Gene: RNF216

54476
CAHH|TRIAD3|U7I1|UBCE7IP1|ZIN
ring finger protein 216
protein-coding
7p22.1
Ensembl:ENSG00000011275 MIM:609948 Vega:OTTHUMG00000155500 UniprotKB:Q9NWF9
NG_029374.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.385e-1 (AD)  3.395e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs852519chr7:5656494 (GRCh38.p7)C>A / C>G / C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg27006914chr7:5717968RNF2162.200e-9Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SEC24C0.927
SYVN10.924
KHSRP0.924
TADA2B0.921
ZNF3840.92
SMG50.919
PI4KB0.916
SMG70.915
ELAVL10.914
YY10.913

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.724
OR4F29-0.662
OR6C74-0.272
KLRC2-0.243
KLRB1-0.241
HMHB1-0.23
IFNG-0.23
C5orf64-0.214
MTRNR2L9-0.211
NANOGNB-0.21

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D020106AcrylamideAcrylamide results in decreased expression of RNF216 mRNA28959563
D001151ArsenicArsenic affects the expression of RNF216 mRNA18414638
D001151ArsenicArsenic affects the methylation of RNF216 gene25304211
D001280AtrazineAtrazine results in decreased expression of RNF216 mRNA22378314
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of RNF216 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RNF216 mRNA22228805
C006780bisphenol Abisphenol A results in increased expression of RNF216 mRNA26063408
C006780bisphenol Abisphenol A results in increased methylation of RNF216 promoter27312807
C006780bisphenol Abisphenol A affects the expression of RNF216 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of RNF216 mRNA26079696
C584509C646 compoundC646 compound results in increased expression of RNF216 mRNA26191083
D003520CyclophosphamideCyclophosphamide results in decreased expression of RNF216 mRNA27281708
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of RNF216 mRNA21318169
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of RNF216 mRNA22079256
C082360fipronilfipronil results in decreased expression of RNF216 mRNA23962444
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RNF216 mRNA25613284
D016912Levonorgestrel[testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of RNF216 mRNA19074003
D010100OxygenOxygen deficiency results in increased expression of RNF216 mRNA24205000
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of RNF216 mRNA18593933
D010795Phthalic AcidsPhthalic Acids results in decreased expression of RNF216 mRNA21061450
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of RNF216 mRNA19710929
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of RNF216 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of RNF216 mRNA22079256
D012834SilverSilver results in decreased expression of RNF216 mRNA27131904
C010792testosterone undecanoate[testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of RNF216 mRNA19074003
C010792testosterone undecanoatetestosterone undecanoate results in increased expression of RNF216 mRNA19074003
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RNF216 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RNF216 mRNA19465110
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RNF216 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of RNF216 mRNA28065790
C057693troglitazonetroglitazone results in decreased expression of RNF216 mRNA28973697
C025643vinclozolinvinclozolin results in increased expression of RNF216 mRNA18940246
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of RNF216 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI19893624  
GO:0046872metal ion binding-IEA-  
GO:0061630ubiquitin protein ligase activity-EXP19893624  
GO ID GO Term Qualifier Evidence PubMed
GO:0006915apoptotic process-IEA-  
GO:0016032viral process-IEA-  
GO:0032480negative regulation of type I interferon production-TAS-  
GO:0032648regulation of interferon-beta production-IDA19893624  
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process-IDA19893624  
GO:0050691regulation of defense response to virus by host-IDA19893624  
GO:0070936protein K48-linked ubiquitination-IDA19893624  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168928DDX58/IFIH1-mediated induction of interferon-alpha/betaTAS
R-HSA-936440Negative regulators of DDX58/IFIH1 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal