Gene: CPVL

54504
HVLP
carboxypeptidase, vitellogenic like
protein-coding
7p14.3
Ensembl:ENSG00000106066 MIM:609780 Vega:OTTHUMG00000023669 UniprotKB:Q9H3G5
NC_000007.14
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.626e-1 (AD)  8.077e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs13238274chr7:29140719 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs7776819chr7:29091146 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg00233633chr7:29153560CPVL7.800e-10Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AOAH0.902
TBXAS10.887
SYK0.877
TLR60.869
TLR70.868
RUNX10.868
MS4A70.867
PTPRC0.866
SIRPB20.864
TLR10.863

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNIP3-0.441
SOHLH1-0.436
NXPH3-0.432
CPLX3-0.421
RTN4R-0.42
NEUROD6-0.413
WNT7A-0.412
ASPDH-0.402
HES5-0.388
CHRNA4-0.388

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPVL mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPVL mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPVL mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPVL mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPVL mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPVL mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of CPVL mRNA22230336
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CPVL mRNA24449571
C547126AZM551248AZM551248 results in decreased expression of CPVL mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CPVL mRNA20106945|2231617
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of CPVL mRNA26496021
C006780bisphenol Abisphenol A affects the expression of CPVL mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of CPVL mRNA28079927
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of CPVL mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of CPVL mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CPVL gene28505145
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CPVL mRNA18804290
D019327Copper SulfateCopper Sulfate results in decreased expression of CPVL mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of CPVL mRNA25562108|2798913
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of CPVL mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of CPVL mRNA28302478
C118739entinostatentinostat results in increased expression of CPVL mRNA27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CPVL mRNA23550701
D007213IndomethacinIndomethacin results in increased expression of CPVL mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CPVL mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of CPVL mRNA27392435
C544151jinfukangjinfukang results in increased expression of CPVL mRNA27392435
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of CPVL mRNA18192897
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CPVL mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CPVL mRNA28001369
D008942MitoxantroneCPVL protein affects the susceptibility to Mitoxantrone16217747
C523799MRK 003MRK 003 results in decreased expression of CPVL mRNA21169257
C029938nickel sulfatenickel sulfate results in increased expression of CPVL mRNA22714537
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of CPVL mRNA23948077
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPVL mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of CPVL mRNA26272509
D011794QuercetinQuercetin results in decreased expression of CPVL mRNA21632981
C017947sodium arsenitesodium arsenite results in increased expression of CPVL mRNA12727804
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CPVL mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CPVL mRNA17275934
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CPVL mRNA25613284
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPVL mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of CPVL mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPVL mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CPVL mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of CPVL mRNA19101580|2317975
C034028vanadyl sulfatevanadyl sulfate results in increased expression of CPVL mRNA16330358
C111237vorinostatvorinostat results in increased expression of CPVL mRNA27188386
C088658zoledronic acidzoledronic acid results in decreased expression of CPVL mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004185serine-type carboxypeptidase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0051603proteolysis involved in cellular protein catabolic process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal