Gene: POU2AF1

5450
BOB1|OBF-1|OBF1|OCAB
POU class 2 associating factor 1
protein-coding
11q23.1
Ensembl:ENSG00000110777 MIM:601206 Vega:OTTHUMG00000166659 UniprotKB:Q16633
NC_000011.10
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.586e-1 (AD)  3.519e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4356268chr11:111379925 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FXYD40.847
BTBD160.841
CLCA40.838
RHBDL20.83
ZFP570.826
RASGRP30.825
FOLH10.808
KIF60.807
ST180.806
LRRC630.804

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CUX2-0.479
TCERG1L-0.465
PCDH8-0.456
BEAN1-0.45
CDH22-0.444
CHRNA2-0.437
GPR153-0.436
PRDM11-0.432
MGAT5B-0.429
ASB2-0.428

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of POU2AF1 mRNA"27567155
D020106AcrylamideAcrylamide results in decreased expression of POU2AF1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of POU2AF1 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of POU2AF1 mRNA21298039
D0150812-Naphthylamine2-Naphthylamine results in decreased expression of POU2AF1 mRNA18247414
C547126AZM551248AZM551248 results in increased expression of POU2AF1 mRNA22323515
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of POU2AF1 mRNA26377693
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of POU2AF1 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of POU2AF1 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of POU2AF1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of POU2AF1 mRNA18247414|2623829
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of POU2AF1 mRNA21632981
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of POU2AF1 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of POU2AF1 mRNA21569818
C006780bisphenol Abisphenol A affects the methylation of POU2AF1 promoter27415467
C006780bisphenol Abisphenol A results in decreased expression of POU2AF1 mRNA25181051
D002737ChloropreneChloroprene results in decreased expression of POU2AF1 mRNA23125180
D002737ChloropreneChloroprene results in decreased expression of POU2AF1 mRNA23125180
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of POU2AF1 mRNA27858113
D003300CopperCopper deficiency results in increased expression of POU2AF1 mRNA26033743
D016572CyclosporineCyclosporine results in decreased expression of POU2AF1 mRNA25562108
D004008DiclofenacDiclofenac results in decreased expression of POU2AF1 mRNA26934552
C000944dicrotophosdicrotophos results in increased expression of POU2AF1 mRNA28302478
D019422Dietary SucroseDietary Sucrose results in increased expression of POU2AF1 mRNA26033743
D002117CalcitriolCalcitriol results in decreased expression of POU2AF1 mRNA12875902
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of POU2AF1 mRNA17555576
C039281furanfuran results in decreased expression of POU2AF1 mRNA25539665
C039281furanfuran results in increased expression of POU2AF1 mRNA27387713
D019833GenisteinGenistein results in increased expression of POU2AF1 mRNA22553218
D005839GentamicinsGentamicins results in increased expression of POU2AF1 mRNA22061828
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to POU2AF1 enhancer]24332044
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of POU2AF1 mRNA24332044|2675264
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of POU2AF1 protein24332044
C045463leflunomideleflunomide results in increased expression of POU2AF1 mRNA28988120
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of POU2AF1 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of POU2AF1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of POU2AF1 mRNA"25554681
D009532NickelNickel results in increased expression of POU2AF1 mRNA24768652|2558310
D009538NicotineNicotine results in decreased expression of POU2AF1 mRNA18247414
C484027oligofectamineoligofectamine results in increased expression of POU2AF1 mRNA14668052
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of POU2AF1 mRNA25729387
D011794QuercetinQuercetin results in decreased expression of POU2AF1 mRNA21632981
D012834SilverSilver results in increased expression of POU2AF1 mRNA27131904
C016104sodium bichromatesodium bichromate results in increased expression of POU2AF1 mRNA22561333
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of POU2AF1 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of POU2AF1 mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of POU2AF1 mRNA20159946
C009495titanium dioxidetitanium dioxide results in decreased expression of POU2AF1 mRNA27760801
C009495titanium dioxidetitanium dioxide results in increased expression of POU2AF1 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of POU2AF1 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of POU2AF1 mRNA12875902
D014241TrichloroethyleneTrichloroethylene results in increased methylation of POU2AF1 gene27618143
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of POU2AF1 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of POU2AF1 mRNA29024780
D014635Valproic AcidValproic Acid results in increased methylation of POU2AF1 gene29154799
D014750VincristineVincristine results in decreased expression of POU2AF1 mRNA23649840
D015032ZincZinc deficiency results in increased expression of POU2AF1 mRNA22171008

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA11380252  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IMP10329190  10541551  
GO:0000979RNA polymerase II core promoter sequence-specific DNA binding-IMP10541551  
GO:0003712transcription coregulator activity-TAS7859290  
GO:0003713transcription coactivator activity-IMP11380252  
GO:0005515protein binding-IPI11483518  
GO ID GO Term Qualifier Evidence PubMed
GO:0006366transcription by RNA polymerase II-TAS7859290  
GO:0006959humoral immune response-TAS7859290  
GO:0045944positive regulation of transcription by RNA polymerase II-IGI11380252  
GO ID GO Term Qualifier Evidence PubMed
GO:0090575RNA polymerase II transcription factor complex-IDA11380252  
GO:0090575RNA polymerase II transcription factor complex-IMP10329190  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26735770Network Analysis of Lung Transcriptomics Reveals a Distinct B-Cell Signature in Emphysema. (2016 Jun 1)Faner RAm J Respir Crit Care Med
26927796POU2AF1 Functions in the Human Airway Epithelium To Regulate Expression of Host Defense Genes. (2016 Apr 1)Zhou HJ Immunol