Gene: DHX29

54505
DDX29
DExH-box helicase 29
protein-coding
5q11.2
Ensembl:ENSG00000067248 MIM:612720 Vega:OTTHUMG00000162313 UniprotKB:Q7Z478
NG_051592.1
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.243e-1 (AD)  2.054e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs897669chr5:55263144 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg05573019chr5:54601993DHX29Gene body4.004e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FBXO380.931
BCLAF10.929
COG30.92
TEX100.918
ARCN10.915
PPP6C0.914
SRSF110.913
RIOK30.913
FAF20.908
TRIP120.908

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.634
OR4F29-0.606
MTRNR2L9-0.288
MTRNR2L6-0.278
MTRNR2L10-0.265
OR4F16-0.238
NKX6-1-0.237
KLRB1-0.223
KLRC2-0.222
C8orf74-0.218

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0152621,6-hexamethylene diisocyanate"1,6-hexamethylene diisocyanate affects the expression of DHX29 mRNA"19527780
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of DHX29 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of DHX29 mRNA19770486
C018453ammonium hexachloroplatinateammonium hexachloroplatinate affects the expression of DHX29 mRNA19527780
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DHX29 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DHX29 mRNA"26238291
C006780bisphenol Abisphenol A results in decreased expression of DHX29 mRNA25047013
C006780bisphenol Abisphenol A results in increased expression of DHX29 mRNA21932408
D019256Cadmium ChlorideCadmium Chloride affects the expression of DHX29 mRNA18804290
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of DHX29 gene20938992
C000944dicrotophosdicrotophos results in decreased expression of DHX29 mRNA28302478
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of DHX29 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DHX29 mRNA17942748
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of DHX29 gene20938992
D005839GentamicinsGentamicins results in increased expression of DHX29 mRNA22061828
C492448ICG 001ICG 001 results in decreased expression of DHX29 mRNA26191083
C492448ICG 001ICG 001 results in increased expression of DHX29 mRNA26191083
C544151jinfukangjinfukang results in decreased expression of DHX29 mRNA27392435
C008261lead acetate[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of DHX29 mRNA22839698
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of DHX29 gene20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of DHX29 mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of DHX29 mRNA"25554681
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of DHX29 mRNA23948077
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of DHX29 mRNA27153767
D011794QuercetinQuercetin results in decreased expression of DHX29 mRNA21632981
C017947sodium arsenitesodium arsenite results in decreased expression of DHX29 mRNA22714537
C004648testosterone enanthatetestosterone enanthate affects the expression of DHX29 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DHX29 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DHX29 mRNA17942748
D013752TetracyclineTetracycline results in increased expression of DHX29 mRNA16917069
C009495titanium dioxidetitanium dioxide results in decreased expression of DHX29 mRNA27760801
C015559trimellitic anhydridetrimellitic anhydride affects the expression of DHX29 mRNA19527780
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of DHX29 gene25560391
C017803zinc protoporphyrin[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of DHX29 mRNA22839698

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22681889  
GO:0003743translation initiation factor activity-IEA-  
GO:0005524ATP binding-IEA-  
GO:0034459ATP-dependent 3'-5' RNA helicase activity-IBA21873635  
GO:0043024ribosomal small subunit binding-IDA23706745  
GO:0045296cadherin binding-HDA25468996  
GO ID GO Term Qualifier Evidence PubMed
GO:0006413translational initiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IBA21873635  
GO:0016282eukaryotic 43S preinitiation complex-IDA23706745  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal