Gene: ANKIB1

54467
-
ankyrin repeat and IBR domain containing 1
protein-coding
7q21.2
Ensembl:ENSG00000001629 Vega:OTTHUMG00000155859 UniprotKB:Q9P2G1
NC_000007.14
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.008e-1 (AD)  2.158e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12740chr7:92399988 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs12704637chr7:92245372 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RDX0.906
SOS20.899
FMNL20.894
KTN10.885
STAG20.882
ACBD50.878
SPAG90.874
BBX0.873
PHF30.872
ZNF240.871

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.57
OR4F5-0.537
PRTN3-0.262
NPW-0.26
SHISA8-0.253
KCNG2-0.252
ASGR2-0.242
NKX6-3-0.238
TGFBR3L-0.236
TNFRSF18-0.232

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of ANKIB1 mRNA21420995
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ANKIB1 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of ANKIB1 mRNA20458559
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ANKIB1 mRNA"19150397
D004958EstradiolEstradiol results in decreased expression of ANKIB1 mRNA19167446
C053541bicalutamidebicalutamide results in increased expression of ANKIB1 mRNA16631469
C006780bisphenol Abisphenol A results in increased expression of ANKIB1 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of ANKIB1 mRNA25181051
D019327Copper SulfateCopper Sulfate results in increased expression of ANKIB1 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of ANKIB1 mRNA20106945
D004726EndosulfanEndosulfan results in increased expression of ANKIB1 mRNA26615145
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ANKIB1 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ANKIB1 mRNA28196854
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of ANKIB1 mRNA17183730
D006997Hypochlorous AcidHypochlorous Acid results in increased expression of ANKIB1 mRNA19376150
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of ANKIB1 mRNA25729387
D010795Phthalic AcidsPhthalic Acids results in increased expression of ANKIB1 mRNA21061450
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ANKIB1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ANKIB1 mRNA22079256
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of ANKIB1 mRNA28903501
D011374ProgesteroneProgesterone results in decreased expression of ANKIB1 mRNA23018184
D011374ProgesteroneProgesterone results in increased expression of ANKIB1 mRNA23018184
C045950propiconazolepropiconazole results in increased expression of ANKIB1 mRNA21278054
D012834SilverSilver results in decreased expression of ANKIB1 mRNA27131904
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ANKIB1 mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ANKIB1 mRNA19465110
D013853ThioacetamideThioacetamide results in increased expression of ANKIB1 mRNA23411599
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of ANKIB1 mRNA25729387
D014212TretinoinTretinoin results in increased expression of ANKIB1 mRNA23724009
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of ANKIB1 mRNA17183730
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ANKIB1 gene25560391
D019287Zinc SulfateZinc Sulfate results in decreased expression of ANKIB1 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI20195357  
GO:0031624ubiquitin conjugating enzyme binding-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO:0061630ubiquitin protein ligase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000209protein polyubiquitination-IBA21873635  
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000151ubiquitin ligase complex-IBA21873635  
GO:0005737cytoplasm-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal