Gene: SMOX

54498
C20orf16|PAO|PAO-1|PAO1|PAOH|PAOH1|SMO
spermine oxidase
protein-coding
20p13
Ensembl:ENSG00000088826 MIM:615854 Vega:OTTHUMG00000031777 UniprotKB:Q9NWM0
NC_000020.11
PubMed
0   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.174e-2 (AD)  7.336e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FAM181B0.879
PON20.879
DDR10.874
PBXIP10.866
SOX20.862
ITPKB0.859
PHGDH0.859
KLF150.859
EZR0.858
EPHX10.858

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF860-0.527
ARHGAP20-0.523
TYRP1-0.516
COL19A1-0.511
EPHA3-0.502
SAMD5-0.495
CDH7-0.493
KCNH1-0.493
CNTN6-0.49
OSBPL10-0.489

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00127SpermineSmall Molecule71-44-3Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of SMOX mRNA"25614096
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of SMOX mRNA"23829299
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of SMOX mRNA"18648102
D000079AcetaldehydeAcetaldehyde results in increased expression of SMOX mRNA23707493
D000079AcetaldehydeSMOX results in increased susceptibility to Acetaldehyde23707493
D000079Acetaldehyde[SMOX results in increased susceptibility to Acetaldehyde] which results in increased abundance of Acrolein23707493
D000082AcetaminophenAcetaminophen results in increased expression of SMOX mRNA11793227|2223033
D000082AcetaminophenAcetaminophen affects the expression of SMOX mRNA17562736
D000171Acrolein[SMOX results in increased susceptibility to Acetaldehyde] which results in increased abundance of Acrolein23707493
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SMOX mRNA21641981|2210060
D000393Air PollutantsAir Pollutants analog results in increased expression of SMOX mRNA21757418
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of SMOX mRNA"23195993
D000638AmiodaroneAmiodarone results in increased expression of SMOX mRNA19774075
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SMOX mRNA24449571
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of SMOX mRNA"24160326
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of SMOX mRNA"18687144
D001280AtrazineAtrazine results in increased expression of SMOX mRNA22378314
D001379AzathioprineAzathioprine results in increased expression of SMOX mRNA22623647
C547126AZM551248AZM551248 results in decreased expression of SMOX mRNA22323515
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with sodium bichromate] results in decreased expression of SMOX mRNA21632023
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SMOX mRNA20106945|2163298
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of SMOX mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SMOX mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SMOX mRNA19770486
D004958EstradiolESR2 protein affects the reaction [Estradiol results in increased expression of SMOX mRNA]14699072
D004958EstradiolEstradiol affects the expression of SMOX mRNA14699072
D004958EstradiolEstradiol results in increased expression of SMOX mRNA23019147|2686566
C006780bisphenol Abisphenol A results in increased expression of SMOX mRNA29275510
C006780bisphenol Abisphenol A results in decreased methylation of SMOX promoter27312807
C006780bisphenol Abisphenol A affects the expression of SMOX mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of SMOX mRNA20147733
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of SMOX mRNA15336504
D002110CaffeineCaffeine results in increased expression of SMOX mRNA11793227
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of SMOX mRNA27339419
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SMOX mRNA20938992
D002996ClomipheneClomiphene results in decreased expression of SMOX mRNA26865669
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of SMOX mRNA24690739
D019327Copper SulfateCopper Sulfate results in increased expression of SMOX mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of SMOX mRNA20106945|2556210
C007262deoxynivalenoldeoxynivalenol results in increased expression of SMOX mRNA26763390
D003907DexamethasoneDexamethasone results in decreased expression of SMOX mRNA25047013
C016366dibenzothiophenedibenzothiophene results in increased expression of SMOX mRNA23656968
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of SMOX mRNA28962523
D002945CisplatinCisplatin results in increased expression of SMOX mRNA24280081|2759478
D002945CisplatinCisplatin results in increased expression of SMOX mRNA15464296|1547189
D004041Dietary FatsDietary Fats results in decreased expression of SMOX mRNA18042831
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of SMOX mRNA17942915|2453584
D004052DiethylnitrosamineMET protein inhibits the reaction [Diethylnitrosamine results in increased expression of SMOX mRNA]17942915
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of SMOX mRNA26865669
D002117CalcitriolCalcitriol results in increased expression of SMOX mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of SMOX mRNA21592394
D004147DioxinsDioxins affects the expression of SMOX mRNA20463971
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of SMOX mRNA24690739
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of SMOX mRNA22079256
D004970EstroneEstrone results in increased expression of SMOX mRNA26865669
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SMOX mRNA17557909
D008656MestranolMestranol results in increased expression of SMOX mRNA26865669
D005472Fluorouracil[oxaliplatin co-treated with Fluorouracil] results in increased expression of and results in increased activity of SMOX protein17987291
D005472Fluorouracil[oxaliplatin co-treated with Fluorouracil] results in increased expression of SMOX mRNA17987291
D005485FlutamideFlutamide results in decreased expression of SMOX mRNA21126777
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SMOX mRNA20938992
C070081fulvestrantfulvestrant results in decreased expression of SMOX mRNA26865669
D019833GenisteinGenistein results in increased expression of SMOX mRNA23019147|2686566
D005839GentamicinsGentamicins results in decreased expression of SMOX mRNA22061828
D005947GlucoseGlucose results in increased expression of SMOX mRNA17178593
D006589HexestrolHexestrol results in increased expression of SMOX mRNA26865669
D017313FenretinideFenretinide results in increased expression of SMOX mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SMOX mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SMOX mRNA24796395
D007649KetamineKetamine results in increased expression of SMOX mRNA20080153
D007854LeadLead affects the expression of SMOX mRNA28903495
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in decreased expression of SMOX mRNA20843944
D008694MethamphetamineMethamphetamine results in increased expression of SMOX mRNA26307267
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SMOX mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SMOX mRNA23458150
C523799MRK 003SMOX results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SMOX mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SMOX mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in increased expression of SMOX mRNA19812364
D009532NickelNickel results in increased expression of SMOX mRNA23195993
C510784ormosil[ormosil binds to Polyethylene Glycols] which results in increased expression of SMOX mRNA24888373
C030110oxaliplatin[oxaliplatin co-treated with Fluorouracil] results in increased expression of and results in increased activity of SMOX protein17987291
C030110oxaliplatin[oxaliplatin co-treated with Fluorouracil] results in increased expression of SMOX mRNA17987291
D000073878Palm OilPalm Oil results in decreased expression of SMOX mRNA18042831
D010269ParaquatParaquat results in decreased expression of SMOX mRNA21371552
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of SMOX mRNA18593933
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of SMOX mRNA28511854
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of SMOX mRNA17097637
D010634PhenobarbitalPhenobarbital affects the expression of SMOX mRNA19159669
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SMOX mRNA19710929
D010938Plant OilsPlant Oils results in increased expression of SMOX mRNA23370395
D011092Polyethylene Glycols[ormosil binds to Polyethylene Glycols] which results in increased expression of SMOX mRNA24888373
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of SMOX mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of SMOX mRNA22079256
D011794QuercetinQuercetin results in increased expression of SMOX mRNA21632981
D012643SeleniumSelenium results in increased expression of SMOX mRNA19244175
D017632Asbestos, Serpentine"Asbestos, Serpentine affects the expression of SMOX mRNA"24160326
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of SMOX mRNA25895662
D012834SilverSilver results in increased expression of SMOX mRNA26014281
D012834SilverSilver results in increased expression of SMOX mRNA27131904
C016104sodium bichromate[Benzo(a)pyrene co-treated with sodium bichromate] results in decreased expression of SMOX mRNA21632023
D018038Sodium SeleniteSodium Selenite results in decreased expression of SMOX mRNA18175754
D013095Spermidine[SMOX protein results in increased oxidation of Spermine] which results in increased abundance of Spermidine23707493
D013096SpermineSMOX protein results in increased oxidation of Spermine23707493
D013096Spermine[SMOX protein results in increased oxidation of Spermine] which results in increased abundance of Spermidine23707493
D014284TriiodothyronineTriiodothyronine results in increased expression of SMOX mRNA19228888
C061133tamibarotenetamibarotene results in increased expression of SMOX mRNA15498508
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of SMOX mRNA21592394
D013739TestosteroneTestosterone results in increased expression of SMOX mRNA21592394
D013739TestosteroneTestosterone results in increased expression of SMOX mRNA20403060
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SMOX mRNA16443690
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SMOX mRNA12377990
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SMOX mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SMOX mRNA25613284
D013849ThimerosalThimerosal results in decreased expression of SMOX mRNA27188386
D013853ThioacetamideThioacetamide results in increased expression of SMOX mRNA11793227
D014212TretinoinTretinoin results in increased expression of SMOX mRNA15498508|1605412
C012589trichostatin Atrichostatin A results in increased expression of SMOX mRNA28542535
C012589trichostatin Atrichostatin A results in increased expression of SMOX mRNA15901671
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SMOX mRNA"26179874
D014520UrethaneUrethane results in increased expression of SMOX mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of SMOX gene29154799
D014635Valproic AcidValproic Acid affects the expression of SMOX mRNA17292431
D014635Valproic AcidValproic Acid results in increased expression of SMOX mRNA15901671
C029297vinylidene chloridevinylidene chloride results in increased expression of SMOX mRNA26682919
D014810Vitamin EVitamin E results in increased expression of SMOX mRNA19244175
D024483Vitamin K 3Vitamin K 3 affects the expression of SMOX mRNA20044591
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of SMOX mRNA18593933
C088658zoledronic acidzoledronic acid results in decreased expression of SMOX mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0016491oxidoreductase activity-IBA21873635  
GO:0046592polyamine oxidase activity-IBA21873635  
GO:0046592polyamine oxidase activity-IDA12477380  
GO:0052894norspermine:oxygen oxidoreductase activity-IEA-  
GO:0052895N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity-IEA-  
GO:0052901spermine:oxygen oxidoreductase (spermidine-forming) activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006596polyamine biosynthetic process-TAS-  
GO:0006598polyamine catabolic process-IDA12477380  
GO:0046208spermine catabolic process-IBA21873635  
GO:0046208spermine catabolic process-IEA-  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-TAS-  
GO:0031965nuclear membrane-IDA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-140179Amine Oxidase reactionsTAS
R-HSA-141334PAOs oxidise polyamines to aminesTAS
R-HSA-1430728MetabolismTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-351200Interconversion of polyaminesTAS
R-HSA-351202Metabolism of polyaminesTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal