Gene: POR

5447
CPR|CYPOR|P450R
cytochrome p450 oxidoreductase
protein-coding
7q11.23
Ensembl:ENSG00000127948 MIM:124015 Vega:OTTHUMG00000130413 UniprotKB:P16435
NG_008930.1
PubMed
OD|ND|AD
45   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.348e-1 (AD)  5.054e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TKT0.886
SMARCB10.884
LMAN20.882
SURF40.881
KHSRP0.878
SDF40.877
TPRA10.877
P4HB0.874
NUCB10.873
HM130.871

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.681
OR4F29-0.629
CETP-0.327
FCRL1-0.302
HMHB1-0.283
CTNNA3-0.282
OR6C74-0.278
KLRB1-0.268
KRT73-0.259
CPA3-0.259

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB03147Flavin adenine dinucleotideSmall Molecule146-14-5ApprovedTarget
DB03247Flavin mononucleotideSmall Molecule146-17-8Approved|InvestigationalTarget
DB034612'-Monophosphoadenosine 5'-DiphosphoriboseSmall MoleculeExperimentalTarget
DB00166Lipoic AcidSmall Molecule1200-22-2Approved|Investigational|NutraceuticalEnzyme
DB00305MitomycinSmall Molecule50-07-7ApprovedEnzyme
DB00665NilutamideSmall Molecule63612-50-0Approved|InvestigationalEnzyme
DB00694DaunorubicinSmall Molecule20830-81-3ApprovedEnzyme
DB00698NitrofurantoinSmall Molecule67-20-9ApprovedEnzyme
DB00865BenzphetamineSmall Molecule156-08-1Approved|IllicitEnzyme
DB00997DoxorubicinSmall Molecule23214-92-8Approved|InvestigationalEnzyme
DB01466EthylmorphineSmall Molecule76-58-4Approved|IllicitEnzyme
DB03247Flavin mononucleotideSmall Molecule146-17-8Approved|InvestigationalEnzyme
DB06263AmrubicinSmall Molecule110267-81-7Approved|InvestigationalEnzyme
DB09332KappadioneSmall Molecule131-13-5ApprovedEnzyme
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of POR mRNA"26377693
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione affects the expression of POR mRNA"19162173
C51721412-hydroxyellipticine[CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine]22390216
C51721412-hydroxyellipticine[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine22390216
C5859551-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acidKetoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]24120545
C5859551-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid24120545
C5859551-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acidPOR protein results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid24120545
C5859551-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acidQuercetin inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]24120545
C5859551-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acidThioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]24120545
C5859551-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acidTranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]24120545
C0374131,3-dinitropyrene"[CYP1A1 protein co-treated with POR protein] results in decreased metabolism of 1,3-dinitropyrene"11113705
C0374131,3-dinitropyrene"[CYP1A2 protein co-treated with POR protein] results in decreased metabolism of 1,3-dinitropyrene"11113705
C0374131,3-dinitropyrene"[CYP1B1 protein co-treated with POR protein] results in decreased metabolism of 1,3-dinitropyrene"11113705
C51721513-hydroxyellipticine[CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine]22390216
C51721513-hydroxyellipticineCYB5A protein promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine]22390216
C51721513-hydroxyellipticine[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine22390216
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of POR mRNA"19850644|2890350
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of POR mRNA]"19850644
C0333091,6-dinitropyrene"POR protein affects the metabolism of 1,6-dinitropyrene"2180560
C0333101,8-dinitropyrene"[CYP1A1 protein co-treated with POR protein] results in increased metabolism of 1,8-dinitropyrene"11113705
C0333101,8-dinitropyrene"[CYP1B1 protein co-treated with POR protein] results in increased metabolism of 1,8-dinitropyrene"11113705
C0333101,8-dinitropyrene"POR protein affects the metabolism of 1,8-dinitropyrene"2180560
C0243361-phenylazo-2-naphthol[CYP1A1 protein co-treated with POR protein] results in increased metabolism of 1-phenylazo-2-naphthol24530354
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of POR mRNA19933214
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of POR mRNA"25614096
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of POR mRNA"20056577|2729130
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of POR mRNA"28433925
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of POR mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"[POR protein co-treated with CYP3A4 protein] affects the susceptibility to 2,5,2',5'-tetrachlorobiphenyl"27913846
C1177762,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone"POR protein results in increased reduction of 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone"17256129
C1177762,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone"POR protein results in increased reduction of and results in increased activity of 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone"17015278
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of POR mRNA"21346803
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"[CYP1A2 protein co-treated with POR protein co-treated with OAT protein] results in increased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"10503888|9581821
C0369892-amino-3,4-dimethylimidazo(4,5-f)quinoline"[CYP1A2 protein co-treated with POR protein co-treated with OAT protein] results in increased susceptibility to 2-amino-3,4-dimethylimidazo(4,5-f)quinoline"10503888|9581821
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"[CYP1A2 protein co-treated with POR protein co-treated with OAT protein] results in increased susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"10503888|9581821
C0292162-amino-3-methylimidazo(4,5-f)quinoline"[CYP1A2 protein co-treated with POR protein co-treated with OAT protein] results in increased susceptibility to 2-amino-3-methylimidazo(4,5-f)quinoline"10503888|9581821
C0178222-amino-9H-pyrido(2,3-b)indole"POR gene mutant form results in decreased metabolism of and results in increased susceptibility to 2-amino-9H-pyrido(2,3-b)indole"26583703
C0312782-chloroethyl ethyl sulfide2-chloroethyl ethyl sulfide results in decreased activity of POR protein20561902
C0312782-chloroethyl ethyl sulfide[POR protein co-treated with 2-chloroethyl ethyl sulfide] results in increased chemical synthesis of Hydrogen Peroxide20561902
C0312782-chloroethyl ethyl sulfide2-chloroethyl ethyl sulfide results in decreased activity of POR protein20561902
C0312782-chloroethyl ethyl sulfide2-chloroethyl ethyl sulfide results in decreased activity of POR protein20561902
C0490302-nitrofluoranthene[CYP1B1 protein co-treated with POR protein] results in decreased metabolism of 2-nitrofluoranthene11113705
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of POR mRNA]"19467301
C0191333-amino-1-methyl-5H-pyrido(4,3-b)indole"3-amino-1-methyl-5H-pyrido(4,3-b)indole promotes the reaction [purpurin results in increased activity of POR protein]"12744663
C0191333-amino-1-methyl-5H-pyrido(4,3-b)indole"3-amino-1-methyl-5H-pyrido(4,3-b)indole results in decreased activity of POR protein"12744663
C1172203-nitrobenzanthrone[POR protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone20545351
C1172203-nitrobenzanthronePOR protein results in increased activity of and results in increased reduction of 3-nitrobenzanthrone20545351
C0336433-nitrofluoranthene[CYP1B1 protein co-treated with POR protein] results in decreased metabolism of 3-nitrofluoranthene11113705
C0286764-acetylaminofluorene4-acetylaminofluorene results in increased expression of POR mRNA15089088
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanonePOR affects the susceptibility to 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone22710403
C1047746',7'-dihydroxybergamottin"6',7'-dihydroxybergamottin results in decreased activity of POR protein"23146034
C0594447,12-dimethylbenz(a)anthracene-DNA adduct"POR protein results in decreased abundance of 7,12-dimethylbenz(a)anthracene-DNA adduct"22595614
C0775807-(deoxyadenosin-N(6)-yl)aristolactam IPOR protein results in increased activity of 7-(deoxyadenosin-N(6)-yl)aristolactam I15386410
C0775807-(deoxyadenosin-N(6)-yl)aristolactam ICYP1A1 protein affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]21932800
C0775807-(deoxyadenosin-N(6)-yl)aristolactam I[CYP1A1 protein co-treated with CYP1A2 protein] affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]21932800
C0775807-(deoxyadenosin-N(6)-yl)aristolactam I[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]21932800
C4056997-(deoxyadenosin-N(6)--yl)aristolactam IICYP1A1 protein affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]21932800
C4056997-(deoxyadenosin-N(6)--yl)aristolactam II[CYP1A1 protein co-treated with CYP1A2 protein] affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]21932800
C4056997-(deoxyadenosin-N(6)--yl)aristolactam II[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]21932800
C0775797-(deoxyguanosin-N(2)-yl)aristolactam ICYP1A1 protein affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]21932800
C0775797-(deoxyguanosin-N(2)-yl)aristolactam I[CYP1A1 protein co-treated with CYP1A2 protein] affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]21932800
C0775797-(deoxyguanosin-N(2)-yl)aristolactam I[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]21932800
C0554407-hydroxyellipticine[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 7-hydroxyellipticine22390216
C0671348-oxo-7-hydrodeoxyguanosine[Nitrofurazone co-treated with POR protein co-treated with Copper] results in increased abundance of 8-oxo-7-hydrodeoxyguanosine15488632
C0080099-hydroxyellipticine[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 9-hydroxyellipticine22390216
D000082AcetaminophenAcetaminophen results in increased expression of POR mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of POR mRNA17562736
D000082AcetaminophenPOR protein affects the metabolism of Acetaminophen15328377
D000082AcetaminophenPOR protein results in increased metabolism of Acetaminophen12566435
D000082AcetaminophenPOR protein results in increased susceptibility to Acetaminophen15550675|2137674
D000082AcetaminophenAcetaminophen results in increased expression of POR mRNA17202762
D019342Acetic AcidPOR protein results in increased metabolism of Acetic Acid analog21933969
D019342Acetic AcidPOR protein results in increased metabolism of Acetic Acid analog21933969
D000242Cyclic AMPCyclic AMP results in increased expression of POR mRNA25576683
D016604Aflatoxin B1Aflatoxin B1 affects the expression of POR protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of POR mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of POR gene27153756
D016604Aflatoxin B1[CYP3A7 co-treated with POR] results in increased susceptibility to Aflatoxin B17625840
D016604Aflatoxin B1[POR protein co-treated with CYP3A4 protein] results in increased susceptibility to Aflatoxin B127913846
D000452AldrinAldrin results in decreased expression of POR mRNA18579281
C010845aluminum chloridealuminum chloride results in decreased activity of POR protein17994580
C010845aluminum chlorideEdetic Acid inhibits the reaction [aluminum chloride results in decreased activity of POR protein]17994580
C100057ametrynePOR protein promotes the reaction [CYP1A2 protein results in increased metabolism of ametryne]8971136
D000638AmiodaroneAmiodarone affects the expression of POR mRNA18355885
C014983amitrazamitraz results in increased activity of POR protein15350676
D000639AmitriptylineAmitriptyline affects the expression of POR mRNA18355885
D000643Ammonium ChlorideAmmonium Chloride affects the expression of POR mRNA16483693
C030419andrographolide[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of POR mRNA19737545
C023650aniline[CYP2E1 protein co-treated with POR protein] results in increased hydroxylation of aniline2292581
D000872AnthocyaninsAnthocyanins results in increased expression of POR mRNA18803703
C000228aristolochic acid IPOR protein results in increased metabolism of aristolochic acid I26845733
C000228aristolochic acid ICYP1A1 protein affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]21932800
C000228aristolochic acid I[CYP1A1 protein co-treated with CYP1A2 protein] affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]21932800
C000228aristolochic acid IPOR protein affects the abundance of and affects the metabolism of aristolochic acid I21362632
C000228aristolochic acid IPOR protein affects the abundance of aristolochic acid I metabolite21362632
C000228aristolochic acid I[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]21932800
C000228aristolochic acid IPOR protein results in increased metabolism of aristolochic acid I26845733
D017636Asbestos, Amphibole"Asbestos, Amphibole affects the expression of POR protein"20855422
C017032asiatic acid"asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in increased activity of POR protein]"29108773
D001241AspirinAspirin results in decreased expression of POR mRNA15928584
C005948astaxanthineastaxanthine results in decreased activity of POR protein21414371
C005948astaxanthineastaxanthine results in increased expression of POR protein21414371
D001280AtrazineAtrazine results in increased expression of POR mRNA22378314
C059265bemitradinebemitradine results in increased expression of POR mRNA15089088
D001554BenzeneBenzene results in increased expression of POR mRNA19162166
D001554BenzeneBenzene results in increased activity of POR protein3080823
C018003benzo(a)pyrene-3,6-quinone"POR protein results in increased activity of benzo(a)pyrene-3,6-quinone"9703276
C017228benzo(a)pyrene 7,8-dihydrodiol"[[CYP1A1 protein co-treated with POR protein co-treated with EPHX1 protein] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene 7,8-dihydrodiol"24530354
C043931benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA"Masoprocol inhibits the reaction [POR protein affects the reaction [Benzo(a)pyrene results in increased chemical synthesis of benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA]]"28111842
C043931benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA"Phenolphthalein inhibits the reaction [POR protein affects the reaction [Benzo(a)pyrene results in increased chemical synthesis of benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA]]"28111842
C043931benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA"POR protein affects the reaction [Benzo(a)pyrene results in increased chemical synthesis of benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA]"28111842
C043931benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA"resveratrol inhibits the reaction [POR protein affects the reaction [Benzo(a)pyrene results in increased chemical synthesis of benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA]]"28111842
C056612benzo(a)pyrene-DNA adductPOR protein results in decreased abundance of benzo(a)pyrene-DNA adduct22759596
C056612benzo(a)pyrene-DNA adductCYB5A protein promotes the reaction [[[CYP1A1 protein co-treated with POR protein] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-DNA adduct]24530354
C056612benzo(a)pyrene-DNA adduct[[CYP1A1 protein co-treated with POR protein] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-DNA adduct24530354
C056612benzo(a)pyrene-DNA adductEPHX1 protein affects the reaction [CYB5A protein promotes the reaction [[[CYP1A1 protein co-treated with POR protein] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-DNA adduct]]24530354
D019324beta-Naphthoflavone[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of POR mRNA19737545
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of POR mRNA21295105
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of POR mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of POR mRNA20106945
D001564Benzo(a)pyrene[[POR protein co-treated with CYP3A4 protein] results in increased susceptibility to Benzo(a)pyrene] which results in increased mutagenesis of HPRT1 gene27913846
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of POR mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of POR protein19449198
D001564Benzo(a)pyreneCapsaicin inhibits the reaction [Benzo(a)pyrene results in increased expression of POR protein]19449198
D001564Benzo(a)pyrene"[lipopolysaccharide, E coli O55-B5 co-treated with Benzo(a)pyrene] affects the expression of POR mRNA"28987381
D001564Benzo(a)pyrene"Masoprocol inhibits the reaction [POR protein affects the reaction [Benzo(a)pyrene results in increased chemical synthesis of benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA]]"28111842
D001564Benzo(a)pyrene"Phenolphthalein inhibits the reaction [POR protein affects the reaction [Benzo(a)pyrene results in increased chemical synthesis of benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA]]"28111842
D001564Benzo(a)pyrenePOR protein affects the reaction [Benzo(a)pyrene affects the expression of SP1 protein]21987461
D001564Benzo(a)pyrenePOR protein affects the reaction [Benzo(a)pyrene results in increased abundance of F2-Isoprostanes]21987461
D001564Benzo(a)pyrenePOR protein affects the reaction [Benzo(a)pyrene results in increased activity of and results in increased expression of NQO1 protein]21362632
D001564Benzo(a)pyrene"POR protein affects the reaction [Benzo(a)pyrene results in increased chemical synthesis of benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA]"28111842
D001564Benzo(a)pyrenePOR protein affects the reaction [Benzo(a)pyrene results in increased expression of CYB5A protein]22759596
D001564Benzo(a)pyrenePOR protein affects the reaction [Benzo(a)pyrene results in increased expression of EPHX1 protein]22759596
D001564Benzo(a)pyrenePOR protein affects the reaction [Benzo(a)pyrene results in increased expression of GRIN2A protein]21987461
D001564Benzo(a)pyrenePOR protein affects the reaction [Benzo(a)pyrene results in increased expression of SP4 protein]21987461
D001564Benzo(a)pyrenePOR protein affects the reaction [Benzo(a)pyrene results in increased mutagenesis of PIGA gene]28111842
D001564Benzo(a)pyrenePOR protein affects the susceptibility to Benzo(a)pyrene28111842
D001564Benzo(a)pyrenePOR protein results in decreased susceptibility to Benzo(a)pyrene24530354
D001564Benzo(a)pyrenePOR protein results in increased metabolism of Benzo(a)pyrene21987461
D001564Benzo(a)pyrenePOR protein results in increased susceptibility to Benzo(a)pyrene21376747
D001564Benzo(a)pyrene"resveratrol inhibits the reaction [POR protein affects the reaction [Benzo(a)pyrene results in increased chemical synthesis of benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA]]"28111842
D001564Benzo(a)pyreneCYB5A protein promotes the reaction [[CYP1A1 protein co-treated with POR protein] results in increased oxidation of Benzo(a)pyrene]24530354
D001564Benzo(a)pyreneCYB5A protein promotes the reaction [[[CYP1A1 protein co-treated with POR protein] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-DNA adduct]24530354
D001564Benzo(a)pyrene[CYP1A1 protein co-treated with POR protein co-treated with EPHX1 protein] results in increased oxidation of Benzo(a)pyrene24530354
D001564Benzo(a)pyrene"[[CYP1A1 protein co-treated with POR protein co-treated with EPHX1 protein] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene 7,8-dihydrodiol"24530354
D001564Benzo(a)pyrene[CYP1A1 protein co-treated with POR protein] results in increased oxidation of Benzo(a)pyrene24530354
D001564Benzo(a)pyrene[[CYP1A1 protein co-treated with POR protein] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-DNA adduct24530354
D001564Benzo(a)pyreneEPHX1 protein affects the reaction [CYB5A protein promotes the reaction [[[CYP1A1 protein co-treated with POR protein] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-DNA adduct]]24530354
D001589Benzphetamine[CYP2E1 protein co-treated with POR protein] results in decreased methylation of Benzphetamine2292581
D001594Benzyl ViologenBenzyl Viologen results in increased expression of POR mRNA22846377
C023888beta-hexachlorocyclohexanebeta-hexachlorocyclohexane results in increased expression of POR mRNA25270620
C095105bexarotenebexarotene results in increased expression of POR mRNA16648578
D001629BezafibrateBezafibrate results in increased activity of POR protein7606338
C016266bilirubin glucuronatePOR gene mutant form results in increased abundance of bilirubin glucuronate25147274
C006780bisphenol Abisphenol A affects the expression of POR mRNA21786754
C006780bisphenol Abisphenol A promotes the reaction [POR protein binds to ESR1 protein]27156127
C006780bisphenol Abisphenol A results in increased expression of POR mRNA29275510
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of POR mRNA"28433925
C006780bisphenol Abisphenol A affects the expression of POR mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of POR protein24752506
C006780bisphenol Abisphenol A results in increased expression of POR mRNA25181051
C032036bromobenzenebromobenzene results in increased expression of POR mRNA12628495
D002065BuspironeBuspirone results in increased expression of POR mRNA24136188
D002087ButyratesButyrates results in increased expression of POR mRNA14674679
C028031cadmium acetatecadmium acetate affects the expression of POR mRNA16249259
D019256Cadmium ChlorideCadmium Chloride results in decreased activity of POR protein17113746
D019256Cadmium ChlorideCadmium Chloride results in increased activity of POR protein20934533
D019256Cadmium ChlorideCadmium Chloride results in increased expression of POR protein24527689
D019256Cadmium Chloridediphenyleneiodonium inhibits the reaction [Cadmium Chloride results in increased activity of POR protein]20934533
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of POR mRNA11958953
D002211CapsaicinCapsaicin inhibits the reaction [Benzo(a)pyrene results in increased expression of POR protein]19449198
D002220CarbamazepineCarbamazepine results in increased expression of POR mRNA17112801
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of POR mRNA27339419
C006923carvonePOR protein results in increased susceptibility to carvone analog21376747
D002635Chenodeoxycholic AcidPOR gene mutant form results in increased abundance of Chenodeoxycholic Acid25034404
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of POR mRNA18178546
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of POR protein8471063
D002725ChloroformPOR protein affects the susceptibility to Chloroform23732084
D002725ChloroformPOR results in decreased susceptibility to Chloroform18031782
D019826Cholic AcidCholic Acid results in increased expression of POR mRNA17521389
D019826Cholic AcidPOR gene mutant form results in decreased abundance of Cholic Acid25034404
C022990chromic chloridechromic chloride results in decreased activity of POR protein17113746
C039671ciglitazone[ciglitazone binds to PPARG protein alternative form] which results in increased expression of POR mRNA16197558
C039671ciglitazone[ciglitazone binds to PPARG protein] which results in increased expression of POR mRNA16197558
D002922CiguatoxinsCiguatoxins affects the expression of POR mRNA18353800
C012843cinnamic aldehydecinnamic aldehyde results in increased expression of POR mRNA19000754
C503589cis-9, trans-11-conjugated linoleic acid"cis-9, trans-11-conjugated linoleic acid results in decreased expression of POR mRNA"17217560
D002994ClofibrateClofibrate results in decreased expression of POR mRNA17585979
D002994ClofibrateClofibrate results in increased activity of POR protein7606338
D002994ClofibrateClofibrate results in increased expression of POR mRNA12851107|1508908
D002994ClofibrateClofibrate results in increased expression of POR protein18670166
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of POR mRNA17602206
D002997ClomipramineClomipramine affects the expression of POR mRNA18355885
D060729Coal AshCoal Ash results in increased activity of POR protein4049429
C018021cobaltous chloridecobaltous chloride results in increased expression of POR mRNA21139344
D009249NADP[CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine]22390216
D009249NADP[CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine]22390216
D009249NADPCYB5A protein promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine]22390216
D009249NADP[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine22390216
D009249NADP[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine22390216
D009249NADP[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 7-hydroxyellipticine22390216
D009249NADP[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 9-hydroxyellipticine22390216
D009249NADP[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased oxidation of ellipticine22390216
D009249NADPdiphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased metabolism of NADP]21215309
D009249NADPdiphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Paraquat] which results in increased metabolism of NADP]21215309
D009249NADPKetoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]24120545
D009249NADP[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid24120545
D009249NADPNADP promotes the reaction [[POR protein results in increased metabolism of Diquat] which results in increased metabolism of Oxygen]21215309
D009249NADPNADP promotes the reaction [[POR protein results in increased metabolism of Paraquat] which results in increased metabolism of Oxygen]21215309
D009249NADP[POR protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone20545351
D009249NADP[POR protein co-treated with NADP] results in increased chemical synthesis of Hydrogen Peroxide20561902
D009249NADP[POR protein results in increased metabolism of Diquat] which results in increased metabolism of NADP21215309
D009249NADP[POR protein results in increased metabolism of Paraquat] which results in increased metabolism of NADP21215309
D009249NADPQuercetin inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]24120545
D009249NADPThioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]24120545
D009249NADPTranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]24120545
D009249NADPdiphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased metabolism of NADP]21215309
D009249NADP[POR protein results in increased metabolism of Diquat] which results in increased metabolism of NADP21215309
D009249NADPNADP affects the reaction [POR protein affects the metabolism of Nitrofurantoin]18206659
D009249NADPNADP promotes the reaction [POR protein results in increased reduction of Vitamin K 3]27558805
D009249NADPCAT protein promotes the reaction [Oxygen inhibits the reaction [[Fe(III)-EDTA co-treated with NADP co-treated with POR protein] results in increased reduction of sodium chromate(VI)]]7741258
D009249NADP[Fe(III)-EDTA co-treated with NADP co-treated with POR protein] results in increased reduction of sodium chromate(VI)7741258
D009249NADPHEPES promotes the reaction [[Fe(III)-EDTA co-treated with NADP co-treated with POR protein] results in increased reduction of sodium chromate(VI)]7741258
D009249NADPMannitol inhibits the reaction [Oxygen inhibits the reaction [[Fe(III)-EDTA co-treated with NADP co-treated with POR protein] results in increased reduction of sodium chromate(VI)]]7741258
D009249NADPOxygen inhibits the reaction [[Fe(III)-EDTA co-treated with NADP co-treated with POR protein] results in increased reduction of sodium chromate(VI)]7741258
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of POR mRNA20971185
D003300CopperCopper results in decreased expression of POR mRNA22465980
D003300Copper[Nitrofurazone co-treated with POR protein co-treated with Copper] results in increased abundance of 8-oxo-7-hydrodeoxyguanosine15488632
D019327Copper SulfateCopper Sulfate results in decreased expression of POR mRNA18579281
C029892cupric chloridecupric chloride results in increased expression of POR mRNA24650576
C029892cupric chloridecupric chloride results in decreased expression of POR mRNA19515434
D003513CycloheximideCycloheximide results in decreased expression of POR protein27496950
D003513CycloheximidePOR protein mutant form promotes the reaction [Cycloheximide results in decreased expression of POR protein]27496950
D003520CyclophosphamidePOR promotes the reaction [CYP2B6 results in increased susceptibility to Cyclophosphamide]9766669
D003520CyclophosphamidePOR promotes the reaction [CYP2C18 results in increased susceptibility to Cyclophosphamide]9766669
D003520CyclophosphamidePOR protein promotes the reaction [CYP2B6 protein results in increased susceptibility to Cyclophosphamide]10919648
D003520CyclophosphamideCyclophosphamide results in increased expression of POR mRNA11599041
D016572CyclosporineCyclosporine results in decreased expression of POR mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of POR mRNA25562108
C093628cyproconazolecyproconazole results in increased expression of POR mRNA22334560|2397080
C093628cyproconazoleNR1I3 promotes the reaction [cyproconazole results in increased expression of POR mRNA]25656644
C093628cyproconazole[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of POR mRNA29038839
C093628cyproconazole[cyproconazole co-treated with epoxiconazole] results in increased expression of POR mRNA29038839
C093628cyproconazolecyproconazole results in increased expression of POR mRNA29038839
C031071decanoic acid[CYP2E1 protein co-treated with POR protein] results in increased hydroxylation of decanoic acid2292581
D003671DEETDEET results in increased expression of POR mRNA27091632
D003671DEET[fipronil co-treated with DEET] results in increased expression of POR mRNA27091632
D003840Deoxycholic AcidPOR gene mutant form results in decreased abundance of Deoxycholic Acid25034404
C009997desmethylmisonidazoledesmethylmisonidazole inhibits the reaction [POR protein results in increased metabolism of Misonidazole]6802140
D003907Dexamethasone[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of POR mRNA24848799
D003907Dexamethasone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of POR mRNA16054899
D003907DexamethasoneDexamethasone results in increased expression of POR mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in increased expression of POR mRNA]20032058
C012279dibutylnitrosamine[CYP2E1 protein co-treated with POR protein co-treated with CYB5B protein] results in increased susceptibility to dibutylnitrosamine11733072
C012279dibutylnitrosamine[CYP2E1 protein co-treated with POR protein] results in increased susceptibility to dibutylnitrosamine11035158
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of POR mRNA17379624|2126653
C055869dichlobanilPOR protein results in decreased susceptibility to dichlobanil20840855
D0151013,3'-Dichlorobenzidine"POR protein affects the metabolism of 3,3'-Dichlorobenzidine"3130202
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of POR mRNA27392435
D002945CisplatinCisplatin results in increased expression of POR mRNA15464296
D004008DiclofenacPOR affects the susceptibility to Diclofenac25820915
D004008DiclofenacPOR results in increased oxidation of Diclofenac25820915
C121718dicyclanildicyclanil results in increased expression of POR mRNA15664270
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of POR mRNA]"19467301
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of POR mRNA28433925
D004041Dietary FatsDietary Fats results in decreased expression of POR mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of POR mRNA19467301
D004041Dietary Fats[Quercetin co-treated with Dietary Fats] affects the expression of POR mRNA23359794
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of POR mRNA28433925
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of POR mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of POR mRNA]19850644
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of POR mRNA"28433925
D004052Diethylnitrosamine[CYP2E1 protein co-treated with POR protein co-treated with CYB5B protein] results in increased susceptibility to Diethylnitrosamine11733072
D004052Diethylnitrosamine[CYP2E1 protein co-treated with POR protein] results in increased susceptibility to Diethylnitrosamine11035158
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of POR mRNA15492232
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Piperonyl Butoxide] results in increased expression of POR mRNA19690152|2010138
D004052DiethylnitrosamineNR1I3 protein affects the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of POR mRNA]15492232
D004052Diethylnitrosamine[Piperonyl Butoxide co-treated with Diethylnitrosamine] results in increased expression of POR mRNA19690152
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of POR mRNA21295105
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of POR mRNA18164116
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of POR mRNA17602206
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of POR mRNA18544905
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with kojic acid] results in increased expression of POR mRNA18544905
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of POR mRNA"22485181
D0151279,10-Dimethyl-1,2-benzanthracene"POR protein affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1B1 protein]"22595614
D0151279,10-Dimethyl-1,2-benzanthracene"POR protein results in decreased abundance of 9,10-Dimethyl-1,2-benzanthracene"22595614
D0198131,2-Dimethylhydrazine"1,2-Dimethylhydrazine results in increased activity of POR protein"19497424|2910877
D0198131,2-Dimethylhydrazine"asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in increased activity of POR protein]"29108773
D0198131,2-Dimethylhydrazine"hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased activity of POR protein]"19497424
D004128Dimethylnitrosamine[CYP2E1 protein co-treated with POR protein co-treated with CYB5B protein] results in increased susceptibility to Dimethylnitrosamine11733072
D004128Dimethylnitrosamine[CYP2E1 protein co-treated with POR protein] results in decreased methylation of Dimethylnitrosamine2292581
D004121Dimethyl SulfoxideDimethyl Sulfoxide inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]11368792
D004121Dimethyl SulfoxideDimethyl Sulfoxide promotes the reaction [Hemin inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]]11368792
D004121Dimethyl SulfoxideDimethyl Sulfoxide promotes the reaction [Hemin results in decreased activity of POR protein]11368792
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in decreased activity of POR protein11368792
D004121Dimethyl SulfoxideHemin promotes the reaction [Dimethyl Sulfoxide inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]]11368792
D004121Dimethyl SulfoxideHemin promotes the reaction [Dimethyl Sulfoxide results in decreased activity of POR protein]11368792
D004121Dimethyl SulfoxideDimethyl Sulfoxide inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical]21215309
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [Cadmium Chloride results in increased activity of POR protein]20934533
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide]21215309
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides]21215309
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased metabolism of NADP]21215309
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased metabolism of Oxygen]21215309
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Paraquat] which results in increased abundance of Hydrogen Peroxide]21215309
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Paraquat] which results in increased abundance of Superoxides]21215309
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Paraquat] which results in increased metabolism of NADP]21215309
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Paraquat] which results in increased metabolism of Oxygen]21215309
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide]21215309
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical]21215309
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides]21215309
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased metabolism of NADP]21215309
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [POR protein affects the metabolism of Nitrofurantoin]18206659
C031291diphenyliodoniumdiphenyliodonium results in decreased activity of POR protein16841314
D004178DiquatCAT protein inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide]21215309
D004178Diquatdiphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide]21215309
D004178Diquatdiphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides]21215309
D004178Diquatdiphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased metabolism of NADP]21215309
D004178Diquatdiphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased metabolism of Oxygen]21215309
D004178Diquat[Iron co-treated with POR protein] results in increased metabolism of Diquat21215309
D004178Diquat[[Iron co-treated with POR protein] results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical21215309
D004178DiquatNADP promotes the reaction [[POR protein results in increased metabolism of Diquat] which results in increased metabolism of Oxygen]21215309
D004178DiquatPOR protein results in increased metabolism of Diquat21215309
D004178Diquat[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide21215309
D004178Diquat[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical21215309
D004178Diquat[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides21215309
D004178Diquat[POR protein results in increased metabolism of Diquat] which results in increased metabolism of NADP21215309
D004178Diquat[POR protein results in increased metabolism of Diquat] which results in increased metabolism of Oxygen21215309
D004178DiquatCAT protein inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide]21215309
D004178DiquatDimethyl Sulfoxide inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical]21215309
D004178Diquatdiphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide]21215309
D004178Diquatdiphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical]21215309
D004178Diquatdiphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides]21215309
D004178Diquatdiphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased metabolism of NADP]21215309
D004178DiquatPOR protein results in increased metabolism of Diquat21215309
D004178Diquat[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide21215309
D004178Diquat[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical21215309
D004178Diquat[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides21215309
D004178Diquat[POR protein results in increased metabolism of Diquat] which results in increased metabolism of NADP21215309
C067311docetaxelPOR mRNA results in increased susceptibility to docetaxel15239142
D004317DoxorubicinPOR mRNA results in decreased susceptibility to Doxorubicin16322897
D004317DoxorubicinPOR protein affects the metabolism of and results in increased activity of Doxorubicin15942634
D004391DustDust results in increased expression of POR mRNA17805423
C509867E804 bisindoleE804 bisindole results in increased expression of POR mRNA23107598
D004492Edetic AcidEdetic Acid inhibits the reaction [aluminum chloride results in decreased activity of POR protein]17994580
D004492Edetic AcidEdetic Acid inhibits the reaction [thallium chloride results in decreased activity of POR protein]17994580
C034192ellipticine[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased oxidation of ellipticine22390216
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of POR mRNA12655031
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of POR mRNA20064776
C045651epigallocatechin gallateepigallocatechin gallate results in increased activity of POR protein15998352
C109476epoxiconazoleepoxiconazole results in increased expression of POR mRNA22334560
C109476epoxiconazole[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of POR mRNA29038839
C109476epoxiconazole[cyproconazole co-treated with epoxiconazole] results in increased expression of POR mRNA29038839
C109476epoxiconazoleepoxiconazole results in increased expression of POR mRNA29038839
C074283estradiol 3-benzoateestradiol 3-benzoate results in decreased expression of POR protein24752506
D000431EthanolEthanol results in increased expression of POR mRNA19167417
D000431EthanolEthanol results in increased activity of POR protein28442378
D000431Ethanolzingerone inhibits the reaction [Ethanol results in increased activity of POR protein]28442378
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of POR protein10787101
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of POR mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of POR mRNA17942748
C098546ethyl tert-butyl etherethyl tert-butyl ether results in increased expression of POR protein24090815
D028441F2-IsoprostanesPOR protein affects the reaction [Benzo(a)pyrene results in increased abundance of F2-Isoprostanes]21987461
C019179Fe(III)-EDTACAT protein promotes the reaction [Oxygen inhibits the reaction [[Fe(III)-EDTA co-treated with NADP co-treated with POR protein] results in increased reduction of sodium chromate(VI)]]7741258
C019179Fe(III)-EDTA[Fe(III)-EDTA co-treated with NADP co-treated with POR protein] results in increased reduction of sodium chromate(VI)7741258
C019179Fe(III)-EDTAHEPES promotes the reaction [[Fe(III)-EDTA co-treated with NADP co-treated with POR protein] results in increased reduction of sodium chromate(VI)]7741258
C019179Fe(III)-EDTAMannitol inhibits the reaction [Oxygen inhibits the reaction [[Fe(III)-EDTA co-treated with NADP co-treated with POR protein] results in increased reduction of sodium chromate(VI)]]7741258
C019179Fe(III)-EDTAOxygen inhibits the reaction [[Fe(III)-EDTA co-treated with NADP co-treated with POR protein] results in increased reduction of sodium chromate(VI)]7741258
D011345FenofibrateFenofibrate results in increased expression of POR mRNA25572481
D011345FenofibrateFenofibrate results in increased expression of POR mRNA16707586
C082360fipronil[fipronil co-treated with DEET] results in increased expression of POR mRNA27091632
C082360fipronilfipronil results in increased expression of POR mRNA27091632
D005415FlavinsFlavins promotes the reaction [POR protein results in increased metabolism of Misonidazole]6802140
D015725FluconazoleFluconazole results in increased expression of POR mRNA16730040|2565664
D015725FluconazoleNR1I3 promotes the reaction [Fluconazole results in increased expression of POR mRNA]25656644
D015725FluconazoleFluconazole results in decreased expression of POR mRNA16643972
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of POR mRNA15089088
C061365flusilazoleflusilazole results in increased expression of POR mRNA28263823
D005485FlutamideFlutamide results in decreased expression of POR mRNA21126777
D005485FlutamideFlutamide results in decreased expression of POR mRNA24793618
D005485FlutamideFlutamide results in increased expression of POR mRNA24136188
D005503Food AdditivesFood Additives results in increased expression of POR mRNA18803703
C069837fullerene C60fullerene C60 results in increased expression of POR mRNA19167457
C039281furanfuran results in increased expression of POR mRNA26194646
D015248GemfibrozilGemfibrozil results in increased activity of POR protein7606338
D006000Glycocholic AcidPOR gene mutant form results in decreased abundance of Glycocholic Acid25034404
D006002Glycodeoxycholic AcidPOR gene mutant form results in increased abundance of Glycodeoxycholic Acid25034404
C027746glycolithocholic acidPOR gene mutant form results in increased abundance of glycolithocholic acid25034404
D006046Gold[Polyethyleneimine binds to Gold] which results in decreased expression of POR mRNA28433809
D006118GriseofulvinGriseofulvin affects the expression of POR mRNA12735108
C010176halofuginonehalofuginone results in decreased expression of POR mRNA17180598
D006418Heme[CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine]22390216
D006418Heme[CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine]22390216
D006427HeminDimethyl Sulfoxide promotes the reaction [Hemin inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]]11368792
D006427HeminDimethyl Sulfoxide promotes the reaction [Hemin results in decreased activity of POR protein]11368792
D006427HeminHemin inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]11368792
D006427HeminHemin promotes the reaction [Dimethyl Sulfoxide inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]]11368792
D006427HeminHemin promotes the reaction [Dimethyl Sulfoxide results in decreased activity of POR protein]11368792
D006427HeminHemin results in decreased activity of POR protein11368792
C013015hesperetin"hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased activity of POR protein]"19497424
D006581HexachlorobenzeneHexachlorobenzene results in decreased expression of POR mRNA15159207
C007931hexacyanoferrate IIIPOR protein results in increased reduction of hexacyanoferrate III18678259
D006861Hydrogen PeroxideCAT protein inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide]21215309
D006861Hydrogen PeroxideCAT protein inhibits the reaction [[POR protein results in increased metabolism of Paraquat] which results in increased abundance of Hydrogen Peroxide]21215309
D006861Hydrogen Peroxidediphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide]21215309
D006861Hydrogen Peroxidediphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Paraquat] which results in increased abundance of Hydrogen Peroxide]21215309
D006861Hydrogen Peroxide[POR protein co-treated with 2-chloroethyl ethyl sulfide] results in increased chemical synthesis of Hydrogen Peroxide20561902
D006861Hydrogen Peroxide[POR protein co-treated with NADP] results in increased chemical synthesis of Hydrogen Peroxide20561902
D006861Hydrogen PeroxidePOR protein results in increased abundance of Hydrogen Peroxide25061110
D006861Hydrogen PeroxidePOR protein results in increased chemical synthesis of Hydrogen Peroxide20561902
D006861Hydrogen Peroxide[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide21215309
D006861Hydrogen Peroxide[POR protein results in increased metabolism of Paraquat] which results in increased abundance of Hydrogen Peroxide21215309
D006861Hydrogen PeroxideCAT protein inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide]21215309
D006861Hydrogen Peroxidediphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide]21215309
D006861Hydrogen Peroxide[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide21215309
D006861Hydrogen PeroxidePOR protein promotes the reaction [Vitamin K 3 results in increased chemical synthesis of Hydrogen Peroxide]27558805
D006861Hydrogen PeroxidePOR protein results in increased chemical synthesis of Hydrogen Peroxide27558805
D006531HEPESHEPES promotes the reaction [[Fe(III)-EDTA co-treated with NADP co-treated with POR protein] results in increased reduction of sodium chromate(VI)]7741258
D017665Hydroxyl Radical[[Iron co-treated with POR protein] results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical21215309
D017665Hydroxyl Radical[[Iron co-treated with POR protein] results in increased metabolism of Paraquat] which results in increased abundance of Hydroxyl Radical21215309
D017665Hydroxyl Radical[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical21215309
D017665Hydroxyl RadicalDimethyl Sulfoxide inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical]21215309
D017665Hydroxyl Radicaldiphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical]21215309
D017665Hydroxyl Radical[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical21215309
C001654hyperforinhyperforin results in increased expression of POR mRNA24259679
D007069IfosfamidePOR promotes the reaction [CYP2B6 results in increased susceptibility to Ifosfamide]9766669
D007069IfosfamidePOR promotes the reaction [CYP2C18 results in increased susceptibility to Ifosfamide]9766669
D007099ImipramineImipramine affects the expression of POR mRNA18355885
C051890irinotecanPOR mRNA results in increased susceptibility to irinotecan15239142
D007501Iron[Iron co-treated with POR protein] results in increased metabolism of Diquat21215309
D007501Iron[[Iron co-treated with POR protein] results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical21215309
D007501Iron[Iron co-treated with POR protein] results in increased metabolism of Paraquat21215309
D007501Iron[[Iron co-treated with POR protein] results in increased metabolism of Paraquat] which results in increased abundance of Hydroxyl Radical21215309
D0150561-Methyl-3-isobutylxanthine[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of POR mRNA24848799
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of POR mRNA16054899
D007538IsoniazidIsoniazid results in decreased expression of POR mRNA28619387
D007538Isoniazidsilybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of POR mRNA]28619387
D007538Isoniazid[Zidovudine co-treated with Isoniazid] results in decreased expression of POR mRNA28619387
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of POR mRNA27392435
C544151jinfukangjinfukang results in increased expression of POR mRNA27392435
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of POR protein17337753
D007654KetoconazoleKetoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]24120545
D007654KetoconazoleKetoconazole results in increased expression of POR protein17966066
D007654KetoconazoleKetoconazole affects the expression of POR mRNA18355885
C011890kojic acid[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of POR mRNA18544905
C011890kojic acid[Diethylnitrosamine co-treated with kojic acid] results in increased expression of POR mRNA18544905
D007848Laurates[CYP2E1 protein co-treated with POR protein] results in increased hydroxylation of Laurates2292581
C045463leflunomideleflunomide results in increased expression of POR mRNA28988120
C045463leflunomideleflunomide results in increased expression of POR mRNA24136188
D001556LindaneLindane results in increased expression of POR mRNA17785943
C482199lipopolysaccharide, E coli O55-B5"[lipopolysaccharide, E coli O55-B5 co-treated with Benzo(a)pyrene] affects the expression of POR mRNA"28987381
D008070Lipopolysaccharides[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of POR mRNA22777745
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of POR mRNA12057914
D008095Lithocholic AcidPOR gene mutant form results in increased abundance of Lithocholic Acid25034404
D058185Magnetite NanoparticlesMagnetite Nanoparticles results in increased expression of POR mRNA25532727
D008353MannitolMannitol inhibits the reaction [Oxygen inhibits the reaction [[Fe(III)-EDTA co-treated with NADP co-treated with POR protein] results in increased reduction of sodium chromate(VI)]]7741258
D009637Masoprocol"Masoprocol inhibits the reaction [POR protein affects the reaction [Benzo(a)pyrene results in increased chemical synthesis of benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA]]"28111842
C051790menadione semiquinonePOR protein results in increased chemical synthesis of menadione semiquinone27558805
D008627Mercuric ChlorideMercuric Chloride results in decreased activity of POR protein17113746
D008627Mercuric ChlorideMercuric Chloride results in increased expression of POR mRNA20353558
D008701MethapyrileneMethapyrilene results in increased expression of POR mRNA15089088
D008727MethotrexateMethotrexate affects the expression of POR mRNA18502557
C066998methoxy-morpholinyl-doxorubicin[CYP3A4 protein co-treated with POR protein] results in increased metabolism of methoxy-morpholinyl-doxorubicin15465924
D008748MethylcholanthreneMethylcholanthrene inhibits the reaction [POR gene mutant form results in decreased expression of CYP3A11 mRNA]23846873
D008748MethylcholanthreneMethylcholanthrene results in increased activity of POR protein22978700
D008748MethylcholanthreneMethylcholanthrene results in increased expression of and results in increased activity of POR protein23169610
D008748MethylcholanthreneMethylcholanthrene results in increased expression of POR mRNA23169610
D008748MethylcholanthrenePOR gene mutant form inhibits the reaction [Methylcholanthrene affects the expression of CYP2D9 protein]23169610
D008748MethylcholanthrenePOR gene mutant form inhibits the reaction [Methylcholanthrene results in decreased expression of MUP2 mRNA]23169610
D008748MethylcholanthrenePOR gene mutant form inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]23169610
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of POR mRNA"20188158
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of POR protein26558463
D008920MisonidazolePOR protein results in increased reduction of Misonidazole3005827
D008920Misonidazoledesmethylmisonidazole inhibits the reaction [POR protein results in increased metabolism of Misonidazole]6802140
D008920MisonidazoleFlavins promotes the reaction [POR protein results in increased metabolism of Misonidazole]6802140
D008920MisonidazoleNitrofurantoin inhibits the reaction [POR protein results in increased metabolism of Misonidazole]6802140
D008920MisonidazoleNitrofurazone inhibits the reaction [POR protein results in increased metabolism of Misonidazole]6802140
D008920MisonidazoleParaquat promotes the reaction [POR protein results in increased metabolism of Misonidazole]6802140
D008920MisonidazolePOR protein results in increased metabolism of Misonidazole6802140
D016685MitomycinPOR mRNA results in increased susceptibility to Mitomycin15239142
D016685MitomycinPOR protein results in increased susceptibility to Mitomycin21386838
C437683motexafin gadoliniummotexafin gadolinium binds to POR protein17018578
C437683motexafin gadolinium[motexafin gadolinium binds to POR protein] which results in decreased activity of HMOX117018578
C500085muraglitazarmuraglitazar results in increased expression of POR mRNA21515302
C004821muricholic acidPOR gene mutant form results in decreased abundance of muricholic acid25034404
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of POR mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of POR mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of POR mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of POR mRNA"25554681
C031721naphthalenenaphthalene results in decreased expression of POR protein19438287
C051752nefazodonenefazodone results in increased expression of POR mRNA24136188
D019829NevirapineNevirapine metabolite results in increased expression of POR mRNA23947594
D019829NevirapineNevirapine results in increased expression of POR mRNA23947594
C022838nickel chloridenickel chloride results in decreased activity of POR protein17113746
C012655nimesulidenimesulide results in increased expression of POR mRNA24136188
D009582NitrofurantoinPOR protein results in increased metabolism of Nitrofurantoin18206659
D009582NitrofurantoinPOR protein results in increased metabolism of Nitrofurantoin18206659
D009582NitrofurantoinPOR protein results in increased metabolism of Nitrofurantoin18206659
D009582Nitrofurantoindiphenyleneiodonium inhibits the reaction [POR protein affects the metabolism of Nitrofurantoin]18206659
D009582NitrofurantoinNADP affects the reaction [POR protein affects the metabolism of Nitrofurantoin]18206659
D009582NitrofurantoinNitrofurantoin inhibits the reaction [POR protein results in increased metabolism of Misonidazole]6802140
D009582NitrofurantoinPOR protein affects the metabolism of Nitrofurantoin18206659
D009583Nitrofurazone[Nitrofurazone co-treated with POR protein co-treated with Copper] results in increased abundance of 8-oxo-7-hydrodeoxyguanosine15488632
D009583NitrofurazoneNitrofurazone inhibits the reaction [POR protein results in increased metabolism of Misonidazole]6802140
D009602Nitrosamines[CYP2E1 protein co-treated with POR protein co-treated with CYB5B protein] results in increased susceptibility to Nitrosamines11733072
C013161N-nitroso(di-n-propyl)amine[CYP2E1 protein co-treated with POR protein co-treated with CYB5B protein] results in increased susceptibility to N-nitroso(di-n-propyl)amine11733072
C013161N-nitroso(di-n-propyl)amine[CYP2E1 protein co-treated with POR protein] results in increased susceptibility to N-nitroso(di-n-propyl)amine11035158
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of POR mRNA20971185
C016340o,p'-DDT"o,p'-DDT affects the expression of POR mRNA"17984292
C012466oxadiazonoxadiazon results in increased expression of POR mRNA26710982
D010098OxycodoneOxycodone results in increased expression of POR mRNA23439660
D010100Oxygendiphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased metabolism of Oxygen]21215309
D010100Oxygendiphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Paraquat] which results in increased metabolism of Oxygen]21215309
D010100OxygenNADP promotes the reaction [[POR protein results in increased metabolism of Diquat] which results in increased metabolism of Oxygen]21215309
D010100OxygenNADP promotes the reaction [[POR protein results in increased metabolism of Paraquat] which results in increased metabolism of Oxygen]21215309
D010100OxygenPOR protein inhibits the reaction [Oxygen deficiency affects the localization of HMOX1 protein]22545110
D010100Oxygen[POR protein results in increased metabolism of Diquat] which results in increased metabolism of Oxygen21215309
D010100Oxygen[POR protein results in increased metabolism of Paraquat] which results in increased metabolism of Oxygen21215309
D010100OxygenCAT protein promotes the reaction [Oxygen inhibits the reaction [[Fe(III)-EDTA co-treated with NADP co-treated with POR protein] results in increased reduction of sodium chromate(VI)]]7741258
D010100OxygenMannitol inhibits the reaction [Oxygen inhibits the reaction [[Fe(III)-EDTA co-treated with NADP co-treated with POR protein] results in increased reduction of sodium chromate(VI)]]7741258
D010100OxygenOxygen inhibits the reaction [[Fe(III)-EDTA co-treated with NADP co-treated with POR protein] results in increased reduction of sodium chromate(VI)]7741258
D017239PaclitaxelPOR mRNA results in increased susceptibility to Paclitaxel15239142
D000073878Palm OilPalm Oil results in decreased expression of POR mRNA18042831
C016030pantogabpantogab results in increased expression of POR mRNA17379144
D010269ParaquatCAT protein inhibits the reaction [[POR protein results in increased metabolism of Paraquat] which results in increased abundance of Hydrogen Peroxide]21215309
D010269Paraquatdiphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Paraquat] which results in increased abundance of Hydrogen Peroxide]21215309
D010269Paraquatdiphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Paraquat] which results in increased abundance of Superoxides]21215309
D010269Paraquatdiphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Paraquat] which results in increased metabolism of NADP]21215309
D010269Paraquatdiphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Paraquat] which results in increased metabolism of Oxygen]21215309
D010269Paraquat[Iron co-treated with POR protein] results in increased metabolism of Paraquat21215309
D010269Paraquat[[Iron co-treated with POR protein] results in increased metabolism of Paraquat] which results in increased abundance of Hydroxyl Radical21215309
D010269ParaquatNADP promotes the reaction [[POR protein results in increased metabolism of Paraquat] which results in increased metabolism of Oxygen]21215309
D010269ParaquatPOR protein results in increased metabolism of Paraquat21215309
D010269Paraquat[POR protein results in increased metabolism of Paraquat] which results in increased abundance of Hydrogen Peroxide21215309
D010269Paraquat[POR protein results in increased metabolism of Paraquat] which results in increased abundance of Superoxides21215309
D010269Paraquat[POR protein results in increased metabolism of Paraquat] which results in increased metabolism of NADP21215309
D010269Paraquat[POR protein results in increased metabolism of Paraquat] which results in increased metabolism of Oxygen21215309
D010269ParaquatPOR protein results in increased susceptibility to Paraquat16495354
D010269ParaquatPOR protein results in increased susceptibility to Paraquat16495354
D010269ParaquatParaquat affects the expression of POR mRNA16854511
D010269ParaquatParaquat promotes the reaction [POR protein results in increased metabolism of Misonidazole]6802140
D010269ParaquatParaquat results in increased expression of POR mRNA17935786|2284637
D010416PentachlorophenolPentachlorophenol results in increased expression of POR mRNA18486366
D010424PentobarbitalPOR protein affects the susceptibility to Pentobarbital15328377
D010424PentobarbitalPOR protein results in increased export of Pentobarbital12697746
D010424PentobarbitalPOR protein results in increased metabolism of Pentobarbital12566435|1269774
C033094perfluorobutyric acidperfluorobutyric acid analog results in increased expression of POR mRNA21878386
C036567perfluorodecanoic acidperfluorodecanoic acid results in increased expression of POR mRNA23567314
C522391perfluorododecanoic acidperfluorododecanoic acid results in increased expression of POR mRNA23567314
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in increased expression of POR mRNA23567314
C479228perfluorohexanoic acidperfluorohexanoic acid results in increased expression of POR mRNA23567314
C101815perfluoro-n-heptanoic acidperfluoro-n-heptanoic acid results in increased expression of POR mRNA23567314
C101816perfluoro-n-nonanoic acidperfluoro-n-nonanoic acid results in increased expression of POR mRNA23567314
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of POR mRNA23567314
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of POR mRNA23567314
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of POR mRNA20936131
C076994perfluorooctane sulfonic acidPPARA protein inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of POR mRNA]20936131
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of POR mRNA23567314
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of POR mRNA18281256
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of POR mRNA18467677|2093613
C023036perfluorooctanoic acidPPARA protein promotes the reaction [perfluorooctanoic acid results in increased expression of POR mRNA]18467677
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of POR mRNA19162173
D010634PhenobarbitalPhenobarbital affects the expression of POR mRNA19159669
D010634PhenobarbitalPhenobarbital results in increased expression of POR mRNA19084549
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of POR mRNA15492232
D010634PhenobarbitalNR1I3 protein affects the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of POR mRNA]15492232
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of POR mRNA]19482888
D010634PhenobarbitalNR1I3 protein promotes the reaction [Phenobarbital results in increased expression of POR mRNA]19850644
D010634PhenobarbitalPhenobarbital results in increased activity of POR protein12051692
D010634PhenobarbitalPhenobarbital results in increased expression of POR mRNA19270015|1948288
D010634PhenobarbitalPhenobarbital results in increased expression of POR protein23091169
D010634PhenobarbitalPhenobarbital affects the activity of POR protein12807726
D010634PhenobarbitalPhenobarbital results in increased expression of POR mRNA12807726
D010634PhenobarbitalPhenobarbital results in increased expression of POR mRNA15089088|1694001
D010634PhenobarbitalPhenobarbital results in increased expression of POR protein24090815
D020113Phenolphthalein"Phenolphthalein inhibits the reaction [POR protein affects the reaction [Benzo(a)pyrene results in increased chemical synthesis of benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA]]"28111842
D010672PhenytoinPhenytoin results in increased activity of POR protein12051692
D010795Phthalic AcidsPhthalic Acids results in decreased expression of POR mRNA15728792
C060836pioglitazonepioglitazone results in increased expression of POR mRNA16597547
D010882Piperonyl Butoxide[Diethylnitrosamine co-treated with Piperonyl Butoxide] results in increased expression of POR mRNA19690152|2010138
D010882Piperonyl Butoxide[Piperonyl Butoxide co-treated with Diethylnitrosamine] results in increased expression of POR mRNA19690152
D010882Piperonyl ButoxidePiperonyl Butoxide results in increased expression of POR mRNA17014948|1969015
D010882Piperonyl ButoxidePiperonyl Butoxide results in increased expression of POR mRNA22484513
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of POR mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of POR mRNA17426115|1830175
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of POR mRNA]19850644
C006253pirinixic acidpirinixic acid results in increased expression of POR mRNA19162173
D010936Plant ExtractsNR1I3 gene mutant form inhibits the reaction [Plant Extracts results in increased expression of POR mRNA]26115596
D010936Plant Extracts[NR1I3 gene mutant form results in decreased susceptibility to Plant Extracts] inhibits the reaction [Plant Extracts results in increased expression of POR mRNA]26115596
D010936Plant ExtractsPlant Extracts results in increased expression of POR mRNA26115596
D011094Polyethyleneimine[Polyethyleneimine binds to Gold] which results in decreased expression of POR mRNA28433809
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of POR mRNA28903501
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of POR mRNA19162173
C045362prochloraz[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of POR mRNA29038839
C045950propiconazolepropiconazole results in increased expression of POR mRNA22334560|2397080
C045950propiconazolepropiconazole results in increased expression of POR mRNA19409404
D011441PropylthiouracilPropylthiouracil results in decreased expression of POR mRNA24780913
D015237DinoprostDinoprost results in increased expression of POR mRNA11517196
C010313pseudocumenepseudocumene results in decreased expression of POR protein17337753
C511975purpurin"3-amino-1-methyl-5H-pyrido(4,3-b)indole promotes the reaction [purpurin results in increased activity of POR protein]"12744663
C511975purpurinpurpurin results in increased activity of POR protein12744663
C010423pyrithione zincpyrithione zinc results in decreased expression of POR mRNA21424779
D011794QuercetinQuercetin inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]24120545
D011794QuercetinQuercetin results in decreased activity of POR protein14633740
D011794QuercetinQuercetin results in increased activity of POR protein15998352
D011794Quercetin[Quercetin co-treated with Dietary Fats] affects the expression of POR mRNA23359794
C059514resveratrol"resveratrol inhibits the reaction [POR protein affects the reaction [Benzo(a)pyrene results in increased chemical synthesis of benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA]]"28111842
C059514resveratrolresveratrol results in increased expression of POR protein25505154
C059514resveratrolresveratrol affects the expression of POR mRNA15748624
C059514resveratrolresveratrol results in increased expression of POR mRNA25905778
D012293RifampinRifampin results in increased activity of POR protein12051692
C089730rosiglitazonerosiglitazone results in increased expression of POR mRNA25572481
C089730rosiglitazone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of POR mRNA16054899
C089730rosiglitazonerosiglitazone results in increased expression of POR mRNA24848799
C089730rosiglitazonerosiglitazone results in increased expression of POR mRNA16597547|2151530
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of POR mRNA21427059
D012524SarinSarin results in decreased expression of POR mRNA19522546
D012524SarinSarin results in increased expression of POR mRNA19522546
D012643SeleniumSelenium results in increased expression of POR mRNA19244175
C009250sevofluranesevoflurane affects the expression of POR mRNA15967596
C440975silybinsilybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of POR mRNA]28619387
C017947sodium arsenitesodium arsenite affects the expression of POR mRNA19590694
C017947sodium arsenitesodium arsenite results in decreased expression of POR mRNA12760830
C017947sodium arsenitesodium arsenite results in increased expression of POR mRNA12016162
C017947sodium arsenitesodium arsenite results in decreased expression of POR mRNA11353140
C016104sodium bichromatesodium bichromate results in increased expression of POR mRNA12325037
C028982sodium chromate(VI)CAT protein promotes the reaction [Oxygen inhibits the reaction [[Fe(III)-EDTA co-treated with NADP co-treated with POR protein] results in increased reduction of sodium chromate(VI)]]7741258
C028982sodium chromate(VI)[Fe(III)-EDTA co-treated with NADP co-treated with POR protein] results in increased reduction of sodium chromate(VI)7741258
C028982sodium chromate(VI)HEPES promotes the reaction [[Fe(III)-EDTA co-treated with NADP co-treated with POR protein] results in increased reduction of sodium chromate(VI)]7741258
C028982sodium chromate(VI)Mannitol inhibits the reaction [Oxygen inhibits the reaction [[Fe(III)-EDTA co-treated with NADP co-treated with POR protein] results in increased reduction of sodium chromate(VI)]]7741258
C028982sodium chromate(VI)Oxygen inhibits the reaction [[Fe(III)-EDTA co-treated with NADP co-treated with POR protein] results in increased reduction of sodium chromate(VI)]7741258
D012969Sodium FluorideSodium Fluoride results in decreased expression of POR protein27548804
D053260SootSoot results in decreased expression of POR mRNA21914721
C075117squalestatin 1squalestatin 1 results in increased expression of POR mRNA27225895
C075117squalestatin 1squalestatin 1 results in increased expression of POR mRNA27225895
D013311StreptozocinStreptozocin results in increased expression of POR mRNA25905778
D020058StyrenePOR protein results in increased metabolism of Styrene22386858
D020058StyrenePOR protein results in increased susceptibility to Styrene22386858
C013690styrene oxidePOR protein results in increased chemical synthesis of styrene oxide22386858
D013481Superoxidesdiphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides]21215309
D013481Superoxidesdiphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Paraquat] which results in increased abundance of Superoxides]21215309
D013481Superoxides[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides21215309
D013481Superoxides[POR protein results in increased metabolism of Paraquat] which results in increased abundance of Superoxides21215309
D013481Superoxidesdiphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides]21215309
D013481Superoxides[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides21215309
D013481SuperoxidesPOR protein results in increased chemical synthesis of Superoxides27558805
C446685systhanesysthane results in increased expression of POR mRNA19409404
D0150852,4,5-Trichlorophenoxyacetic Acid"2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of POR mRNA"18579281
D016559TacrolimusPOR polymorphism affects the susceptibility to Tacrolimus24113216
C061133tamibarotenetamibarotene results in increased expression of POR mRNA15498508
D013629TamoxifenTamoxifen affects the expression of POR mRNA20937368
D013629TamoxifenTamoxifen results in increased expression of POR mRNA15089088
D013655Taurochenodeoxycholic AcidPOR gene mutant form results in increased abundance of Taurochenodeoxycholic Acid25034404
D013656Taurocholic AcidPOR gene mutant form results in decreased abundance of Taurocholic Acid25034404
D013657Taurodeoxycholic AcidPOR gene mutant form affects the abundance of Taurodeoxycholic Acid25034404
D013658Taurolithocholic AcidPOR gene mutant form results in increased abundance of Taurolithocholic Acid25034404
C031655tauroursodeoxycholic acidPOR gene mutant form affects the abundance of tauroursodeoxycholic acid25034404
C087114tebuconazoleNR1I3 promotes the reaction [tebuconazole results in increased expression of POR mRNA]25656644
C087114tebuconazoletebuconazole results in increased expression of POR mRNA25656644
C010347terbutrynePOR protein promotes the reaction [CYP1A2 protein results in increased metabolism of terbutryne]8971136
C501413tesaglitazartesaglitazar results in increased expression of POR mRNA21515302
D013739TestosteronePOR protein affects the metabolism of Testosterone15328377
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in increased expression of POR mRNA]20032058
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of POR mRNA20106945|2163298
D013749TetrachlorodibenzodioxinAHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of POR mRNA]22978700
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of POR mRNA21570461
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of POR mRNA"28433925
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of POR mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to POR gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of POR mRNA16960034|1794905
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of POR mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of POR mRNA21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of POR mRNA16960034
C027549thallium chlorideEdetic Acid inhibits the reaction [thallium chloride results in decreased activity of POR protein]17994580
C027549thallium chloridethallium chloride results in decreased activity of POR protein17994580
D008063Thioctic AcidThioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]24120545
D008063Thioctic AcidThioctic Acid results in decreased activity of POR protein16391466
D008063Thioctic AcidCYP1A1 protein affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]21932800
D008063Thioctic Acid[CYP1A1 protein co-treated with CYP1A2 protein] affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]21932800
D008063Thioctic Acid[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]21932800
D008063Thioctic AcidThioctic Acid results in decreased activity of POR protein21932800
D013974ThyroxineThyroxine results in increased expression of POR mRNA23935926
C049947tirapazaminePOR protein promotes the reaction [CYP2B6 protein results in increased susceptibility to tirapazamine]10919648
C009495titanium dioxidetitanium dioxide results in decreased expression of POR mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of POR mRNA27404394
D014050TolueneToluene affects the expression of POR mRNA18653662
D014050TolueneToluene results in increased activity of POR protein3080823
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in decreased expression of POR mRNA"17217560
D014191TranylcypromineTranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]24120545
D014212TretinoinTretinoin results in increased expression of POR mRNA15498508|1589460
C032910triadimefontriadimefon results in increased expression of POR mRNA19409404
C011559tributyltintributyltin results in increased expression of POR mRNA24848799
D014241TrichloroethylenePPARA protein inhibits the reaction [Trichloroethylene results in decreased expression of POR mRNA]15363585
C012589trichostatin Atrichostatin A affects the expression of POR mRNA28542535
C001899triptolidePOR protein affects the susceptibility to triptolide21596114
C001899triptolidePOR protein results in increased hydroxylation of and results in decreased abundance of triptolide21596114
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of POR mRNA"26179874
C057693troglitazonetroglitazone results in increased expression of POR mRNA19631733|2557248
C057693troglitazonetroglitazone results in increased expression of POR mRNA16597547
C112106UAB 30UAB 30 results in increased expression of POR mRNA23292798
D014520UrethaneUrethane results in increased expression of POR mRNA28818685
C073339usnic acid[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of POR mRNA22777745
C406224valdecoxibvaldecoxib results in increased expression of POR mRNA24136188
D014635Valproic AcidValproic Acid results in increased expression of POR mRNA29154799
D014635Valproic AcidValproic Acid affects the expression of POR mRNA17292431
D014635Valproic AcidValproic Acid results in increased expression of POR mRNA19136453|2142705
D001335Vehicle EmissionsVehicle Emissions affects the methylation of POR gene25560391
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of POR mRNA19165385
C025643vinclozolinvinclozolin results in decreased expression of POR mRNA23034163
D014800VitalliumVitallium analog results in increased expression of POR mRNA23825117
D014810Vitamin EVitamin E results in increased expression of POR mRNA19244175
D024483Vitamin K 3Vitamin K 3 results in increased expression of POR mRNA27558805
D024483Vitamin K 3NADP promotes the reaction [POR protein results in increased reduction of Vitamin K 3]27558805
D024483Vitamin K 3POR protein promotes the reaction [Vitamin K 3 results in increased chemical synthesis of Hydrogen Peroxide]27558805
D024483Vitamin K 3POR protein results in increased reduction of Vitamin K 327558805
D014859WarfarinPOR gene SNP affects the susceptibility to Warfarin27488389
D014992XylenesXylenes results in increased activity of POR protein3080823
D015215Zidovudinesilybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of POR mRNA]28619387
D015215Zidovudine[Zidovudine co-treated with Isoniazid] results in decreased expression of POR mRNA28619387
D015215ZidovudineZidovudine results in decreased expression of POR mRNA28619387
D015032ZincZinc deficiency results in decreased expression of POR mRNA12672911
D015032ZincZinc deficiency results in increased expression of POR mRNA19111725
D015032ZincZinc deficiency results in increased expression of POR protein8069767
D015032ZincZinc results in increased expression of POR mRNA17074742
D019287Zinc SulfateZinc Sulfate results in increased expression of POR mRNA17074742
C013738zingeronezingerone inhibits the reaction [Ethanol results in increased activity of POR protein]28442378

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003958NADPH-hemoprotein reductase activity-IBA21873635  
GO:0003958NADPH-hemoprotein reductase activity-IDA19448135  
GO:0003958NADPH-hemoprotein reductase activity-TAS2513880  10048323  
GO:0004128cytochrome-b5 reductase activity, acting on NAD(P)H-IEA-  
GO:0005515protein binding-IPI21081644  
GO:0008941nitric oxide dioxygenase activity-IEA-  
GO:0009055electron transfer activity-IEA-  
GO:0010181FMN binding-IBA21873635  
GO:0010181FMN binding-IEA-  
GO:0016491oxidoreductase activity-IBA21873635  
GO:0016709oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen-IBA21873635  
GO:0016787hydrolase activity-IEA-  
GO:0019899enzyme binding-IEA-  
GO:0047726iron-cytochrome-c reductase activity-IEA-  
GO:0050660flavin adenine dinucleotide binding-IBA21873635  
GO:0050660flavin adenine dinucleotide binding-IEA-  
GO:0050661NADP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0003420regulation of growth plate cartilage chondrocyte proliferation-IEA-  
GO:0006805xenobiotic metabolic process-TAS-  
GO:0007584response to nutrient-IEA-  
GO:0009437carnitine metabolic process-IEA-  
GO:0009725response to hormone-IBA21873635  
GO:0009812flavonoid metabolic process-IEA-  
GO:0018393internal peptidyl-lysine acetylation-IEA-  
GO:0019395fatty acid oxidation-IEA-  
GO:0022900electron transport chain-IEA-  
GO:0032332positive regulation of chondrocyte differentiation-IEA-  
GO:0032770positive regulation of monooxygenase activity-IDA19448135  
GO:0042493response to drug-IEA-  
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process-IEA-  
GO:0043602nitrate catabolic process-IEA-  
GO:0045542positive regulation of cholesterol biosynthetic process-IEA-  
GO:0045880positive regulation of smoothened signaling pathway-IEA-  
GO:0046210nitric oxide catabolic process-IEA-  
GO:0055114oxidation-reduction process-IDA19448135  
GO:0055114oxidation-reduction process-TAS10048323  
GO:0060192negative regulation of lipase activity-IEA-  
GO:0070988demethylation-IEA-  
GO:0071372cellular response to follicle-stimulating hormone stimulus-IEA-  
GO:0071375cellular response to peptide hormone stimulus-IEA-  
GO:0090031positive regulation of steroid hormone biosynthetic process-IEA-  
GO:0090346cellular organofluorine metabolic process-IDA19448135  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IEA-  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005829cytosol-IBA21873635  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA9618440  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211897Cytochrome P450 - arranged by substrate typeTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27815364Predictors of Variation in CYP2A6 mRNA, Protein, and Enzyme Activity in a Human Liver Bank: Influence of Genetic and Nongenetic Factors. (2017 Jan)Tanner JAJ Pharmacol Exp Ther
28712959Associations between long-term exposure to air pollution, glycosylated hemoglobin and diabetes. (2017 Oct)Honda TInt J Hyg Environ Health
26669712P450 (Cytochrome) Oxidoreductase Gene (POR) Common Variant (POR*28) Significantly Alters CYP2C9 Activity in Swedish, But Not in Korean Healthy Subjects. (2015 Dec)Hatta FHOMICS
25049215Gender differences in smoking among U.S. working adults. (2014 Oct)Syamlal GAm J Prev Med
22246422Influence of cytochrome P450 oxidoreductase genetic polymorphisms on CYP1A2 activity and inducibility by smoking. (2012 Feb)Dobrinas MPharmacogenet Genomics
26948458Genetic systems for a new approach to risk of progression of diabetic retinopathy. (2016 May)Pinazo-Duran MDArch Soc Esp Oftalmol
10089951Epidemiological analysis of site relationships of synchronous and metachronous multiple primary cancers in the National Cancer Center, Japan, 1962-1996. (1999 Feb)Kaneko SJpn J Clin Oncol
19863367Prevalence of chronic obstructive pulmonary disease in the U.S. working population: an analysis of data from the 1997-2004 National Health Interview Survey. (2009 Oct)Bang KMCOPD
20943827The role of parents, friends and teachers in adolescents' cigarette smoking and tombak dipping in Sudan. (2011 Mar)El-Amin Sel-TTob Control
29533167Systematic Transcreation of Self-Help Smoking Cessation Materials for Hispanic/Latino Smokers: Improving Cultural Relevance and Acceptability. (2018)Pineiro BJ Health Commun
9279292Chronic work stress is associated with atherogenic lipids and elevated fibrinogen in middle-aged men. (1997 Aug)Siegrist JJ Intern Med
27305182The Nursing Diagnosis of risk for pressure ulcer: content validation. (2016 Jun 14)Santos CTRev Lat Am Enfermagem
26123203Functional POR A503V is associated with the risk of bladder cancer in a Chinese population. (2015 Jun 30)Xiao XSci Rep
26858165Differences between Men and Women in Time Trends in Lung Cancer Mortality in Spain (1980-2013). (2016 Jun)Martin-Sanchez JCArch Bronconeumol
18544207Risk factors for symptoms of childhood asthma, allergic rhinoconjunctivitis and eczema in the Pacific: an ISAAC Phase III study. (2008 Jul)Foliaki SInt J Tuberc Lung Dis
22237992Prevalence and sociodemographic correlates of antinuclear antibodies in the United States. (2012 Jul)Satoh MArthritis Rheum
9168291Characteristics of women with and without breast augmentation. (1997 May 28)Cook LSJAMA
27271371Correlation of Cytochrome P450 Oxidoreductase Expression with the Expression of 10 Isoforms of Cytochrome P450 in Human Liver. (2016 Aug)Zhang HFDrug Metab Dispos
27660057Associations of cytochrome P450 oxidoreductase genetic polymorphisms with smoking cessation in a Chinese population. (2016 Dec)Li HHum Genet
9730028Characteristics related to the prevalence of minimal or mild endometriosis in infertile women. Canadian Collaborative Group on Endometriosis. (1998 Sep)Berube SEpidemiology
25331779Optimizing post-operative Crohn's disease treatment. (2014)Domenech EAnn Gastroenterol
25288136Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. (2015 May)Cornelis MCMol Psychiatry
27832238Smoking control: challenges and achievements. (2016 Jul-Aug)Silva LCJ Bras Pneumol
28678924Persistent Depressive Symptoms are Independent Predictors of Low-Grade Inflammation Onset Among Healthy Individuals. (2017 Jun 29)Franco FGMArq Bras Cardiol
23953181Metabolic syndrome and impaired health-related quality of life and in non-Hispanic White, non-Hispanic Blacks and Mexican-American Adults. (2013 Jul-Sep)Okosun ISDiabetes Metab Syndr
26851750The association between socioeconomic status and tumour stage at diagnosis of ovarian cancer: A pooled analysis of 18 case-control studies. (2016 Apr)Praestegaard CCancer Epidemiol
19936495Health behaviors among older adults with hypertension, Brazil, 2006. (2009 Nov)Lima e Costa MFRev Saude Publica
28528797A case-control study of non-AIDS-defining cancers in a prospective cohort of HIV-infected patients. (2018 Apr 23)Rodriguez Arrondo FMed Clin (Barc)
27706438[Social impact of literacy in the household: analysis of the association with smoking in illiterate co-residents in Brazil]. (2016 Jun)Ribeiro FGRev Panam Salud Publica
11605150Low fecal elastase-1 in type I diabetes mellitus. (2001 Oct)Icks AZ Gastroenterol
10320854High effort, low reward, and cardiovascular risk factors in employed Swedish men and women: baseline results from the WOLF Study. (1998 Sep)Peter RJ Epidemiol Community Health
27858151Chimney sweeps in Sweden: a questionnaire-based assessment of long-term changes in work conditions, and current eye and airway symptoms. (2017 Feb)Alhamdow AInt Arch Occup Environ Health
27683790THE ALCOHOL CONSUMPTION IS AMENDED AFTER BARIATRIC SURGERY? AN INTEGRATIVE REVIEW. (2016)Gregorio VDArq Bras Cir Dig
26617474Cultural Acceptability of a Smoking Relapse Prevention Intervention for Pregnant Women in Puerto Rico: Providers' Feedback. (2011 Sep)Litvin EBHisp Health Care Int
27759785PYOGENIC LIVER ABSCESS: DIAGNOSTIC AND THERAPEUTIC MANAGEMENT. (2016 Jul-Sep)Santos-Rosa OMArq Bras Cir Dig
21764051Passive smoking and behavioural problems in children: results from the LISAplus prospective birth cohort study. (2011 Nov)Tiesler CMEnviron Res
28746533Frequency of indeterminate results from an interferon-gamma release assay among HIV-infected individuals. (2017 May-Jun)Oliveira SMDVLJ Bras Pneumol
27533270Differences in foot self-care and lifestyle between men and women with diabetes mellitus. (2016 Aug 15)Rossaneis MARev Lat Am Enfermagem
24897523Self-reported adherence to medical treatment, breastfeeding behaviour, and disease activity during the postpartum period in women with Crohn's disease. (2014 Aug)Julsgaard MScand J Gastroenterol
28591252Impact of the Use of Different Diagnostic Criteria in the Prevalence of Dyslipidemia in Pregnant Women. (2017 Jul)Feitosa ACRArq Bras Cardiol
24448396Variation in P450 oxidoreductase (POR) A503V and flavin-containing monooxygenase (FMO)-3 E158K is associated with minor alterations in nicotine metabolism, but does not alter cigarette consumption. (2014 Mar)Chenoweth MJPharmacogenet Genomics
20583169Epidemiology of congenital idiopathic talipes equinovarus in Iowa, 1997-2005. (2010 Jul)Kancherla VAm J Med Genet A
24417179Influence of medical treatment, smoking and disease activity on pregnancy outcomes in Crohn's disease. (2014 Mar)Julsgaard MScand J Gastroenterol
23317262Association between GSTM1 polymorphism and nasopharyngeal cancer susceptibility: a meta-analysis. (2012)Sun ZFAsian Pac J Cancer Prev
27557802The interactive association of smoking and drinking levels with presence of periodontitis in South Korean adults. (2016 Aug 25)Lee MBMC Oral Health