPhosphatidylcholines inhibits the reaction [PON3 protein results in increased metabolism of Lovastatin]12615656
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PON3 mRNA19710929
C045950propiconazolepropiconazole results in increased expression of PON3 mRNA21278054|2233456
D011441PropylthiouracilPropylthiouracil results in decreased expression of PON3 mRNA24780913
D015474IsotretinoinIsotretinoin results in decreased expression of PON3 mRNA20436886
D012431RutinRutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PON3 mRNA]25478064
D012431RutinRutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PON3 protein]25478064
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PON3 mRNA23806026|2589566
C016104sodium bichromatesodium bichromate results in decreased expression of PON3 mRNA24612858
C016104sodium bichromatesodium bichromate affects the expression of PON3 mRNA22110744
D012969Sodium FluorideSodium Fluoride results in increased expression of PON3 protein28918527
D013148SpironolactonePON3 protein results in increased hydrolysis of Spironolactone15772423
D013467SulindacSulindac results in decreased expression of PON3 mRNA24136188
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PON3 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PON3 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PON3 mRNA16497791|2600607
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PON3 protein16497791
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PON3 mRNA25613284
D014635Valproic AcidValproic Acid results in decreased methylation of PON3 gene29154799
C025643vinclozolinvinclozolin affects the expression of PON3 mRNA19015723
C029297vinylidene chloridevinylidene chloride results in increased expression of PON3 mRNA26682919
D014810Vitamin EVitamin E results in increased activity of PON3 protein12615656
D024483Vitamin K 3Vitamin K 3 affects the expression of PON3 mRNA20044591
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of PON3 mRNA"25208076

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004063aryldialkylphosphatase activity-IEA-  
GO:0004064arylesterase activity-IBA21873635  
GO:0004064arylesterase activity-IDA15772423  
GO:0004064arylesterase activity-NAS8661009  
GO:0016788hydrolase activity, acting on ester bonds-IBA21873635  
GO:00187333,4-dihydrocoumarin hydrolase activity-IEA-  
GO:0042803protein homodimerization activity-IDA15772423  
GO:0046872metal ion binding-IEA-  
GO:0102007acyl-L-homoserine-lactone lactonohydrolase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0009636response to toxic substance-IBA21873635  
GO:0010124phenylacetate catabolic process-IEA-  
GO:0016311dephosphorylation-IEA-  
GO:0019372lipoxygenase pathway-TAS-  
GO:0019439aromatic compound catabolic process-IDA15772423  
GO:0032929negative regulation of superoxide anion generation-IEA-  
GO:0046226coumarin catabolic process-IEA-  
GO:0046395carboxylic acid catabolic process-IDA15772423  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0043231intracellular membrane-bounded organelle-IEA-  
GO:0070062extracellular exosome-HDA19199708  
KEGG ID KEGG Term
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-2142688Synthesis of 5-eicosatetraenoic acidsTAS
R-HSA-2142753Arachidonic acid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8978868Fatty acid metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
16239632Evaluation of the paraoxonases as candidate genes for stroke: Gln192Arg polymorphism in the paraoxonase 1 gene is associated with increased risk of stroke. (2005 Nov)Ranade KStroke
14996478PON1 M/L55 mutation protects high-risk patients against coronary artery disease. (2004 Mar)Oliveira SAInt J Cardiol
14636952Human paraoxonase gene cluster polymorphisms as predictors of coronary heart disease risk in the prospective Northwick Park Heart Study II. (2003 Nov 20)Robertson KSBiochim Biophys Acta
27142338Prostate tumor DNA methylation is associated with cigarette smoking and adverse prostate cancer outcomes. (2016 Jul 15)Shui IMCancer
25606379Effect of PON1 gene polymorphisms in Turkish patients with hepatocellular carcinoma. (2013 Dec)Akkiz HMeta Gene