Gene: PRMT7

54496
SBIDDS
protein arginine methyltransferase 7
protein-coding
16q22.1
Ensembl:ENSG00000132600 MIM:610087 Vega:OTTHUMG00000137556 UniprotKB:Q9NVM4
NG_054896.1
SNP Mapped
1   ANCO-SNPs
AD
0   
1.690e-1 (AD)  9.796e-2 (ND)   (Frontal_Cortex)
6.210e-1 (AD)  6.571e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1111571chr16:68329278 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SARS20.93
RABL2B0.928
IFT1720.922
BRF10.921
ENDOV0.921
DMAP10.92
P4HTM0.917
MAN1B10.916
DDX510.915
L3MBTL20.914

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.521
MTRNR2L9-0.478
OR4F29-0.474
MTRNR2L6-0.467
MTRNR2L10-0.44
CXCR2-0.426
KCNJ15-0.425
FCGR3B-0.423
MTRNR2L8-0.414
CST7-0.41

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of PRMT7 mRNA"27291303
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PRMT7 mRNA"19114083
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of PRMT7 mRNA"20406850
D000082AcetaminophenAcetaminophen affects the expression of PRMT7 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of PRMT7 gene27153756
D001280AtrazineAtrazine results in increased expression of PRMT7 mRNA25929836
D001280AtrazineAtrazine results in decreased expression of PRMT7 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PRMT7 mRNA22228805
D001599BerberineBerberine results in increased expression of PRMT7 mRNA27311644
D004958Estradiol[Progesterone co-treated with Estradiol] affects the expression of PRMT7 mRNA17404688
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of PRMT7 mRNA22079614
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of PRMT7 mRNA28472532
C018021cobaltous chloridecobaltous chloride results in increased expression of PRMT7 mRNA24612858
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of PRMT7 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of PRMT7 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of PRMT7 mRNA20106945
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of PRMT7 mRNA23640034
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of PRMT7 mRNA]27941970
D004147DioxinsDioxins affects the expression of PRMT7 mRNA20463971
D004221DisulfiramDisulfiram results in decreased expression of PRMT7 mRNA20530235
D004317DoxorubicinDoxorubicin affects the expression of PRMT7 mRNA15699352
D004317DoxorubicinPRMT7 protein results in decreased susceptibility to Doxorubicin15699352
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PRMT7 mRNA17555576
D005485FlutamideFlutamide results in increased expression of PRMT7 mRNA24136188
C069837fullerene C60fullerene C60 results in decreased expression of PRMT7 mRNA19167457
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PRMT7 mRNA25613284
C544151jinfukangjinfukang results in increased expression of PRMT7 mRNA27392435
C045463leflunomideleflunomide results in decreased expression of PRMT7 mRNA28988120
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PRMT7 mRNA26011545
D009151Mustard GasMustard Gas results in increased expression of PRMT7 mRNA26392148
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PRMT7 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PRMT7 mRNA"25554681
C028007nickel monoxidenickel monoxide results in decreased expression of PRMT7 mRNA19167457
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of PRMT7 mRNA20971185
D010416PentachlorophenolPentachlorophenol results in increased expression of PRMT7 mRNA23892564
D010634PhenobarbitalPhenobarbital results in increased expression of PRMT7 mRNA19162173
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PRMT7 mRNA19710929
D010936Plant ExtractsPlant Extracts results in increased expression of PRMT7 mRNA23557933
D011374Progesterone[Progesterone co-treated with Estradiol] affects the expression of PRMT7 mRNA17404688
C009277sodium arsenatesodium arsenate results in increased expression of PRMT7 mRNA23922661
C017947sodium arsenitesodium arsenite results in increased expression of PRMT7 mRNA28595984
C016104sodium bichromatesodium bichromate results in increased expression of PRMT7 mRNA25993096
D012969Sodium FluorideSodium Fluoride results in increased expression of PRMT7 protein28918527
D013629TamoxifenTamoxifen affects the expression of PRMT7 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PRMT7 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PRMT7 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PRMT7 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of PRMT7 mRNA23411599
D013893ThiramThiram results in decreased expression of PRMT7 mRNA20530235
D014212TretinoinTretinoin results in increased expression of PRMT7 mRNA20530235
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of PRMT7 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PRMT7 mRNA"26179874

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008469histone-arginine N-methyltransferase activity-IBA21873635  
GO:0008469histone-arginine N-methyltransferase activity-IDA15494416  
GO:0008757S-adenosylmethionine-dependent methyltransferase activity-IDA15044439  
GO:0016274protein-arginine N-methyltransferase activity-TAS-  
GO:0016277[myelin basic protein]-arginine N-methyltransferase activity-IDA15494416  
GO:0035241protein-arginine omega-N monomethyltransferase activity-IBA21873635  
GO:0035241protein-arginine omega-N monomethyltransferase activity-IDA15044439  19110445  
GO:0035242protein-arginine omega-N asymmetric methyltransferase activity-IBA21873635  
GO:0035243protein-arginine omega-N symmetric methyltransferase activity-IDA15494416  19110445  
GO:0035243protein-arginine omega-N symmetric methyltransferase activity-IMP17709427  
GO:0042393histone binding-IC15494416  
GO:0043021ribonucleoprotein complex binding-IPI17709427  
GO:0044020histone methyltransferase activity (H4-R3 specific)-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000387spliceosomal snRNP assembly-IMP17709427  
GO:0006349regulation of gene expression by genetic imprinting-ISS-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IBA21873635  
GO:0016571histone methylation-IDA15494416  
GO:0018216peptidyl-arginine methylation-IDA15044439  
GO:0018216peptidyl-arginine methylation-IMP17709427  
GO:0019918peptidyl-arginine methylation, to symmetrical-dimethyl arginine-IEA-  
GO:0019919peptidyl-arginine methylation, to asymmetrical-dimethyl arginine-IBA21873635  
GO:0019919peptidyl-arginine methylation, to asymmetrical-dimethyl arginineNOTIBA21873635  
GO:0019919peptidyl-arginine methylation, to asymmetrical-dimethyl arginine-IEA-  
GO:0030154cell differentiation-IEA-  
GO:0034969histone arginine methylation-IBA21873635  
GO:0034969histone arginine methylation-ISS-  
GO:0043046DNA methylation involved in gamete generation-ISS-  
GO:0043393regulation of protein binding-IC15044439  
GO:0043985histone H4-R3 methylation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001650fibrillar center-IDA-  
GO:0005634nucleus-IDA15494416  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA15494416  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-3214858RMTs methylate histone argininesTAS
R-HSA-3247509Chromatin modifying enzymesTAS
R-HSA-4839726Chromatin organizationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal