Gene: DGCR8

54487
C22orf12|DGCRK6|Gy1|pasha
DGCR8, microprocessor complex subunit
protein-coding
22q11.21
Ensembl:ENSG00000128191 MIM:609030 Vega:OTTHUMG00000150503 UniprotKB:Q8WYQ5
NG_022931.1
PubMed
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.168e-1 (AD)  8.834e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NXF10.897
SRCAP0.893
HECTD30.89
SETD1A0.889
CNOT30.886
TSC10.884
GOLGA30.883
SMPD40.881
USP190.879
ACIN10.876

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.574
OR4F29-0.545
RPE65-0.322
TRDN-0.313
KLRC2-0.313
AGTR1-0.305
PON3-0.302
ODAM-0.301
SIM1-0.296
IAPP-0.294

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of DGCR8 mRNA"21346803
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of DGCR8 mRNA19770486
C006632arsenic trioxidearsenic trioxide results in decreased expression of DGCR8 mRNA22521957
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DGCR8 mRNA22228805
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of DGCR8 mRNA26496021
C044887beta-methylcholinebeta-methylcholine affects the expression of DGCR8 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of DGCR8 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of DGCR8 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of DGCR8 mRNA26496021
C018021cobaltous chloridecobaltous chloride results in decreased expression of DGCR8 mRNA19376846
D019327Copper SulfateCopper Sulfate results in decreased expression of DGCR8 mRNA19789285
D019327Copper SulfateCopper Sulfate results in increased expression of DGCR8 mRNA19789285
D003703DemecolcineDemecolcine results in decreased expression of DGCR8 mRNA23649840
D003976DiazinonDiazinon results in increased methylation of DGCR8 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of DGCR8 mRNA21266533
C000944dicrotophosdicrotophos results in increased expression of DGCR8 mRNA28302478
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of DGCR8 protein23301498
D005485FlutamideFlutamide results in decreased expression of DGCR8 mRNA24793618
D006418HemeDGCR8 protein binds to Heme21454614
D006418HemeDGCR8 protein mutant form binds to Heme21454614
C492448ICG 001ICG 001 results in increased expression of DGCR8 mRNA26191083
C051890irinotecanirinotecan analog results in decreased expression of DGCR8 mRNA18927307
D048628KetolidesKetolides analog results in increased expression of DGCR8 mRNA24967691
C008261lead acetatelead acetate results in decreased expression of DGCR8 mRNA11578147
C045463leflunomideleflunomide results in decreased expression of DGCR8 mRNA28988120
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of DGCR8 mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of DGCR8 mRNA"25554681|2562005
D010416PentachlorophenolPentachlorophenol results in increased expression of DGCR8 mRNA24642059
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of DGCR8 mRNA19710929
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of DGCR8 mRNA19710929
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of DGCR8 mRNA21334430
C045362prochlorazprochloraz results in increased expression of DGCR8 mRNA21470553
D011794QuercetinQuercetin results in increased expression of DGCR8 mRNA21632981
D012643Selenium[Selenium co-treated with Vitamin E] results in increased expression of DGCR8 mRNA19244175
D012643SeleniumSelenium results in increased expression of DGCR8 mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of DGCR8 mRNA25895662
D053260SootDGCR8 gene SNP affects the susceptibility to Soot20211803
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DGCR8 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DGCR8 mRNA28213091
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of DGCR8 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of DGCR8 mRNA25979313
D014750VincristineVincristine results in decreased expression of DGCR8 mRNA23649840
D014810Vitamin E[Selenium co-treated with Vitamin E] results in increased expression of DGCR8 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003725double-stranded RNA binding-IDA17704815  
GO:0004525ribonuclease III activitycontributes_toIDA15574589  
GO:0005515protein binding-IPI15574589  19626115  22222205  22796965  23602568  23995758  
24581491  25416956  26321680  26496610  
GO:0020037heme binding-IDA24449907  24910438  
GO:0042802identical protein binding-IPI15574589  17159994  
GO:0042803protein homodimerization activity-IDA15574589  
GO:0046872metal ion binding-IEA-  
GO:0070878primary miRNA binding-IDA24910438  
GO ID GO Term Qualifier Evidence PubMed
GO:0031053primary miRNA processing-IDA15531877  15574589  24449907  24910438  
GO:0072091regulation of stem cell proliferation-IEA-  
GO:0090502RNA phosphodiester bond hydrolysis, endonucleolytic-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA15574589  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IEA-  
GO:0005737cytoplasm-IDA-  
GO:0014069postsynaptic density-IEA-  
GO:0070877microprocessor complex-IDA15574589  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-203927MicroRNA (miRNA) biogenesisTAS
R-HSA-211000Gene Silencing by RNATAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23398123Downregulation of the microRNA biogenesis components and its association with poor prognosis in hepatocellular carcinoma. (2013 May)Kitagawa NCancer Sci
25495208Association of microRNA biogenesis pathway gene variants and alcohol dependence risk. (2015 Mar)Gedik HDNA Cell Biol